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Overexpression of β3/γ2 chains of laminin-5 and MMP7 in biliary cancer

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World Journal of Gastroenterology 2009年第31期15卷 3865-3873页

作者： Toshikuni Oka Hiroyuki Yamamoto Shigeru Sasaki Masanori Ii Keiichi Hizaki Hiroaki Taniguchi yasushi Adachi Kohzoh Imai Yasuhisa Shinomura First Department of Internal Medicine Sapporo Medical University School of Medicine Sapporo Medical University

AIM： To clarify the clinicopathological significance of laminin-5 y2 （LNγ2） and 133 （LNI33） chains and MMP7 expression in biliary tract cancer. METHODS： We analyzed the association between immunohistochemically detected LNγ2, LNβ3, and MMP7 expression in biliary tract cancer and clinicopathological characteristics. Activity of MMP7 was analyzed by casein zymography. An in vitro invasion assay after treatment with MMP7-specific siRNA was performed. RESULTS： LNγ2 expression was predominantly observed in carcinoma cells at the invasive front. LNγ2 expression was seen in 57% of patients with biliary tract cancer, and was associated with depth of invasion, histologic type, and advanced stage. The expression pattern of LNβ3 was classified Into two types： invasive front dominant type （38%） and diffuse type （28%）.The invasive front dominant type was associated with histologic type and advanced stage. MMP7 positivity was correlated with LNγ2 or LNβ3 expression but not with clinicopathological characteristics. Active MMP7 detected by casein zymography was correlated with depth of invasion and advanced stage. Downregulation of MMP7 expression by siRNA resulted in a significant decrease in biliary tract cancer cell invasion in ***： Our results suggest that LNγ2 and LNβ3, in conjunction with MMP7, play a key role in the progression of biliary tract cancer.

关键词： Biliary tract cancer Laminin-5 Laminin γ2 Laminin β3 MMP7

Genetic and epigenetic characteristics of gastric cancers with JC virus T-antigen

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World Journal of Gastroenterology 2009年第44期15卷 5579-5585页

作者： Satoshi Yamaoka Hiroyuki Yamamoto Katsuhiko Nosho Hiroaki Taniguchi yasushi Adachi Shigeru Sasaki Yoshiaki Arimura Kohzoh Imai Yasuhisa Shinomura First Department of Internal Medicine Sapporo Medical UniversitySapporo 060-8543 Japan Sapporo Medical University Sapporo 060-8556 Japan

AIM： To clarify the significance of JC virus （JCV） T-antigen （T-Ag） expression in human gastric cancer. METHODS： We investigated the relationship between TAg detected by immunohistochemistry and Epstein- Barr virus （EBV） infection, microsatellite instability （MSI）, and genetic and epigenetic alterations in gastric cancers. Mutations in the p53,β-catenin, K/MS, BRAF, PIK3CA genes were analyzed by PCR- single strand conformation polymorphism and DNA sequencing. Allelic losses were determined by PCR at 7 microsatellite loci. Aberrant DNA methylation was analyzed by MethyLight assay. RESULTS： JCV T-Ag protein expression was found in 49% of 90 gastric cancer tissues. TAg positivity was not correlated with clinicopathological characteristics. TAg expression was detected in a similar percentage of EBV positive cancers （4 of 9, 44%） and EBV negative cancers （35 of 73, 48%）. TAg expression was detected in a significantly lower percentage of MSI-H cancers （14%） than in non MSI-H cancers （55%, P = 0.005）. TAg expression was detected in a significantly higher percentage of cancers with nuclear/cytoplasmic localization of β-catenin （15 of 21, 71%） than in cancers without （42%, P = 0.018）. p53 mutations were detected in a significantly lower percentage of T-Ag positive cancers （32%） than in TAg negative cancers （57%, P = 0.018）. TAg positive gastric cancers showed a significant increase in the allelic losses and aberrant methylation compared with T-Ag negative gastric cancers （P = 0.008 and P = 0.003）. CONCLUSION： The results suggest that JCV T-Ag is involved in gastric carcinogenesis through multiple mechanisms of genetic and epigenetic alterations.

关键词： JC virus T-antigen Epstein-Barr virus Microsatellite instability Gastric cancer

Rectosigmoid findings are not associated with proximal colon cancer: Analysis of 6 196 consecutive cases undergoing total colonoscopy

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World Journal of Gastroenterology 2005年第15期11卷 2249-2254页

作者： Makoto Okamoto Takao Kawabe Yutaka Yamaji Jun Kato Tsuneo Ikenoue Goichi Togo Haruhiko Yoshida yasushi Shiratori Masao Omata Department of Gastroenterology

AIM: To review the risk of proximal colon cancer in patients undergoing ***: We estimated the risk of advanced proximal adenomas and cancers in 6 196 consecutive patients that underwent colonoscopy (mean age 60 years, 65% males,without prior history of colorectal examination). Neoplasms were classified as diminutive adenoma (5 mm or less),small adenoma (6-9 mm), advanced adenoma (10 mm or more, with villous component or high-grade dysplasia)and cancer (invasive adenocarcinoma). The sites of neoplasms were defined as rectosigmoid (rectum and sigmoid colon) and proximal colon (from cecum to descending colon).RESULTS: The trend of the prevalence of advanced proximal adenoma was to increase with severe rectosigmoid findings, while the prevalence of proximal colon cancer did not increase with severe rectosigmoid findings. Among the 157 patients with proximal colon cancer, 74% had no neoplasm in the rectosigmoid colon. Multivariate logisticregression analysis revealed that age was the main predictor of proximal colon cancer and existence of rectosigmoid adenoma was not a predictor of proximal colon ***: Sigmoidoscopy is inadequate for colorectal cancer screening, especially in older populations.

关键词： Colorectal cancer Advanced adenoma Rectosigmoid colon Proximal colon

Visualization of Understanding of Media Characteristics Using Analytic Hierarchy Process

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Computer Technology and Application 2013年第10期4卷 563-567页

作者： yasushi Gotoh Institute of Education and Student Affair Niigata University Niigata City 950-2181 Japan

The purpose of this study is to design a tool, adapted to students＇ individual contexts and to enable students to reflect on their understanding of media characteristics. AHP （analytic hierarchy process） is a structured technique for organizing and analyzing complex decisions. Using AHP, students have to define appropriate criteria and priorities for using media. It is expected that students＂ understanding of the characteristics of different types of media will emerge through reflection. Seventy two university students took part in this research. They were asked to prioritize their *** obtaining information about current affairs using sets of media such as TV, books, newspapers and web pages, Twitter and Facebook. AHP enables us to visualize a ＂real＂ understanding of media characteristics and students can reflect on that basis. As far as ＂information sources and media＂ is concerned, a few students indicated that it was the information source itself that was important rather than the type of media. Our tool fulfils the role of encouraging this type of reflection.

关键词： Media literacy visualization understanding of media characteristics.

A Sputtering Deposition of Al Enhances the Output Reproducibility in a Conducting Rubber Force Sensor

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Journal of Sensor Technology 2016年第3期6卷 46-55页

作者： Masato Ohmukai yasushi Kami Department of Electrical and Computer Engineering Akashi College of Technology Akashi Hyogo Japan

Compressive force sensors or pressure sensors are indispensable to tactile sensors in humanoid robots. It is investigated that low-cost electro-conducting rubber sheets are applied to the force sensor, of which the biggest problem is its poor reproducibility. It was found that the aluminum deposition by a vacuum evaporation method shows excellent characteristics but suffers deterioration by a radiation heating effect. The aluminum electrode was deposited by a sputtering method, known to have an advantage of a low-temperature method, and the reproducibility of the output was improved.

关键词： Conducting Rubber Force Sensor Electrode Magnetron Sputtering Reproducibility

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A DOSE OF VITALITY

Beijing Review 2018年第45期61卷 18-19页

作者： yasushi Ito the Institute of Social Science the University of Tokyo

Japanese Prime Minister Shinzo Abe＇s visit to China in October, the first by a Japanese government head to Chinasince 2011, indicates that Japan-China ties have returned to the right track. In addition to a host of major outcomes, the Japanese and Chinese governments reached consensus on third-party market cooperation. During his meeting with Chinese President Xi Jinping, Abe said the China-proposed Belt and Road Initiative is promising and expressed Japan＇s willingness to beef up cooperation with China in wide areas, including the exploration of third-party markets.

关键词：中国政府日本政府剂量活力第三方日本人合作市场

Inflammatory pseudotumor of the liver and peripheral eosinophilia in autoimmune pancreatitis

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World Journal of Gastroenterology 2005年第6期11卷 922-925页

作者： Naoki Sasahira Takao Kawabe Akira Nakamura Kenji Shimura Haruhisa Shimura Ei Itobayashi Manabu Asada yasushi Shiratori Masao Omata Department of Gastroenterology

AIM: Inflammatory pseudotumor (IPT) of the liver is a rare benign lesion, the etiology of which remains *** is not associated with any particular diseases apart from phlebitis and Crohn's ***: A middle-aged male with hepatic IPT and peripheral eosinophilia associated with autoimmune pancreatitis (AIP) was selected for this study and review of ***: A 59-year-old male was admitted with obstructive jaundice, marked eosinophilia (1 343/mm3)and hypergammaglobulinemia (4 145 mg/dL). Imaging techniques revealed dilatation of the intrahepatic bile duct,stenosis of the common bile duct with diffuse wall thickening, gallbladder wall thickening, irregular narrowing of the pancreatic duct, and swelling of the pancreatic parenchyma. Multiple liver masses were also demonstrated and diagnosed as IPT by biopsy specimens. Six months later, the abnormal features of the biliary tree remarkably improved by the oral administration of prednisolone, and the liver masses disappeared. The swelling of the pancreatic head also improved. The peripheral eosinophil count normalized. IPT associated with AIP, as we know,has not been reported in the literature. The clinical features of the present case mimicked those of pancreatic cancer with liver metastasis. This case deserves to be documented to prevent misdiagnosis of similar cases.

关键词： Inflammatory pseudotumor Autoimmune pancreatitis

Hepatic portal venous gas in pancreatic solitary metastasis from an esophageal squamous cell carcinoma

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Hepatobiliary & Pancreatic Diseases International 2013年第1期12卷 103-105页

作者： Takeshi Sawada yasushi Adachi Manabu Noda Kimishige Akino Takefumi Kikuchi Hiroaki Mita Yoshifumi Ishii Takao Endo Division of Gastroenterology Sapporo Shirakaba-dai Hospital Department of Pathology Sapporo Shirakaba-dai Hospital

BACKGROUND:Hepatic portal venous gas(HPVG) is a rare entity commonly associated with intestinal necrosis and fatal outcome,and various underlying diseases have been *** solitary metastasis without local extension is also rare in esophageal squamous cell ***:This report describes an interesting and unusual case of HPVG arising from pancreatic *** revealed pathogenesis of HPVG and synchronous tumors of the esophagus and ***:A 73-year-old man developed synchronous double tumor in the esophagus and pancreas several months before acute abdomen and his death,which were generated by *** revealed that HPVG was caused by gastric wall infarction owing to expansion of an isolated pancreatic metastasis from esophageal squamous cell ***:This is the first case of HPVG that was derived from pancreatic tumor *** he had been diagnosed with solitary pancreatic metastasis from esophageal squamous cell carcinoma in the first time,he might have an option for chemotherapy,which could let him live longer.

关键词： hepatic portal venous gas solitary pancreatic tumor metastasis

Identification of the layered morphology of the esophageal wall by optical coherence tomography

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World Journal of Gastroenterology 2009年第35期15卷 4402-4409页

作者： Satoshi Yokosawa Tomoyuki Koike yasushi Kitagawa Waku Hatta Kaname Uno Yasuhiko Abe Katsunori Iijima Akira Imatani Shuichi Ohara Tooru Shimosegawa Division of Gastroenterology Tohoku University Graduate School of Medicine1-1Seiryo-machiAoba-kuSendai Miyagi 980-8574Japan

AIM： To assess each layer of the optical coherence tomography （OCT） image of the esophageal wall with reference to the histological structure, METHODS： Resected specimens of fresh pig esophagus was used as a model for the esophageal wall. We injected cyanoacrylate adhesive into the specimens to create a marker, and scanned them using a miniature OCT probe. The localization of these markers was assessed in the OCT images. Then we compared the OCT-imaged morphology with the corresponding histological section, guided by the cyanoacrylate adhesive markers. We prepared a second set of experiments using nylon sutures as markers. RESULTS： The OCT image of the esophageal specimen has a clear five-layered morphology. First, it consisted of a relatively less reflective layer; second, a more reflective layer; third, a less reflective layer; fourth, a more reflective layer; and fifth, a less reflective layer. Comparing the OCT images with marked histological sections showed that the first layer corresponded to stratified squamous epithelium; the second to lamina propria; the third to muscularis mucosa; fourth, submucosa; and fifth, muscularis propria with deeper structures of the esophageal wa CONCLUSION： We demonstrated that the OCT image of the normal esophageal wall showed a five- layered morphology, which corresponds to histological esophageal wall components.

关键词： Optical coherence tomography Esophagus Muscularis mucosa Esophageal squamous cellcarcinoma Endoscopic ultrasonography