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阿帕替尼治疗原发和复发胶质瘤的不良反应差异性分析

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中华实验外科杂志 2024年第9期41卷 1949-1951页

作者：毛冲冲张庆浩冯亚文赵海彪刘献志郑州大学第一附属医院神经外科郑州450000

目的探究阿帕替尼在治疗原发及复发胶质瘤时出现各类不良反应是否存在差异及其剂量相关性.方法本研究纳入2016年8月至2019年9月在郑州大学第一附属医院接受阿帕替尼治疗的103例脑胶质瘤患者并进行回顾性分析,获取患者临床资料、阿帕... 详细信息

目的探究阿帕替尼在治疗原发及复发胶质瘤时出现各类不良反应是否存在差异及其剂量相关性.方法本研究纳入2016年8月至2019年9月在郑州大学第一附属医院接受阿帕替尼治疗的103例脑胶质瘤患者并进行回顾性分析,获取患者临床资料、阿帕替尼应用方案及不良反应情况.卡方检验和Logistic回归用于挖掘独立相关因素.结果 103例应用阿帕替尼的患者中共有44例出现不同类型的不良反应,主要包括血压升高16例(15.53%)、手足综合征11例(10.68%)、胃肠道反应10例(9.71%)等,这些不良反应在复发胶质瘤中出现的频率[47.19%(42/89)]高于原发胶质瘤[14.29%(2/14)],且差异有统计学意义(P0.05).结论阿帕替尼在治疗原发及复发胶质瘤时出现不良反应存在明显差异,但未发现存在剂量相关性.

关键词：胶质瘤阿帕替尼并发症

近12a江西省酸雨时空变化及受酸性气体影响研究

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赣南师范大学学报 2024年第3期45卷 101-110页

作者：黄秀珍杜超冯雅雯王宵君李松涛郑彬赣南师范大学地理与环境工程学院江西赣州341000

基于2010-2021年江西省酸雨观测数据及大气污染物排放数据,采用GIS空间插值等方法,分析讨论了江西省酸雨时空变化特征及大气污染物变化情况,以期为江西省实现社会经济与环境之间的协调可持续发展提供理论支撑.结果表明:Ⅰ2010-2021年江... 详细信息

基于2010-2021年江西省酸雨观测数据及大气污染物排放数据,采用GIS空间插值等方法,分析讨论了江西省酸雨时空变化特征及大气污染物变化情况,以期为江西省实现社会经济与环境之间的协调可持续发展提供理论支撑.结果表明:Ⅰ2010-2021年江西省酸雨污染状况整体减弱,降水年均pH值从4.9上升到5.5,酸雨频率从78%下降到25%.夏秋季节酸雨污染程度较低,春冬季节相反;Ⅱ江西省酸雨空间分布特征明显,赣东北地区酸雨出现频率高,呈东北-西南走向.酸雨情况从第一季度到第三季度,除九江、宜春外,其余城市酸雨情况均加重,其中赣南地区加重程度明显,且各地级市酸雨污染情况月份特征显著;Ⅲ大气SO_(2)浓度下降比例与酸雨频率下降比例高度拟合,且与降水年均pH值的线性相关程度最高,是影响江西省酸雨发生的主要原因之一.SO_(2)、NO_(X)工业排放量下降是影响江西省酸雨污染减轻的主要因素.

关键词：酸雨变化趋势时空分布酸性气体江西省

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术前血清学指标对脑胶质瘤分级和异柠檬酸脱氢酶状态具有预测意义

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中华实验外科杂志 2024年第6期41卷 1291-1294页

作者：毛冲冲张庆浩于洋邱锴冯亚文刘献志郑州大学第一附属医院神经外科郑州450000

目的探讨术前血清学指标对弥漫性胶质瘤异柠檬酸脱氢酶(IDH)突变和世界卫生组织(WHO)级别的预测意义。方法本研究共纳入1058例在郑州大学第一附属医院接受手术治疗的WHOⅡ~Ⅳ级胶质瘤患者,获取患者临床资料和术前血清学指标并检测IDH突... 详细信息

目的探讨术前血清学指标对弥漫性胶质瘤异柠檬酸脱氢酶(IDH)突变和世界卫生组织(WHO)级别的预测意义。方法本研究共纳入1058例在郑州大学第一附属医院接受手术治疗的WHOⅡ~Ⅳ级胶质瘤患者,获取患者临床资料和术前血清学指标并检测IDH突变。t检验和Logistic回归用于挖掘独立相关因素,通过ROC曲线评估血清学指标对WHO级别和IDH突变的预测意义。结果在独立样本t检验中,IDH野生组PDW(P<0.05)、MPV(P<0.001)高于IDH突变组,IDH野生组AGR(P<0.001)低于IDH突变组。WHOⅣ级组的PDW(P<0.05)、MPV(P<0.001)、NLR(P<0.05)、PLR(P<0.05)和SII(P<0.05)高于WHOⅡ~Ⅲ级组,WHO IV级组的AGR(P<0.001)低于WHOⅡ~Ⅲ级组。Logistic回归分析显示年龄(P<0.001)、MPV(P<0.001)和AGR(P<0.001)是IDH突变的独立预测因子。此外,较高的年龄(P<0.001)、MPV(P<0.001)和PLR(P<0.05)以及较低的AGR(P<0.001)预示着较高的WHO级别。通过绘制ROC曲线,结果显示MPV、AGR和年龄联合应用对IDH突变有最好的预测效果,曲线下面积(AUC)为0.789。对于WHO级别,MPV、PLR、AGR和年龄的联合预测更为有效和准确,AUC为0.774。结论术前血清学指标联合患者年龄可有效预测弥漫性胶质瘤患者IDH突变和WHO级别。

关键词：胶质瘤血清学指标异柠檬酸脱氢酶世界卫生组织预测模型

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无症状胶质瘤的差异性基因表达及其富集分析

中华实验外科杂志 2024年第5期41卷 1055-1057页

作者：冯亚文毛冲冲耿俊杰邱锴赵海彪刘献志郑州大学第一附属医院神经外科郑州450052

目的:分析有无症状世界卫生组织(WHO)2级脑胶质瘤的差异表达基因和相关富集通路,为胶质瘤的综合诊疗寻找新的靶点。方法:选取于2018年1月至2019年12月间在郑州大学第一附属医院神经外科接受手术治疗的27例WHO 2级脑胶质瘤患者[年龄(42.1... 详细信息

目的:分析有无症状世界卫生组织(WHO)2级脑胶质瘤的差异表达基因和相关富集通路,为胶质瘤的综合诊疗寻找新的靶点。方法:选取于2018年1月至2019年12月间在郑州大学第一附属医院神经外科接受手术治疗的27例WHO 2级脑胶质瘤患者[年龄(42.1±11.2)岁]进行本次研究。获取其临床随访资料和测序数据,将其分为无症状组(9例)和有症状组(18例)。通过R语言软件对比分析两组患者基因表达的差异。通过Metascape网站进行富集分析寻找相关富集通路。结果:在27例WHO 2级胶质瘤患者中,共筛选出127个差异表达基因,其中52上调基因,75个下调基因,并且在"急性炎性反应"、"血液循环"、"硫化合物结合"和"神经活性配体-受体相互作用"等通路中富集。结论:无症状WHO 2级胶质瘤具有特异性的基因表达差异并存在相关富集通路。

关键词：神经胶质瘤低级别差异表达基因富集分析

Stabilizing semi-transparent perovskite solar cells with a polymer composite hole transport layer

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Nano Research 2024年第3期17卷 1500-1507页

作者： Yongbin Jin Huiping feng Zheng Fang Liu Yang Kaikai Liu Bingru Deng Jingfu Chen Xueling Chen yawen Zhong Jinxin Yang Chengbo Tian Liqiang Xie Zhanhua Wei Xiamen Key Laboratory of Optoelectronic Materials and Advanced Manufacturing Institute of Luminescent Materials and Information DisplaysCollege of Materials Science and EngineeringHuaqiao UniversityXiamen 361021China

Semi-transparent perovskite solar cells(ST-PSCs)have broad applications in building integrated ***,the stability of ST-PSCs needs to be improved,especially in n-i-p ST-PSCs since the doped 2,2',7,7'-tetrakis(N,N-di-p-methoxyphenyl-amine)-9,9'-spirobifluorene(Spiro-OMeTAD)is unstable at elevated temperatures and high *** this work,aπ-conjugated polymer poly[(2,6-(4,8-bis(5-(2-ethylhexyl)thiophene-2-yl)-benzo[1,2-b:4,5-b']dithiophene))-alt-(5,5-(1',3'-di-2-thienyl-5',7'-bis(2-ethylhexyl)benzo[1',2'-c:4',5'-c']dithiophene-4,8-dione)](PBDB-T)is selected to form a polymer composite hole transport layer(HTL)with *** sulfur atom of the thiophene unit and the carbonyl group of the polymer interact with the undercoordinated Pb2+at the perovskite surface,which stabilizes the perovskite/HTL interface and passivates the interfacial *** incorporation of the polymer also increases the glass transition temperature and the moisture resistance of *** a result,we obtain ST-PSCs with a champion efficiency of 13.71%and an average visible light transmittance of 36.04%.Therefore,a high light utilization efficiency of 4.94%can be ***,the encapsulated device can maintain 84%of the initial efficiency after 751 h under continuous one-sun illumination(at 30%relative humidity)at the open circuit and the unencapsulated device can maintain 80%of the initial efficiency after maximum power tracking for more than 1250 h under continuous one-sun illumination.

关键词： semi-transparent solar cells π-conjugated polymer composite hole transport layer building integrated photovoltaics

Neural stem cell-derived exosomes promote mitochondrial biogenesis and restore abnormal protein distribution in a mouse model of Alzheimer's disease

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Neural Regeneration Research 2024年第7期19卷 1593-1601页

作者： Bo Li Yujie Chen Yan Zhou Xuanran feng Guojun Gu Shuang Han Nianhao Cheng yawen Sun Yiming Zhang Jiahui Cheng Qi Zhang Wei Zhang Jianhui Liu Department of Radiology Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Morphology and Spatial Multi-Omics Technology Platform Shanghai Institute of Nutrition and HealthChinese Academy of SciencesShanghaiChina Department of Anesthesiology Tongji HospitalSchool of MedicineTongji UniversityShanghaiChina Department of Blood Transfusion Huashan HospitalFudan UniversityShanghaiChina

Mitochondrial dysfunction is a hallmark of Alzheimer’s *** previously showed that neural stem cell-derived extracellular vesicles improved mitochondrial function in the cortex of AP P/PS1 *** Alzheimer’s disease affects the entire brain,further research is needed to elucidate alterations in mitochondrial metabolism in the brain as a ***,we investigated the expression of several important mitochondrial biogenesis-related cytokines in multiple brain regions after treatment with neural stem cell-derived exosomes and used a combination of whole brain clearing,immunostaining,and lightsheet imaging to clarify their spatial ***,to clarify whether the sirtuin 1(SIRT1)-related pathway plays a regulatory role in neural stem cell-de rived exosomes interfering with mitochondrial functional changes,we generated a novel nervous system-SIRT1 conditional knoc kout AP P/PS1mouse *** findings demonstrate that neural stem cell-de rived exosomes significantly increase SIRT1 levels,enhance the production of mitochondrial biogenesis-related fa ctors,and inhibit astrocyte activation,but do not suppress amyloid-β***,neural stem cell-derived exosomes may be a useful therapeutic strategy for Alzheimer’s disease that activates the SIRT1-PGC1αsignaling pathway and increases NRF1 and COXIV synthesis to improve mitochondrial *** addition,we showed that the spatial distribution of mitochondrial biogenesis-related factors is disrupted in Alzheimer’s disease,and that neural stem cell-derived exosome treatment can reverse this effect,indicating that neural stem cell-derived exosomes promote mitochondrial biogenesis.

关键词： Alzheimer’s disease mitochondrial biogenesis neural stem cell-derived exosome SIRT1-PGC1α regional brain distribution whole brain clearing and imaging

A Mini-review for the Application of Bacterial Cellulose-based Composites

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Paper And Biomaterials 2023年第1期8卷 1-11页

作者： Weiyin Su Zhixin Wang Zeyu Chang yawen feng Xi Yao Meng Wang Kun Wang Jianxin Jiang MOE Engineering Research Center of Forestry Biomass Materials and Bioenergy College of Materials Science and TechnologyBeijing Forestry UniversityBeijing100083China International Centre for Bamboo and Rattan Beijing100102China China National Pulp and Paper Research Institute Co. Ltd.Beijing100102China

Countries are duly focusing more on biomass resources because of the increasing oil *** to their excellent properties,such as natural characteristics,good mechanical performance,and outstanding chemical properties,cellulose-based materials are highly valued as promising bioderived nanomaterials,especially bacterial cellulose(BC).The main advantage lies in eliminating the problem of removing lignin and hemicellulose from woody ***,the use of BC reduces the consumption of wood,the excessive use of which aggravates global ***,we summarize the applications of BC composites in filter,medical,and conductive materials,and other *** review contributes to further expand the applications of this renewable polymer.

关键词： bacterial cellulose functional composites application sustainable materials

Modulating the interfacial microenvironment via zwitterionic additive for long-cycling aqueous Zn-ion batteries

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Science China Materials 2024年第9期67卷 2898-2907页

作者： yawen Xie Shuang feng Jiechang Gao Tao Cheng Liang Zhang Institute of Functional Nano&Soft Materials(FUNSOM) Soochow UniversitySuzhou215123China Jiangsu Key Laboratory of Advanced Negative Carbon Technologies Soochow UniversitySuzhou215123China

Aqueous zinc-ion batteries(AZIBs)have garnered extensive attention as promising energy storage systems because of the advantages of low cost and high ***,severe parasitic reactions at the Zn anode surface pose a huge challenge for the practical application of AZIBs,especially the intricate hydrogen evolution reaction(HER)and Zn dendrite ***,zwitterionic taurine with isoelectric point property is introduced as an electrolyte additive to construct a passivation layer by adapting its net charge to the microenvironment variation for stabilizing the Zn *** experimental and theoretical results reveal that taurine can not only in-situ form a hydrophobic and zincophilic layer on the Zn anode surface via the chelation with Zn^(2+)in the alkaline interfacial microenvironment,but also buffer the pH change dynamically,thus effectively suppressing the HER and Zn dendrite *** a consequence,the taurine-containing electrolyte enables a stable cycling of Zn anodes in symmetric Zn∥Zn cells for more than 1800 h under a deep plating/stripping condition(5 mA cm^(-2)and 5 mAh cm^(-2)).More encouragingly,the full cells coupled with the NH_(4)V_(4)O_(10)cathode can also exhibit an excellent capacity retention of 89.8%after 1200 *** efficient strategy with an environmental adaptive additive offers valuable insights for mitigating the side reactions to achieve practical AZIBs and beyond.

关键词： aqueous zinc-ion batteries passivation layer pH buffer interfacial microenvironment zwitterionic additive

Shenqi Fuzheng injection alleviates chemotherapy-induced cachexia by restoring glucocorticoid signaling in hypothalamus

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Journal of Pharmaceutical Analysis 2024年第3期14卷 431-434页

作者： Entezar Berik Zijia Zhang Wei Li yawen Liu Sihan Chen Wenyong Wu Zhaojun Wang Xinqin Kong Wenqiang Pei Huiqing Dong Huali Long Min Lei Jennifer Yiyang Wang Liangfeng Liu Jinjun Hou Jing feng Zhaoxia Li Wanying Wu De-an Guo Beijing Key Lab of TCM Collateral Disease Theory Research School of Traditional Chinese MedicineCapital Medical UniversityBeijing100069China National Engineering Research Center of TCM Standardization Technology Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai201203China University of Chinese Academy of Sciences Beijing100049China School of Chinese Materia Medica Nanjing University of Chinese MedicineNanjing210029China Limin Pharmaceutical Factory Livzon Group LimitedShaoguanGuangdong512028China Guangdong Corporate Key Laboratory of High-End Liquid Medicine R&D IndustrilizationShaoguanGuangdong512028China Center for Neurological and Psychiatric Research and Drug Discovery Shanghai Institute of Materia MedicaChinese Academy of ScienceShanghai201203China

Chemotherapy-induced cachexia(CIC)is a debilitating condition characterized by weight loss,muscle atrophy,and anorexia[1].While peripheral mechanisms of cachexia have been extensively studied,the involvement of the central nervous system(CNS)in CIC is often *** drugs cause stress responses and inflammation,which may impact the hypothalamus and disrupt systemic energy and neuroendocrine *** hypothalamic roles in regulating these processes can provide insights into CIC's mechanisms and aid in developing novel therapies.

关键词： injection drugs glucocorticoid chemotherapy