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Implementation of parallel adder using combinatorial logic architecture

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Chinese Journal of Lasers 1992年第4期 81-86页

作者： yarning wu, liren liu, zhijiang wang(Shanghai Institute of Optics and Fine Mechanics,Academia Sinica, P.O.Box 800-216, Shanghai 201800 China)

The algorithm and optical implementation of full parallel adder using combina-torial logic architecture have been suggested in this *** hybrid full parallel adder,which can perform multiple bits addition simultaneously,is implemented by utilizing VLSItechnology and acoustooptic Bragg *** algorithm has the advantages of high parallelismand easy optical *** full parallel adder finishes n-bit addition within the du-ration Tdif the pipeline architecture is employed,whose hardware complexity is O(n~2).

关键词： combinatorial logic full parallel addition hybrid architecture hardware complexity.

Optical stack filters using parallel fuzzy logic

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Chinese Journal of Lasers 1993年第3期 73-80页

作者： yarning wu, liren liu, zhijiang wang(Shanghai Institute of Optics & Fine Mechanics, Academia Sinica, P. 0. Box 800-216, Shanghai 201800, Chian)

Stack filters are more general and robust nonlinear filters than median filter, which possess threshold decomposition and stacking properties. Stack filters can be carried out one step using optical parallel fuzzy logic technique instead of three steps in threshold decomposition. All window, width 3 stack filters but two trivial stack filters are expressed in unified expression with coefficiencies to choose desired stack filter, so they are realized by an optical approach, window 3×3 separable stack filters can be realized by cascading the window width 3 stack filters. Window width 5 stack filters can be realized using the same method.

关键词： stack filters parallel fuzzy logic threshold decomposition stacking property positive Boolean function positive fuzzy function

Distinct clinical profiles and mutation landscapes of gliomas originating from the neocortex,mesocortex,and cerebellum

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Genes & Diseases 2024年第1期11卷 53-56页

作者： Ye Cheng Lei Zhang Xiaolong wu Hiroaki Wakimoto Haoming Geng Yukui Wei Geng Xu Xinru Xiao Jie Bai Yaming wang Zeliang Hu Leiming wang Qingtang Lian Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijing 100053China Brain Tumor Research Center Massachusetts General HospitalDepartment of NeurosurgeryHarvard Medical SchoolBostonMA02134USA Department of Pathology Xuanwu HospitalCapital Medical UniversityBeijing 100053China

Gliomas originating from anatomically and developmentally distinct brain regions have different clinical ***,the molecular landscape underlying this difference remains *** analyzed key molecular mutations via sequencing and correlated them with clinical characteristics in 180 adult patients with gliomas originating from the neocortex,mesocortex,and *** of cerebellar origin had significantly longer survival than those of supratentorial origin,consistent with higher rates of mutation in key genes associated with supratentorial gliomas.

关键词： clinical cortex glioma

LociScan,a tool for screening genetic marker combinations for plant variety discrimination

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The Crop Journal 2024年第2期12卷 583-593页

作者： Yang Yang Hongli Tian Hongmei Yi Zi Shi Lu wang Yaming Fan Fengge wang Jiuran Zhao Beijing Key Laboratory of Maize DNA Fingerprinting and Molecular Breeding Maize Research InstituteBeijing Academy of Agriculture and Forestry SciencesBeijing 100097China

To reduce the cost and increase the efficiency of plant genetic marker fingerprinting for variety discrimination,it is desirable to identify the optimal marker *** describe a marker combination screening model based on the genetic algorithm(GA)and implemented in a software tool,Loci ***-based variety discrimination power provided the largest optimization space among multiple fitness *** GA parameters,an increase in population size and generation number enlarged optimization depth but also calculation *** algorithm afforded the same optimization depth as GA but vastly increased calculation *** comparison with two other software tools,Loci Scan accommodated missing data,reduced calculation time,and offered more fitness *** large datasets,the sample size of training data exerted the strongest influence on calculation time,whereas the marker size of training data showed no effect,and target marker number had limited effect on analysis speed.

关键词： Plant variety discrimination Genetic marker combination Variety discrimination power Genetic algorithm

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Phototriggered targeting of nanocarriers for drug delivery

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Nano Research 2018年第10期11卷 5424-5438页

作者： Yafei Li yarning Zhang Weiping wang Dr. Li Dak-Sum Research Centre The University ofHong Kong-Karolinska Institutet Collaboration in Regenerative Medicine The University of Hong Kong Hong Kong China Department of Pharmacology and Pharmacy Li Ka Shing Faculty of Medicine The University ofHong Kong Hong Kong China

Stimuli-triggered targeting of drug delivery systems can both increase the therapeutic efficacy and lower toxicity by selectively delivering drugs at target sites with high specificity and efficiency. Light is a convenient and powerful stimulus for use in such drug delivery systems because it is readily available and noninvasive and offers excellent spatiotemporal control. The power and wavelength of light can be finely tuned for different photoresponsive systems to achieve efficient targeting at the tissue, cellular, or subcellular levels. Here, we have reviewed the various mechanisms for phototriggered targeting （phototargeting） of drug nanocarriers. We have discussed the three main phototargeting strategies：（1） targeting ligand activation; （2） particle size reduction; and （3） blood vessel disruption.

关键词： photocleavable groups photorelease photoresponsive nanoparticles phototargeting stimuli-responsive drug delivery targeted drug delivery

Mechanical properties,thermal conductivity and defect formation energies of samarium immobilization in Gd_(2)Zr_(2)O_(7):First-principles study and irradiation experiment

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Journal of Rare Earths 2023年第3期41卷 422-433,I0004页

作者： Yuhao wang Jiahu Ouyang Tao Wei Gui Cao Zhanguo liu Zhaoying Ding Yujin wang Yaming wang Key Laboratory of Advanced Structural-Functional Integration Materials&Green Manufacturing Technology School of Materials Science and EngineeringHarbin Institute of TechnologyHarbin 150001China Nuclear Fuel Cycle Research Theme Australian Nuclear Science and Technology OrganisationLocked Bag 2001Kirrawee DCNSW2232Australia

A density functional theory(DFT)study was employed to investigate the mechanical property,thermal conductivity,Debye temperature,electronic structure and defect chemistry of(Gd_(1-x)Sm_(x))_(2)Zr_(2)O_(7).All the(Gd_(1-x)Sm_(x))_(2)Zr_(2)O_(7) compounds exhibit an excellent structural and mechanical stability(Gd_(0.25)Sm_(0.75))_(2)Zr_(2)O_(7) has the lowest Young’s modulus of 213.7 GPa,the largest Possion’s ratio of 0.292,the lowest Debye temperature of 491.8 K and the lowest thermal *** calculated thermal conductivities of(Gd_(1-x)Sm_(x))_(2)Zr_(2)O_(7) are 1.17-1.21 W/(m·K)by the Clark’s model and 1.32-1.36 W/(m·K)by the Cahall’s model,*** formation energies of O vacancies at 48f site are negative,which increase with the Sm content,however,the formation energies of O vacancies at 8b site are almost *** addition,Sm partly occupying the Gd-site reduces distinctly the formation energies of defects such as A-site vacancies,cation antisite defects,anion Frenkel pairs of oxygen at 8b site and cation interstitials,which suggests that Sm-doped Gd_(2)Zr_(2)O_(7),especially equimolar GdSmZr_(2)O_(7),has a better irradiation *** the 16 MeVTa-ion irradiation at a fluence of 1×10^(14) or 2×10^(14) ions/cm^(2),the crystal structure of GdSmZr_(2)O_(7) transforms from pyrochlore to a defect fluorite without obvious amorphous phase.

关键词： Pyrochlores First-principles calculations Mechanical properties Defect formation energies Ion irradiation Rare earths

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Influence of Cr on the Electronic Properties of Passive Film on B30 Alloy in NaOH Solution

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Chemical Research in Chinese Universities 2015年第4期31卷 603-610页

作者： SHANG Yongbin XIAO Shuqin QIU Xiaolin WEI yarning Xi'an Changqing Technology & Engineering Co. Ltd. Xi'an 710018 P R. China Oil & Gas Technology Institute Changqing Oil Field Company Xi'an 710018 P R. China National Engineering Laboratory for Exploration and Development of Low-permeability Oil & Gas Fields Xi'an 710018 P R. China

The influence of Cr on the electronic properties of the passive film on B30 alloy in NaOH solution was studied via electrochemical impedance spectra（EIS）, potentiodynamic curve and Mott-Schottky plot. The Cr doped in the passive film on B30 alloy was detected by X-ray photoelectron spectroscopy（XPS）. XPS results show that Cr203 appeared on the passive film, which implied the enhanced anti-corrosion of B30 alloy. The passive film showed a p-type semi-conductive character. The acceptor density（NA） was in an order of magnitude of 1022 cm-3, and NA de- creased with the increment of Cr. EIS results show that the film resistance（Rf） increased with increasing the amount of Cr. The diffusion coefficient（D0） was calculated to be in a range of 10^-16---10^-17 cm-2/s on the basement of point defect modcl（PDM）.

关键词： Electrochemcal impedance spectrum X-Ray photoelectron spectroscopy Passive film

A biepitope,adjuvant-free,self-assembled influenza nanovaccine provides cross-protection against H3N2 and H1N1 viruses in mice

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Nano Research 2022年第9期15卷 8304-8314页

作者： Yongbo Qiao YaXin Zhang Jie Chen Shenghui Jin yarning Shan National Engineering Laboratory for AIDS Vaccine School of Life SciencesJilin UniversityChangchun 130012Chin

Currently,the incorporation of multiple epitopes into vaccines is more desirable than the incorporation of a single antigen for universal influenza vaccine ***,epitopes induce poor immune *** the use of adjuvants can overcome this obstacle,it may raise new *** antigen delivery vehicles that can function as both antigen carriers and intrinsic adjuvants are highly desired for vaccine ***,we report a biepitope nanovaccine that provides complete protection in mice against H3N2 virus as well as partial protection against H1N1 *** vaccine(3MCD-f)consists of two conserved epitopes(matrix protein 2 ectodomain(M2e)and CDhelix),and these epitopes were presented on the surface of ferritin in a sequential tandem *** immunization with 3MCD-f in the absence of adjuvant induces robust humoral and cellular immune *** results provide a proof of concept for the 3MCD-f nanovaccine that might be an ideal candidate for future influenza pandemics.

关键词： influenza universal vaccine multi-epitope nanovaccine

Photo-triggered nucleus targeting for cancer drug delivery

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Nano Research 2021年第8期14卷 2630-2636页

作者： Yafei Li Wen Lv Lang wang yarning Zhang Lipeng Yang Tianyi wang Linyong Zhu Yufeng wang Weiping wang Department of Pharmacology and Pharmacy Li Ka Shing Faculty of MedicineThe University of Hong KongHong KongChina Dr.Li Dak-Sum Research Centre The University of Hong KongHong KongChina Department of Chemistry The University of Hong Kong Hong Kong China School of Chemistry and Molecular Engineering East China University of Science and Technology Shanghai 200030China

Here,we report a strategy to deliver drug nanoparticles into cells with nucleus-targeting ability under a spatiotemporal *** nanoparticles were constructed through self-assembly of photoresponsive prodrugs and free *** incorporating a nucleus localization sequence in the system,drug nanoparticles could be delivered into nuclei upon visible light *** drug nanoparticles showed high drug loading capacity and specific nucleus-targeting ability,which efficiently killed cancer *** self-assembly strategy could be applied to other hydrophobic drugs and targeting ligands for photo-controlled organelle-targeted drug delivery.

关键词： phototargeting dePEGylation nucleus targeting coumarin photoresponsive prodrugs