Photo-triggered nucleus targeting for cancer drug delivery

作     者：Yafei Li Wen Lv Lang Wang Yarning Zhang Lipeng Yang Tianyi Wang Linyong Zhu Yufeng Wang Weiping Wang Yafei Li;Wen Lv;Lang Wang;Yaming Zhang;Lipeng Yang;Tianyi Wang;Linyong Zhu;Yufeng Wang;Weiping Wang

作者机构：Department of Pharmacology and PharmacyLi Ka Shing Faculty of MedicineThe University of Hong KongHong KongChina Dr.Li Dak-Sum Research CentreThe University of Hong KongHong KongChina Department of ChemistryThe University of Hong Kong Hong Kong China School of Chemistry and Molecular Engineering East China University of Science and TechnologyShanghai 200030China 

出 版 物：《Nano Research》 (纳米研究（英文版）)

年 卷 期：2021年第14卷第8期

页      面：2630-2636页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the Research Grants Council of Hong Kong(Early Career Scheme,No.27115220) Ming Wai Lau Centre for Reparative Medicine Associate Member Program,and Young Scientists Fund of the National Natural Science Foundation of China(No.81803469) We thank Dr.Jenny Lam at The University of Hong Kong for providing the A549 cell line.We acknowledge the assistance of The University of Hong Kong Li Ka Shing Faculty of Medicine Faculty Core Facility 

主　　题：phototargeting dePEGylation nucleus targeting coumarin photoresponsive prodrugs 

摘      要：Here,we report a strategy to deliver drug nanoparticles into cells with nucleus-targeting ability under a spatiotemporal *** nanoparticles were constructed through self-assembly of photoresponsive prodrugs and free *** incorporating a nucleus localization sequence in the system,drug nanoparticles could be delivered into nuclei upon visible light *** drug nanoparticles showed high drug loading capacity and specific nucleus-targeting ability,which efficiently killed cancer *** self-assembly strategy could be applied to other hydrophobic drugs and targeting ligands for photo-controlled organelle-targeted drug delivery.