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E2FBP1 antagonizes the p16^(INK4A)-Rb tumor suppressor machinery for growth suppression and cellular senescence by regulating promyelocytic leukemia protein stability

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International Journal of Oral Science 2011年第4期3卷 200-208页

作者： yayoi fukuyo Akiko Takahashi Eiji Hara Nobuo Horikoshi Tej K. Pandita Takuma Nakajima Department of Immunology Tulane National Primate Research Center Section of Bacterial Pathogenesis Graduate School Tokyo Medical and Dental University Division of Cancer Biology The Cancer Institute Japanese Foundation for Cancer Research Division of Molecular Radiation Biology Department of Radiation Oncology University of Texas Southwestern Medical Center

Cellular senescence is an irreversible cell cycle arrest triggered by the activation of oncogenes or mitogenic signaling as well as the enforced expression of tumor suppressors such as p53, p16INK4A and promyelocytic leukemia protein （PML） in normal cells. E2F-binding protein 1 （E2FBP1）, a transcription regulator for E2F, induces PML reduction and suppresses the formation of PML-nuclear bodies, whereas the down-regulation of E2FBP1 provokes the PML-dependent premature senescence in human normal fibroblasts. Here we report that the depletion of E2FBP1 induces the accumulation of PML through the Ras-dependent activation of MAP kinase signaling. The cellular levels of p16INK4A and p53 are elevated during premature senescence induced by depletion of E2FBP1, and the depletion of p16INK4A, but not p53 rescued senescent cells from growth arrest. Therefore, the premature senescence induced by E2FBP1 depletion is achieved through the pl6INK4A-Rb pathway. Similar to human normal fibroblasts, the growth inhibition induced by E2FBP1 depletion is also observed in human tumor cells with intact p16INK4A and Rb. These results suggest that E2FBP1 functions as a critical antagonist to the pI6INK4A-Rb tumor suppressor machinery by regulating PML stability.

关键词： E2F-binding protein 1 senescence cell cycle ubiquitin promyelocytic leukemia protein

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Genomic medicine in clinical practice:national genomic medicine program in Japan

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Cancer Biology & Medicine 2024年第1期21卷 4-9页

作者： Teruhiko Yoshida Yasushi Yatabe Ken Kato Genichiro Ishii Akinobu Hamada Hiroyuki Mano Kuniko Sunami Noboru Yamamoto Takashi Kohno Department of Genetic Medicine and Services National Cancer Center HospitalTokyo 104-0045Japan Department of Diagnostic Pathology National Cancer Center HospitalTokyo 104-0045Japan Clinical Research Support Offce Clinical Research Coordinating SectionBiobank Translational Research Support SectionNational Cancer Center HospitalTokyo 104-0045Japan Department of Pathology and Clinical Laboratories National Cancer Center Hospital EastChiba 277-8577Japan Division of Molecular Pharmacology National Cancer Center Research InstituteTokyo 104-0045Japan National Cancer Center Research Institute Tokyo 104-0045Japan Department of Laboratory Medicine National Cancer Center HospitalTokyo 104-0045Japan Department of Experimental Therapeutics National Cancer Center HospitalTokyo 104-0045Japan Division of Genome Biology National Cancer Center Research InstituteTokyo 104-0045Japan

Cancer statistics in Japan Cancer is the most common cause of death in Japan based on Statistics 2021~*** statistics were first gathered,infectious diseases,such as tuberculosis,and cerebrovascular disease have been the main causes of death in *** surpassed cerebrovascular disease as the main cause of death in 1981,and the number of cancer deaths has *** 38,000 people died of cancer in *** National Cancer Center(NCC)reported that the 5-year survival rate for patients with cancer was improving(62%for males and 66.9%for females)in a population-based cancer registry.

关键词： Cancer cancer death

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Development of a Self-Assessment Questionnaire for Nurses’ Risk-Taking Behavior in Medication

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Health 2022年第1期14卷 1-22页

作者： yayoi Imura Chiharu Akazawa Faculty of Nursing Shijonawate Gakuen University Osaka Japan Faculty of Nursing Osaka Medical and Pharmaceutical University Osaka Japan

Purpose: The purpose of this study was to prepare a self-assessment questionnaire for nurses’ risk-taking behavior (RTB) in medication and to develop a reliable and valid questionnaire. Method: In the first study, a draft of the self-evaluation questionnaire for nurses’ RTB in medication was prepared based on the literature study and qualitative analysis of important case information included in the Project to Collect Medical Near-miss/Adverse Event Information Annual Report of the Ministry of Health, Labor and Welfare. Following the studies, face validity was confirmed, and a questionnaire survey was conducted for nurses who oversee medication nationwide to verify the reliability and validity. Result: The number of subjects was 586 (valid response rate: 94.1%). Item analysis and exploratory factor analysis showed that 4 factors and 12 items for the RTBs in daily life and 4 factors and 20 items for RTBs in medication could be extracted. Confirmatory factor analysis confirmed the fit of the hypothetical model obtained by exploratory factor analysis. In addition, Cronbach’s α coefficient was 0.888. Thus, high reliability and validity were obtained. A correlation was found by comparing the total scores of each RTB factor with the incident/accident group, and a standard for self-evaluation value could be established (p Conclusions: We were able to develop a self-assessment questionnaire for nurses’ risk-taking behavior in medication. This questionnaire will be used by nurses to find out their trends.

关键词： Self-Assessment Questionnaire Risk-Taking Behavior Nurses Medication

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Establishment of induced pluripotent stem cells from aged mice using bone marrow-derived myeloid cells

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分子细胞生物学报:英文版 2011年第2期3卷 91-98页

作者： Zhao Cheng Sachiko Ito Naomi Nishio Hengyi Xiao Rong Zhang Haruhiko Suzuki yayoi Okawa Toyoaki Murohara Ken-ichi Isobe Department of Immunology Nagoya University Graduate School of Medicine65 Turumai-choShowa-kuNagoyaAichi 466-8520Japan Laboratory for Geriatrics State Key Laboratory of BiotherapySichuan UniversityChengdu 610041China Department of Functioning Activation National Institute for Longevity SciencesNational Center for Geriatrics GerontologyAichi 463-0003Japan Department of Cardiology Nagoya University Graduate School of Medicine65 Turumai-choShowa-kuNagoyaAichi 466-8520Japan

If induced pluripotent stem(iPS)cells are to be used to treat damaged tissues or repair organs in elderly patients,it will be necessary to establish iPS cells from their *** determine the feasibility of using this technology with elderly patients,we asked if it was indeed possible to establish iPS cells from the bone marrow(BM)of aged *** cells from aged C57BL/6 mice carrying the green fluorescence protein(GFP)gene were cultured with granulocyte macrophage-colony stimulating factor(GM-CSF)for 4 *** factors(Oct3/4,Sox2,Klf4 and c-Myc)were introduced into the BM-derived myeloid(BM-M)*** efficiency of generating iPS cells from aged BM cultured in GM-CSF was ***,we succeeded in obtaining BM-M-iPS cells from aged C57BL/6 mice,which carried *** BM-M-iPS cells expressed SSEA-1 and Pou5f1 and were positive for alkaline phosphatase *** iPS cells did make teratoma with three germ layers following injection into syngeneic C57BL/6 mice,and can be differentiated to three germ layers in *** co-culturing with OP9,the BM-M-iPS cells can be differentiated to the myeloid *** differentiated BM-M-iPS cells proliferated well in the presence of GM-CSF,and lost expression of Nanog and Pou5f1,at least in part,due to methylation of their *** the contrary,Tnf and Il1b gene expression was upregulated and their promoters were hypomethylated.

关键词： induced pluripotent stem cells aged mouse bone marrow myeloid cells gene expression methylation ChIP assay

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Retrocaval liver lifting maneuver and modifications of total hepatic vascular exclusion for liver tumor resection

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World Journal of Hepatology 2016年第8期8卷 411-420页

作者： Saiho Ko Yuuki Kirihatayfa yayoi Matsumoto Tadataka Takagi Masanori Matsusaka Tomohide Mukogawa Hirofumi Ishikawa Akihiko Watanabe Department of Surgery Nara Prefecture General Medical Center

AIM: To evaluate the efficacy of technical modifications of total hepatic vascular exclusion(THVE) for hepatectomy involving inferior vena cava(IVC).METHODS: Of 301 patients who underwent hepatectomy during the immediate previous 5-year period, 8(2.7%) required THVE or modified methods of IVC cross-clamping for resection of liver tumors with massive involvement of the IVC. Seven of the patients had diagnosis of colorectal liver metastases and 1 had diagnosis of hepatocellular carcinoma. All tumors involved the IVC, and THVE was unavoidable for combined resection of the IVC in all 8 of the patients. Technical modifications of THVE were applied to minimize the extent and duration of vascular occlusion, thereby reducing the risk of ***: Broad dissection of the space behind the IVC coupled with lifting up of the liver from the retrocaval space was effective for controlling bleeding around the IVC before and during THVE. The procedures facilitate modification of the positioning of the cranial IVC cross-clamp. Switching the cranial IVC cross-clamp from supra- to retrohepatic IVC or to the confluence of hepatic vein decreased duration of the THVE while restoring hepatic blood flow or systemic circulation via the IVC. Oblique cranial IVC cross-clamping avoided ischemia of the remnant hemi-liver. With these technicalmodifications, the mean duration of THVE was 13.4 ± 8.4 min, which was extremely shorter than that previously reported in the literature. Recovery of liver function was smooth and uneventful for all 8 patients. There was no case of mortality, re-operation, or severe complication(i.e., Clavien-Dindo grade of Ⅲ or more).CONCLUSION: The retrocaval liver lifting maneuver and modifications of cranial cross-clamping were useful for minimizing duration of THVE.

关键词： Total hepatic vascular exclusion Retrocaval liver lifting maneuver Oblique clamping Switching the clamp Hepatectomy

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从美华书馆的“多语种”印刷看中日两国印刷史

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艺术与设计 2023年第1期277卷 161-164页

作者：宫坂弥代生日本中央大学政策文化总合研究所

18世纪末基督教传教士为了便于在中国印刷用于传教的出版物,在所到传教之处开设了印刷所。其中最有名的两所是伦敦传道会的墨海书馆和美国长老会的美华书馆(The American Presbyterian Mission Press)。众所周知,美华书馆和商务印书馆... 详细信息

18世纪末基督教传教士为了便于在中国印刷用于传教的出版物,在所到传教之处开设了印刷所。其中最有名的两所是伦敦传道会的墨海书馆和美国长老会的美华书馆(The American Presbyterian Mission Press)。众所周知,美华书馆和商务印书馆有密切的联系。另外,日本首家开创金属活字的活版印刷所本木昌造,曾经邀请过美华书馆的负责人姜别利到日本长崎来传授印刷技术。从此看来,在研究中日两国印刷史时,美华书馆至关重要。

关键词：美华书馆美国长老会基督教传教士印刷史传道会印刷技术活版印刷金属活字

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Gender Differences in the Cognition About the Changeability of Body

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Sociology Study 2014年第6期4卷 538-543页

作者： Minako Ohmura yayoi Kojima Yojiro Nakataa, Yoko Sawamiya Yoko Sawamiya Rissho University Japan Saitama Gakuen University Japan University of Tsukuba Japan

This study examined gender differences in the cognition of the changeability of different parts of the body. The body was divided into six parts：＂eyes＂, ＂hair＂, ＂upper body＂, ＂lower body＂, ＂facial features＂, and ＂skin＂, and male and female cognition about the changeability of each body part was compared. The participants were 205 undergraduate students （145 female students and 60 male studentsl） enrolled in a university in Japan. The female and male students showed a similarity in their cognition of＂hair＂ as easily changeable and ＂facial features＂ as difficult to change. In addition, there was a difference between the male and female students in the cognition of the changeability of the ＂eyes＂, with the females perceiving a high level of changeability and men, a low changeability. This result suggests that female students believe in the effectiveness of makeup for covering cosmetic flaws of the eye.

关键词： Body satisfaction changeability cognition

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Cerebral aneurysms and inflammation

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Neuroimmunology and Neuroinflammation 2015年第1期2卷 55-58页

作者： Toshihiro Yokoi Makoto Saito yayoi Yoshimura Keiichi Tsuji Kazuhiko Nozaki Department of Neurosurgery Shiga University of Medical ScienceShiga 520-2192Japan

Multiple inflammatory factors,playing a crucial role in cerebral aneurysm formation,have been *** necrosis factor‑alpha(TNF‑α)has been revealed to have a close connection with several risk factors that affect aneurysm *** expression in aneurysm walls of mRNA for TNF‑αhas been observed in *** therapeutic interventions to reduce the formation of cerebral aneurysms may include the inhibition of mediators of inflammation.

关键词： Cerebral aneurysm inflammation molecular biology

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A Case of Acute Renal Failure Associated with IgG4-Related Disease Presenting Both Tubulointerstitial Nephritis and Retroperitoneal Fibrosis

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Open Journal of Nephrology 2016年第3期6卷 86-92页

作者： Hirohito Sugawara Hideki Takizawa Norihito Moniwa Naoki Takamatsu Yusuke Ohashi yayoi Ogawa Department of Nephrology Teine-Keijinkai Hospital Sapporo Japan Department of General Internal Medicine Teine-Keijinkai Hospital Sapporo Japan Hokkaido Renal Pathology Center Sapporo Japan

We report a case of IgG4-related disease presenting both tubulointerstitial nephritis and retroperitoneal fibrosis causing acute renal failure in a 63-year-old male. He was admitted to our hospital because of acute renal failure requiring emergent hemodialysis. Computed tomography showed a soft-tissue density mass with an irregular border in the retroperitoneum. The mass involved bilateral ureters and had caused acute renal failure by bilateral hydronephrosis. Because of a history of uveitis and high IgG4 levels, we considered a diagnosis of retroperitoneal fibrosis, IgG4-related disease. Kidney biopsy revealed IgG4-related kidney disease with interstitial nephritis. After relief of urinary obstruction by inserting ureteral catheters into the bilateral ureters, renal function recovered.

关键词： IgG4 Related Disease IgG4 Related Tubulointerstitial Nephritis Retroperitoneal Fibrosis Acute Renal Failure

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What factors are associated with premature death among professional baseball players in Japan?

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Health 2013年第4期5卷 757-760页

作者： Hideyuki Kanda Satoshi Tsuboi Masayoshi Tsuji Takeyasu Kakamu yayoi Mori Takehito Hayakawa Tetsuhito Fukushima Department of Epidemiology and Public Health School of Medicine Yokohama City University Yokohama Japan Department of Hygiene and Preventive Medicine Fukushima Medical University Fukushima Japan

The aim of this study is to clarify factors related to premature death among Japanese professional baseball players by a case-control analysis. The subjects are two matching groups of 622 Japan Professional Baseball (JPB) league players, those deceased and those surviving. Cases and controls are matched by birth year. All players debuted on the first string between 1934 and 2003, and are listed in The Official Baseball Encyclopedia of Japan. To compare means and frequencies of characteristics between deceased and surviving groups, t-tests and chi-square tests were used. A logistic regression analysis was assessed contributions of each independent variable on death. Significant differences between deceased and surviving players were observed in this study;deceased players had higher body mass indexes and longer careers. Furthermore, logistic regression analysis confirmed that body mass index and career length were statistically significant determinants of death for baseball players. This is the first report to examine factors of death for professional baseball players except employing data attained from Major League Baseball.

关键词： Factors of Death Professional Baseball Player Body Mass Index Career Length

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