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Inverse relationship between platelet Akt activity and hippocampal atrophy:A pilot case-control study in patients with diabetes mellitus

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World Journal of Clinical Cases 2024年第2期12卷 302-313页

作者： Haruhiko Tokuda Takamitsu Hori Daisuke mizutani Tomoyuki Hioki Kumi Kojima Takashi Onuma Yukiko Enomoto Tomoaki Doi Rie Matsushima-Nishiwaki Shinji Ogura Hiroki Iida Toru Iwama Takashi Sakurai Osamu Kozawa Department of Metabolic Research Research InstituteNational Center for Geriatrics and GerontologyObu 474-8511Japan Department of Clinical Laboratory National Center for Geriatrics and GerontologyObu 474-8511Japan Department of Pharmacology Gifu University Graduate School of MedicineGifu 501-1194Japan Department of Neurosurgery Gifu University Graduate School of MedicineGifu 501-1194Japan Department of Dermatology Central Japan International Medical CenterMinokamo 505-8510Japan Department of Anesthesiology and Pain Medicine Gifu University Graduate School of MedicineGifu 501-1194Japan Department of Emergency Medicine Faculty of MedicineUniversity of ToyamaToyama 930-0194Japan Department of Emergency and Disaster Medicine Gifu University Graduate School of MedicineGifu 501-1194Japan Research Institute National Center for Geriatrics and GerontologyObu 474-8511Japan

BACKGroUND Akt plays diverse roles in *** is involved in the pathogenesis of type 2 diabetes mellitus(T2DM),which is caused by insulin *** also plays a vital role in human platelet ***,the hippocampus is closely associated with memory and learning,and a decrease in hippocampal volume is reportedly associated with an insulin-resistant phenotype in T2DM patients without *** To investigate the relationship between Akt phosphorylation in unstimulated platelets and the hippocampal volume in T2DM *** Platelet-rich plasma(PRP)was prepared from the venous blood of patients with T2DM or age-matched *** pellet lysate of the centrifuged PRP was subjected to western blotting to analyse the phosphorylation of Akt,p38 mitogen-activated protein(MAP)kinase and glyceraldehyde 3-phosphate dehydrogenase(GAPDH).Phosphorylation levels were quantified by densitometric *** volume was analysed using a voxel-based specific regional analysis system for Alzheimer’s disease on magnetic resonance imaging,which proposes the Z-score as a parameter that reflects hippocampal *** The levels of phosphorylated Akt corrected with phosphorylated p38 MAP kinase were inversely correlated with the Z-scores in the T2DM subjects,whereas the levels of phosphorylated Akt corrected with GAPDH were ***,this relationship was not observed in the control *** These results suggest that an inverse relationship may exist between platelet Akt activation and hippocampal atrophy in T2DM *** findings provide insight into the molecular mechanisms underlying T2DM hippocampal atrophy.

关键词： Akt Platelet Hippocampal atrophy Magnetic resonance imaging Diabetes mellitus

Zoonotic human liver flukes,a type 1 biocarcinogen,in freshwater fishes:genetic analysis and confirmation of molluscan vectors and reservoir hosts in Bangladesh

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Infectious Diseases of Poverty 2024年第3期13卷 73-88页

作者： Sharmin Shahid Labony Md.Abdul Alim Muhammad Mehedi Hasan Md.Shahadat Hossain Sharmin Akter Joydeep Paul Thahsin Farjana Md.Haydar Ali Mohammad Zahangir Alam Takeshi Hatta Hayato Kawada Keiko mizutani Naotoshi Tsuji null Anisuzzaman Department of Parasitology Faculty of Veterinary ScienceBangladesh Agricultural UniversityMymensingh 2202Bangladesh Department of Fisheries Technology Faculty of FisheriesBangladesh Agricultural UniversityMymensingh 2202Bangladesh Department of Biotechnology School of Life Sciences&BiotechnologyAdamas UniversityBarasat-Barrackpore RdJagannathpurKolkataWest Bengal 700126India Department of Pathology and Parasitology Hajee Mohammad Danesh Science and Technology UniversityDinajpur 5200Bangladesh Department of Parasitology and Tropical Medicine Kitasato University School of Medicine1-15-1 KitasatoMinamiSagamiharaKanagawa 252-0374Japan Department of Molecular and Cellular Parasitology Kitasato University Graduate School of Medical Sciences1-15-1 KitasatoMinamiSagamiharaKanagawa 252-0373Japan

Background Opisthorchiid flukes,particularly Opisthorchis viverrini,Opisthorchis felineus,Clonorchis sinensis,and Metorchis *** the most common fish-borne zoonotic human liver flukes(hLFs).Liver fluke infections are more prevalent in resource-deprived and underprivileged *** herein estimated the prevalence of the metacercariae(MC)of major hLFs in common large freshwater fishes(lFWF)marketed for human consumption from some selected areas of Bangladesh along with detection of their molluscan vectors and *** The current status of fish-borne zoonotic hLF infections in lFWF was investigated along with their molluscan vectors and mammalian reservoir hosts in Mymensingh and Kishoreganj in Bangladesh from July 2018-June 2022 using conventional and multiple molecular techniques,such as PCR,PCR-restriction fragment length polymorphism(RFLP),sequencing,and bioinformatic *** infection rate of fishes was analyzed using the Z-test and the loads of MC were compared using the chi-squared(χ^(2))*** The MC of ***,Opisthorchis spp.,and Metorchis *** detected in 11 species of common and popular *** lFWF,the estimated prevalence was 18.7%and the mean load was 137.4±149.8 MC per 100 g of *** prevalence was the highest(P0.05)distributed between the head and body of *** infection rate was slightly higher in cultured(19.6%)*** MC of ***,***,***,and Metorchis orientalis in fishes were confirmed using PCR,PCR-RFLP and *** cercariae of opisthorchiid(Pleurolophocercus cercariae)flukes were only recovered from Bithynia spp.(3.9%,42 out of 1089).The ova of hLFs from dogs(4.3%,5 out of 116)and cats(6.0%,6 out of 100),and adult flukes(***)from ducks(41.1%113 out of 275)were *** The MC of

关键词： Human liver fluke Freshwater fish Molluscan vector Reservoir host Bangladesh

The Nadanhada Terrane in Relation to Mesozoic Tectonics on Continental Margins of East Asia

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Acta Geologica Sinica(English Edition) 1990年第1期64卷 15-29页

作者： mizutani Shinjiro Department of Earth Sciences Nagoya University464-01 NagoyaJapan

The Nadanhada terrane, a Jurassic disrupted terrane in Heilongjiang Province of China, is principallycomposed of Permo-Carboniferous limestone and greenstone, Triassic bedded chert and middle Jurassicsiliceous shale, all enclosed within younger (presumably Late Jurassic-Early Cretaceous) clastics. Palaeon-tological and lithological characteristics and structural features of these formations are entirely identical tothose of the Mino terrane of the Japanese Islands. Prior to opening of the Sea of Japan, these terranesformed a single superterrane together with the Western Sikhote-Alin terrane. Tectono-stratigraphic terranesvery similar to the Nadanhada and Mino terranes are also found in the Ryukyu arc, the Philippines andprobably in Borneo. All these terranes constituted a belt of accretionary complexes during Late Jurassicand / or Early Cretaceous time along the eastern continental margin of Asia after completion of the Triassiccollage of the Chinese continent.

关键词： Mesozoic formations Carboniferous limestone shale Continental Cretaceous sedimentary Jurassic bedded

A COMBINATORIAL ASPECT OF A DISCRETE-TIME SEMI-INFINITE LOTKA-VOLTERRA EQUATION

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Journal of Systems Science & Complexity 2010年第1期23卷 71-80页

作者： Shuhei KAMIOKA Satoru mizutani Department of Applied Mathematics and Physics Graduate School of InformaticsKyoto University KDDI Corporation Garden Air Tower

A graph is introduced,which allows of a combinatorial interpretation of a discrete-timesemi-infinite Lotka-Volterra (dLV) *** particular,Hankel determinants used in a determinantsolution to the dLV equation are evaluated,via the Gessel-Viennot method,in terms of ***,the recurrence of the dLV equation describing its time-evolution is equivalentlyexpressed as a time-evolution of weight of specific subgraphs.

关键词： Combinatorial proofs discrete integrable systems dynamics on graphs Gessel-Viennot method Hankel determinants non-intersecting paths weighted paths on labeled graphs.

Analysis of Machinable Structures and Their Wettability of rotary Ultrasonic Texturing Method

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Chinese Journal of Mechanical Engineering 2016年第6期29卷 1187-1192页

作者： XU Shaolin SHIMADA Keita mizutani Masayoshi KURIYAGAWA Tsunemoto Division of Biomechanical Engineering Graduate School of Biomedical Engineering Tohoku University Department of Mechanical Systems Engineering Graduate School of Engineering Tohoku University

Tailored surface textures at the micro- or nanoscale dimensions are widely used to get required functional performances. rotary ultrasonic texturing （RUT） technique has been proved to be capable of fabricating periodic micro- and nanostructures. In the present study, diamond tools with geometrically defined cutting edges were designed for fabricating different types of tailored surface textures using the RUT method. Surface generation mechanisms and machinable structures of the RUT process are analyzed and simulated with a 3D-CAD program. Textured surfaces generated by using a triangular pyramid cutting tip are constructed. Different textural patterns from several micrometers to several tens of micrometers with few burrs were successfully fabricated, which proved that tools with a proper two-rake-face design are capable of removing cutting chips efficiently along a sinusoidal cutting locus in the RUT process. Technical applications of the textured surfaces are also discussed. Wetting properties of textured aluminum surfaces were evaluated by combining the test of surface roughness features. The results show that the real surface area of the textured aluminum surfaces almost doubled by comparing with that of a flat surface, and anisotropic wetting properties were obtained due to the obvious directional textural features.

关键词： rotary ultrasonic texturing geometrically defined cutting edges surface generation mechanisms machinable structures,wetting properties

Bed morphology and grain size characteristics around a spur dyke

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International Journal of Sediment Research 2012年第2期27卷 141-155+157+156页

作者： Hao ZHANG Hajime NAKAGAWA Hideaki mizutani Disaster Prevention Research Institute Kyoto UniversityJapan 2. Department of Civil and Earth Resources EngineeringKyoto UniversityJapan

This paper presents an experimental study on the local bed morphology and grain size characteristics around an impermeable spur dyke.A series of experiments are conducted with different types of sediment *** is found that the heterogeneity of the sediment exerts an influence on detailed bed topographies around the spur dyke,but does not influence the typical features of scour-deposition *** mean grain size and the geometric standard deviation of the bed sediment are two important and practical parameters in characterizing the changes of the bed morphologies and the bed compositions around the spur *** sediment sorting process plays a crucial role in the grain size distribution,and the process occurs longitudinally,laterally and *** the proximity of the spur dyke,the bed is generally coarsened from upstream to downstream and sand ribbons consisting of fine particles are *** the scour hole,the bottom sediment is coarser than that at the top.

关键词： Spur dyke Non-uniform sediment Local scour Grain size distribution Sand ribbon

Recent advances in ultrasonic-assisted machining for the fabrication of micro/nano-textured surfaces

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Frontiers of Mechanical Engineering 2017年第1期12卷 33-45页

作者： Shaolin XU Tsunemoto KURIYAGAWA Keita SHIMADA Masayoshi mizutani Division of Biomechanical Engineering Graduate School of BiomedicalEngineering Tohoku University Sendai 980-8579 Japan Department of Mechanical Systems Engineering Graduate School ofEngineering Tohoku University Sendai 980-8579 Japan

In this paper, the state of art of ultrasonic- assisted machining technologies used for fabrication of micro/nano-textured surfaces is reviewed. Diamond machining is the most widely used method in industry for manufacturing precision parts. For fabrication of fine structures on surfaces, conventional diamond machining methods are competitive by considering the precision of structures, but have limitations at machinable structures and machining efficiency, which have been proved to be partly solved by the integration of ultrasonic vibration motion. In this paper, existing ultrasonic-assisted machin- ing methods for fabricating fine surface structures are reviewed and classified, and a rotary ultrasonic texturing （RUT） technology is mainly introduced by presenting the construction of vibration spindles, the texturing principles, and the applications of textured surfaces. Some new ideas and experimental results are presented. Finally, the challenges in using the RUT method to fabricate micro/ nano-textured surfaces are discussed with respect to texturing strategies, machinable structures, and tool wear.

关键词： ultrasonic-assisted machining textured sur-face micro/nano-structures functional performance

Ghost Imaging with Deep Learning for Position Mapping of Weakly Scattered Light Source

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Nanomanufacturing and Metrology 2021年第1期4卷 37-45页

作者： yasuh.ro mizutani Shoma Kataoka Tsutomu Uenohara yasuh.ro Takaya Department of Mechanical Engineering Osaka UniversityOsaka 565-0871Japan

We propose ghost imaging(GI)with deep learning to improve detection ***,which uses an illumination light with random patterns and a single-pixel detector,is correlation-based and thus suitable for detecting weak ***,its detection time is too long for practical *** overcome this problem,we applied a convolutional neural network that was constructed based on a classification of the causes of ghost image degradation.A feasibility experiment showed that when using a digital mirror device projector and a photodiode,the proposed method improved the quality of ghost images.

关键词： Inspection Metrology Defect mapping Ghost imaging Single-pixel imaging Deep learning Weak light imaging

Foreword to the Special Issue on Micro- and Nano-Metrology in Japan(I)

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Nanomanufacturing and Metrology 2021年第2期4卷 1-2页

作者： Yuki Shimizu yasuh.ro mizutani Masaki Michihata Department of Finemechanics Tohoku UniversitySendai 9808579Japan Department of Mechanical Engineering Osaka UniversitySuita 5650871Japan Department of Precision Engineering The University of TokyoBunkyo 1138654Japan

Micro-and nano-metrology occupies an important position in modern production engineering where higher-precision machining is required.A visualization of the process is indispensable for the creation of new technologies in stateof-the-art manufacturing that deals with the geometrical quantity in micrometers/*** micro-and nano-metrology is thus becoming more and more important as the platform of various manufacturing technologies,as well as strategic tools for responding to rapidly changing fabrication techniques in many scientific and industrial fields.

关键词： metrology becoming Japan