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高性能功能微球:聚集诱导发光在疾病诊断领域的应用

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科学 2024年第1期76卷 14-16页

作者：胡亚新谢莉刘勇王志明华南理工大学广州广东省大湾区华南理工大学聚集诱导发光高等研究院广州510530

聚集诱导发光材料在聚集状态下具有高发光效率、大斯托克斯位移和优异的稳定性。基于这些特点,其与纳米微球材料复合的高性能功能微球在生物传感、生物成像和诊疗、光电器件等领域已经有广泛应用,在环境研究、农业畜牧业和食品制药领域... 详细信息

聚集诱导发光材料在聚集状态下具有高发光效率、大斯托克斯位移和优异的稳定性。基于这些特点,其与纳米微球材料复合的高性能功能微球在生物传感、生物成像和诊疗、光电器件等领域已经有广泛应用,在环境研究、农业畜牧业和食品制药领域也展现出巨大的应用潜力。

关键词：聚集诱导发光纳米微球生物标志物检测

Cucurbit[8]uril-regulated face-to-face dimerization assembly enhanced photosensitization and photocatalysis

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Science China Chemistry 2024年第5期67卷 1605-1612页

作者： Haigen Nie Die hu Zhiyao Zeng Yan Fan yaxin Zhai Xin-Long Ni Key Laboratory of Chemical Biology and Traditional Chinese Medicine Ministry of Educational of ChinaKey Laboratory of the Assembly and Application of Organic Functional Molecules of Hunan ProvinceCollege of Chemistry and Chemical EngineeringHunan Normal UniversityChangsha 410081China Key Laboratory of Low-Dimensional Quantum Structures and Quantum Control of Ministry of Education Department of PhysicsHunan Normal UniversityChangsha 410081China

In water, N,N′-diarylpyridinium thiazolo[5,4-d]thiazole guests(G1–G3) were encapsulated by cucurbit[8]uril(Q[8]) to construct Q[8]_(3)/G_(2) complexes, in which the encapsulated G molecules exist as an exact face-to-face dimer. These complexation behaviors have been indicated by proton nuclear magnetic resonance(~1H NMR) spectroscopy and isothermal titration calorimetry(ITC),and have been confirmed by X-ray single crystal structural analysis of Q[8]_(3)/G2_(2). While free guests G1–G3 have no ability to sensitize singlet oxygen, they all become effective singlet oxygen sensitizers when complexed with Q[8]. By irradiation of white light, Q[8]_(3)/G_(2) complexes induced selective oxidation of aryl sulfide to aryl sulfoxide in good yields and selective oxidation of dimethyl sulfide(DMS) to dimethyl sulfoxide(DMSO) in excellent yields without over-oxidation to dimethyl sulfone(DMSO_(2))even for elongated irradiation. High-yield photo-oxidation of DMS to DMSO_(2) was only achieved by irradiation of blue light in the presence of Q[8]_(3)/G1_(2), which was also effective in photobleaching of Rhodamine B in water. The higher photo-oxidation power of Q[8]_(3)/G1_(2) has been ascribed to an additional generation of reactive oxygen species besides singlet oxygen.

关键词： host-guest interaction dimerization macrocycles photosensitization

Promoted catalytic performance of Ag-Mn bimetal catalysts synthesized through reduction route

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Journal of Environmental Sciences 2024年第3期137卷 358-369页

作者： Wenkai hu Tao Guo Kaiyao Ma Xu Li Wangting Luo Mingzhi Wu Hao Guo yaxin Zhang Wenfeng Shangguan School of Chemical Engineering and Technology Xinjiang UniversityUrumchi 830017China Research Center for Combustion and Environmental Technology Shanghai Jiao Tong UniversityShanghai 200240China

VOCs can exert great harm to both human and environment,and catalytic oxidation is believed to be an effective technique to eliminate these *** this paper,Ag-Mn bimetal catalysts with 10 wt.%of silver were synthesized using doping,impregnation,and reduction methods respectively,and then they were applied to the catalytic oxidation of *** series of characterizations it showed that the loading of silver using reduction method significantly resulted in improved physico-chemical properties of manganese oxides,such as larger surface area and pore volume,higher proportion of surface Mn~(3+)and Mn~(4+),stronger reducibility and more active of surface oxygen species,which were all beneficial to its catalytic *** a result,the Ag-Mn catalysts synthesized by reduction method showed a lower T_(90)value(equals to the temperature at which 90%of initial benzene was removed)of 203℃.Besides,both the used and fresh Ag-Mn catalysts synthesized by reduction method showed preferable stability in this research.

关键词： Ag-Mn Benzene oxidation Catalytic performance Reduction route

Potential modifying effect of grip strength on the association between glycated hemoglobin(HbA1c)and all-cause mortality in older adults with type 2 diabetes:Evidence from UK Biobank

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Chinese Medical Journal 2024年第12期137卷 1501-1503页

作者： Jingyi Lu yaxin Wang Yun Shen Yifei Mo Xiaojing Ma Gang hu Jian Zhou Department of Endocrinology and Metabolism Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai Clinical Center for DiabetesShanghai Key Clinical Center for Metabolic DiseaseShanghai Key Laboratory of Diabetes MellitusShanghai 200233China Shanghai Diabetes Institute Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200233China Pennington Biomedical Research Center Baton RougeLA 70808USA

To the Editor:Frailty status represents one of the core determinants for the individualization of glycated hemoglobin(HbA1c)targets in the elderly ***,the most validated tools to quantify frailty,which are complex and involve multiple dimensions of assessment,are rarely used in the clinical practice of diabetes ***,a simple and practical metric for the evaluation of frailty is *** strength is an easily measurable,objective,and reproducible metric for assessing frailty status.[1]It is correlated with overall muscle strength and has been reported to be signicantly related to important health outcomes both in the general population[2,3]and in patients with diabetes.[4]Therefore,grip strength could be a useful marker for patient strati-cation in diabetes *** this context,this study aimed to examine the associations between HbA1c and all-cause mortality across categories of grip strength,as a measure of frailty status,in older adults with type 2 diabetes in the UK *** researches had applied to access the UK Biobank database with the application approval number of 82812.

关键词： diabetes mortality strength

A one-step reverse-transcription recombinase aided PCR assay for the rapid and sensitive detection of human enteroviruses

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Biosafety and Health 2023年第2期5卷 126-131页

作者： Xiuli Sun huanhuan Lu Yanqing Tie Mengchuan Zhao Ruiqing Zhang Zhenlu Sun Guohao Fan Fengyu Li Fengyu Tian yaxin hu Mengyi Zhang Xinxin Shen Xuejun Ma Zhishan Feng North China University of Science and Technology Tangshan 063210China Hebei General Hospital Shijiazhuang 050051China NHC Key Laboratory of Medical Virology and Viral Diseases National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China National Laboratory for Poliomyelitis National Institute for Viral Disease Control and Prevention of the Chinese Center for Disease Control and PreventionBeijing 102206China Hebei Key Laboratory of Molecular Medicine Shijiazhuang 050051China Hebei Clinical Research Center for Laboratory Medicine Shijiazhuang 050051China Department of Laboratory Medicine Children's Hospital of Hebei ProvinceShijiazhuang 050031China Yantai Center for Disease Control and Prevention Yantai 264003China

human enteroviruses(HEVs)include many different types that cause a wide range of diseases,and an effective method of genus-level identification has therefore significant clinical ***,quantitative real-time reverse transcription polymerase chain reaction(qRT-PCR),the gold-standard method,still has shortfalls in diagnostic sensitivity and *** we established a one-step real-time reverse-transcription recombinase-aided PCR assay(RT-RAP)to detect HEV fragment within an *** RT-RAP assay showed a detection limit of 5 copies/μL using recombinant plasmids and was extensively verified using 15 HEV *** 15 types of HEV(species A-C),the sensitivity of RT-RAP was approximately 2-8 folds lower than that of the qRT-PCR in 9 types,and no-cross reaction with other viruses was ***-RAP was further applied to analyze CSF and fecal specimens;the clinical performance demonstrated that the RT-RAP and the commercial qRT-PCR kit provided consistent *** results indicated that RT-RAP assay may be a promising approach for rapid and sensitive detection of HEV.

关键词： human enteroviruses Nucleic acid detection RT-RAP assay

Exploring the role of iron in Fe_(5)Ni_(4)S_(8)toward oxygen evolution through modulation of electronic orbital occupancy

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Journal of Energy Chemistry 2024年第5期92卷 52-62页

作者： Zhengyan Du Zeshuo Meng Haoteng Sun Yifan Li Chao Jiang yaxin Li Xiaoying hu Yi Cui Shansheng Yu Hongwei Tian Key Laboratory of Automobile Materials of MOE School of Materials Science and EngineeringJilin UniversityChangchun 130012JilinChina College of Science and Laboratory of Materials Design and Quantum Simulation Changchun UniversityChangchun 130022JilinChina i-lab Vacuum Interconnected Nanotech Workstation(Nano-X)Suzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of SciencesSuzhou 215123JiangsuChina Department of Chemistry Brown UniversityRI 02912United States

Ni-Fe-based catalysts are considered to be among the most active catalysts for the oxygen evolution reaction(OER)under alkaline conditions,with Fe playing a crucial ***,Fe leaching occurs during the reaction due to thermodynamic instability,which has resulted in conflicting reports within the literature regarding its *** clarify this point,we propose a strategy consisting of modulating the electronic orbital occupancy to suppress the extensive loss of Fe atoms during the OER *** calculations,in-situ X-ray photoelectron spectroscopy,molecular dynamics simulations,and a series of characterization showed that the stable presence of Fe not only accelerates the electron transfer process but also optimizes the reaction barriers of the oxygen evolution intermediates,promoting the phase transition of Fe_(5)Ni_(4)S_(8)to highly active catalytic *** modulated Fe_(5)Ni_(4)S_(8)-based pre-catalysts exhibit improved OER activity and long-term *** study provides a novel perspective for understanding the role of Fe in the OER process.

关键词： Oxygenevolution Fe_(5)Ni_(4)S_(8) Electronic orbital occupancy modulation Reconstruction dynamics

保险产品开发管理之监管制度构建——基于域外产品适合性的法律规制研究

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湖北警官学院学报 2022年第6期35卷 150-159页

作者：胡雅心中南财经政法大学法学院湖北武汉430073

提升保险产品适合性是保险学界关注的重要问题,保险公司的产品开发管理直接影响保险消费者能否购买到合适产品。针对保险产品开发管理,我国《保险法》要求保险公司建立精算报告和合规报告制度,并由监管机构审批保险公司设计的保险条款... 详细信息

提升保险产品适合性是保险学界关注的重要问题,保险公司的产品开发管理直接影响保险消费者能否购买到合适产品。针对保险产品开发管理,我国《保险法》要求保险公司建立精算报告和合规报告制度,并由监管机构审批保险公司设计的保险条款和保险费率。然而保险产品开发过程复杂,现有的监管制度不足以保证保险消费者购买到合适的保险产品。结合域外法律规制的经验,我国保险公司应该通过建立科学有效的产品开发管理机制,对适合该保险产品的客户以及销售方式统筹安排,以书面文件形式提交监管部门统一审批。

关键词：保险产品适合性消费者保护风险评级产品开发管理重要信息文件审批

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儿童、青年与老年人在知觉和高阶元认知监控上的年龄差异

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心理发展与教育 2023年第2期39卷 153-160页

作者：董肖肖刘岩胡亚欣辽宁师范大学心理学院大连116029 郑州商学院郑州451200 郑州市惠济区艺术小学郑州450000

元认知是以监测和控制为核心的动态调节活动。本研究以9岁儿童、年轻人和老年人为研究对象,分别采用选点任务和词对学习任务,在知觉元认知和高阶元认知层次考察元认知监测和控制及其关系随年龄变化的特点。结果显示:(1)儿童的知觉元认... 详细信息

元认知是以监测和控制为核心的动态调节活动。本研究以9岁儿童、年轻人和老年人为研究对象,分别采用选点任务和词对学习任务,在知觉元认知和高阶元认知层次考察元认知监测和控制及其关系随年龄变化的特点。结果显示:(1)儿童的知觉元认知和高阶元认知监控能力大都低于年轻人;(2)老年人的知觉元认知能力与年轻人相似,但高阶元认知能力则低于年轻人;(3)老年人和年轻人一样能够在记忆监测中利用控制线索,而9岁儿童尚未表现出这种能力。本研究从发展的角度,支持了知觉元认知与高阶元认知能力具有领域特殊性的理论假设,并对监测和控制的关系发展进行了讨论。

关键词：知觉元认知高阶元认知监测控制发展

human mobility data in the COVID-19 pandemic:characteristics,applications,and challenges

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International Journal of Digital Earth 2021年第9期14卷 1126-1147页

作者： Tao hu Siqin Wang Bing She Mengxi Zhang Xiao huang Yunhe Cui Jacob Khuri yaxin hu Xiaokang Fu Xiaoyue Wang Peixiao Wang Xinyan Zhu Shuming Bao Wendy Guan Zhenlong Li Department of Geography Oklahoma State UniversityStillwaterOKUSA Center for Geographic Analysis Harvard UniversityCambridgeMAUSA School of Earth and Environmental Sciences The University of QueenslandSt LuciaAustralia Institute for Social Research University of MichiganAnn ArborMIUSA School of Health Ball State UniversityMuncieINUSA Department of Geosciences University of ArkansasFayettevilleARUSA Department of Geography University of ConnecticutStorrsCTUSA Lake Erie College of Osteopathic Medicine Seton Hill UniversityGreensburgPAUSA School of Resource and Environmental Sciences Wuhan UniversityWuhanPeople’s Republic of China State Key Laboratory of Information Engineering in Surveying Mapping and Remote SensingWuhan UniversityWuhanPeople’s Republic of China China Data Institute Ann ArborMIUSA Geoinformation and Big Data Research Laboratory Department of GeographyUniversity of South CarolinaColumbiaSCUSA

The COVID-19 pandemic poses unprecedented challenges around the *** studies have applied mobility data to explore spatiotemporal trends over time,investigate associations with other variables,and predict or simulate the spread of *** objective was to provide a comprehensive overview of human mobility open data to guide researchers and policymakers in conducting data-driven evaluations and decision-making for the COVID-19 pandemic and other infectious disease *** summarized the mobility data usage in COVID-19 studies by reviewing recent publications on COVID-19 and human mobility from a data-oriented *** identified three major sources of mobility data:public transit systems,mobile operators,and mobile phone *** approaches have been commonly used to estimate human mobility:public transit-based flow,social activity patterns,index-based mobility data,and social media-derived mobility *** compared mobility datasets’characteristics by assessing data privacy,quality,space–time coverage,high-performance data storage and processing,and *** also present challenges and future directions of using mobility *** review makes a pivotal contribution to understanding the use of and access to human mobility data in the COVID-19 pandemic and future disease outbreaks.

关键词： COVID-19 public health human mobility open data mobile phone mobility index