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全身凝血-炎症标志物在预测急性A型主动脉夹层预后中的价值研究进展

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中华全科医学 2024年第8期22卷 1403-1407页

作者：宋鑫宇左亚群陈哲平金延武山东大学第二医院麻醉科山东济南250033

急性A型主动脉夹层(ATAAD)是以主动脉解剖病理改变、全身炎症反应、凝血功能紊乱为特征的一种复杂的、极为凶险的心血管疾病,对人类的生命和健康构成严重威胁。目前高龄、肥胖、术前神经损伤、大量输血、手术时间、组织器官灌注不良以... 详细信息

急性A型主动脉夹层(ATAAD)是以主动脉解剖病理改变、全身炎症反应、凝血功能紊乱为特征的一种复杂的、极为凶险的心血管疾病,对人类的生命和健康构成严重威胁。目前高龄、肥胖、术前神经损伤、大量输血、手术时间、组织器官灌注不良以及由于心脏压塞或冠状动脉灌注不良导致的血流动力学损害等危险因素被认为是ATAAD患者死亡的独立预测因子,但这些危险因素仍不能满足临床实践的需要。ATAAD常并存炎症反应和凝血功能障碍,凝血与炎症反应之间存在着复杂的交互作用,共同参与ATAAD的发生发展。研究报道,凝血与炎症标志物有助于评估ATAAD患者的预后,将其纳入临床预测模型(CPMs)相较于传统预测模型的预测效能更佳。为此,本文回顾并综述全身凝血-炎症标志物与ATAAD患者预后的相关性及其在预测模型建立中的作用研究进展,为临床早期诊断、早期危险分层、早期临床干预提供新思路。

关键词：急性A型主动脉夹层预后凝血炎症标志物预测价值临床预测模型

Enumeration and molecular characterization of circulating tumor cell using an in vivo capture system in squamous cell carcinoma of head and neck

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Chinese Journal of Cancer Research 2017年第3期29卷 196-203页

作者： Haidong Zhang Shanchun Gong yaqun Liu Longjun Liang Shuangba He Qingxiang Zhang Mingyuan Si Zhenkun Yu Otorhinolaryngology and Head and Neck Surgery Department Nanjing Tongren HospitalSchool of MedicineSoutheast UniversityNanjing 211100China

Objective: Detection rate and isolation yield of circulating tumor cell (CTC) are low in squamous cell carcinoma of head and neck (SCCHN) with in vitro approaches due to limited sample volumes. In this study, we applied the CellCollector to capture CTC in vivo from peripheral blood. Methods: In total, the study included 22 cases with 37 times of detection. All of the patients were newly diagnosed with locally advanced or metastatic SCCHN, including laryngocarcinoma (40.9%, 9/22) and hypopharyngeal carcinoma (59.1%, 13/22). All patients received CTC analysis before treatment. Three patients received induction chemotherapy. Sixteen patients received surgical therapy, of which 13 patients received postoperative detection. Two patients received both induction chemotherapy and surgery treatment. Patients underwent two successive CellCollector applications 24 h before and 7 d after surgical therapy. Nine healthy volunteers were enrolled as the control group. Epidermal growth factor receptor variant type III (EGFRVIII) expression was analyzed with fluorescent dye labeled antibody. Results: With CellCollector isolation, 72.7% (16/22) of the patients were positive for >= 1 CTC (CTC; range, 1-17 cells) before treatments and 46.7% (7/15) of patients were CTC positive for >= 1 CTC (CTC; range, 1-29 cells) after surgical therapy. Moreover, the detection rate of CellCollector (82.4%, 14/17; CTC count range, 0-17) in advanced SCCHN (stage III-IV) was much higher than that in early stages (stage I-II, 40.0%, 2/5; CTC count range, 0-2) (P<0.05). EGFRVIII expression of CTC was also analyzed with fluorescence staining. One CTCEGFRVIII-positive patient was detected from six CTC-positive patients, and the positive expression of EGFRVIII was also found in the tumor tissue of this patient. Conclusions: In vivo detection of CTCs had high sensitivity in SCCHN, which might improve CTC application in clinic.

关键词： CellCollector SCCHN in vivo CTC detection

Dietary supplementation of yeast cell wall improves the gastrointestinal development of weaned calves

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Animal Nutrition 2020年第4期6卷 507-512页

作者： Jian Ma Ali M.Shah yaqun Shao Zhisheng Wang Huawei Zou Kun Kang Low Carbon Breeding Cattle and Safety Production University Key Laboratory of Sichuan Province Animal Nutrition InstituteSichuan Agricultural UniversityChengdu 611130China Angel Yeast Co. Ltd.Yichang 443000China

The purpose of this study was to investigate the potential benefits of yeast cell wall(YCW)on the gastrointestinal development of weaned *** healthy Holstein male calves(BW=92±8.29 kg and 60±5 d of age)were randomly allocated into 2 groups:CON with no YCW,and YCW(accounted for0.16%of the basal diet).The dietary concentrate-to-roughage ratio was 40:*** the calves were fed regularly twice a day at 09:00 and 16:00 and had free access to *** experiment lasted for 60 *** results showed that calves fed YCW showed higher(P<0.05)length,width,and surface area of papillae in the ventral sac of the rumen as compared to *** the dorsal sac of the rumen,the muscularis thickness was thicker(P<0.05)in the YCW group when compared with CON *** villus height of YCW calves was higher(P<0.05)than that of CON in the *** supplemented with YCW also showed a higher(P<0.05)villus height-to-crypt depth ratio in the *** YCW calves exhibited a greater(P<0.05)thickness of the wall in the duodenum and *** supplemented with YCW improved(P<0.05)the claudin 1 mRNA expression in the ileum and occludin mRNA expression in the jejunum and *** YCW increased(P<0.05)the contents of secretory immunoglobulin A in the jejunum and ileum of *** conclusion,dietary supplementation with YCW could improve the gastrointestinal development of weaned calves.

关键词： Weaned calf Yeast cell wall Ruminal histology Intestinal histology Intestinal barrier function Gastrointestinal development

A comparative investigation of the properties of coal-water slurries prepared from Australia and Shenhua coals

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Mining Science and Technology 2011年第3期21卷 343-347页

作者： Yun Zengjie Wu Guoguang Meng Xianliang Zhang Yuliang Shi Frank He yaqun Luo Xiaoqiang School of Chemical Engineering and Technology China University of Mining and Technology Xuzhou 221008 China Julius Kruttschnitt Mineral Research Centre Brisbane 4068 Australia

Two coal samples of similar rank were chosen from Australia and China to investigate the differences in Coal-Water Slurry （CWS） made from them. The effect of ash content and particle size gradation on these properties was also studied. Different grinding times were used when grinding the two coals and particle size analysis of these ground coals was used to select samples with a ＂double-peak＂ particle size distri- bution. All the ＂double-peak＂ samples were used to prepare a CWS. The concentration, viscosity, fluidity, and stability of each CWS were measured. The results show that the properties ofa CWS prepared from a coal sample with a ＂double-peak＂ size distribution are better than those CWS prepared from samples with a mono-modal particle distribution. The ash content of Australian coal is 21.72g higher than the ash content of Shenhua coal. The highest coal concentration in slurry from the Australia coal is 11.01% higher than in CWS from the Shenhua coat. The fluidity and stability of the CWS prepared from the Australian coal are both better than the fluidity and stability of slurry prepared from Shenhua coal. High ash content in the Australian coal imnroves the nulning results of a CWS made from it.

关键词： Coal-Water Slurry"Double-peak" gradationSlurry ability Rheological property Stability

高速铁路国产超声波测风仪凝冻检测与加热装置设计

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铁路计算机应用 2024年第7期33卷 20-26页

作者：李亚群张弛武明生杨毕宣郭志华北京经纬信息技术有限公司北京100081 华云升达(北京)气象科技有限责任公司北京102200

高速铁路自然灾害及异物侵限监测系统中既有的进口超声波测风仪在运用中存在凝冻天气下功能失效的情况。研制了抗凝冻、采用测风与加热功能一体化设计的国产化超声波测风仪,以替代进口。文章基于超声波凝冻检测原理及国产超声波测风仪... 详细信息

高速铁路自然灾害及异物侵限监测系统中既有的进口超声波测风仪在运用中存在凝冻天气下功能失效的情况。研制了抗凝冻、采用测风与加热功能一体化设计的国产化超声波测风仪,以替代进口。文章基于超声波凝冻检测原理及国产超声波测风仪主体结构设计,提出超声波测风仪凝冻检测与加热装置设计;该装置采用双判据加热控制逻辑启动加热组件工作,加热组件置于测风仪内部、与测风探头内部构件紧密贴合,具有较高加热效率。在长白山天池气象站的外场试验表明:当凝冻发生时,凝冻检测与加热装置能对测风仪关键部位进行加热,有效防止测风功能失效。同时,通过凝冻条件下对比测试,发现无凝冻检测与加热功能的测风仪与带凝冻检测与加热功能的超声测风仪所采集的测风数据存在较大偏差。后续将开展深入研究,查明误差根源后改进其设计。

关键词：高速铁路自然灾害及异物侵限监测系统超声波测风仪失效国产化凝冻检测加热

Effects of the grinding process on the preparation and qualities of CWS

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Mining Science and Technology 2011年第6期21卷 767-771页

作者： Yuliang Zhang Guoguang Wu Xianliang Meng Zengjie Yun Frank Shi yaqun He Xiaoqiang Luo School of Chemical Engineering and Technology China University of Mining ＆ Technology Xu.zhou 221008 China Julius Kruttschnitt Mineral Research Centre Brisbane 4068 Australia

Two different grinding processes were examined to determine the effect grinding has on the quality of a CWS. A series of slurries was prepared from Australian (Au) and Chinese (YZ) coals. Both types of coal were ground by a Chinese (CUMT) and an Australian (JK) grinding process. The performance tests of the prepared CWS showed that fluidity of all slurries was acceptable. The concentration of the CWS from YZ coal ground by the CUMT grinding process was higher than when the JK grinding process was used. The highest concentration was 70.14% in this case. The concentration of the CWS prepared from Au coal by the JK grinding process was higher than when the CUMT grinding process was used. The highest con- centration in this case was 70.97%. These differences are caused by the particle size distribution devel- oped during the different grinding processes.

关键词： Coal water slurry "Double-peak" gradation Slurry ability Grinding process Stability Fluidity

Genome-wide variants of Eurasian facial shape differentiation and a prospective model of DNA based face prediction

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Journal of Genetics and Genomics 2018年第8期45卷 419-432页

作者： Lu Qiao Yajun Yang Pengcheng Fu Sile Hu Hang zhou Shouneng Peng Jingze Tan Yan Lu Haiyi Lou Dongsheng Lu Sijie Wu Jing Guo Li Jin yaqun Guan Sijia Wang Shuhua Xu Kun Tang Chinese Academy of Sciences (CAS) Key Laboratory of Computational Biology CAS-MPG Partner Institute for Computational Biology (PICB) Shanghai Institutes for Biological Sciences University of Chinese Academy of Sciences CAS Shanghai 200031 China State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology School of Life Sciences Fudan University Shanghai 200433 China Fudan-Taizhou Institute of Health Sciences Taizhou 225300 China Department of Neurology The First People's Hospital of Chenzhou Hunan 423000 China Collaborative Innovation Center of Genetics and Development Shanghai 200438 China Department of Biochemistry and Molecular Biology Preclinical Medicine College Xinjiang Medical University Urumqi 830011 China Center for Excellence in Animal Evolution and Genetics Chinese Academy of Sciences Kunming 650223 China School of Life Science and Technology ShanghaiTech University Shanghai 201210 China

It is a long-standing question as to which genes define the characteristic facial features among different ethnic groups. In this study, we use Uyghurs, an ancient admixed population to query the genetic bases why Europeans and Han Chinese look different. Facial traits were analyzed based on high-dense 3D facial images; numerous biometric spaces were examined for divergent facial features between European and Han Chinese, ranging from inter-landmark distances to dense shape geometrics, Genome-wide associ- ation studies （GWAS） were conducted on a discovery panel of Uyghurs, Six significant loci were iden- tified, four of which, rs1868752, rs118078182, rs60159418 at or near UBASH3B, COL23A1, PCDH7 and rs17868256 were replicated in independent cohorts of Uyghurs or Southern Han Chinese. A prospective model was also developed to predict 3D faces based on top GWAS signals and tested in hypothetic forensic scenarios.

关键词： Genome-wide association study Dense 3D facial image Ancestry-divergent phenotypes Face prediction Forensic scenario

MOF衍生的Co-CNT纳米片阵列高效催化氢气析出反应

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山东化工 2024年第4期53卷 18-21页

作者：张兴云朱子娴王小禛刘亚群王敏张祥临沂大学化学化工学院山东临沂276000

制备便宜、活性高的催化剂以实现高效地氢气析出反应具有较高挑战性。以自支撑的Co金属有机框架为前驱体,通过一步碳化制备了泡沫镍支撑的嵌入了Co纳米粒子的碳纳米管组成的纳米片阵列(简写为Co-CNT/NF)。该Co-CNT/NF在碱性条件下展现... 详细信息

制备便宜、活性高的催化剂以实现高效地氢气析出反应具有较高挑战性。以自支撑的Co金属有机框架为前驱体,通过一步碳化制备了泡沫镍支撑的嵌入了Co纳米粒子的碳纳米管组成的纳米片阵列(简写为Co-CNT/NF)。该Co-CNT/NF在碱性条件下展现了良好的催化氢气析出反应性能。当传递10 A·cm^(-2)的电流时,Co-CNT/NF仅需-134 mV的过电势,且催化活性至少可以保持12 h。较小的电阻和丰富的催化位点是导致Co-CNT/NF高催化活性的主要因素。这种简便、高效的催化剂合成方法,将为金属有机框架衍生的新型催化剂开发及在能源存储方面的应用提供新启发。

关键词：金属有机框架钴纳米粒子碳纳米管电催化氢气析出反应

维普期刊数据库博看期刊

Boosting the Ni-Zn interplay via O/N dual coordination for high-efficiency CO_(2) electroreduction

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Carbon Energy 2023年第4期5卷 68-80页

作者： Ying Zhang Hailei Jiang Anuj Kumar Hongchuan Zhang Zongge Li Tongxin Xu Yuan Pan yaqun Wang Zhiming Liu Guoxin Zhang Zifeng Yan State Key Laboratory of Heavy Oil Processing College of Chemistry and Chemical EngineeringChina University of Petroleum(East China)QingdaoShandongChina Department of Chemistry Institute of Humanities and Applied ScienceGLA UniversityMathuraIndia College of Chemistry and Chemical Engineering Liaocheng UniversityLiaochengShandongChina Al‐Ion Battery Research Center College of Energy Storage TechnologyShandong University of Science and TechnologyQingdaoShandongChina Shandong Engineering Laboratory for Preparation and Application of High‐performance Carbon‐Materials College of Electromechanical EngineeringQingdao University of Science and TechnologyQingdaoShandongChina

Design of supportive atomic sites with a controllably adjusted coordinating environment is essential to advancing the reduction of CO_(2) to value-added fuels and chemicals and to achieving carbon ***,atomic Ni(Zn)sites that are uniquely coordinated with ternary Zn(Ni)/N/O ligands were successfully decorated on formamide-derived porous carbon nanomaterials,possibly forming an atomic structure of Ni(N_(2)O_(1))-Zn(N_(2)O_(1)),as studied by combining X-ray photoelectron spectroscopy and X-ray absorption *** the mediation of additional O coordination,the Ni-Zn dual site induces significantly decreased desorption of molecular *** NiZn-NC decorated with rich Ni(N_(2)O_(1))-Zn(N_(2)O_(1))sites remarkably gained>97%CO Faraday efficiency over a wide potential range of -0.8 to -1.1 V(relative to reversible hydrogen electrode).Density functional theory computations suggest that the N/O dual coordination effectively modulates the electronic structure of the Ni-Zn duplex and optimizes the adsorption and conversion properties of CO_(2) and subsequent *** from the conventional pathway of using Ni as the active site in the Ni-Zn duplex,it is found that the Ni-neighboring Zn sites in the Ni(N_(2)O_(1))-Zn(N_(2)O_(1))coordination showed much lower energy barriers of the CO_(2) protonation step and the subsequent dehydroxylation step.

关键词： atomic dispersion carbon materials CO_(2)reduction formamide metal-nitrogen-carbon