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Meningeal lymphatic vessel crosstalk with central nervous system immune cells in aging and neurodegenerative diseases

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Neural Regeneration Research 2025年第3期20卷 763-778页

作者： Minghuang Gao Xinyue Wang Shijie Su Weicheng Feng Yaona Lai Kongli Huang Dandan cao qi Wang Science and Technology Innovation Center Guangzhou University of Chinese MedicineGuangzhouGuangdong ProvinceChina Institute of Clinical Pharmacology Guangzhou University of Chinese MedicineGuangzhouGuangdong ProvinceChina The Sixth Affiliated Hospital Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina

Meningeal lymphatic vessels form a relationship between the nervous system and periphery, which is relevant in both health and disease. Meningeal lymphatic vessels not only play a key role in the drainage of brain metabolites but also contribute to antigen delivery and immune cell activation. The advent of novel genomic technologies has enabled rapid progress in the characterization of myeloid and lymphoid cells and their interactions with meningeal lymphatic vessels within the central nervous system. In this review, we provide an overview of the multifaceted roles of meningeal lymphatic vessels within the context of the central nervous system immune network, highlighting recent discoveries on the immunological niche provided by meningeal lymphatic vessels. Furthermore, we delve into the mechanisms of crosstalk between meningeal lymphatic vessels and immune cells in the central nervous system under both homeostatic conditions and neurodegenerative diseases, discussing how these interactions shape the pathological outcomes. Regulation of meningeal lymphatic vessel function and structure can influence lymphatic drainage, cerebrospinal fluid-borne immune modulators, and immune cell populations in aging and neurodegenerative disorders, thereby playing a key role in shaping meningeal and brain parenchyma immunity.

关键词： central nervous system meningeal lymphatic vessels immunity myeloid cells lymphatic cells neurodegenerative disease

Role of the globus pallidus in motor and non-motor symptoms of Parkinson's disease

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Neural Regeneration Research 2025年第6期20卷 1628-1643页

作者： Yimiao Jiang Zengxin qi Huixian Zhu Kangli Shen Ruiqi Liu Chenxin Fang Weiwei Lou Yifan Jiang Wangrui Yuan Xin cao Liang Chen qianxing Zhuang Department of Physiology School of MedicineNantong UniversityNantongJiangsu ProvinceChina Department of Neurosurgery Huashan HospitalShanghai Medical CollegeFudan UniversityShanghaiChina National Center for Neurological Disorders ShanghaiChina Shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration ShanghaiChina State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Institute of Brain ScienceFudan UniversityShanghaiChina

The globus pallidus plays a pivotal role in the basal ganglia circuit. Parkinson's disease is characterized by degeneration of dopamine-producing cells in the substantia nigra, which leads to dopamine deficiency in the brain that subsequently manifests as various motor and non-motor symptoms. This review aims to summarize the involvement of the globus pallidus in both motor and non-motor manifestations of Parkinson's disease. The firing activities of parvalbumin neurons in the medial globus pallidus, including both the firing rate and pattern, exhibit strong correlations with the bradykinesia and rigidity associated with Parkinson's disease. Increased beta oscillations, which are highly correlated with bradykinesia and rigidity, are regulated by the lateral globus pallidus. Furthermore,bradykinesia and rigidity are strongly linked to the loss of dopaminergic projections within the cortical-basal ganglia-thalamocortical loop. Resting tremors are attributed to the transmission of pathological signals from the basal ganglia through the motor cortex to the cerebellum-ventral intermediate nucleus circuit. The cortico–striato–pallidal loop is responsible for mediating pallidi-associated sleep disorders. Medication and deep brain stimulation are the primary therapeutic strategies addressing the globus pallidus in Parkinson's disease. Medication is the primary treatment for motor symptoms in the early stages of Parkinson's disease, while deep brain stimulation has been clinically proven to be effective in alleviating symptoms in patients with advanced Parkinson's disease,particularly for the movement disorders caused by levodopa. Deep brain stimulation targeting the globus pallidus internus can improve motor function in patients with tremordominant and non-tremor-dominant Parkinson's disease, while deep brain stimulation targeting the globus pallidus externus can alter the temporal pattern of neural activity throughout the basal ganglia–thalamus network. Therefore, the comp

关键词： anxiety basal ganglia bradykinesia deep brain stimulation depression globus pallidus externus globus pallidus internus lateral globus pallidus medial globus pallidus neural circuit Parkinson's disease

Electrocatalytic cleavage of a lignin β-O-4 model compound and coupling with nitrogen-containing aromatics using Prussian blue analogue-derived nickel–cobalt spinel

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Journal of Energy Chemistry 2025年第1期100卷 628-636页

作者： Yi qi Xueying Chen Bowen Liu Xuliang Lin Xueqing qiu Yanlin qin Guangdong Provincial Key Laboratory of Plant Resources Biorefinery School of Chemical Engineering and Light Industry Guangdong University of Technology Guangdong Provincial Laboratory of Chemistry and Fine Chemical Engineering Jieyang Center Guangdong Basic Research Center of Excellence for Ecological Security and Green Development Guangdong University of Technology

Electrochemical conversion of lignin for the production of high-value heterocyclic aromatic compounds has great *** demonstrate the targeted synthesis and cation modulation of NiCo2O4spinel nanoboxes,synthesized via cation exchange and calcination *** catalysts exhibit excellent efficacy in the electrocatalytic conversion of lignin model compounds,specifically 2-phenoxy-1-phenylethanol,into nitrogen-containing aromatics,achieving high conversion rates and *** catalysts were synthesized via a cation exchange and calcination oxidation process,using Prussian blue nanocubes as *** porous architecture and polymetallic composition of the NiCo2O4spinel demonstrated superior performance in electrocatalytic oxidative coupling,achieving a 99.2 wt%conversion rate of the 2-phenoxy-1-phenylethanol with selectivities of 37.5 wt%for quinoline derivatives and 31.5 wt%for *** innovations include the development of a sustainable one-pot synthesis method for quinoline derivatives,the elucidation of a multistage reaction pathway involving cao bond cleavage,hydroxyaldol condensation,and CAN bond formation,and a deeper mechanistic understanding derived from DFT *** work establishes a new strategy for lignin valorization,offering a sustainable route to produce high-value nitrogen-containing aromatics from renewable biomass under mild conditions,without the need for additional reagents.

关键词： Spinel Biomass valorization Electrocatalysis Lignin oxidation Coupling

Progress in studying entanglement and steering from the macroscopic view

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Science China(Physics,Mechanics & Astronomy) 2021年第1期64卷 114-115页

作者： ye cao School of Physics Beijing Institute of TechnologyBeijing 100081China

Magnons,the collective excitation of magnetically ordered materials,have attracted considerable interest for their low energy consumption,long coherence time and useful working frequency from gigahertz to ***,magnons can coherently interact with phonons,microwave and optical photons,as well as superconducting qubits,as schematically depicted in Figure 1,providing a novel platform to achieve hybrid quantum systems[1].Hybridizing distinct quantum systems with multitasking capabilities is critical in quantum information processing,because a single quantum system cannot keep pace with the fast development of quantum information and satisfy the requirement of building perfect quantum information networks[2].The emergying field cavity spintronics has inspired many interesting physics like nonreciprocal microwave propagation and energy level attraction,together with quite a few applications such as magnon sensors and magnon-photon transducers.

关键词： quantum microwave Figure

Fermi polarons in a driven-dissipative background medium

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Science China(Physics,Mechanics & Astronomy) 2022年第11期65卷 97-106页

作者： ye cao Jing Zhou School of Physics Beijing Institute of TechnologyBeijing 100081China Department of Science Chongqing University of Posts and TelecommunicationsChongqing 400065China

The study of the polaron of an open quantum system plays an important role in verifying the effectiveness of an approximate many-body theory and predicting novel quantum phenomena in open quantum systems. In a pioneering work, Piazza et al.(2021) proposed a Fermi-polaron scheme with a lossy impurity, which exhibits a novel long-lived attractive polaron branch in the quantum Zeno limit. However, we have encountered a counterpart problem in which an impurity interacting with an open quantum bath scatters exciting polarons, which is what we focus on. In this work, we determine through analytical research the molecular state under the two limits of vanishingly small and infinitely large dissipation intensities as well as the reason why the dissipation range leads to a decrease in the gap between the molecular state and the molecule-hole continuum in the former *** spectrum functions of molecular and polaron states with different dissipation ranges and loss rates are investigated. We find the spectral signals of molecular and polaron states will first diffuse and then revive as the dissipation increases. Moreover, we show that the attractive and repulsive polarons respond differently to an increasing dissipation range in our model. Finally, we exhibit the polaron energy, residue, effective mass, and two-body decay for mass-balanced and imbalanced systems. Our results might be useful for cold-atom experiments on open quantum systems.

关键词： quantum Zeno dynamics open systems quantum statistical methods decoherence

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Solution-phase Synthesis of One-dimensional Semiconductor Nanostructures

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Journal of Materials Science & Technology 2008年第4期24卷 529-540页

作者： Jianfeng ye Limin qi Beijing National Laboratory for Molecular Sciences （BNLMS） State Key Laboratory for Structural Chemistry of Unstable and Stable Species College of Chemistry Peking University Beijing 100871 China

The synthesis of one-dimensional （1D） semiconductor nanostructures has been studied intensively for a wide range of materials due to their unique structural and physical properties and promising potential for future technological applications. Among various strategies for synthesizing 1D semiconductor nanostructures, solution-phase synthetic routes are advantageous in terms of cost, throughput, modulation of composition, and the potential for large-scale and environmentally benign production. This article gives a concise review on the recent developments in the solution-phase synthesis of ID semiconductor nanostructures of different compositions, sizes, shapes, and architectures. We first introduce several typical solution-phase synthetic routes based on controlled precipitation from homogeneous solutions, including hydrothermal/solvothermal process, solution-liquid-solid （SLS） process, high-temperature organic-solution process, and low-temperature aqueous-solution process. Subsequently, we discuss two solution-phase synthetic strategies involving solid tem- plates or substrates, such as the chemical transformation of 1D sacrificial templates and the oriented growth of 1D nanostructure arrays on solid substrates. Finally, prospects of the solution-phase approaches to 1D semiconductor nanostructures will be briefly discussed.

关键词： Solution-phase synthesis One-dimensional Nanostructures Semiconductor

Enhanced thermoelectric performance of Bi2Se3/TiO2 composite

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Rare Metals 2020年第8期39卷 887-894页

作者： Yu-Xi Yang ye-Hao Wu qi Zhang Gao-Shao cao Tie-Jun Zhu Xin-Bing Zhao State Key Laboratory of Silicon Materials School of Materials Science and EngineeringZhejiang UniversityHangzhou 310027China

Bi2(Te,Se)3 alloys are conventional commercial thermoelectric materials for solid-state refrigeration around room *** recent years,much attention has been paid to various advanced thermoelectric composite materials due to the unique thermoelectric *** this work,Bi2Se3/TiO2 composites were prepared by hot pressing the plate-like Bi2Se3 powders coated in situ with hydrolyzed hytetabutyl-n-butyl titanate(TNBT),and therefore numerous TiO2 in micrometer size could be formed on the interface of Bi2Se3 *** carrier concentration in Bi2Se3 matrix is optimized subject to the addition of n-type semiconductor TiO2,contributing to a significant improved power *** the meantime,the lattice thermal conductivity is also suppressed due to the enhanced phonon scattering at Bi2Se3/TiO2 interface and amorphous TiO2 *** a consequence,a peak figure of merit(zT)of 0.41 is obtained at 525 K in Bi2Se3/15 mol%TiO2 composites,nearly 50%augment over the pristine Bi2Se3 binary compound.

关键词： Bi2(Te,Se)3 Thermoelectric materials TiO2 Composite

Recent advances in fabrication of monolayer colloidal crystals and their inverse replicas

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Science China Chemistry 2014年第1期57卷 58-69页

作者： ye XiaoZhou qi LiMin Beijing National Laboratory for Molecular Sciences State Key Laboratory for Structural Chemistry of Unstable and Stable Species College of Chemistry Peking University

Monolayer colloidal crystals(MCCs)are two-dimensional(2D)colloidal crystals consisting of a monolayer of monodisperse colloidal particles arrayed with a 2D periodic *** recent years,MCCs have attracted intensive interest because they can act as 2D photonic crystals and be used as versatile templates for fabrication of various 2D nanostructure *** this review,we provide an overview of the recent progress in the controllable fabrication of MCCs and their inverse ***,some newly-developed methods for the self-assembly of MCCs based on different strategies including interfacial assembly and convective assembly are ***,some representative novel methods regarding the fabrication of various functional2D inverse replicas of MCCs,such as 2D arrays of nanobowls,nanocaps,and hollow spheres,as well as 2D monolayer inverse opals(MIOs),are *** addition,the potential applications of MCCs and their inverse replicas are discussed.

关键词： monolayer colloidal crystals,2D inverse replica,nanosphere lithography,self-assembly,replication,fabrication method

A comparative analysis of differentially expressed genes in rostral and caudal regions after spinal cord injury in rats

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Neural Regeneration Research 2022年第10期17卷 2267-2271页

作者： Xue-Min cao Sheng-Long Li Yu-qi cao ye-Hua Lv Ya-Xian Wang Bin Yu Chun Yao Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology ProductsCo-innovation Center of NeuroregenerationNantong UniversityNantongJiangsu ProvinceChina

The initial mechanical damage of a spinal cord injury(SCI)triggers a progressive secondary injury cascade,which is a complicated process integrating multiple systems and *** is crucial to explore the molecular and biological process alterations that occur after SCI for therapy *** differences between the rostral and caudal regions around an SCI lesion have received little ***,we analyzed the differentially expressed genes between rostral and caudal sites after injury to determine the biological processes in these two segments after *** identified a set of differentially expressed genes,including Col3a1,Col1a1,Dcn,Fn1,Kcnk3,and Nrg1,between rostral and caudal regions at different time points following *** enrichment analysis indicated that these genes were involved in response to mechanical stimulus,blood vessel development,and brain *** then chose Col3a1,Col1a1,Dcn,Fn1,Kcnk3,and Nrg1 for quantitative real-time PCR and Fn1 for immunostaining *** results indicate alterations in different biological events enriched in the rostral and caudal lesion areas,providing new insights into the pathology of SCI.

关键词： biological process caudal differentially expressed genes Gene Ontology hemisection immunostaining Rattus norvegicus RNA-sequencing rostral spinal cord injury