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Optimal sequential therapy using tyrosine kinase inhibitors as the first-line treatment in patients with metastatic renal cell carcinoma: A nationwide multicenter study

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Asian Journal of Urology 2024年第3期11卷 450-459页

作者： Jung Ki Jo seong Il seo MinYong Kang Jinsoo Chung Cheol Kwak Sung-Hoo Hong Cheryn Song Jae Young Park Chang Wook Jeong seok Hwan Choi Sung Han Kim Eu Chang Hwang Chan Ho Lee Hakmin Lee Department of Urology Medical and Digital EngineeringCollege of MedicineHanyang UniversitySeoulRepublic of Korea Department of Urology Samsung Medical CenterSungkyunkwan University School of MedicineSeoulRepublic of Korea Department of Urology National Cancer CenterGoyangRepublic of Korea Department of Urology Seoul National University HospitalSeoulRepublic of Korea Department of Urology Kangnam St Mary’s HospitalSeoulRepublic of Korea Department of Urology Asan Medical CenterSeoulRepublic of Korea Department of Urology Korea University Ansan HospitalAnsanRepublic of Korea Department of Urology Kyungpook National University HospitalDaeguRepublic of Korea Department of Urology Chonnam National University Hwasun HospitalHwasunRepublic of Korea Department of Urology Inje University Busan Paik HospitalBusanRepublic of Korea Department of Urology Seoul National University Bundang HospitalSeongnamRepublic of Korea

Objective:The purpose of the study was to identify the best sequence of therapy beginning with a tyrosine kinase inhibitor(TKI)as the first-line therapy for patients with metastatic renal cell carcinoma(mRCC)in terms of overall survival(OS),progression-free survival(PFS),and rates of discontinuation and adverse effects during the treatment ***:This is a retrospective,nationwide multicenter study of patients with mRCC after diagnosis at 10 different tertiary medical centers in Korea from January 1992 to December *** focused on patients at either“favorable”or“intermediate”risk according to the International mRCC Database Consortium criteria,and they were followed up(median 335 days).Finally,a total of 1409 patients were selected as the study *** generated a Cox proportional hazard model adjusted for covariates,and the different therapy schemes were statistically tested in terms of OS as well as *** addition,frequencies of discontinuation and adverse events were compared among the therapy ***:Of the primary patterns of treatment sequences(24 sequences),“sunitinib epazopanib”and“sunitinibeeverolimuseimmunotherapy”showed the most beneficial results in both OS and PFS with significantly lower hazards than“sunitinib”,which is the most commonly treated agent in *** that the“TKIeTKI”structure showed relatively higher discontinuation rates with higher adverse effects,the overall beneficial sequence would be“sunitinibeeverolimuseimmunotherapy”.Conclusion:Among several sequential therapy starting with TKIs,“sunitinibeeverolimuse immunotherapy”was found to be the best scheme for mRCC patients with“favorable”or“intermediate”risks.

关键词： Tyrosinekinase inhibitor Metastaticrenalcell carcinoma Overall survival Progression-free survival

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Realizing High Thermoelectric Performance in n-Type Se-Free Bi2Te3 Materials by Spontaneous Incorporation of FeTe2 Nanoinclusions

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Energy & Environmental Materials 2024年第4期7卷 344-354页

作者： Jamil Ur Rahman Woo Hyun Nam Yong-Jae Jung Jong Ho Won Jong-Min Oh Nguyen Van Du Gul Rahman Víctor M.García-Suárez Ran He Kornelius Nielsch Jung Young Cho Won-seon seo Jong Wook Roh Sang-il Kim Soonil Lee Kyu Hyoung Lee Hyun Sik Kim Weon Ho Shin Leibniz Institute for Solid State and Materials Research Advanced Materials Convergence R&D Division Korea Institute of Ceramic Engineering & Technology Department of Electronic Materials Engineering Kwangwoon University Department of Energy Engineering Dankook University Faculty of Fundamental Science Phenikaa University Department of Physics Quaid-i-Azam University Departamento de Física Universidad de Oviedo Nanomaterials and Nanotechnology Research Center-CINN Department of Materials Science and Engineering Yonsei University School of Nano & Materials Science and Engineering Kyungpook National University Department of Materials Science and Engineering University of Seoul School of Materials Science and Engineering Changwon National University

Bi2Te3-based materials have drawn much attention from the thermoelectric community due to their excellent thermoelectric performance near room ***,the stability of existing n-type Bi2（Te,Se）3materials is still low due to the evaporation energy of Se (37.70 kJ mol-1) being much lower than that of Te (52.55 kJ mol-1).The evaporated Se from the material causes problems in interconnects of the module while degrading the efficiency.

关键词： Bi2Te3 energy harvesting FeTe2 nanoinclusion n-type materials thermoelectric

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Immunoglobulin G4-related spinal pachymeningitis:A case report

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World Journal of Clinical Cases 2024年第32期12卷 6551-6558页

作者： Tae-seok Chae Da-Sol Kim Gi-Wook Kim Yu Hui Won Myoung-Hwan Ko Sung-Hee Park Jeong-Hwan seo Department of Physical Medicine&Rehabilitation Jeonbuk National University Medical SchoolJeonju 54907South Korea Department of Physical Medicine&Rehabilitation Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University HospitalJeonju 54907South Korea

BACKGROUND Immunoglobulin G4-related disease(IgG4-RD)is a complex immune-mediated condition that causes fibrotic inflammation in several organs.A significant clinical feature of IgG4-RD is hypertrophic pachymeningitis,which manifests as inflammation of the dura mater in intracranial or spinal *** IgG4-RD can affect multiple areas,the spine is a relatively rare site compared to the more frequent involvement of intracranial *** SUMMARY A 70-year-old male presented to our hospital with a two-day history of fever,altered mental status,and generalized *** initial brain magnetic resonance imaging(MRI)revealed multiple small infarcts across various cerebral *** the second day after admission,a physical examination revealed motor weakness in both lower extremities and diminished sensation in the right lower *** evaluation revealed findings consistent with acute motor sensory *** initial management with intravenous immunoglobulin for presumed Guillain-Barrésyndrome,the patient exhibited progressive worsening of motor *** the 45th day of hospitalization,an enhanced MRI of the entire spine,focusing specifically on the thoracic 9 to lumbar 1 vertebral level,raised the suspicion of IgG4-related spinal ***,the patient was administered oral prednisolone and participated in a comprehensive rehabilitation program that included gait training and lower extremity strengthening *** IgG4-related spinal pachymeningitis,diagnosed on MRI,was treated with corticosteroids and a structured rehabilitation regimen,leading to significant improvement.

关键词： Immunoglobulin G4 related disease Immunoglobulin G4 related spinal pachymeningitis Manual motor test Electromyography Magnetic resonance imaging Case report

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Statistical determination of significant curved I-girder bridge seismic response parameters

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Earthquake Engineering and Engineering Vibration 2013年第2期12卷 251-260页

作者： Junwon seo Department of Civil Construction & Environmental EngineeringIowa State University

Curved steel bridges are commonly used at interchanges in transportation networks and more of these structures continue to be designed and built in the United States. Though the use of these bridges continues to increase in locations that experience high seismicity, the effects of curvature and other parameters on their seismic behaviors have been neglected in current risk assessment tools. These tools can evaluate the seismic vulnerability of a transportation network using fragility curves. One critical component of fragility curve development for curved steel bridges is the completion of sensitivity analyses that help identify influential parameters related to their seismic response. In this study, an accessible inventory of existing curved steel girder bridges located primarily in the Mid-Atlantic United States （MAUS） was used to establish statistical characteristics used as inputs for a seismic sensitivity study. Critical seismic response quantities were captured using 3D nonlinear finite element models. Influential parameters from these quantities were identified using statistical tools that incorporate experimental Plackett-Burman Design （PBD）, which included Pareto optimal plots and prediction profiler techniques. The findings revealed that the potential variation in the influential parameters included number of spans, radius of curvature, maximum span length, girder spacing, and cross-frame spacing. These parameters showed varying levels of influence on the critical bridge response.

关键词： Plackett-Burman design pareto plot prediction profiler statistical characteristics steel bridge seismic response

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Intensive-visible-light-responsive ANbO_(2)N(A = Sr, Ba) synthesized from layered perovskite A_(5)Nb_(4)O_(15) for enhanced photoelectrochemical water splitting

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Journal of Energy Chemistry 2022年第5期31卷 529-537页

作者： Sukanya Ramaraj Jeongsuk seo Departmentof Chemistry.College of Natural Sciences Chonnam National University.77 Yongbong-ro Buk-gu Gwangju 61186Republicof Korea

Nb-based, perovskite-type oxynitrides ANb(O,N)_(3)(A = Sr, Ba) have been significantly attractive semiconductor materials for photoelectrochemical(PEC) water splitting due to their absorption abilities of intensive-visible-light. However, PEC activities of these perovskites are relatively low due to reduction of Nb species during nitridation leading to the generation of anion defects and impurity ***, we propose nitridation of A-rich, layered perovskite A_(5)Nb_(4)O_(15) as starting oxides for general synthesis of photoactive ANbO_(2)N. These layered perovskite A_(5)Nb_(4)O_(15) were completely transformed to single phase perovskite-type ANbO_(2)N by nitridation. Wavelength onsets of light absorption were observed at 700 nm for SrNbO_(2)N and at 740 nm for BaNbO_(2)N. According to X-ray photoelectron spectroscopy results,excess Lewis base A species significantly suppressed the generation of reduced species such as Nb^(4+) and Nb^(3+)during nitridation, although it led to an amorphous surface of the as-prepared *** annealing in Ar largely enhanced surface crystallinity of ANbO_(2)N. As a result, Co(OH)_(x)/ANbO_(2)N/FTO photoanodes, prepared by loading Co(OH)_(x) electrocatalyst, showed high photocurrent density of 1.6(A = Sr) and 2.4 m A cm^(-2)(A = Ba) at 1.23 VRHEunder AM 1.5 G simulated sunlight. These results demonstrate that A-rich layered perovskite A_(5)Nb_(4)O_(15)are effective starting precursors for preparing lowdefective ANbO_(2)N, thus improving PEC water splitting activity.

关键词： Perovskite-type oxynitride CaNbO_(2)N SrNbO_(2)N BaNbO_(2)N A-rich starting oxide Surface heat treatment Ar annealing Solar water oxidation

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Mott insulator-superfluid phase transition in a detuned multi-connected Jaynes-Cummings lattice

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Science China(Physics,Mechanics & Astronomy) 2015年第7期58卷 17-22页

作者： seo Kangjun TIAN Lin School of Natural Sciences University of California

The connectivity and tunability of superconducting quantum devices provide a rich platform to build quantum simulators and study novel many-body physics. Here we study quantum phase transition in a detuned multi-connected Jaynes-Cummings lattice, which can be constructed with superconducting circuits. This model is composed of alternatively connected qubits and cavity *** a numerical method, we show that by varying the detuning between the qubits and the cavities, a phase transition from the superfluid phase to the Mott insulator phase occurs at commensurate fillings in a one-dimensional array. We study the phase transition in lattices with symmetric and asymmetric couplings, respectively.

关键词： superconducting quantum devices quantum simulation Jaynes-Cummings lattice phase transition

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Surface-enhanced Raman spectroscopy for emerging contaminant analysis in drinking water

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Frontiers of Environmental Science & Engineering 2023年第5期17卷 51-65页

作者： seo Won Cho Haoran Wei Environmental Chemistry and Technology Program University of Wisconsin–MadisonMadisonWI 53706USA Department of Civil and Environmental Engineering University of Wisconsin–MadisonMadisonWI 53706USA

Emerging contaminants(ECs)in drinking water pose threats to public health due to their environmental prevalence and potential *** occurrence of ECs in our drinking water supplies depends on their physicochemical properties,discharging rate,and susceptibility to removal by water treatment *** health effects of long-term exposure to ECs justify their regular monitoring in drinking water *** this review article,we will summarize the current status and future opportunities of surface-enhanced Raman spectroscopy(SERS)for EC analysis in drinking *** principles of SERS are first introduced and a comparison of SERS and liquid chromatography-tandem mass spectrometry in terms of cost,time,sensitivity,and availability is ***,we discuss the strategies for designing effective SERS sensors for EC analysis based on five categories—per-and polyfluoroalkyl substances,novel pesticides,pharmaceuticals,endocrine-disrupting chemicals,and *** addition to maximizing the intrinsic enhancement factors of SERS substrates,strategies to improve hot spot accessibilities to the targeting ECs are equally *** is a review article focusing on SERS analysis of ECs in drinking *** discussions are not only guided by numerous endeavors to advance SERS technology but also by the drinking water regulatory policy.

关键词： Emerging contaminant Surface-enhanced Raman spectroscopy Drinking water monitoring Sensor Regulatory policy

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Recent advances in plant membrane-bound transcription factor research: Emphasis on intracellular movement

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Journal of Integrative Plant Biology 2014年第4期56卷 334-342页

作者： Pil Joon seo Department of Bioactive Material Sciences Chonbuk National University Research Center of Bioactive Materials Chonbuk National University Department of Chemistry and Research Institute of Physics and Chemistry Chonbuk National University

Transcription factors constitute numerous signal transduction networks and play a central role in gene expression regulation. Recent studies have shown that a limited portion of transcription factors are anchored in the cellular membrane, storing as dormant forms. Upon exposure to environmental and developmental cues, these transcription factors are released from the membrane and translocated to the nucleus, where they regulate associated target genes. As this process skips both transcriptional and translational regulations, it guarantees prompt response to external and internal signals. Membrane- bound transcription factors （MTFs） undergo several unique steps that are not involved in the action of canonical nuclear transcription factors： proteolytic processing and intracellular movement. Recently, alternative splicing has also emerged as a mechanism to liberate MTFs from the cellular membranes, establishing an additional activation scheme independent of proteolytic processing. Multiple layers of MTF regulation add complexity to transcriptional regulatory scheme and ensure elaborate action of MTFs. In this review, we provide an overview of recent findings on MTFs in plants and highlight the molecular mechanisms underlying MTF liberation from cellular membranes with an emphasis on intracellular movement.

关键词： Alternative splicing basic leucine zipper membrane-boundtranscription factor bZIP28 intracellular movement membrane-bound transcription factor NTL proteolytic processing

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Effectiveness Analysis of DVFS and DPM in Mobile Devices

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Journal of Computer Science & Technology 2012年第4期27卷 781-790页

作者： Youngbin seo Jeongki Kim Euiseong seo Computer Science and Engineering Major University of Science and Technology217 Gajeong-roYuseong-guDaejeon 305-350Korea Electronics and Communications Research Institute 138 GajengnoYuseong-guDaejeonKorea College of Information and Communication Engineering Sungkyunkwan University2066 Seubu-roJangan-gu Suwon 440-746Korea

The demand for high-performance embedded processors in multimedia mobile electronics is growing and their power consumption thus increasingly threatens battery lifetime. It is usually believed that the dynamic voltage and frequency scaling （DVFS） feature saves significant energy by changing the performance levels of processors to match the performance demands of applications on the fly. However, because the energy efficiency of embedded processors is rapidly improving, the effectiveness of DVFS is expected to change. In this paper, we analyze the benefit of DVFS in state-of-the-art mobile embedded platforms in comparison to those in servers or PCs. To obtain a clearer view of the relationship between power and performance, we develop a measurement methodology that can synchronize time series for power consumption with those for processor utilization. The results show that DVFS hardly improves the energy efficiency of mobile multimedia electronics, and can even significantly worsen energy efficiency and performance in some cases. According to this observation, we suggest that power management for mobile electronics should concentrate on adaptive and intelligent power management for peripherM devices. As a preliminary design, we implement an adaptive network interface card （NIC） speed control that reduces power consumption by 1070 when NIC is not heavily used. Our results provide valuable insights into the design of power management schemes for future mobile embedded systems.

关键词： dynamic voltage scaling power management battery management energy eiffciency smart phone

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A Novel Transparent and Auditable Fog-Assisted Cloud Storage with Compensation Mechanism

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Tsinghua Science and Technology 2020年第1期25卷 28-43页

作者： Donghyun Kim Junggab Son Daehee seo Yeojin Kim Hyobin Kim Jung Taek seo Department of Computer Science Kennesaw State UniversityMariettaGA 30060USA Department of Information Security Engineering Soonchunhyang UniversityAsan 31538South Korea

This paper introduces a new fog-assisted cloud storage which can achieve much higher throughput compared to the traditional cloud-only storage architecture by reducing the traffics toward the cloud storage. The fog-storage service providers are transparency to end-users and therefore, no modification on the end-user devices is necessary. This new system is featured with(1) a stronger audit scheme which is naturally coupled with the proposed architecture and does not suffer from the replay attack and(2) a transparent and efficient compensation mechanism for the fog-storage service providers. We provide rigorous theoretical analysis on the correctness and soundness of the proposed system. To the best of our knowledge, this is the first paper to discuss about a storage data audit scheme for fog-assisted cloud storage as well as the compensation mechanism for the service providers of the fog-storage service providers.

关键词： fog computing cloud computing network storage data audit merkle hash tree integer factorization payment transparency

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