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2型糖尿病患者血糖控制与MRI脑白质高信号体积的相关性

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分子影像学杂志 2024年第9期47卷 967-971页

作者：夏娅园刘培培李林慧洪霞师毅冰徐州医科大学徐州临床学院江苏徐州221009 徐州市中心医院影像科江苏徐州221009 南通大学附属医院影像科江苏南通226001

目的研究2型糖尿病(T2DM)患者血糖相关指标及血糖控制情况对MRI脑白质高信号(WMH)体积的影响。方法本研究为回顾性病例对照研究,以2022年7月~2023年12月就诊于徐州市中心医院的149例T2DM患者为研究对象,按糖化血红蛋白(HbA1c)水平将其... 详细信息

目的研究2型糖尿病(T2DM)患者血糖相关指标及血糖控制情况对MRI脑白质高信号(WMH)体积的影响。方法本研究为回顾性病例对照研究,以2022年7月~2023年12月就诊于徐州市中心医院的149例T2DM患者为研究对象,按糖化血红蛋白(HbA1c)水平将其分为血糖控制达标组(HbA1c<7%,n=66)和未达标组(HbA1c≥7%,n=83),收集所有患者住院期间完成的颅脑MRI检查图像及相关血液学检查结果。采用ITK-SNAP软件对患者的WMH进行勾画并得出体积。采用多重线性回归分析法,分析T2DM患者血糖控制情况与WMH体积之间的相关性。结果T2DM患者的HbA1c水平与WMH体积有关;血糖控制不达标组的WMH体积、T2DM病程、高血压、空腹血糖、餐后2h血糖、空腹胰岛素水平、甘油三酯均高于血糖控制达标组(P<0.05)。校正年龄、性别及其他危险因素之后的多重线性回归分析结果表明,在T2DM患者中,WMH体积与血糖控制情况之间存在线性关系。结论T2DM患者血糖控制情况是WMH体积的重要影响因素,血糖控制较差者易获得更高的WMH体积,这为有WMH相关发病风险的个体提供了强化预防策略和监测早期治疗的依据。

关键词： 2型糖尿病血糖控制磁共振成像脑白质高信号相关性

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氨氧化菌及其在中国池塘养殖水质调控过程中的应用

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中国农学通报 2022年第33期38卷 145-151页

作者：陆诗敏李雅媛刘翀刘兴国鲍旭腾田昌凤顾兆俊周亮吴凡中国水产科学研究院渔业机械仪器研究所上海200092 农业农村部水产养殖设施工程重点实验室上海200092 上海海洋大学水产与生命学院上海201306

氨氮是池塘养殖尾水治理过程中需着重考虑的一种污染物,池塘养殖环境氨氮氧化去除主要依赖氨氧化细菌、氨氧化古菌和厌氧氨氧化菌。本研究介绍了在自然界中已发现的几种氨氧化菌的氮素代谢机理,并结合池塘生态系统特征,着重从温度、pH... 详细信息

氨氮是池塘养殖尾水治理过程中需着重考虑的一种污染物,池塘养殖环境氨氮氧化去除主要依赖氨氧化细菌、氨氧化古菌和厌氧氨氧化菌。本研究介绍了在自然界中已发现的几种氨氧化菌的氮素代谢机理,并结合池塘生态系统特征,着重从温度、pH、溶解氧、附着基质和光照角度,阐释氨氧化菌对池塘养殖水体的生态调控机制。基于氨氧化菌附着生活习性,现已研发出多种异位池塘养殖水质净化技术,在一定程度上,这些技术能发挥净水效果,但普遍存在占地面积大,造价高、效率低等问题。目前,中国池塘养殖水体处理领域,在氨氧化微生物菌剂和高效微生物反应器应用及研发方面比较薄弱。建议未来强化池塘低温高效氨氧化菌株筛选和富集培养研究,促进结构紧凑型水处理微生物反应器研发,丰富淡水池塘养殖尾水氨氮去除手段。

关键词：氨氮氨氧化细菌氨氧化古菌附着载体光照

Metal–Oleate Complex?Derived Bimetallic Oxides Nanoparticles Encapsulated in 3D Graphene Networks as Anodes for Efficient lithium Storage with Pseudocapacitance

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Nano-Micro Letters 2019年第1期11卷 250-263页

作者： Yingying Cao Kaiming Geng Hongbo Geng Huixiang Ang Jie Pei yayuan liu Xueqin Cao Junwei Zheng Hongwei Gu Key Laboratory of Organic Synthesis of Jiangsu Province College of Chemistry Chemical Engineering and Materials Science and Collaborative Innovation Center of Suzhou Nano Science and TechnologySoochow University School of Chemical Engineering and light Industry Guangdong University of Technology School of Chemical and Biomedical Engineering Nanyang Technological University College of Physics Optoelectronic and Energy Soochow University

In this manuscript, we have demonstrated the delicate design and synthesis of bimetallic oxides nanoparticles derived from metal–oleate complex embedded in 3D graphene networks(MnO/CoMn_2O_4  GN), as an anode material for lithium ion batteries. The novel synthesis of the MnO/CoMn_2O_4  GN consists of thermal decomposition of metal–oleate complex containing cobalt and manganese metals and oleate ligand, forming bimetallic oxides nanoparticles, followed by a selfassembly route with reduced graphene oxides. The MnO/CoMn_2O_4  GN composite, with a unique architecture of bimetallic oxides nanoparticles encapsulated in 3D graphene networks, rationally integrates several benefits including shortening the di usion path of li^+ ions, improving electrical conductivity and mitigating volume variation during cycling. Studies show that the electrochemical reaction processes of MnO/Co Mn_2O_4  GN electrodes are dominated by the pseudocapacitive behavior, leading to fast li^+ charge/discharge reactions. As a result, the MnO/CoMn_2O_4  GN manifests high initial specific capacity, stable cycling performance, and excellent rate capability.

关键词： Metal–oleate complex Bimetallic oxides nanoparticles Porous architecture 3D graphene networks lithium ion batteries

3种包装方式对龙滩珍珠李常温贮藏品质的影响

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食品研究与开发 2024年第13期45卷 70-77页

作者：黄展文韦林艳李明娟游向荣张雅媛王颖周葵广西农业科学院花卉研究所广西南宁530007 广西农业科学院农产品加工研究所广西南宁530007 广西果蔬贮藏与加工新技术重点实验室广西南宁530007

以龙滩珍珠李为材料,采用保鲜袋、硅窗袋和保鲜盒包装后置于常温(25±1)℃贮藏21 d,探讨3种不同包装方式对龙滩珍珠李果实采后贮藏品质的影响。结果表明,随着贮藏时间的延长,3种包装的果实失重率、腐烂率、a^(*)值和可溶性固形物(total ... 详细信息

以龙滩珍珠李为材料,采用保鲜袋、硅窗袋和保鲜盒包装后置于常温(25±1)℃贮藏21 d,探讨3种不同包装方式对龙滩珍珠李果实采后贮藏品质的影响。结果表明,随着贮藏时间的延长,3种包装的果实失重率、腐烂率、a^(*)值和可溶性固形物(total soluble solid,TSS)/可滴定酸(titratable acidity,TA)均不断升高,L^(*)值、硬度、咀嚼性、弹性、内聚性、TSS、还原糖(reducing sugar,RS)、TA和VC不断下降;果实呼吸速率先升高后降低,贮藏14 d时均达到呼吸高峰。保鲜袋包装可抑制果实失重率、a^(*)值和TSS/TA的升高,可延缓L^(*)值、TSS、RS和TA的下降,可抑制果实呼吸强度,降低呼吸峰值;保鲜盒包装可延缓果实腐烂率的升高,抑制果实全质构特性和VC含量的下降,但果皮失水皱缩。可见,保鲜袋包装的保鲜效果最好,可以有效抑制果实品质劣变,延缓果实衰老进程。

关键词：龙滩珍珠李包装方式常温贮藏果实品质呼吸速率

Engineering the surface of liCoO2 electrodes using atomic layer deposition for stable high-voltage lithium ion batteries

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Nano Research 2017年第11期10卷 3754-3764页

作者： Jin Xie Jie Zhao yayuan liu Haotian Wang Chong liu Tong Wu Po-Chun Hsu Dingchang lin Yang Jin Yi Cui Department of Materials Science and Engineering Stanford University Stanford CA 94305 USA Department of Applied Physics Stanford University Stanford CA 94305 USA Department of Materials Science and Engineering Stanford University Stanford CA 94305 USA Stanford Institute for Materials and Energy Sciences SLAC National Accelerator Laboratory Menlo Park CA 94025 USA

Developing advanced technologies to stabilize positive electrodes of lithium ion batteries under high-voltage operation is becoming increasingly important,owing to the potential to achieve substantially enhanced energy density for applications such as portable electronics and electrical ***,we deposited chemically inert and ionically conductive liAlO2 interfacial layers on liCoO2 electrodes using the atomic layer deposition *** prolonged cycling at high-voltage,the liAlO2 coating not only prevented interfacial reactions between the liCoO2 electrode and electrolyte,as confirmed by electrochemical impedance spectroscopy and Raman characterizations,but also allowed lithium ions to freely diffuse into liCoO2 without sacrificing the power *** a result,a capacity value close to 200 mA＆#183;h＆#183;g-1 was achieved for the liCoO2 electrodes with commercial level loading densities,cycled at the cut-off potential of 4.6 V ***＋/li for 50 stable cycles;this represents a 40% capacity gain,compared with the values obtained for commercial samples cycled at the cut-off potential of 4.2 V ***＋/li.

关键词： lithium ion batteries lithium cobalt oxide atomic layer deposition

乳黄消散治疗临床型奶牛乳房炎效果及抗炎作用机制研究

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中兽医医药杂志 2024年第5期43卷 60-66页

作者：牟小青尚立宏杨胜安杨峰丁学智杨雅媛武小虎吕亚楠武凡琳李宏胜梁斌中国农业科学院兰州畜牧与兽药研究所农业农村部兽用药物创制重点实验室甘肃省新兽药重点实验室甘肃兰州730050 甘肃省动物疫病预防控制中心甘肃兰州730046 辽宁省岫岩满族自治县农业农村局农业综合执法队辽宁岫岩114300

探讨不同剂量的乳黄消散对临床型奶牛乳房炎治疗效果及抗炎作用机制,为乳黄消散的开发和应用提供理论依据。将40头患临床型乳房炎的奶牛随机分为3个试验组和1个药物对照组,每组10头,另选10头健康泌乳奶牛作为正常对照组。其中3个试验组... 详细信息

探讨不同剂量的乳黄消散对临床型奶牛乳房炎治疗效果及抗炎作用机制,为乳黄消散的开发和应用提供理论依据。将40头患临床型乳房炎的奶牛随机分为3个试验组和1个药物对照组,每组10头,另选10头健康泌乳奶牛作为正常对照组。其中3个试验组分别按剂量300 g/d、400 g/d、500 g/d灌服乳黄消散,药物对照组灌服公英散300 g/d,灌服不超过5 d,健康对照组不做任何处理。观察不同剂量的乳黄消散和公英散对临床型奶牛乳房炎的疗效、细菌转阴率、体细胞数、血清和乳清中炎症因子变化情况。结果显示,乳黄消散低剂量组、中剂量组和高剂量组对临床型乳房炎的治愈率分别为60.00%、70.00%和80.00%;乳黄消散3个剂量组和公英散对照组奶牛乳汁体细胞数均明显降低,且在停药后14 d各组奶牛乳汁体细胞数均下降到每毫升20万个以内;治疗结束停药后,乳黄消散3个治疗组的细菌总转阴率平均为89.06%;与给药前比较,乳黄消散和公英散均可显著降低奶牛血液和乳清中IL-6、IL-1β、IL-8和TNF-α等炎症因子的水平。乳黄消散3个剂量组对临床型奶牛乳房炎均具有良好的治疗效果,能显著降低患病奶牛乳汁体细胞数、清除或抑制乳汁中致病菌,并可显著降低奶牛血液和乳清中炎症因子表达水平,其中以高剂量组效果最佳。

关键词：奶牛乳房炎乳黄消散治愈率抗炎作用

Micro-nanofiber composite biomimetic conduits promote long-gap peripheral nerve regeneration in canine models

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Bioactive Materials 2023年第12期30卷 98-115页

作者： Xianhao Dong Yueyue Yang Zheheng Bao Adam C.Midgley Feiyi li Shuxin Dai Zhuangzhuang Yang Jin Wang lihua liu Wenlei li yayuan Zheng Siyang liu Yang liu Weijian Yu Jun liu Meng Fan Meifeng Zhu Zhongyang Shen Gu Xiaosong Deling Kong State Key Laboratory of Medicinal Chemical Biology The Key Laboratory of Bioactive MaterialsMinistry of EducationCollege of Life ScienceNankai UniversityTianjinChina Department of Orthopaedics Tianjin First Central HospitalSchool of MedicineNankai UniversityTianjinChina Department of Radiology Tianjin First Central HospitalTianjin Medical Imaging InstituteSchool of MedicineNankai UniversityTianjinChina Institute of Transplantation Medicine NHC Key Laboratory for Critical Care MedicineTianjin First Central HospitalSchool of MedicineNankai UniversityTianjinChina Haihe Laboratory of Sustainable Chemical Transformations Keyan West RoadTianjin300192China Jiangsu Key Laboratory of Neuroregeneration Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury RepairCo-innovation Center ofNeuroregenerationNMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology ProductsNantong UniversityNantongChina Outpatient Department Tianjin First Central HospitalSchool of MedicineNankai UniversityTianjinChina Clinical School/College of Orthopedics Tianjin Medical UniversityTianjinChina Department of Joint Tianjin HospitalTianjinChina

Peripheral nerve injuries may result in severe long-gap interruptions that are challenging to *** is the gold standard surgical approach for repairing long-gap nerve injuries but can result in prominent donor-site ***,imitating the native neural microarchitecture using synthetic conduits is expected to offer an alternative strategy for improving nerve ***,we designed nerve conduits composed of high-resolution anisotropic microfiber grid-cordes with randomly organized nanofiber sheaths to interrogate the positive effects of these biomimetic structures on peripheral nerve ***tropic microfiber-grids demonstrated the capacity to directionally guide Schwann cells and *** sheaths conveyed adequate elasticity and permeability,whilst exhibiting a barrier function against the infiltration of *** then used the composite nerve conduits bridge 30-mm long sciatic nerve defects in canine *** 12 months post-implant,the morphometric and histological recovery,gait recovery,electrophysiological function,and degree of muscle atrophy were *** newly regenerated nerve tissue that formed within the composite nerve conduits showed restored neurological functions that were superior compared to sheaths-only scaffolds and Neurolac nerve conduit *** findings demonstrate the feasibility of using synthetic biophysical cues to effectively bridge long-gap peripheral nerve injuries and indicates the promising clinical application prospects of biomimetic composite nerve conduits.

关键词： composite fiber injuries

Identification of potential therapeutic targets for vitiligo by deep-network analysis strategy from multi-omics data

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Identification of potential therapeutic targets for vitiligo...

2019中国化学会第十五届全国计算（机）化学学术会议

作者：王吉烨 Zengrui Wu yayuan Peng Weihua li Guixia liu Yun Tang 华东理工大学 Shanghai Key Laboratory of New Drug Design School of Pharmacy East China University of Science and Technology

Vitiligo is an acquired depigmenting skin disease that affects 0.5% to 2% of the world population.1 The current available therapeutic options are not satisfactory for many patients because of time-consuming, adverse reactions and the complex pathogenesis of vitiligo.2 With the advent of post-genomic era, multi-omics data from the genome, transcriptome, proteome and interactome, are conducive to systemically understand the pathogenesis of vitiligo.3 In order to find potential therapeutic targets in vitiligo-gene network（VGNet）, greedy articulation points removal（GAPR） method has been recently developed to analyze articulation points（APs） in the initial and deep network using a linear-time algorithm based on depth-first search.4 Therefore, we proposed a deep-network analysis framework to identify potential therapeutic targets from multi-omics data for vitiligo, including（1） to construct the VGNet from multi-omics data, and（2） to analyze APs of the VGNet via GAPR method. The deep-network analysis strategy stood out among the popular network analysis by showing superior stability and recall rate（88%） from an independent dataset of TTD（Therapeutic Target Database）5. By systematically integrating multi-omics data from previous genome-wide linkage and association studies, transcriptomics data and human protein-protein interactions（PPIs）6, the VGNet was constructed in this way including 592 unique proteins（nodes） and 1,248 PPIs（edges）. Based on GAPR method, 201 nodes were defined as APs in the VGNet, among which the genes mainly belong to Th17 cell differentiation, oxidative stress, cell cycle and apoptosis biological processes. In consideration of targets tractability, 26 novel and 3 previously reported targets were identified and showed great potential in revealing the pathogenesis of vitiligo by using drug-target interactions from ChEMBL database7. Furthermore, combined with anti-vitiligo network pharmacology and proteomic analysis, it was preliminarily verified that 6 t

关键词： vitiligo multi-omics data vitiligo-gene network deep-network analysis strategy therapeutic target

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汽车覆盖件面轮廓度误差的测量

汽车技术 2006年第6期 32-34页

作者：王亚元李正盛江苏大学

介绍了面轮廓度公差的定义及面轮廓度误差的各种测量方法。提出了一种能够获取物体表面多数据(点坐标)、对被测物体无材质要求,并适合于测量面积大且易变形的覆盖件类零件面轮廓度误差的结构光测量方法。阐述了结构光光栅投影三维测量... 详细信息

介绍了面轮廓度公差的定义及面轮廓度误差的各种测量方法。提出了一种能够获取物体表面多数据(点坐标)、对被测物体无材质要求,并适合于测量面积大且易变形的覆盖件类零件面轮廓度误差的结构光测量方法。阐述了结构光光栅投影三维测量技术的原理,以某汽车内饰件为例。介绍了利用该原理测量覆盖件表面轮廓度误差的过程。

关键词：覆盖件面轮廓度误差结构光法光栅投影