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中国人群经典型家族性腺瘤性息肉病的临床、病理和分子特征

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中华结直肠疾病电子杂志 2024年第1期13卷 38-44页

作者：卢斌张天琪徐烨刘方奇武警上海市总队医院外二科上海201103 复旦大学附属肿瘤医院大肠外科上海200032

目的分析中国人群经典型家族性腺瘤性息肉病(FAP)患者的临床病理特征以及基因型和表型的关系。方法纳入2006年1月至2022年12月复旦大学附属肿瘤医院诊治的69例经典型FAP患者为研究对象,通过二代测序技术行基因检测,分析患者的临床病理... 详细信息

目的分析中国人群经典型家族性腺瘤性息肉病(FAP)患者的临床病理特征以及基因型和表型的关系。方法纳入2006年1月至2022年12月复旦大学附属肿瘤医院诊治的69例经典型FAP患者为研究对象,通过二代测序技术行基因检测,分析患者的临床病理特征、基因型与临床表型的关系。结果在69例经典型FAP患者中,40例(58%)患者有明确家族史,癌变中位年龄34(28,42)岁;有49例(71%)患者检出APC致病性胚系突变,20例(29%)则未检出,无APC突变的患者平均年龄可能更大(39.2±13.3 vs.34.1±9.9,t=-1.723,P=0.089),合并肠外病变的比例可能较低(30%vs.51%,χ^(2)=2.536,P=0.111);31例患者合并结肠外病变,其中胃和十二指肠息肉(20例)最常见,好发于胃底胃体;其次是硬纤维瘤(13例),多在术后2年内发病,以育龄期女性为主,好发于腹腔和腹壁;还发现甲状腺癌(3例)、子宫肌瘤(2例)和肾上腺肿瘤(1例);p.E1309Dfs突变最常见,与胃十二指肠息肉、硬纤维瘤、子宫肌瘤和肾上腺腺瘤有关;另发现p.Y935^(*)突变的患者可同时合并胃十二指肠息肉、硬纤维瘤和甲状腺癌。结论中国人群经典型FAP患者中,无家族史者较多,无APC突变者合并肠外病变的比例可能较低,探索APC突变和表型的关系有助于该疾病的诊治。

关键词：家族性腺瘤性息肉病胚系突变 APC基因基因型-表型

Application of imaging techniques in pancreaticobiliary maljunction

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World Journal of Clinical Cases 2022年第22期10卷 7642-7652页

作者： Jin-ye Wang Pei-Yuan Mu ye-Kai xu Yuan-Yuan Bai Dong-Hua Shen Department of Hepatobiliary Surgery Postgraduate Training Base of Jinzhou Medical UniversityThe PLA Rocket Force Characteristic Medical CenterBeijing 100088China Department of Hepatobiliary Surgery The PLA Rocket Force Characteristic Medical CenterBeijing 100088China Department of Ultrasound The PLA Rocket Force Characteristic Medical CenterBeijing 100088China

Imaging techniques are useful tools in the diagnosis and treatment of pancreaticobiliary maljunction(PBM).PBM is a precancerous lesion often relative to the disease of the pancreas and biliary tract,for example,cholecystolithiasis,protein plugs,and *** patients with PBM,early diagnosis and timely treatment are highly important,which is largely dependent on imaging *** continuous development of imaging techniques,including endoscopic retrograde cholangiopancreatography,magnetic resonance cholangiopancreatography,computed tomography,ultrasound,and intraoperative cholangiography,has provided appropriate diagnostic and therapeutic tools for *** techniques,including non-invasive and invasive,have distinct advantages and *** purpose of this paper is to review the application of various imaging techniques in the diagnosis and treatment of PBM.

关键词： Pancreaticobiliary maljunction Endoscopic retrograde cholangiopancreatography Magnetic resonance cholangiopancreatography Ultrasound Computed tomography Intraoperative cholangiography

Color-tunable circularly polarized electroluminescence from a helical chiral multiple resonance emitter with B–N bonds

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中国科学:化学英文版 2023年第9期66卷 2612-2620页

作者： Li Yuan Zhen-Long Tu Jun-Wei xu Hua-Xiu Ni Zhi-Ping Mao Wen-ye xu You-xuan Zheng State Key Laboratory of Coordination Chemistry Collaborative Innovation Center of Advanced MicrostructuresJiangsu Key Laboratory of Advanced Organic MaterialsSchool of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023China Shenzhen Institute of Information Technology Shenzhen 518172China School of Materials and Energy University of Electronic Science and Technology of ChinaChengdu 611731China Guangzhou Research&Creativity Biotechnology Co.Ltd. Guangzhou 510700China

Chiral B,N-doped polycyclic aromatic hydrocarbons with circularly polarized luminescence(CPL) and small full-width at halfmaxima(FWHM) are promising multiple resonance(MR) emitters for CP organic light-emitting diodes(CP-OLEDs).This work presents a pair of chiral MR enantiomers,P/M-o[B-N]_(2)N_(2),featuring B–N bonds incorporated within a[7]-helicene *** enantiomers exhibit narrow 0-0 and 0-1 electronic transition bands,whose relative intensity can be fine-tuned by increasing doping concentrations,resulting in redshifts of the emission peak from 542 to 592 *** enantiomers show mirrorsymmetric CPL spectra with an asymmetry factor(|g_(PL)|) of 1.0×10^(-3).The hyperfluorescent CP-OLEDs with double-sensitized emitting layers display a FWHM of 33 nm,an external quantum efficiency of 25.1%,and a|g_(EL)|factor of 7.7×10^(-4).Notably,the CP-OLEDs realize color-tunable CP electroluminescence peak from 553 to 613 nm by regulating the vibrational *** work provides a novel concept for the design of helical CP-MR materials and CP-OLEDs,highlighting their potential for future applications in advanced optoelectronic devices.

关键词： chiral multiple resonance material helical chirality circularly polarized luminescence narrowband emission color-tunable circularly polarized electroluminescence

Stem cell niche-inspired microcarriers with ADSCs encapsulation for diabetic wound treatment

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Bioactive Materials 2023年第8期26卷 159-168页

作者： Xiangyi Wu Haofang Zhu Junyi Che ye xu Qian Tan Yuanjin Zhao Department of Burns and Plastic Surgery Institute of Translational MedicineThe Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing210002China Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)Wenzhou InstituteUniversity of Chinese Academy of SciencesWenzhouZhejiang325000China

Stem cell therapies have made great progress in the treatment of diabetic wounds during recent decades,while their short in vivo residence,alloimmune reactions,undesired behaviors,and dramatic losses of cell functions still hinder the translation of them into ***,inspired by the natural components of stem cell niches,we presented novel microfluidic hydrogel microcarriers with extracellular matrix(ECM)-like composition and adipose-derived stem cells(ADSCs)encapsulation for diabetic wound *** the hydrogel was synthesized by conjugating hyaluronic acid methacryloyl(HAMA)onto the Fibronectin(FN)molecule chain(FN-HAMA),the laden ADSCs in the microcarriers showed improved bioactivities and pro-regenerative *** on these features,we have demonstrated that these ADSCs microcarriers exhibited significant promotion of neovascularization,follicular rejuvenation,and collagen deposition in a mouse diabetic wound *** results indicated that the stem cell niche-inspired FN-HAMA microcarriers with ADSCs encapsulation have great clinical potential for diabetic wound treatment.

关键词： Stem cell Bio-inspired Microfluidics Microcarrier Wound healing Hydrogel

Chronic wounds:pathological characteristics and their stem cell-based therapies

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再生工程(英文) 2023年第1期4卷 81-94页

作者： Xiangyi Wu Haofang Zhu ye xu Bin Kong Qian Tan Department of Burns and Plastic Surgery Institute of Translational MedicineThe Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing 210002China Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging Department of Biomedical Engineering School of MedicineShenzhen UniversityShenzhen 518060China

Chronic wounds are characterized by prolonged healing processes and poor prognoses,which have substantially impacted human health and daily *** treatment strategies have various limitations and ***,fully effective therapeutic approaches remain urgently *** cell(SC)-based therapies have drawn significant attention for their abilities of immunomodulation and *** has been demon-strated that stem cells(SCs)can improve angiogenesis,collagen deposition,and hair rejuvenation,thus facilitating wound *** addition,attempts were performed to facilitate the cell survival,function,retention,and en-graftment of the delivered *** this review,we first introduce the pathological process involved in chronic wound *** that,the mechanism of SCs in promoting chronic wound repair is discussed in ***,we highlight recent SC-based therapies for chronic wound repair ***,we present our views on the remaining challenges and future trends of SC-based therapies for chronic wound treatment.

关键词： Chronic wounds Stem cell Cell scaffold Cell-free therapy Gene modification

Morphology and gene expression of sex‐determining region Y‐box 9 and runt‐related transcription factor 2 in centrifugally compressed cell collagen‐combined constructs (C^(6))

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Biosurface and Biotribology 2023年第3期9卷 78-83页

作者： xu ye Masashi Yamazaki Wataru Ando Norimasa Nakamura Hiromichi Fujie Faculty of System Design Tokyo Metropolitan UniversityTokyoJapan Research Center for Medicine‐Engineering Collaboration TokyoJapan Department of Orthopaedic Surgery Kansai Rosai HospitalAmagasakiJapan Department of Orthopaedic Surgery Osaka University Graduate School of MedicineSuitaJapan Institute for Medical Science in Sports Osaka Health Science UniversityOsakaJapan Center for Advanced Medical Engineering and Informatics Osaka UniversitySuitaJapan

The authors previously developed a scaffold‐free tissue‐engineered construct(TEC)from mesenchymal stem cells(MSCs).Although the TEC exhibited even cell distribution and was successfully applied for cartilage repair in animal models,it is unsuitable for relatively large‐scale cartilage defects due to its small *** solve the problem,the authors recently developed a novel biomaterial,a centrifugally compressed cell‐collagen combined construct(C^(6))from a mixture of MSCs and atelocollagen,both of which are subjected to *** results of the previous study indicated that C^(6) exhibited high cell viability(70%)and sufficient cell distribution similar to that of the *** the present study,the morphology and gene expression of C^(6) were *** ex-amination indicated that C6 is six times thicker(approximately 1 mm)than the TEC after a 7‐day *** C^(6) remained unchanged in scale with increased cell density after a 21‐day *** electron microscopic observation indicated that C^(6) exhibited interconnected and porous microstructures,while the TEC had close‐knit *** transcriptase‐polymerase chain reaction analysis indicated that the expression of sex‐determining region Y‐box 9 and runt‐related transcription factor 2 was significantly higher in C^(6) than that in TEC.

关键词： biomaterials cartilage microstructures

3D coarse-grained DPM simulation of the MIP reaction-regeneration loop

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Particuology 2024年第6期89卷 57-66页

作者： Yanhao ye Shuai Zhang Ji xu Wei Ge State Key Laboratory of Mesoscience and Engineering(formerly State Key Laboratory of Multiphase Complex Systems) Institute of Process EngineeringChinese Academy of SciencesBeijing100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing100049China

The reactor-regenerator loop is the core facility of the maximizing iso-paraffin(MIP)*** the discrete particle method(DPM)simulation can provide detailed information at the particle scale,it has been unable to simulate such a complex loop system due to limitations of coarse-grained(CG)models,computing software,and *** this study,a newly proposed soft-shell CG-DPM model with a CG ratio of up to 800 is used to simulate a 3.5 Mt/a industrial-scale MIP reactor-regenerator *** solid fraction distribution obtained is found to agree well with in-situ *** properties including the distribution of solid fraction,gas and solid velocity,standard derivation of solid fraction with time,temporal distribution of the flow field,and particle residence time distribution are measured in the simulation,which are meaningful to better design and operate such systems in the future.

关键词： Discrete particle method Coarse-grain Maximizing iso-paraffins Full-loop Reaction-regeneration system

一种新型配电网自愈控制的动态重构与故障隔离方法

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电工技术 2024年第13期 77-81页

作者：吴超成朱秋霖许晔杨华东广东电网有限责任公司湛江供电局广东湛江524001

针对配电系统发生故障时网络拓扑结构发生改变影响系统稳定性的问题,提出了一种新型配电网重构与故障隔离的数学模型,该模型对配电网中的自动开关进行动态操作。考虑多个故障及其相关的清除和恢复,该模型包括一种保证网络径向性的新方法... 详细信息

针对配电系统发生故障时网络拓扑结构发生改变影响系统稳定性的问题,提出了一种新型配电网重构与故障隔离的数学模型,该模型对配电网中的自动开关进行动态操作。考虑多个故障及其相关的清除和恢复,该模型包括一种保证网络径向性的新方法,以使生成的树约束与虚拟网络框架相结合。最后,将该模型在一个带有自动开关、分布式电源(DistributedGenerator,DG)和储能系统(EnergyStorageSystem,ESS)的改进IEEE123总线配电系统上进行了测试,因该数学模型被表述为一个混合整数线性规划(MixedIntegerLinearProgram,MILP),所以可用CPLEX等求解器有效地求解。结果表明,所提出的混合整数线性规划模型能有效地对网络进行重构和故障隔离。

关键词：配电系统故障隔离停电管理断路器自愈技术配网重构

Modeling and analysis of air combustion and steam regeneration in methanol to olefins processes

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Chinese Journal of Chemical Engineering 2024年第2期66卷 94-103页

作者： Jinqiang Liang Danzhu Liu Shuliang xu Mao ye Department of Chemical Physics University of Science and Technology of ChinaHefei 230026China National Engineering Research Center of Lower-Carbon Catalysis Technology Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116021China University of Chinese Academy of Sciences Beijing 100049China

Light olefins is the incredibly important materials in chemical *** to olefins(MTO),which provides a non-oil route for light olefins production,received considerable attention in the past ***,the catalyst deactivation is an inevitable feature in MTO processes,and regeneration,therefore,is one of the key steps in industrial MTO *** the MTO catalyst is regenerated by removing the deposited coke via air combustion,which unavoidably transforms coke into carbon dioxide and reduces the carbon utilization *** study shows that the coke species over MTO catalyst can be regenerated via steam,which can promote the light olefins yield as the deactivated coke species can be essentially transferred to industrially useful synthesis gas,is a promising pathway for further MTO processes *** this work,we modelled and analyzed these two MTO regeneration methods in terms of carbon utilization efficiency and technology *** shown,the steam regeneration could achieve a carbon utilization efficiency of 84.31%,compared to 74.74%for air combustion *** MTO processes using steam regeneration can essentially achieve the near-zero carbon *** addition,light olefins production of the MTO processes using steam regeneration is 12.81%higher than that using air combustion *** this regard,steam regeneration could be considered as a potential yet promising regeneration method for further MTO processes,showing not only great environmental benefits but also competitive economic performance.

关键词： Model Methanol to olefins Regeneration Greenhouse gas Processes simulation