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Association between Helicobacter pylori infection,mismatch repair,HER2 and tumor-infiltrating lymphocytes in gastric cancer

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2487-2503页

作者： Carlos A Castaneda Miluska Castillo Luis A Bernabe Joselyn Sanchez Matteo Fassan Katherine Tello Ignacio Ivan Wistuba Ivan Chavez Passiuri Eloy Ruiz Juvenal Sanchez Fernando Barreda Daniel Valdivia yaqueline bazan Milagros Abad-Licham Claudio Mengoa Hugo Fuentes Paola Montenegro Ebert Poquioma Raul Alatrista Claudio J Flores Luis Taxa Faculty of Health Sciences Universidad Cientifica del SurLima 15038Peru GECO PERU Grupo de Estudios Clinicos Oncologicos del PeruLima 15038Peru Department of Research Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Faculty of Human Medicine Universidad Ricardo PalmaLima 15039Peru Department of Medicine Surgical Pathology&Cytopathology UnitUniversity of PaduaPadua 35121Italy Department of Translational Molecular Pathology The University of Texas MD Anderson Cancer CenterHoustonTX 77030United States Department of Abdominal Surgery Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Department of Pathology Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Department of Medical Specialties Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Department of Pathology Instituto Regional de Enfermedades Neoplasicas del NorteTrujillo 13001Peru Faculty of Human Medicine Universidad Privada Antenor OrregoTrujillo 13008Peru Department of Surgery Instituto Regional de Enfermedades Neoplasicas del SurArequipa 04002Peru Department of Medical Oncology Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Department of Epidemiology Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Unidad de Investigación Básica y Traslacional Oncosalud-AUNALima 15038Peru Faculty of Medicine Universidad San Martin de PorresLima 15008Peru

BACKGROUND The influence of Helicobacter-pylori(H.pylori)infection and the characteristics of gastric cancer(GC)on tumor-infiltrating lymphocyte(TIL)levels has not been extensively studied.Analysis of infiltrating-immune-cell subtypes as well as survival is necessary to obtain comprehensive information.AIM To determine the rates of deficient mismatch-repair(dMMR),HER2-status and H.pylori infection and their association with TIL levels in GC.METHODS Samples from 503 resected GC tumors were included and TIL levels were evaluated following the international-TILs-working-group recommendations with assessment of the intratumoral(IT),stromal(ST)and invasive-border(IB)compartments.The density of CD3,CD8 and CD163 immune cells,and dMMR and HER2-status were determined by immunohistochemistry(IHC).H.pylori infection was evaluated by routine histology and quantitative PCR(qPCR)in a subset of samples.RESULTS dMMR was found in 34.4%,HER2+in 5%and H.pylori-positive in 55.7%of samples.High IT-TIL was associated with grade-3(P=0.038),while ST-TIL with grade-1(P<0.001),intestinal-histology(P<0.001)and no-recurrence(P=0.003).dMMR was associated with high TIL levels in the ST(P=0.019)and IB(P=0.01)compartments,and STCD3(P=0.049)and ST-CD8(P=0.05)densities.HER2-was associated with high IT-CD8(P=0.009).H.pylorinegative was associated with high IT-TIL levels(P=0.009)when assessed by routine-histology,and with high TIL levels in the 3 compartments(P=0.002-0.047)and CD8 density in the IT and ST compartments(P=0.001)when assessed by qPCR.A longer overall survival was associated with low IT-CD163(P=0.003)and CD8/CD3(P=0.001 in IT and P=0.002 in ST)and high IT-CD3(P=0.021),ST-CD3(P=0.003)and CD3/CD163(P=0.002).CONCLUSION TIL levels were related to dMMR and H.pylori-negativity.Low CD8/CD3 and high CD163/CD3 were associated with lower recurrence and longer survival.

关键词： Lymphocytes Macrophages Gastric cancer Helicobacter pylori HER2 Mismatch repair

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Cotton pads-derived carbon materials/reduced graphene oxide modified with polypyrrole for electrode of supercapacitors

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Journal of Energy Chemistry 2024年第7期94卷 41-53页

作者： Ofelia MArias-Pinedo Elvis OLopez Ivonne EMonje RSoria-Martinez Antony bazan-Aguilar Clemente Alfredo Luyo Caycho Gabriel Angel Planes Angelica Maria Baena-Moncada Laboratorio de Investigacion de Electroquimica Aplicada Facultad de Ciencias de la Universidad Nacional de IngenieriaAv.Tupac Amaru 210RimacLimaPeru Department of Experimental Low Energy Physics Brazilian Center for Research in Physics(CBPF)Rio de Janeiro22290-180Brazi Universidad Tecnologica del Peri Av.Arequipa 26515046 LimaPeru Centeror theevelopmentof Adanced Materials and Nanotechlogy Universidad NacionaldeIngeneria33LimaP Departamento de Quimica Universidad Nacional de Rio CuartoInstituto de Investigaciones en Tecnologias Energeticas y Materiales Avanzados(IITEMA)Ruta Nac.36Km 601(X5804BYA)RioCuartoCordobaArgentina

This study investigates the influence of electropolymerization conditions on the deposition of polypyrrole(PPy)onto cotton-derived carbon fiber(CF)modified with reduced graphene oxide(rGO)for supercapacitors applications using an experimental/theorical approach.The surface modification of CF by rGO and/or by PPy electrodeposited at 10,25 and 50 mV s^(-1) was thoroughly examined physicochemical and electrochemically.Composite electrodes comprising CF-rGo-PPy,synthesized via electropolymerization at 25 mV s^(-1),demonstrated a remarkable increase in capacitance,showcasing~742 F g^(-1) compared to 153 F g^(-1) for CF.SEM,N_(2)-surface area,XPS,and TD-DFT approach revealed that the higher capacitance observed in CF-rGo-PPy electrodes underscores the influence of morphology and charged nitrogen species on the electrochemical performance of these modified electrodes.Notably,this electrode material achieves a specific capacitance retention of~96%of their initial capacitance after 10000 cycles at 0.5 A g^(-1) measured in a two-electrodes cell configuration.This work also discusses the influence of the scan rate used for pyrrole electropolymerization on the pseudocapacitance contribution of PPy and its possible effect on the porosity of the material.These results highlight the importance of appropriate electropolymerization conditions that allow obtaining the synergistic effect between CF,rGO and PPy.

关键词： Supercapacitors Cotton pads-derived carbon fibers rGO PPy TD-DFT

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Potential impact of genetically modified Lepidoptera-resistant Brassica napus in biodiversity hotspots： Sicily as a theoretical model

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Insect Science 2018年第4期25卷 562-580页

作者： Barbara Manachini Giuseppe bazan Rosario Schicchi Department of Agricultural Food and Forest Sciences University of Palermo Palermo Italy Department of Biological Chemical and Pharmaceutical Sciences and Technologies University of Palermo Palermo Italy

The general increase of the cultivation and trade of Bt transgenic plants resis- tant to Lepidoptera pests raises concerns regarding the conservation of animal and plant biodiversity. Demand for biofuels has increased the cultivation and importation of oilseed rape （Brassica napus L.）, including transgenic lines. In environmental risk assessments （ERAs） for its potential future cultivation as well as for food and feed uses, the impact on wild Brassicaeae relatives and on non-target Lepidoptera should be assessed. Here we consider the potential exposure of butterflies as results of possible cultivation or natural- ization of spilled seed in Sicily （Italy）. Diurnal Lepidoptera, which are pollinators, can be exposed directly to the insecticidal proteins as larvae （mainly of Pieridae） through the host and through the pollen that can deposit on other host plants. Adults can be exposed via pollen and nectar. The flight periods of butterflies were recorded, and they were found to overlap for about 90% of the flowering period ofB. napus for the majority of the species. In addition, B. napus has a high potential to hybridise with endemic taxa belonging to the B. oleracea group. This could lead to an exposure of non-target Lepidoptera if introgression of the Bt gene into a wild population happens. A rank of the risk for butterflies and wild relatives of oilseed rape is given. We conclude that, in environmental risk assessments, attention should be paid to plant-insect interaction especially in a biodiversity hotspot such as Sicily.

关键词： butterflies cross pollination non-target effect oilseed rape protected areas transgenic crop

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Over 9% efficiency achieved for all-polymer solar cells processed by a green solvent

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Science China Chemistry 2017年第8期60卷 1109-1110页

作者： Guillermo C.bazan Departments of Chemistry & Biochemistry and Materials University of California Santa Barbara

Bulk-heterojunction polymer solar cells(PSCs)have attracted considerable attention owning to their potential for fabricating flexible,light-weight and large area solar cell panels via high-throughput roll-to-roll technologies.Compared with conventional PSCs comprising small molecule acceptors,such as fullerenes,all-polymer solar cells(all-PSCs)containing blends of p-type/n-type polymers in the photoactive layer provide advantages including

关键词： PSCs on in is for efficiency achieved for all-polymer solar cells processed by a green solvent Over 9 by

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Acute heart failure as an adverse event of tumor necrosis factor inhibitor therapy in inflammatory bowel disease:A review of the literature

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World Journal of Cardiology 2023年第5期15卷 217-228页

作者： Thais Gagno Grillo Caroline Ferreira da Silva Mazeto Pupo Silveira Ana Elisa Valencise Quaglio Renata de Medeiros Dutra Julio Pinheiro Baima Silmeia Garcia Zanati bazan Ligia Yukie Sassaki Department of Internal Medicine Medical SchoolSão Paulo State UniversityBotucatuBotucatu 18618686Brazil Department of Biophysics and Pharmacology Institute of BiosciencesSão Paulo State UniversityBotucatuBotucatu 18618689Brazil

Tumor necrosis factor inhibitors(anti-TNFs)are widely used therapies for the treatment of inflammatory bowel diseases(IBD);however,their administration is not risk-free.Heart failure(HF),although rare,is a potential adverse event related to administration of these medications.However,the exact mechanism of development of HF remains obscure.TNFαis found in both healthy and damaged hearts.Its effects are concentration-and receptor-dependent,promoting either cardio-protection or cardiomyocyte apoptosis.Experimental rat models with TNFαreceptor knockout showed increased survival rates,less reactive oxygen species formation,and improved diastolic left ventricle pressure.However,clinical trials employing anti-TNF therapy to treat HF had disappointing results,suggesting abolishment of the cardioprotective properties of TNFα,making cardiomyocytes susceptible to apoptosis and oxidation.Thus,patients with IBD who have risk factors should be screened for HF before initiating anti-TNF therapy.This review aims to discuss adverse events associated with the administration of anti-TNF therapy,with a focus on HF,and propose some approaches to avoid cardiac adverse events in patients with IBD.

关键词： Tumor necrosis factor inhibitors Inflammatory bowel disease Heart failure Adverse event TNFαreceptor

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Data driven discovery of conjugated polyelectrolytes for optoelectronic and photocatalytic applications

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npj Computational Materials 2021年第1期7卷 641-649页

作者： Yangyang Wan Fernando Ramirez Xu Zhang Thuc-Quyen Nguyen Guillermo C.bazan Gang Lu Department of Physics and Astronomy California State University NorthridgeNorthridgeCaliforniaUSA Department of Chemistry and Biochemistry University of CaliforniaSanta BarbaraCaliforniaUSA

Conjugated polyelectrolytes(CPEs),comprised of conjugated backbones and pendant ionic functionalities,are versatile organic materials with diverse applications.However,the myriad of possible molecular structures of CPEs render traditional,trial-and-error materials discovery strategy impractical.Here,we tackle this problem using a data-centric approach by incorporating machine learning with high-throughput first-principles calculations.We systematically examine how key materials properties depend on individual structural components of CPEs and from which the structure–property relationships are established.By means of machine learning,we uncover structural features crucial to the CPE properties,and these features are then used as descriptors in the machine learning to predict the properties of unknown CPEs.Lastly,we discover promising CPEs as hole transport materials in halide perovskite-based optoelectronic devices and as photocatalysts for water splitting.Our work could accelerate the discovery of CPEs for optoelectronic and photocatalytic applications.

关键词： conjugated backbone photocatalytic

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羊膜培养液抑制角膜新生血管的实验研究

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中华眼科杂志 2003年第12期39卷 753-756页

作者：马翔 Haydee bazan 李军大连医科大学附属第一临床学院眼科 116011 Department of Ophthalmology Lion Eye CenterLouisiana State University School of Medicine

目的　研究羊膜培养液对小鼠角膜新生血管的抑制作用及机制。方法　应用cornealmicropocket方法 ,将含 10 0ng碱性成纤维细胞生长因子 (bFGF)和 12 %hydronpolymer的缓释颗粒植入角膜层间 ,制备小鼠角膜新生血管模型。实验分对照组、羊... 详细信息

目的　研究羊膜培养液对小鼠角膜新生血管的抑制作用及机制。方法　应用cornealmicropocket方法 ,将含 10 0ng碱性成纤维细胞生长因子 (bFGF)和 12 %hydronpolymer的缓释颗粒植入角膜层间 ,制备小鼠角膜新生血管模型。实验分对照组、羊膜组和去上皮羊膜组 ,每组 10只眼 ,收集各组培养液于模型制作当日起 ,每日滴眼 4次至术后 7d摄片观测角膜新生血管长入情况并处死动物。对脐静脉血管内皮细胞 (HUVEC)进行体外培养 ,并应用Boyden小房技术和荧光结合(CyQUANT)实验分别检测羊膜培养液对HUVEC细胞迁移和细胞增殖的影响。利用酶联免疫吸附(ELISA)法检测各组培养液中金属蛋白酶抑制剂 1(TIMP1)和 2 (TIMP2 )的含量。结果　羊膜培养液明显抑制由bFGF诱发的小鼠角膜新生血管的形成 ,对照组、羊膜组和去上皮羊膜组角膜新生血管面积分别是 (2 4 8± 0 76 )mm2 、(0 6 4± 0 5 2 )mm2 和 (1 96± 0 6 5 )mm2 。羊膜培养液明显抑制血管内皮细胞的迁移和增殖 ,而对照组和去上皮羊膜组对HUVEC细胞迁移无作用。羊膜培养液中TIMP2水平明显增高 ,而TIMP1的含量无变化。结论　羊膜培养液中TIMP1的含量未增加。而羊膜上皮产生或释放大量的TIMP2 ,抑制血管内皮细胞的迁移和增殖。

关键词：羊膜培养液角膜新生血管碱性成纤维细胞生长因子 bFGF 细胞增殖

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血小板活化因子致角膜上皮伤口迟愈合的实验研究

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中华眼科杂志 2004年第3期40卷 151-155页

作者：马翔倪春霞 bazan Haydee 孙洪臣大连医科大学第一临床学院眼科 116011 Department of Ophthalmology Lion Eye CenterLouisiana State University School of Medicine

目的　利用兔去上皮角膜模型 ,研究血小板活化因子 (PAF)对角膜伤口愈合的作用及其分子生物学机制。方法　离体角膜上做正中直径 7mm圆形去上皮角膜伤口。去上皮角膜分为 3组 ,即对照、PAF及BN (PAF拮抗剂 )组 ,培养 4 8h后 ,行角膜上... 详细信息

目的　利用兔去上皮角膜模型 ,研究血小板活化因子 (PAF)对角膜伤口愈合的作用及其分子生物学机制。方法　离体角膜上做正中直径 7mm圆形去上皮角膜伤口。去上皮角膜分为 3组 ,即对照、PAF及BN (PAF拮抗剂 )组 ,培养 4 8h后 ,行角膜上皮染色观察伤口愈合状况。分别对兔角膜上皮 (RCE)和角膜基质 (RCK)细胞进行体外传代培养 ,RCE和RCK细胞经PAF和 (或 )BN处理 ,培养 2 4h ,提纯RNA。应用RT PCR及核酸杂交技术分别检测肝细胞生长因子 (HGF)、角质形成生长因子 (KGF)及表皮生长因子 (EGF)基因在RCK和RCE细胞及HGF受体 (HGF R)基因在RCE细胞中的表达强度。分别应用CyQUANT荧光结合和Boyden小房技术检测PAF对RCE细胞黏附、增殖和迁徙的影响。结果　PAF (10 0nmol/L )明显抑制角膜上皮伤口愈合 ,4 8h对照、PAF和BN组角膜上皮未愈合面积经电脑图像分析分别为 :(6 0± 1.5 )U、(5 8 0± 7 0 )U和 (5 0± 1 0 )U。PAF明显增强RCE细胞黏附作用 ,对照、PAF和BN组每 96孔板贴附细胞数荧光光度平均值分别为 :36 96± 372、790 8± 6 71和 3487± 32 4。RT PCR结果显示 :PAF使HGFmRNA在RCK的表达强度降低 4 .1倍 ,同时明显减弱HGF R在RCE细胞中的表达 ,核酸杂交实验证实PCR结果。结论PAF明显增强RCE细胞的黏附作用 ,

关键词：血小板活化因子伤口愈合实验分子生物学肝细胞生长因子原癌基因蛋白质角膜损伤

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Gold Sterile Ore Acid Generation Evaluation, San Juan Argentina

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Journal of Environmental Protection 2014年第13期5卷 1294-1304页

作者： Vanesa bazan Pedro Sarquis Elena Brandaleze CONICET Instituto de Investigaciones Mineras Universidad Nacional de San Juan San Juan Argentina Instituto de Investigaciones Mineras Universidad Nacional de San Juan San Juan Argentina Metallurgical Department and Technology and Materials Develop Center DEYTEMA Universidad Tecnológica Nacional Facultad Regional de San Nicolás San Nicolás Argentina

One of the problems that mining represents in relation to the natural watercourses is the possible formation of what we call acid mine drainage, which consists in the emission or formation of water effluents of great acidity, usually rich in sulfate and with variable contents in heavy metals. The drainage mentioned is developed from the metal sulfide and sulfate leaching. Researches about the creation of acid drainage suggest that the formation of these depends directly on various factors: primary mineralogy (neutralizer sulfides and minerals), water presence (whether), oxygen diffusion, grain size, microbiological interaction (bacterium), among others. To study these variables and to relate them with geological factors, static (Acid-Base Accounting) and dynamic (Humidity Cell) tests have been developed, among others. The mentioned tests are applied to a case of a gold deposit situated in the Province of San Juan, which is currently very argued because of its mining activity due to its leaching process. In the sterile mineral obtained from the process, kinetics tests were carried out in humidity cells to simulate the natural oxidation of the primary mineral samples. In the obtained leaching, pH values closer to neutrality and a limited solution metal presence were detected, indicating the neutralization ability due to the carbonates ores presence.

关键词： Acid Drainage Sulfide Ores Carbonates Ores

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Argentinean Copper Concentrates: Structural Aspects and Thermal Behaviour

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International Journal of Nonferrous Metallurgy 2013年第4期2卷 128-135页

作者： Vanesa bazan Elena Brandaleze Leandro Santini Pedro Sarquis CONICET—Instituto de Investigaciones Mineras Universidad Nacional de San Juan San Juan Argentina Metallurgical Department and Technology and Materials Develop Center DEYTEMA-Universidad Tecnológica Nacional Facultad Regional de San Nicolás Colón Argentina psarquis@unsj.edu.ar

In Argentina, there are many sources of copper concentrates. Some of them are currently in operation, while others are in the exploration stage. All copper concentrates produced are exported to other countries for copper refinement and to create various finished products. It is desirable that in the near future, these copper concentrates be processed in an Argentinean industrial plant. The aim of this paper was to present the results of a characterisation study carried out on five different copper concentrate samples. The thermal decomposition of the copper concentrates was determined by differential thermal analysis and thermogravimetry (DTA TG). The information was correlated with the chemical composition and the mineralogical phases of the samples identified by X-ray diffraction. A melting test at temperatures of up to 1300℃ was performed to complete the study of the concentrate’s behaviour during heating. After the test, all of the samples were observed by light and electronic scanning microscopy to identify the different phases generated under high-temperature conditions.

关键词： Copper Concentrates Thermal Analysis Pyrometallurgy Mineral Phases

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