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Paediatric gastrointestinal disorders in SARS-CoV-2 infection:Epidemiological and clinical implications

World Journal of Gastroenterology 2021年第16期27卷 1716-1727页

作者： Mohammed Al-Beltagi Nermin Kamal Saeed Adel Salah Bediwy yasser el-sawaf Department of Pediatric Faculty of MedicineTanta UniversityTanta 31527AlgharbiaEgypt Department of Pediatrics University Medical CenterArabian Gulf UniversityManama 26671Bahrain Microbiology Section Pathology DepartmentSalmaniya Medical ComplexManama 12Bahrain Department of Microbiology Royal College of Surgeons in Ireland-BahrainBahrainBusaiteen 15503MuharraqBahrain Department of Chest Diseases Tanta UniversityTanta 31527AlgharbiaEgypt Department of Pulmonology University Medical CenterArabian Gulf UniversityManama 26671Bahrain Department of Tropical Medicine Tanta UniversityTanta 31527AlgharbiaEgypt Department of Gastroenterology University Medical CenterArabian Gulf UniversityManama 26671Bahrain

The coronavirus disease 2019(COVID-19)pandemic is a threat worldwide for individuals of all ages,including *** manifestations could be the initial presenting manifestation in many patients,especially in *** symptoms are more common in patients with severe disease than in patients with non-severe *** 48.1%of patients had a stool sample that was positive for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)viral *** typically form 1%-8%of all laboratoryconfirmed cases of *** manifestations of COVID-19 in children are not rare,with a prevalence between 0 and 88%,and a wide variety of presentations,including diarrhoea,vomiting,and abdominal pain,can develop before,with or after the development of respiratory *** manifestations such as appendicitis or liver injury could also appear,especially in the presence of multisystem inflammatory *** this review,we discussed the epidemiology of COVID-19 gastrointestinal diseases in children as well as their implications on the diagnosis,misdiagnosis,prognosis,and faecal-oral transmission route of COVID-19 and the impact of gastrointestinal diseases on the gut microbiome,child nutrition,and disease management.

关键词： COVID-19 SARS-CoV-2 Gastrointestinal diseases Children Dysbiosis Faecal-oral transmission

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Gut microbiota in various childhood disorders:Implication and indications

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World Journal of Gastroenterology 2022年第18期28卷 1875-1901页

作者： Nermin Kamal Saeed Mohammed Al-Beltagi Adel Salah Bediwy yasser el-sawaf Osama Toema Medical Microbiology Section Department of PathologySalmaniya Medical ComplexMinistry of HealthManama 12Bahrain Microbiology Section Department of PathologyIrish Royal College of SurgeonBusaiteen 15503Bahrain Department of Pediatrics University Medical CenterArabian Gulf UniversityDr.Sulaiman Al Habib Medical GroupManama 26671Bahrain Department of Pediatrics Faculty of MedicineTanta UniversityTanta 31511Egypt Department of Chest Disease Faculty of MedicineTanta UniversityTanta 31527Egypt Department of Pulmonology University Medical CenterArabian Gulf UniversityDr.Sulaiman Al Habib Medical GroupManama 26671Bahrain Department of Tropical Medicine Faculty of MedicineTanta UniversityTanta 31527Egypt Department of Gastroenterology University Medical CenterArabian Gulf UniversityDr.Sulaiman Al-Habib Medical GroupManama 26671Bahrain

Gut microbiota has a significant role in gut development,maturation,and immune system *** exerts considerable effects on the child's physical and mental *** gut microbiota composition and structure depend on many host and microbial *** host factors include age,genetic pool,general health,dietary factors,medication use,the intestine's pH,peristalsis,and transit time,mucus secretions,mucous immunoglobulin,and tissue oxidation-reduction *** microbial factors include nutrient availability,bacterial cooperation or antagonism,and bacterial *** part of the gut has its microbiota due to its specific *** gut microbiota interacts with different body parts,affecting the pathogenesis of many local and systemic *** is a common finding in many childhood disorders such as autism,failure to thrive,nutritional disorders,coeliac disease,Necrotizing Enterocolitis,helicobacter pylori infection,functional gastrointestinal disorders of childhood,inflammatory bowel diseases,and many other gastrointestinal *** is also observed in allergic conditions like atopic dermatitis,allergic rhinitis,and *** can also impact the development and the progression of immune disorders and cardiac disorders,including heart *** supplements could provide some help in managing these ***,we are still in need of more *** this narrative review,we will shed some light on the role of microbiota in the development and management of common childhood disorders.

关键词： Gut microbiota Dysbiosis Children Gastrointestinal disorders Immune disorders Allergic disorders Cardiac disorders

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Immunohistochemical expression of matrix metalloproteinase-9 and 13 in oral squamous cell carcinoma and their role in predicting lymph node metastasis

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World Journal of Methodology 2025年第2期15卷 108-116页

作者： Bhari Sharanesha Manjunatha Keshav T Handge Vandana Sandeep Shah yasser Eid Al-Thobaiti Deepak Gowda Sadashivappa Pateel Department of Basic Oral Medicine and Allied Dental Sciences Taif UniversityAt`Taif 26571MakkahSaudi Arabia Department of Oral and Maxillofacial Pathology Dr.Vasantrao Pawar Medical CollegeHospital and Research CentreNashik 423101MaharashtraIndia Department of Oral Pathology and Microbiology KM Shah Dental College and HospitalSumandeep VidyapeethVadodara 391760GujaratIndia Department of Oral and Maxillofacial Surgery and Diagnostic Sciences Faculty of DentistryTaif UniversityAl-Haweiah 26571 MakkahSaudi Arabia Department of Oral Pathology and Microbiology Faculty of DentistryMAHSA UniversitySelangor 42610Malaysia

BACKGROUND One of the main characteristics of oral squamous cell carcinoma(OSCC)is that it metastasizes to cervical lymph nodes frequently with a high degree of local invasiveness.A primary feature of malignant tumors is their penetration of neighboring tissues,such as lymphatic and blood arteries,due to the tumor cells'capacity to break down the extracellular matrix(ECM).Matrix metalloproteinases(MMPs)constitute a family of proteolytic enzymes that facilitate tissue remo-deling and the degradation of the ***-9 and MMP-13 belong to the group of extracellular matrix degrading enzymes and their expression has been studied in OSCC because of their specific ***-13,a collagenase family member,is thought to play an essential role in the MMP activation cascade by breaking down the fibrillar collagens,whereas MMP-9 is thought to accelerate the growth of *** MMP-13 expression has been associated with tumor behavior and patient prognosis in a number of malignant *** authors wish to thank Jadhav KB for his valuable opinion during the preparation of the manuscript.

关键词： Matrix metalloproteinases Oral squamous cell carcinoma Tumor staging Immunohistochemistry Invasion Lymph node metastasis TNM stage

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Enhancing metformin efficacy with cholecalciferol and taurine in diabetes therapy:Potential and limitations

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World Journal of Diabetes 2025年第1期16卷 22-26页

作者： Gehan el-Akabawy Nabil Eid Department of Basic Medical Sciences College of MedicineAjman UniversityAjman 346United Arab Emirates Department of Anatomy Division of Human BiologySchool of MedicineIMU UniversityKuala Lumpur 57000Malaysia

Diabetes mellitus,particularly type 2 diabetes mellitus(T2DM),poses a significant global health *** management strategies primarily focus on glycemic control;however,there is a growing need for comprehensive approaches addressing the complex pathophysiology of diabetes *** recent study by Attia et al explores the potential of a novel therapy combining metformin with cholecalciferol(vitamin D3)and taurine to mitigate T2DM-related complications in a rat *** findings indicate that this treatment combination improves glycemic control and reduces oxidative stress,inflammation,and lipid ***,the study is limited by a lack of safety profile data and in-depth molecular mechanism *** editorial critically highlights the study's strengths and weaknesses,compares it against other combination therapy research in T2DM,and underscores the need to explore further the mechanisms underpinning the observed therapeutic effects and investigate the safety profile of this novel approach.

关键词： Diabetes Metformin Cholecalciferol Taurine Hyperglycemia Oxidative stress Triglycerides

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Atezolizumab and bevacizumab combination in advanced hepatocellular carcinoma patients:The imperative for safety assessment studies

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World Journal of Clinical Cases 2025年第9期13卷 56-59页

作者： Mina Tharwat Ahmed Tawheed Mohamed el-Kassas Department of Tropical Medicine and Gastroenterology Faculty of MedicineAswan UniversityAswan 81528Egypt Department of Endemic Medicine Faculty of MedicineHelwan UniversityCairo 11795Egypt

Hepatocellular carcinoma(HCC)is the most prevalent cancer of the hepatobiliary tract and the third leading cause of cancer-related mortality *** and bevacizumab combination is currently considered among the frontline treatment modalities for advanced unresectable *** studies examining this combination were focused on evaluating its *** numerous case reports documenting some side effects,there is a limited number of large-scale studies assessing these side *** this article,we comment on the case report by Park et al published recently,reporting a fatal intra-tumoral hemorrhage in a patient with HCC who received systemic therapy in the form of the combination of atezolizumab and bevacizumab.

关键词： Hepatocellular carcinoma Atezolizumab Bevacizumab Hemorrhage Side effects

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Preparation of solar-enhanced AlZnO@carbon nano-substrates for remediation of textile wastewaters

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Journal of Environmental Sciences 2020年第6期32卷 52-68页

作者： Esraa M.el-Fawal Sherif A.Younis yasser M.Moustafa Philippe Serp Central Laboratories Analysis and Evaluation DepartmentEgyptian Petroleum Research InstituteNasr CityCairo 11727Egypt Laboratoire de Chimie de Coordination(LCC) Unite Propre de Recherche(UPR)Du Centre National de La Recherche Scientifique(CNRS)8241Composante de L’Ecole Nationale D’Ingenieurs en Arts Chimiques et Technologiques(ENSIACET)Universite de ToulouseUniversite Paul Sabatier(UPS)Institut National Polytechnique(INP)-LCC4 Allee Emile Monso31030Toulouse Cedex 4France

Photoactive aluminum doped ZnO(AlZnO)was synthesized by sol-gel *** that,AlZnO photocatalyst was deposited on five carbon-based materials(CBMs)using ultrasonic route followed by solid-state mixing using ball *** CBMs used were poly aniline(PANI),carbon nitride(CN),carbon nanotubes(CNT),graphene(G),and carbon nanofibers(CNF).The crystal phases,elemental compositions,morphological,and optical properties of the AlZnO@CBMs composites were *** results revealed that two of AlZnO@CBMs composites exhibited superior bleaching efficiency(100%removal)and photocatalytic stability(three cycles)for 50μmol/L Methylene Blue(MB)contaminated water after 60 min irradiation in visible light at pH 6.5,0.7%H2O2,and 5 g/L inorganic *** optimum conditions,AlZnO@CBMs nanocomposites were employed for the treatment of mixed dyestuffs composed of MB,Methyl Orange(MO),Astrazone Blue FRR(BB 69),and Rhodamine B(RhB)dyes under dark,ultraviolet,visible,and direct *** mixed dyestuffs,the AlZnO@G achieved the highest dye sorption capacity(60.91μmol dye stuffs/g)with kinetic rate 8.22×10^-3 min^-1 in 90 min via multi-layer physisorption(Freundlich isotherm)on graphene *** additions,AlZnO@CN offered the highest photo-kinetic rate(Kphoto)of^54.1×10^-3 min^-1(93.8%after 60 min)under direct ***,the selective radical trapping experiment confirmed that the holes and oxidative superoxide radicals are crucial on dyes photodegradation *** to their superior performance,AlZnO@G and AlZnO@CN nanocomposites can offer an effective in-situ solar-assisted adsorption/photocatalytic remediation of textile wastewater effluents.

关键词： Carbon nanomaterials AlZnO photocatalyst Hybrid adsorption/photo-catalysis Kinetic and isotherm modeling Textile wastewater remediation

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Comparative study of energetic potential from anaerobic digestion and direct combustion of date palm wastes

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Clean Energy 2023年第4期7卷 747-754页

作者： Nabila Lahboubi Omar Kerrou Brahim Sarh Toufik Boushaki Veronica Belandria yasser el Khattabi Hassan el Bari Laboratory of electronic Systems Information ProcessingMechanics and EnergeticsFaculty of Sciences KenitraUniversity Ibn Tofail KenitraKenitraMorocco Institute of Combustion AerothermalReactivity and Environment(ICARE)-CNRS UPR302145071 Orléans Cedex 2France

This work aims to evaluate the technical and environmental feasibility of converting date palm waste from a Moroccan oasis into *** this study,two different scenarios were *** first proposed scenario is the valorization of the date palm substrates using direct combustion(thermochemical conversion)to produce *** second proposed scenario is the valorization of the substrates using combined anaerobic digestion of the substrate and direct combustion of the *** this study,two different date palm wastes are:empty fruit bunch(EFB)and palm leaflet(PL).The experimental lower heating values of the digestates studied are 12.93 and 12.71 MJ/kg,*** results show that using Scenario 1,the estimated output energies for the EFB and PL waste were 1.13 and 1.17 MWh,*** Scenario 2,the EFB and PL output energies were 1.27 and 1.39 MWh,*** study revealed that the combined process is possible as an alternative way to produce ***,combining anaerobic digestion and direct combustion of lignocellulosic waste can contribute to reducing greenhouse gas emissions.

关键词： biomass date palm waste energy direct combustion anaerobic digestion digestate

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Sequence Stratigraphy and Rudist Facies Development of the Upper Barremian-Lower Cenomanian Platform, Northern Sinai, Egypt

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Acta Geologica Sinica(English Edition) 2018年第1期92卷 286-310页

作者： yasser SALAMA Michael GRAMMER Shaban SABER Soheir el-SHAZLY Gouda ABDel-GAWAD Beni-Suef University Faculty of SciencesGeology Department Boone Pickens School of Geology Oklahoma State University

The Lower Cretaceous sections in northern Sinai are composed of the Risan Aneiza(upper Barremian-middle Albian) and the Halal(middle Albian-lower Cenomanian) formations. The facies reflect subtle paleobathymetry from inner to outer ramp facies. The inner ramp facies are peritidal, protected to open marine lagoons, shoals and rudist biostrome facies. The inner ramp facies grade northward into outer ramp deposits. The upper Barremian-lower Cenomanian succession is subdivided into nine depositional sequences correlated with those recognized in the neighbouring Tethyan areas. These sequences are subdivided into 19 medium-scale sequences based on the facies evolution, the recorded hardgrounds and flooding surfaces, interpreted as the result of eustatic sea level changes and local tectonic activities of the early Syrian Arc rifting stage. Each sequence contains a lower retrogradational parasequence set that constituted the transgressive systems tracts and an upper progradational parasequence set that formed the highstand systems tracts. Nine rudist levels are recorded in the upper Barremian through lower Cenomanian succession at Gabal Raghawi. At Gabal Yelleg two rudist levels are found in the Albian. The rudist levels are associated with the highstand systems tract deposits because of the suitability of the trophic conditions in the rudist-dominated ramp.

关键词： Cretaceous sequence stratigraphy rudists Sinai Egypt

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Prediction of COVID-19 Transmission in the United States Using Google Search Trends

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Computers, Materials & Continua 2022年第4期71卷 1751-1768页

作者： Meshrif Alruily Mohamed Ezz Ayman Mohamed Mostafa Nacim Yanes Mostafa Abbas yasser el-Manzalawy College of Computer and Information Sciences Jouf UniversitySakaka72314Saudi Arabia Faculty of Engineering Al-Azhar UniversityCairo11651Egypt Faculty of Computers and Informatics Zagazig UniversityZagazig44519Egypt RIADI Laboratory La Manouba UniversityManouba2010Tunisia Department of Translational Data Science and Informatics GeisingerDanvillePA17822USA

Accurate forecasting of emerging infectious diseases can guide public health officials in making appropriate decisions related to the allocation of public health *** to the exponential spread of the COVID-19 infection worldwide,several computational models for forecasting the transmission and mortality rates of COVID-19 have been proposed in the *** accelerate scientific and public health insights into the spread and impact of COVID-19,Google released the Google COVID-19 search trends symptoms open-access *** objective is to develop 7 and 14-day-ahead forecasting models of COVID-19 transmission and mortality in the US using the Google search trends for COVID-19 related ***,we propose a stacked long short-term memory(SLSTM)architecture for predicting COVID-19 confirmed and death cases using historical time series data combined with auxiliary time series data from the Google COVID-19 search trends symptoms *** the SLSTM networks trained using historical data only as the base models,our base models for 7 and 14-day-ahead forecasting of COVID cases had the mean absolute percentage error(MAPE)values of 6.6%and 8.8%,*** the other side,our proposed models had improved MAPE values of 3.2%and 5.6%,*** 7 and 14-day-ahead forecasting of COVID-19 deaths,the MAPE values of the base models were 4.8%and 11.4%,while the improved MAPE values of our proposed models were 4.7%and 7.8%,*** found that the Google search trends for“pneumonia,”“shortness of breath,”and“fever”are the most informative search trends for predicting COVID-19 *** also found that the search trends for“hypoxia”and“fever”were the most informative trends for forecasting COVID-19 mortality.

关键词： Forecasting COVID-19 transmission and mortality in the US stacked LSTM SARS-COV-2 and google COVID-19 search trends

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A simplified approach to directly consider intact rock anisotropy in Hoek——Brown failure criterion

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Journal of Rock Mechanics and Geotechnical Engineering 2014年第5期6卷 486-492页

作者： Mohamed A.Ismael Hassan F.Imam yasser el-Shayeb Mining Engineering Department Faculty of EngineeringCairo University

Many rock types have naturally occurring inherent anisotropic planes, such as bedding planes, foliation,or flow structures. Such characteristic induces directional features and anisotropy in rocks＇ strength anddeformational properties. The HoekeBrown （HeB） failure criterion is an empirical strength criterionwidely applied to rock mechanics and engineering. A direct modification to HeB failure criterion toaccount for rock anisotropy is considered as the base of the research. Such modification introduced a newdefinition of the anisotropy as direct parameter named the anisotropic parameter （Kb）. However, thecomputation of this parameter takes much experimental work and cannot be calculated in a simple *** aim of this paper is to study the trend of the relation between the degree of anisotropy （Rc） and theminimum value of anisotropic parameter （Kmin）, and to predict the Kmin directly from the uniaxialcompression tests instead of triaxial tests, and also to decrease the amount of experimental work. 2014 Institute of Rock and Soil Mechanics, Chinese Academy of Sciences. Production and hosting byelsevier B.V. All rights reserved.

关键词： Anisotropy Hoek-Brown failure criterion Rock mechanics Anisotropic parameter Degree of anisotropy

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