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畜牧与兽医 2012年第S2期44卷 9-11页

作者： yasushi hara Division of Veterinary Surgery School of Veterinary MedicineNippon Veterinary and Life Science University

Cushing’s disease is a common endocrinopathy in dogs that is caused by an adrenocorticotropic hormone(ACTH)secreting corticotroph *** dogs with Cushing’s disease have been treated by mitotane or trilostane in small animal clinical medicine[1,2,15-17].In humans,however,the first choice f treatment for Cushing’s disease is transsphenoidal hypophysectomy(TSS)[3,4,6].In human clinical medicine,it has been suggested that excessive suppression of cortisol production using these drugs for the patients with Cushing’s disease might delete the negative feedback effect of cortisol to the hypotahalamus and corticotrophs,and result in promoting the growth of ACTH secreting corticotroph adenoma,

关键词： Cushing adenoma suppression delete recurrence promoting choice canine cholesterol routine

Identification of telomere maintenance gene variations related to lung adenocarcinoma risk by genome-wide association and whole genome sequencing analyses

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Cancer Communications 2024年第2期44卷 287-293页

作者： Kouya Shiraishi Atsushi Takahashi Yukihide Momozawa Yataro Daigo Syuzo Kaneko Takahisa Kawaguchi Hideo Kunitoh Shingo Matsumoto Hidehito Horinouchi Akiteru Goto Takayuki Honda Kimihiro Shimizu Masahiro Torasawa Daisuke Takayanagi Motonobu Saito Akira Saito Yuichiro Ohe Shun-ichi Watanabe Koichi Goto Masahiro Tsuboi Katsuya Tsuchihara Sadaaki Takata Tomomi Aoi Atsushi Takano Masashi Kobayashi Yohei Miyagi Kazumi Tanaka Hiroyuki Suzuki Daichi Maeda Takumi Yamaura Maiko Matsuda Yoko Shimada Takaaki Mizuno Hiromi Sakamoto Teruhiko Yoshida yasushi Goto Tatsuya Yoshida Taiki Yamaji Makoto Sonobe Shinichi Toyooka Kazue Yoneda Katsuhiro Masago Fumihiro Tanaka Megumi hara Nobuo Fuse Satoshi S.Nishizuka Noriko Motoi Norie Sawada Yuichiro Nishida Kazuki Kumada Kenji Takeuchi Kozo Tanno yasushi Yatabe Kuniko Sunami Tomoyuki Hishida Yasunari Miyazaki Hidemi Ito Mitsuhiro Amemiya Hirohiko Totsuka Haruhiko Nakayama Tomoyuki Yokose Kazuyoshi Ishigaki Toshiteru Nagashima Yoichi Ohtaki Kazuhiro Imai Ken Takasawa Yoshihiro Minamiya Kazuma Kobayashi Kenichi Okubo Kenji Wakai Atsushi Shimizu Masayuki Yamamoto Motoki Iwasaki Koichi Matsuda Johji Inazawa Yuichi Shiraishi Hiroyoshi Nishikawa Yoshinori Murakami Michiaki Kubo Fumihiko Matsuda Yoichiro Kamatani Ryuji Hamamoto Keitaro Matsuo Takashi Kohno Division of Genome Biology National Cancer Center Research InstituteTokyoJapan Department of Clinical Genomics National Cancer Center Research InstituteTokyoJapan Laboratory for Statistical Analysis Center for Integrative Medical SciencesRIKENYokohamaJapan Department of Genomic Medicine Research InstituteNational Cerebral and Cardiovascular CenterOsakaJapan Laboratory for Genotyping Development Center for Integrative Medical SciencesRIKENYokohamaJapan Center for Antibody and Vaccine Therapy Research HospitalInstitute of Medical ScienceThe University of TokyoTokyoJapan Department of Medical Oncology and Cancer Center and Center for Advanced Medicine against CancerShiga University of Medical ScienceOtsuJapan Division of Medical AI Research and Development National Cancer Center Research InstituteTokyoJapan Center for Genomic Medicine Graduate School of MedicineKyoto UniversityKyotoJapan Department of Medical Oncology Japanese Red Cross Medical CenterTokyoJapan Department of Thoracic Oncology National Cancer Center Hospital EastJapan Department of Thoracic Oncology National Cancer Center HospitalTokyoJapan Department of Cellular and Organ Pathology Graduate School of MedicineAkita UniversityAkitaJapan Department of Respiratory Medicine Tokyo Medical and Dental UniversityBunkyo-kuTokyoJapan Division of General Thoracic Surgery Department of SurgeryShinshu University School of MedicineMatsumotoNaganoJapan Department of General Surgical Science Division of General Thoracic SurgeryGunma University Graduate School of MedicineIntegrative Center of General SurgeryGunma University HospitalGunmaJapan Department of Gastrointestinal Tract Surgery Fukushima Medical University School of MedicineFukushimaJapan StaGen Co. LtdTokyoJapan Division of Thoracic Surgery National Cancer Center HospitalTokyoJapan Department of Thoracic Surgery National Cancer Center Hospital EastChibaJapan Division of Translational Informatics Exploratory Oncology Research and Clinical Trial Center(EPOC

Dear editor,Lung carcinoma is responsible for the highest fatal-ity rate among cancer-related deaths globally,with lung adenocarcinoma(LADC)emerging as the prevailing sub-type.

关键词： adenocarcinoma lung Lung

Indirect inguinal hernia containing portosystemic shunt vessel: A case report

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World Journal of Clinical Cases 2021年第2期9卷 509-515页

作者： Masahiro Yura Kikuo Yo Asuka hara Keita Hayashi Yuki Tajima yasushi Kaneko Hiroto Fujisaki AkiraHirata Kiminori Takano Kumiko Hongo Kimiyasu Yoneyama Motohito Nakagawa Department of Surgery Hiratsuka City HospitalHiratsuka 2540065KanagawaJapan

BACKGROUND Inguinal hernia repair is one of the most common general surgical operations *** present a case of indirect inguinal hernia containing an expanded portosystemic shunt *** SUMMARY We report a 72-year-old man who had a 4 cm×4 cm swelling in the right inguinal region,which disappeared with light manual ***-pelvic computed tomography(CT)revealed a right inguinal hernia containing an expanded portosystemic shunt vessel,which had been noted for 7 years due to liver *** performed Lichtenstein’s herniorrhaphy and identified the hernia sac as being indirect and the shunt vessel existing in the extraperitoneal cavity through the internal inguinal ***,we found two short branches between the expanded shunt vessel and testicular vein in the middle part of the inguinal canal and cut these branches to allow the shunt vessel to return to the extraperitoneal cavity of the *** hernia sac was returned as *** encountered no intraoperative *** discharge,groin seroma requiring puncture at the outpatient clinic was *** If an inguinal hernia patient has portal hypertension,ultrasound should be used to determine the contents of the *** atypical vessels are visualized,they may be shunt vessels and additional CT is recommended to ensure the selection of an adequate approach for safe hernia repair.

关键词： Inguinal hernia Lichtenstein’s herniorrhaphy Portosystemic shunt Portal hypertension Shunt vessel Case report

Unresectable esophageal cancer treated with multiple chemotherapies in combination with chemoradiotherapy:A case report

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World Journal of Clinical Cases 2021年第12期9卷 2801-2810页

作者： Masahiro Yura Kazuo Koyanagi Asuka hara Keita Hayashi Yuki Tajima yasushi Kaneko Hiroto Fujisaki Akira Hirata Kiminori Takano Kumiko Hongo Kikuo Yo Kimiyasu Yoneyama Yoshifumi Tamai Reiko Dehari Motohito Nakagawa Department of Surgery Hiratsuka City HospitalKanagawa 2540065Japan Department of Gastroenterological Surgery Tokai University School of MedicineIsehara 2591193Japan Department of Radiology Hiratsuka City HospitalKanagawa 2540065Japan Department of Surgical Pathology Hiratsuka City HospitalKanagawa 2540065Japan

BACKGROUND Definitive chemoradiotherapy(dCRT)using cisplatin plus 5fluorouracil(CF)with radiation is considered the standard treatment for unresectable locally advanced T4 esophageal squamous cell carcinoma(ESCC).Recently,induction chemotherapy has received attention as an effective treatment *** SUMMARY We report a successful case of a 59-year-old female with unresectable locally advanced T4 ESCC treated by two additional courses of chemotherapy with CF after induction chemotherapy with docetaxel,cisplatin and fluorouracil(DCF)followed by *** esophagogastroduodenoscopy(EGD)detected a type 2 advanced lesion located on the middle part of the esophagus,with *** tomography detected the primary tumor with suspected invasion of the left bronchus and 90°of direct contact with the aorta,and upper mediastinal lymph node *** findings from biopsy revealed squamous cell *** initially performed induction chemotherapy using three courses of DCF,but the lesion was still evaluated unresectable after DCF ***,we subsequently performed dCRT treatment(CF and radiation).After dCRT,prominent reduction of the primary tumor was recognized but a residual tumor with ulceration was detected by *** the patient had some surgical risk,we performed two additional courses of CF and achieved a clinically complete *** 14 mo from last administration of CF chemotherapy,recurrence has not been detected by computed tomography and EGD,and biopsy from the scar formation has revealed no cancer *** We report successful case with tumor remnants even after DCF and subsequent dCRT,for whom a complete response was finally achieved with two additional courses of CF *** CF chemotherapy could be one radical treatment option for residual ESCC after treatment with induction DCF followed by dCRT to avoid salvage surgery,especially for high-risk patients.

关键词： Unresectable esophageal cancer Induction docetaxel,cisplatin and fluorouracil Chemoradiotherapy Complete response Additional chemotherapy Case report

Pancreaticoduodenectomy after neoadjuvant chemotherapy for gastric cancer invading the pancreatic head:A case report

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World Journal of Gastroenterology 2021年第6期27卷 534-544页

作者： Masahiro Yura Kiminori Takano Kiyohiko Adachi Asuka hara Keita Hayashi Yuki Tajima yasushi Kaneko Yoichiro Ikoma Hiroto Fujisaki Akira Hirata Kumiko Hongo Kikuo Yo Kimiyasu Yoneyama Reiko Dehari Kazuo Koyanagi Motohito Nakagawa Department of Surgery Hiratsuka City HospitalHiratsuka 2540065KanagawaJapan Department of Surgical Pathology Hiratsuka City HospitalHiratsuka 2540065KanagawaJapan Department of Gastroenterological Surgery Tokai University School of MedicineIsehara 259193KanagawaJapan

BACKGROUND Pancreaticoduodenectomy(PD)for advanced gastric cancer is rarely performed because of the high morbidity and mortality rates and low survival ***,neoadjuvant chemotherapy for advanced gastric cancer has improved,and chemotherapy combined with trastuzumab may have a preoperative tumorreducing effect,especially for human epidermal growth factor receptor 2(HER2)-positive *** SUMMARY We report a case of successful radical resection with PD after neoadjuvant S-1 plus oxaliplatin(SOX)and trastuzumab in a patient(66-year-old male)with advanced gastric cancer invading the pancreatic *** esophagogastroduodenoscopy detected a type 3 advanced lesion located on the lower part of the stomach obstructing the pyloric *** tomography detected lymph node metastasis and tumor invasion to the pancreatic head without distant *** findings revealed adenocarcinoma and HER2 positivity(immunohistochemical score of 3+).We performed staging laparoscopy and confirmed no liver metastasis,no dissemination,negative lavage cytological findings,and immobility of the distal side of the stomach due to invasion to the *** gastrojejunostomy was performed at that *** course of SOX and three courses of SOX plus trastuzumab were *** computed tomography showed partial response;therefore,PD was performed after neoadjuvant chemotherapy,and pathological radical resection was *** We suggest that radical resection with PD after neoadjuvant chemotherapy plus trastuzumab is an option for locally advanced HER2-positive gastric cancer invading the pancreatic head in the absence of non-curative factors.

关键词： Pancreaticoduodenectomy Gastric cancer Neoadjuvant chemotherapy Trastuzumab Human epidermal growth factor receptor 2 Case report

Distal gastric tube resection with vascular preservation for gastric tube cancer:A case report and review of literature

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World Journal of Gastrointestinal Surgery 2020年第9期12卷 397-406页

作者： Masahiro Yura Kazuo Koyanagi Kiyohiko Adachi Asuka hara Keita Hayashi Yuki Tajima yasushi Kaneko Hiroto Fujisaki Akira Hirata Kiminori Takano Kumiko Hongo Kikuo Yo Kimiyasu Yoneyama Reiko Dehari Motohito Nakagawa Department of Surgery Hiratsuka City HospitalKanagawa 2540065Japan Department of Gastroenterological Surgery Tokai University School of MedicineIsehara 2591193Japan Department of Surgical Pathology Hiratsuka City HospitalKanagawa 2540065Japan

BACKGROUND Survival rates in patients with esophageal cancer undergoing esophagectomy have improved,but the prevalence of gastric tube cancer(GTC)has also *** resection of the gastric tube with lymph node dissection is considered a radical treatment,but GTC surgery is more invasive and involves a higher risk of severe complications or death,particularly in elderly *** SUMMARY We report an elderly patient with early GTC that had invaded the duodenum who was successfully treated with resection of the distal gastric tube and Roux-en-Y(R-Y)*** tumor was a type 0-IIc lesion with ulcer scars surrounding the pyloric *** submucosal resection was not indicated because the primary lesion was submucosally invasive,was undifferentiated type,surrounded the pyloric ring,and had invaded the *** of distal gastric tube with R-Y reconstruction was safely performed,with preservation of the right gastroepiploic artery(RGEA)and right gastric artery(RGA).CONCLUSION Distal resection of the gastric tube with preservation of the RGEA and RGA is a good treatment option for elderly patients with cT1bN0 GTC in the lower part of the gastric tube.

关键词： Gastric tube cancer Distal resection Preservation of right gastroepiploic artery and right gastric artery Elderly patients Duodenal invasion Case report Posterior mediastinal reconstruction

Clinical relevance of fluorodeoxyglucose positron emission tomography/computed tomography and magnifying endoscopy with narrow band imaging in decision-making regarding the treatment strategy for esophageal squamous cell carcinoma

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World Journal of Gastroenterology 2019年第46期25卷 6767-6780页

作者： Kazuhiro Toriyama Masahiro Tajika Tsutomu Tanaka Makoto Ishihara Yutaka Hirayama Sachiyo Onishi Nobumasa Mizuno Takamichi Kuwahara Nozomi Okuno Shinpei Matsumoto Eiichi Sasaki Tetsuya Abe yasushi Yatabe Kazuo hara Keitaro Matsuo Tsuneo Tamaki Yasumasa Niwa Department of Gastroenterology Aichi Cancer Center HospitalNagoya 464-8681Japan Department of Endoscopy Aichi Cancer Center HospitalNagoya 464-8681Japan Department of Gastroenterology Anjo Kosei HospitalAnjo 446-8602Japan Department of Pathology and Molecular Diagnostics Aichi Cancer Center HospitalNagoya 464-8681Japan Department of Gastroenterological Surgery Aichi Cancer Center HospitalNagoya 464-8681Japan Division of Cancer Epidemiology and Prevention Aichi Cancer Center Research InstituteNagoya 464-8681Japan East Nagoya Imaging Diagnosis Center Nagoya 464-0044Japan

BACKGROUND Recent advances in endoscopic technology,especially magnifying endoscopy with narrow band imaging(ME-NBI)enable us to detect superficial esophageal squamous cell carcinoma(ESCC),but determining the appropriate method of resection,endoscopic resection(ER)vs surgical resection,is often ***,several studies have reported that 18F-fluorodeoxyglucose positron emission tomography(FDG-PET)is a useful indicator for decision-making regarding treatment for superficial ***,there are not enough reports on association between FDG-PET uptake and clinicopathological characteristics of superficial ***,there are not enough reports on evaluating the usefulness of combination of FDG-PET and ME-NBI for determining the treatment strategy for superficial *** study evaluated clinical relevance of FDG-PET and ME-NBI in decision-making regarding the treatment strategy for *** To investigate the association between FDG uptake and the clinicopathological characteristics of superficial ESCC and its usefulness of combination of FDG-PET and ME-NBI for determining the treatment strategy for superficial *** A database of all patients with superficial ESCC who had undergone both MENBI and FDG-PET for pre-treatment staging at Aichi Cancer Center Hospital between January 2008 and November 2018 was retrospectively *** uptake was defined positive or negative whether the primary lesion was visualized or could be distinguished from the background,or *** invasion depth of ESCC was classified according to the Japan Esophageal *** endpoint is to evaluate the association between FDG uptake and clinicopathological characteristics of superficial *** endpoint is to investigate the efficacy of combination of FDG-PET and ME-NBI for determining the treatment strategy for superficial *** A total of 82 lesions in 82 patients were ***-PET showed positive uptake in 29(35.4%)*** analysis sh

关键词： ^18F-fluorodeoxyglucose positron emission tomography Magnifying endoscopy Narrow band imaging Superficial esophageal cancer Squamous cell carcinoma Treatment strategy

Successful Cord Blood Transplantation for a CHARGE Syndrome with CHD7 Mutation Showing Characteristic Triad of DiGeorge Syndrome Including Hypoparathyroidism

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Successful Cord Blood Transplantation for a CHARGE Syndrome ...