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Open Journal of Nursing 2024年第8期14卷 401-411页

作者： Aimi Furukawa yasuko Hosoda Graduate School of Nursing Osaka Metropolitan University Osaka Japan

This study aimed to examine the surface and content validity of the Mentoring Function Scale for Novice Nurses, used to assess the mentoring of entry-level nurses, and to refine the scale items. In Study 1, six nurse education researchers, selected using convenience sampling, with five or more years of nursing experience and experience teaching novice nurses, were invited to an expert meeting in July 2015. A group interview was conducted that lasted approximately 120 minutes. Study 2 examined the content validity index. Between September and November 2015, we distributed a self-administered questionnaire survey to 11 participants selected by convenience sampling. The participants included five nurse education researchers with a minimum of five years of nursing experience and experience teaching novice nurses, as well as six clinical nurses with a master’s degree or higher. Finally, 81 questionnaire items were retained from the initial 125 items. The 81-item Mentoring Function Scale for Novice Nurses had higher content validity than the original scale. To further increase the scale’s applicability, future studies should assess its reliability, construct validity, and criterion-related validity.

关键词： Novice Nurses Mentoring Function Surface and Content Validity Item-Level Content Validity Index

Re-evaluation of physical interaction between plant peroxisomes and other organelles using live-cell imaging techniques

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Journal of Integrative Plant Biology 2019年第7期61卷 836-852页

作者： Kazusato Oikawa Makoto Hayashi yasuko Hayashi Mikio Nishimura Biomacromolecules Research Team RIKEN Center for Sustainable Resource Science2-1 HirosawaWakoSaitama 351-0198Japan Department of Bioscience Nagahama Institute of Bio-Scie nee and Technology1266 Tamura-ChoNagahama 526-0829Japan Department of Biology Faculty of scienceNiigata UniversityNiigata 950-2181Japan Department of Cell Biology National Institute for Basic BiologyOkazaki 444-8585Japan

The dynamic behavior of organelles is essential for plant survival under various environmental conditions. Plant organelles, with various functions,migrate along actin filaments and contact other types of organelles, leading to physical interactions at a specific site called the membrane contact site. Recent studies have revealed the importance of physical interactions in maintaining efficient metabolite flow between *** this review, we first summarize peroxisome function under different environmental conditions and growth stages to understand organelle interactions. We then discuss current knowledge regarding the interactions between peroxisome and other organelles, i.e., the oil bodies, chloroplast, and mitochondria from the perspective of metabolic and physiological regulation, with reference to various organelle interactions and techniques for estimating organelle interactions occurring in plant cells.

关键词： physical interaction plant peroxisomes live-cell

By using either endogenous or transplanted stem cells,which could you prefer for neural regeneration？

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Neural Regeneration Research 2018年第10期13卷 1731-1732页

作者： satoru matsuda yukie nakagawa kumi amano yuka ikeda ai tsuji yasuko kitagishi department of food science and nutrition nara women's University，Kita—Uoya，Nishimachi，Nara，Iapa

Neural regeneration by stem cells transplantation：Tissue regeneration and homeostasis are principally dependent on tissue stem cells which possess abilities of self-renewal and differentiation into multidirectional specialized cell *** general,stem cells are critical for normal tissue renewal as well as repair after tissue *** example,mesenchymal stromal cells and endothelial progenitor cells identified in bone marrow could.

关键词： SPINAL-CORD-INJURY ISCHEMIA

Efficacy of probiotics on the modulation of gut microbiota in the treatment of diabetic nephropathy

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World Journal of Diabetes 2022年第3期13卷 150-160页

作者： Nozomi Nagase Yuka Ikeda Ai Tsuji yasuko Kitagishi Satoru Matsuda Department of Food Science and Nutrition Nara Women's UniversityNara 630-8506Japan

Diabetic nephropathy(DN)is a major cause of end-stage renal disease,and therapeutic options for preventing its progression are *** number of patients with DN has been increasing in Asian countries because of westernization of dietary lifestyle,which may be associated with the following changes in gut *** in the gut microbiota composition can lead to an imbalanced gastrointestinal environment that promotes abnormal production of metabolites and/or inflammatory *** microenvironments of the gut could be changed in the different stages of *** particular,altered levels of short chain fatty acids,D-amino acids,and reactive oxygen species biosynthesis in the gut have been shown to be relevant to the pathogenesis of the *** far,evidence suggests that the gut microbiota may play a key role in determining networks in the development of *** directing the gut microbiota deserve further investigation as a new protective therapy in *** this review,we discuss the potential roles of the gut microbiota and future perspectives in the protection and/or treatment of kidneys.

关键词： Diabetic nephropathy Short chain fatty acids Superoxide dismutase Reactive oxygen species D-amino acids Gut microbiota Diabetes mellitus Renal disease

Secretome-microRNA and anti-proliferative APRO family proteins as cancer prevention and stem cell research strategies

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BIOCELL 2022年第5期46卷 1163-1167页

作者： YUKA IKEDA NOZOMI NAGASE AI TSUJI KURUMI TANIGUCHI yasuko KITAGISHI SATORU MATSUDA Department of Food Science and Nutrition Nara Women’s UniversityNara630-8506Japan

Stemness of cancer cells contains limitless self-renewal *** the purpose of proliferation,secretome might exert its effects via the paracrine *** microRNAs enclosed in the secretome of cancer stem cells could regulate the expression of anti-proliferative APRO family *** biological functions of APRO family proteins seems to be quite intricate,however,which might be a key modulator of microRNAs,then could regulate the proliferation of cancer *** addition to affecting proliferation/differentiation during cellular development,APRO family proteins might also play an imperious role on keeping homeostasis in healthy stem cells under a physiological ***,relationship between the microRNAs and the APRO family proteins has attracted much attention in the field of cancer research and regenerative ***,we have described the molecular mechanism behind this interplay that have a potential role in the future promising tools with targeting APRO family proteins for the medical applications.

关键词： Cancer Stem cell Secretome Proliferation APRO family microRNA

Evaluation of rebound tonometer iCare IC200 as compared with IcarePRO and Goldmann applanation tonometer in patients with glaucoma

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Eye and Vision 2021年第1期8卷 244-252页

作者： Shunsuke Nakakura Ryo Asaoka Etsuko Terao Yuki Nagata yasuko Fukuma Satomi Oogi Miku Shiraishi Yoshiaki Kiuchi Department of Ophthalmology Saneikai Tsukazaki Hospital68-1 Aboshi WakuHimeji 671-1227Japan Department of Ophthalmology Seirei Hamamatsu General HospitalHamamatsuShizuokaJapan Seirei Christopher University HamamatsuShizuokaJapan Department of Ophthalmology and Visual Sciences Graduate School of Biomedical SciencesHiroshima UniversityHiroshimaJapan

Background:This study investigated the agreement between a new rebound tonometer,IC200,and IcarePRO and Goldmann applanation tonometry(GAT).Methods:This was a prospective cross-sectional *** measured the intraocular pressure(IOP)in 145 eyes of 145 glaucoma patients in the sitting position using GAT,IcarePRO,and *** and IC200 measurements were also obtained in the supine ***200 measurement was performed using two modes:single six(IC200-single)and automatic(IC200-continuous)six-measurements ***:All tonometers provided high reproducibility in both positions(all intraclass correlation coefficients>0.90),although it was highest with GAT,followed by IC200-continuous and IC200-single and then *** the sitting position,the mean(±SD)IOPs of GAT,IcarePRO,IC200-single,and IC200-continuous were 14.5±2.9 mmHg,13.3±3.2 mmHg,11.6±3.2 mmHg,and 11.5±3.2 mmHg,*** measured with IcarePRO or IC200 were significantly lower than those with GAT,particularly in patients with low *** measured with all tonometers were significantly elevated in the supine position as compared with the sitting position,but this difference was significantly greater with IC200-single and IC200-continuous compared with *** elevation was significant in eyes without bleb versus those with bleb,but this finding was not observed when IOP was measured with *** IOPs of the single and continuous modes of IC200 were interchangeable in both ***:GAT,IcarePRO,and IC200 had sufficiently high reproducibility,but measurements with IcarePRO may not be accurate in the supine *** of IOP in the supine position,especially in eyes with bleb,was more sensitively captured with IC200 than with IcarePRO.

关键词： Glaucoma IC200 IcarePRO Rebound tonometer Goldmann applanation tonometer

Verrucous antral gastritis in relation to Helicobacter pylori infection,nutrition,and gastric atrophy

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Gastroenterology Report 2020年第4期8卷 293-298,I0002页

作者： Naoko Tsuji yasuko Umehara Mamoru Takenaka Yasunori Minami Tomohiro Watanabe Naoshi Nishida Masatoshi Kudo Department of Gastroenterology and Hepatology Kindai University Faculty of MedicineOsaka-SayamaJapan

Background:There have been few studies in the English literature regarding verrucous gastritis(VG).The present study investigated the clinical and endoscopic features of verrucous antral gastritis,especially focusing on Helicobacter pylori infection,nutrition,and gastric ***:We performed a retrospective study of patients who underwent routine endoscopy with indigo carmine chromoendoscopy and a comparative study was conducted between VG-positive and VG-negative *** was subdivided into classical and numerous types based on the number and distribution of verrucous ***,clinical,and endoscopic data including body mass index(BMI),serum albumin and cholesterol,gastric atrophy,reflux oesophagitis,Barrett’s oesophagus,and *** status were *** and multivariable analyses were performed to identify factors associated with ***:We analysed the data of 621 patients undergoing routine endoscopy and found that VG(n=352)was significantly associated with increased BMI(1.12[1.05-1.18],P<0.01),reflux esophagitis(1.96[1.10-3.28],P<0.01),and *** negativity with or without a history of eradication(9.94[6.00-16.47]and 6.12[3.51-10.68],P<0.001,respectively).Numerous-type(n=163)VG was associated with both closed-and open-type gastric atrophy(9.9[4.04-21.37]and 8.10[3.41-19.24],P<0.001,respectively).There were no statistical differences between groups regarding age,sex,total cholesterol,albumin,and bile-colored gastric ***:Verrucous antral gastritis was related to increased BMI,reflux esophagitis,and *** ***-type verrucous lesions were associated with gastric *** indicate that VG may be a physiological phenomenon due to high gastric acidity,mechanical overload,and vulnerability of background mucosa.

关键词： verrucous gastritis chromoendoscopy BMI Helicobacter pylori eradication gastric atrophy

Current status of laparoscopic repeat liver resection for recurrent hepatocellular carcinoma

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Hepatoma Research 2020年第11期6卷 85-91页

作者： Daisuke Hokuto Takeo Nomi Takahiro Yoshikawa yasuko Matsuo Naoki Kamitani Masayuki Sho Department of Surgery Nara Medical UniversityNara 634-8522Japan

Repeat liver resection(RLR)is an effective treatment approach for recurrent hepatocellular carcinoma(HCC)and can provide acceptable long-term outcomes in select *** randomized controlled trials comparing RLR with radiofrequency ablation revealed that the latter approach was associated with a higher rate of early recurrence compared with *** recent advances in laparoscopic liver resection(LLR),RLR has been increasingly performed using *** propensity score-matched studies reported that laparoscopic RLR achieved lower blood loss and shorter hospital stays compared to open ***,laparoscopic RLR requires more advanced techniques because of adhesions formed after the previous liver resection,changes in anatomical landmarks,and deformity of the remnant *** recently described difficulty classification of laparoscopic RLR is based on five factors including type of previous liver resection(open or laparoscopic),number of previous liver resections,surgical procedure used in previous liver resections,tumor location in previous liver resections,and difficulty score of LLR for recurrent *** reviewed the available literature to summarize available evidence suggesting that laparoscopic RLR might be considered a more minimally invasive surgical treatment approach for recurrent HCC as long as the indication for laparoscopic RLR is carefully determined.

关键词： Hepatocellular carcinoma repeat liver resection laparoscopic repeat liver resection

Fabrication of Microporous Film and Microspheres Hybrids

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Open Journal of Organic Polymer Materials 2015年第2期5卷 51-57页

作者： Hossein Taherzadeh yasuko Shimoi Kenji Ogino Graduate School of Bio-Applications and Systems Engineering Tokyo University of Agriculture and Technology Koganei Tokyo Japan

Hybrids consisting of a microporous film and polymeric microspheres were fabricated via a simple method without a special apparatus. Highly ordered microporous polymer films with honeycomb structure were fabricated by a dissipative process utilizing amphiphilic poly(acrylic acid)- block-polystyrene, which was synthesized by atom transfer radical polymerization followed by an acid-catalyzed ester cleavage reaction. In order to embed the microsphere efficiently, the dried microporous films should be soaked in methanol to alter the surface functionality and to improve the wettability of the film surface. The introduction of amino functionality to polystyrene microspheres by seeded polymerization of N,N-dimethylaminoethyl methacrylate drastically improved the embedding efficiency. The effect of open pore size was also investigated.

关键词： Amphiphilic Block Copolymer Microporous Film Hybrid Microsphere Surface Functionality