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香瓜茄干制品的开发及其风味成分分析

保鲜与加工 2024年第5期24卷 77-83页

作者：雷鑫叶雅萍卢万洋伯年国王藤赵明云南农业大学茶学院云南昆明650201 云南农业大学西南中药材种质创新与利用国家地方联合工程研究中心云南省药用植物生物学重点实验室云南昆明650201 云南特色植物提取实验室云南昆明650106

为提高香瓜茄的产品价值和明确其风味物质组成,将香瓜茄去皮、切丁,在30~80℃下进行热风干燥,通过感官评价结合多酚类物质、可溶性糖、游离氨基酸含量的测定与分析优化干燥温度。结果表明:50℃干燥制成的果干具有色泽金黄、奶香兼甜香... 详细信息

为提高香瓜茄的产品价值和明确其风味物质组成,将香瓜茄去皮、切丁,在30~80℃下进行热风干燥,通过感官评价结合多酚类物质、可溶性糖、游离氨基酸含量的测定与分析优化干燥温度。结果表明:50℃干燥制成的果干具有色泽金黄、奶香兼甜香浓郁、滋味甜醇等特征,风味最优,其可溶性糖含量为83.06%±5.07%,高效液相色谱检测到蔗糖(517.19 mg/g)、果糖(262.77 mg/g)和葡萄糖(154.20 mg/g)为主要的甜味物质。全二维气相色谱-飞行时间质谱鉴定到595个挥发性物质,相对含量超过1%的有21个,其中琥珀酸二乙酯(2.64%)、辛酸乙酯(1.69%)等5种呈果香,γ-壬内酯(2.08%)、甘油(1.73%)呈甜香,3,3-二甲基丙烯酸(3.62%)、2-甲基丁酸(3.51%)、己酸(2.08%)呈奶香,构成了果干的奶香甜香浓郁的特征。本研究开发了一种风味优良的香瓜茄果干,明确了其风味物质组成,为后续开发提供了基础。

关键词：香瓜茄水果干制品滋味活度值风味物质全二维气相色谱-飞行时间质谱(GC×GC-TOF MS)

甲苯磺酸索拉非尼联合TACE术用于不可手术切除的局限性肝癌患者治疗的效果分析

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实用癌症杂志 2024年第4期39卷 648-651,677页

作者：朱九荣岳恺叶亚平吴玉卓河南省南阳市中心医院 473000

目的探讨甲苯磺酸索拉非尼联合经肝动脉化疗栓塞术(TACE)用于不可切除的局限性肝癌患者的疗效。方法选取不可手术切除的肝癌患者为研究对象,随机分为对照组和观察组,观察组给予甲苯磺酸索拉非尼联合TACE治疗,对照组行单纯TACE治疗。比较... 详细信息

目的探讨甲苯磺酸索拉非尼联合经肝动脉化疗栓塞术(TACE)用于不可切除的局限性肝癌患者的疗效。方法选取不可手术切除的肝癌患者为研究对象,随机分为对照组和观察组,观察组给予甲苯磺酸索拉非尼联合TACE治疗,对照组行单纯TACE治疗。比较2组患者临床疗效、肿瘤标志物[甲胎蛋白(AFP)、糖类抗原(CA19-9)]水平、肝功能指标[谷丙转氨酶(ALT)、总胆红素(TBil)、白蛋白(Alb)]水平及不良反应发生率。结果对照组客观缓解率为33.33%,观察组客观缓解率为54.17%,差异有统计学意义(P0.05)。结论甲苯磺酸索拉非尼片联合TACE术用于不可手术切除的局限性肝癌患者具有更好的临床疗效,对肝功能的损伤较小,且不增加不良反应,较为安全可靠。

关键词：甲苯磺酸索拉非尼经肝动脉化疗栓塞术局限性肝癌肝功能临床疗效

Lung adeno-squamous carcinoma modeling using oncogenic KRAS activation in human embryonic stem cell-derived alveolar organoids

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Genes & Diseases 2023年第1期10卷 33-36页

作者： Jianqi Feng Lian Li Zhihong Tan Shanshan Zhao Xin Zhang Jinhong Wang yaping ye Ying Lin Zhili Rong Cancer Research Institute School of Basic Medical SciencesState Key Laboratory of Organ Failure ResearchNational Clinical Research Center of Kidney DiseaseKey Laboratory of Organ Failure Research(Ministry of Education)Southern Medical UniversityGuangzhouGuangdong 510515China Dermatology Hospital Southern Medical UniversityGuangzhouGuangdong 510091China Department of Respiration The Third Affiliated Hospital of Southern Medical UniversityGuangzhouGuangdong 510630China Department of Pathology Nanfang Hospital and School of Basic Medical ScienceSouthern Medical UniversityGuangzhouGuangdong 510515China Bioland Laboratory(Guangzhou Regenerative Medicine and Health Guangdong Laboratory) GuangzhouGuangdong 510005China Experimental Education/Administration Center School of Basic Medical ScienceSouthern Medical UniversityGuangzhouGuangdong 510515China

Mutant KRAs is a common driver in lung ***,the occurrence of human lung cancer and its subsequent development after activation of oncogenic KRAS in epithelial cells remain poorly *** are embedded in three-dimensional Matrigel in which tissue-derived human adult stem cells can efficiently grow for a long time,maintaining genetic and phenotypic stability."But until now,the use of organoids to simulate human non-small cell lung cancer has not been reported.

关键词： lung KRAS Lung

Combined strategies for improving the heterologous expression of a novel xylanase from Fusarium oxysporum Fo47 in Pichia pastoris

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Synthetic and Systems Biotechnology 2024年第3期9卷 426-435页

作者： Chun Liu yaping Zhang Chunting ye Fengguang Zhao Yian Chen Shuangyan Han School of Biology and Biological Engineering South China University of TechnologyGuangzhou510640China School of Light Industry and Engineering South China University of TechnologyGuangzhou510640China

Xylanase,an enzyme capable of hydrolyzing non-starch polysaccharides found in grain structures like wheat,has been found to improve the organizational structure of dough and thus increase its *** our past work,one promising xylanase FXYL derived from Fusarium oxysporum Fo47 and first expressed 779.64 U/mL activity in *** has shown significant potential in improving the quality of whole wheat bread,making it become a candidate for development as a new flour *** optimization of expression elements and gene dose,the xylanase activity of FXYL strain carrying three-copies reached 4240.92 U/mL in *** addition,12 factors associated with the three stages of protein expression pathway were co-expressed individually in order in three-copies strain,and the translation factor Pab1 co-expression increased FXYL activity to 8893.53 U/***,combining the most effective or synergistic factors from three stages did not exhibit better results than co-expressing them *** further evaluate the industrial potential,the xylanase activity and protein concentration reached 81184.51 U/mL and 11.8 g/L in a 5 L fed-batch *** engineering strategies improved the expression of xylanase FXYL by more than 104-fold,providing valuable insights for the cost-effective industrial application of FXYL in the baking field.

关键词： Xylanase Pichia pastoris Heterologous protein Secretion expression

A Complete Solution to the Chromatic Equivalence Class of Graph Bn-8,1,4

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Journal of Mathematical Research with Applications 2012年第3期32卷 253-268页

作者： yaping MAO,Chengfu ye,Shumin ZHANG Department of Mathematics,Qinghai Normal University,Qinghai 810008,P.R.China Department of Mathematics Qinghai Normal University Qinghai 810008

Two graphs are defined to be adjointly equivalent if and only if their complements are chromatically *** the properties of the adjoint polynomials and the fourth character R;（G）,the adjoint equivalence class of graph B;is *** to the relations between adjoint polynomial and chromatic polynomial,we also simultaneously determine the chromatic equivalence class of B;that is the complement of B;.

关键词： chromatic equivalence class adjoint polynomial the smallest real root the fourth character.

Unraveling the stereoscopic gene transcriptional landscape of zebrafish using Fish SED,a fish spatial expression database with multispecies scalability

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Science China(Life Sciences) 2024年第4期67卷 843-846页

作者： Cheng Guo Weidong ye Danying Cao Mijuan Shi Wanting Zhang Yingyin Cheng yaping Wang Xiao-Qin Xia Institute of Hydrobiology Chinese Academy of SciencesWuhan 430072China College of Advanced Agricultural Sciences University of Chinese Academy of SciencesBeijingChina The Innovative Academy of Seed Design Chinese Academy of SciencesBeijing 100101China

Dear Editor,The expression profile demonstrates how each gene was expressed in the target tissue or cell at a given *** heterogeneity is a biological concept characterized by the presence of numerous cells with varying functions and expression profiles within organ/tissue *** is also cell-to-cell signaling,which implies that the extracellular environment and spatial location influence intracellular transcription,resulting in spatial heterogeneity of gene expression within the same cell type.

关键词： landscape fish database

Preparation of Nanometric Particles of Aluminum Nitride by Pyrolysis of Diethylaluminun Azide

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International Journal of Minerals,Metallurgy and Materials 1997年第4期11卷 43-46页

作者： ye yaping ZHOU Keyan GAO Thznxian SUN Yu LU Bingling(Applied Science School, USTB, Beijing 100083, China)(School of Chemical Engineering, Dalian University of Technology)

Thermal stabilities of diethylaluminum azide were studied by means of theoretical analysis and *** results have shown that diethylaluminum and azid be heated to vigorous refluxing under vacuum(400 Pa) at temperature as high as 420℃ without incident of explosion and decomposes smoothly during 460 ～580℃ to form nanometric particles of aluminum nitride in the aerosol synthesis reactor. A new way of preparing nanometric parties of aluminum nitrideis found.

关键词： aluminum nitride nanometric particle preparation diethylaluminum azide

发动蛋白1在结直肠癌中的表达和临床意义及其与自噬的关系

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中国医师杂志 2023年第11期25卷 1661-1667,1672页

作者：邹佳媛冶亚平南方医科大学基础医学院病理学系广州510515 佛山市顺德区第三人民医院病理科佛山528311 南方医科大学南方医院病理科广州510515

目的分析发动蛋白1(DNM1)基因表达与结直肠癌(CRC)患者临床病理参数及预后的关系,探究DNM1与自噬机制的关联。方法应用肿瘤基因组图谱(TCGA)数据库分析DNM1在CRC患者正常肠黏膜与癌组织中、肿瘤早期(TNMⅠ期与Ⅱ期)与晚期(TNMⅢ期与Ⅳ期... 详细信息

目的分析发动蛋白1(DNM1)基因表达与结直肠癌(CRC)患者临床病理参数及预后的关系,探究DNM1与自噬机制的关联。方法应用肿瘤基因组图谱(TCGA)数据库分析DNM1在CRC患者正常肠黏膜与癌组织中、肿瘤早期(TNMⅠ期与Ⅱ期)与晚期(TNMⅢ期与Ⅳ期)癌组织中的mRNA水平差异,用Kaplan-Meier法进行生存时间估计及预后分析;用免疫组织化学染色检测118例CRC患者癌组织的DNM1蛋白表达情况,分析其表达特点与临床病理参数及预后的关系;用基因集富集分析(GSEA)CRC患者癌组织中DNM1与自噬相关的信号通路;使用共聚焦显微镜检测并分析DNM1(和其他5个自噬相关蛋白ATG9B、ULK1、Beclin-1、P62/SQSTM1、ATG16L1)与自噬标志物微管相关蛋白1轻链3(LC3)的免疫荧光双染色的皮尔逊相关系数(PCC)。结果DNM1在CRC肿瘤组织中表达升高,在肿瘤晚期的表达显著升高(P<0.05);Kaplan-Meier生存分析示:DNM1的表达量与肿瘤预后负相关[HR=1.71,95%CI(1.21,2.40),P<0.01]。DNM1阳性强度与肿瘤的浸润深度、淋巴结转移、癌结节、远处转移、神经及脉管侵犯、分化程度、组织学分型、特殊组织学分型有关(均P<0.01)。有序logistic回归模型验证了肿瘤分化及DNM1的阳性程度均为CRC患者不良预后的危险因素,DNM1强阳性与腺癌复发正相关(P<0.05)。DNM1高表达涉及负调控雷帕霉素靶蛋白复合物1(mTORC1)、磷脂酰肌醇3激酶/蛋白激酶B/雷帕霉素靶蛋白(PI3K/AKT/mTOR)等自噬的关键信号通路(P<0.05,FDR<0.001)。六组免疫荧光双染色中DNM1与LC3B两基因表达模式的相关性最大。结论DNM1高表达是CRC患者的不良预后因素,可能通过正向调控自噬与肿瘤进展有关。

关键词：结直肠肿瘤发动蛋白1 自噬

唐山市2000～2010年湿地景观格局演变及驱动力分析

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水电能源科学 2014年第4期32卷 139-142页

作者：胡晓叶亚平河海大学水文水资源学院江苏南京210098

以唐山市遥感数据为基础，运用景观生态学研究方法、转移矩阵法和主成分分析法分析唐山市2000~2010年湿地动态变化、景观格局演变及其驱动力。结果表明，与2000年相比，2010年唐山市湿地总面积下降2 410.65 hm2，不同类型的湿地表现... 详细信息

以唐山市遥感数据为基础，运用景观生态学研究方法、转移矩阵法和主成分分析法分析唐山市2000~2010年湿地动态变化、景观格局演变及其驱动力。结果表明，与2000年相比，2010年唐山市湿地总面积下降2 410.65 hm2，不同类型的湿地表现为不同的变化趋势；除了人工水渠之外，城市化过程对各类型湿地均有一定程度的占用；唐山市湿地形状趋于复杂化，破碎化逐渐加剧；社会经济发展水平、总人口、农业发展水平及气候条件是影响唐山市湿地景观格局演变的主要驱动力。

关键词：湿地遥感数据景观格局驱动力