Recent advances in plant membrane-bound transcription factor research: Emphasis on intracellular movement

作     者：Pil Joon Seo 

作者机构：Department of Bioactive Material SciencesChonbuk National University Research Center of Bioactive Materials Chonbuk National University Department of Chemistry and Research Institute of Physics and ChemistryChonbuk National University 

出 版 物：《Journal of Integrative Plant Biology》 (植物学报（英文版）)

年 卷 期：2014年第56卷第4期

页      面：334-342页

核心收录：

学科分类：0710[理学-生物学] 090601[农学-基础兽医学] 07[理学] 09[农学] 0906[农学-兽医学] 071007[理学-遗传学] 0901[农学-作物学] 090102[农学-作物遗传育种] 

基　　金：supported by Basic Science Research Program through the National Research Foundation of Korea(NRF)funded by the Ministry of Education(NRF-2013R1A1A1004831) research funds of Chonbuk National University in 2012 

主　　题：Alternative splicing basic leucine zipper membrane-boundtranscription factor bZIP28 intracellular movement membrane-bound transcription factor NTL proteolytic processing 

摘      要：Transcription factors constitute numerous signal transduction networks and play a central role in gene expression regulation. Recent studies have shown that a limited portion of transcription factors are anchored in the cellular membrane, storing as dormant forms. Upon exposure to environmental and developmental cues, these transcription factors are released from the membrane and translocated to the nucleus, where they regulate associated target genes. As this process skips both transcriptional and translational regulations, it guarantees prompt response to external and internal signals. Membrane- bound transcription factors （MTFs） undergo several unique steps that are not involved in the action of canonical nuclear transcription factors： proteolytic processing and intracellular movement. Recently, alternative splicing has also emerged as a mechanism to liberate MTFs from the cellular membranes, establishing an additional activation scheme independent of proteolytic processing. Multiple layers of MTF regulation add complexity to transcriptional regulatory scheme and ensure elaborate action of MTFs. In this review, we provide an overview of recent findings on MTFs in plants and highlight the molecular mechanisms underlying MTF liberation from cellular membranes with an emphasis on intracellular movement.