Lung adeno-squamous carcinoma modeling using oncogenic KRAS activation in human embryonic stem cell-derived alveolar organoids
作者机构：Cancer Research InstituteSchool of Basic Medical SciencesState Key Laboratory of Organ Failure ResearchNational Clinical Research Center of Kidney DiseaseKey Laboratory of Organ Failure Research(Ministry of Education)Southern Medical UniversityGuangzhouGuangdong 510515China Dermatology HospitalSouthern Medical UniversityGuangzhouGuangdong 510091China Department of RespirationThe Third Affiliated Hospital of Southern Medical UniversityGuangzhouGuangdong 510630China Department of PathologyNanfang Hospital and School of Basic Medical ScienceSouthern Medical UniversityGuangzhouGuangdong 510515China Bioland Laboratory(Guangzhou Regenerative Medicine and Health Guangdong Laboratory)GuangzhouGuangdong 510005China Experimental Education/Administration CenterSchool of Basic Medical ScienceSouthern Medical UniversityGuangzhouGuangdong 510515China
出 版 物：《Genes & Diseases》 (基因与疾病（英文）)
年 卷 期：2023年第10卷第1期
页 面：33-36页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：This work was supported by the National Natural Science Foundation of China(No.82070002,82072329 and 81872511) Frontier Research Program of Bioland Laboratory(Guangzhou Regenerative Medicine and Health GuangdongLaboratory,Guangdong,China)(No.2018GZR110105005)
摘 要：Mutant KRAs is a common driver in lung ***,the occurrence of human lung cancer and its subsequent development after activation of oncogenic KRAS in epithelial cells remain poorly *** are embedded in three-dimensional Matrigel in which tissue-derived human adult stem cells can efficiently grow for a long time,maintaining genetic and phenotypic stability.But until now,the use of organoids to simulate human non-small cell lung cancer has not been reported.
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