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Prolonged Consumption of Dietary Advanced Lipoxidation End Products contributes to renal impairment in mice through Dysregulated Intestinal homeostasis

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Food Science and human Wellness 2024年

作者： Yaya Wang Lu Dong yaozhong hu Tianchang Zhang Ruican Wang Linqing Nie Junping Wang Yan Zhang Shuo Wang Tianjin Key Laboratory of Food Science and Health School of Medicine Nankai University State Key Laboratory of Food Nutrition and Safety Key Laboratory of Food Nutrition and Safety College of Food Engineering and Biotechnology Tianjin University of Science and Technology

Heat processing of food has been well validated as the trigger to generate heat-processing side product of advanced lipoxidation end products (ALEs)， which potentially engenders the threat on systemic health or progression of diseases， especially the accumulated effect after long-term intake. Thus， the study was proposed to evaluate the effect of dietary ALEs on health after long-term ingestion， specifically through simulating the intake of dietary ALE in mice within 9 months to investigate the intervention effect and underlying mechanism. The unexpected observation of renal insufficiency or impairment after long-term intake of dietary ALEs indicated the negative impact on renal health， which has been verified by the pathological analysis. Further studies revealed that a high-ALEs diet disrupted the intestinal barrier， with enhanced impact after disturbing the gut microbiota to potentially lower the abundance of beneficial microbiome through producing nephrotoxic metabolites. Correlation analysis showed that the proliferation of harmful bacteria and the reduction of beneficial bacteria were strongly correlated with intestinal barrier damage and the development of renal insufficiency. Furthermore， the underlying mechanism was unveiled as that ALEs could inhibit AMPK/SIRT1 signaling to fundamentally induce renal inflammation and oxidative stress. Thus， it was revealed that long-term intake of dietary ALE could result in renal impairment， and the results emphasized the control or intervention on dietary ALE to decrease to accumulated impairment on systemic health.

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Solvability of Parabolic Anderson Equation with Fractional Gaussian Noise

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Communications in Mathematics and Statistics 2023年第3期11卷 563-582页

作者： Zhen-Qing Chen yaozhong hu Department of Mathematics University of WashingtonSeattleWA98195USA Department of Mathematical and Statistical Sciences University of Alberta at EdmontonEdmontonT6G 2G1Canada

This paper provides necessary as well as sufﬁcient conditions on the hurst parameters so that the continuous time parabolic Anderson model ∂u/∂t=1/2△+u˙W on[0,∞)×R^(d) with d≥1 has a unique randomﬁeld solution,where W(t,x)is a fractional Brownian sheet on[0,∞)×Rd and formally ˙W=∂d+1/∂t+∂x_(1)…∂x_(d)=W(t,x).When the noise W(t,x) is white in time,our condition is both necessary and sufﬁcient when the initial data u(0,x)is bounded between two positive *** the noise is fractional in time with hurst parameter H_(0)>1/2,our sufﬁcient condition,which improves the known results in the literature,is different from the necessary one.

关键词： Stochastic heat equation Fractional Brownian fields Wiener chaos expansion Random field solution Necessary condition sufficient condition Moment bounds

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混沌脉冲组电场作用下油中液滴的聚结特性

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石油学报（石油加工） 2024年第3期40卷 744-752页

作者：龚海峰方原余保彭烨胡耀中廖培尧殷宏李书龙重庆工商大学废油资源化技术与装备教育部工程研究中心重庆400067 重庆工商大学制造装备机构设计与控制重庆市重点实验室重庆400067 重庆工商大学环境与资源学院重庆400067 安徽国孚润滑油工业有限公司安徽安庆246000

混沌脉冲组(CPG)电场可用于乳化液破乳,但是乳化液滴在油中的聚结特性尚不清楚。通过数值方法研究了油中液滴在混沌脉冲组电场中的聚结特性以及电场参数对液滴聚结过程的影响。结果表明:CPG电场作用下液滴聚结过程可分为6个阶段,各阶段... 详细信息

混沌脉冲组(CPG)电场可用于乳化液破乳,但是乳化液滴在油中的聚结特性尚不清楚。通过数值方法研究了油中液滴在混沌脉冲组电场中的聚结特性以及电场参数对液滴聚结过程的影响。结果表明:CPG电场作用下液滴聚结过程可分为6个阶段,各阶段的呈现与电场作用时间和电场休止时间相关,其中第Ⅲ阶段的持续时间对聚结时间影响较大;占空比影响液滴聚结过程的状态以及聚结时间;电场强度的增加对液滴聚结状态无显著影响,但明显缩短聚结时间,当电场强度从500 kV/m增加到700 kV/m,液滴聚结时间从0.400 s减小到0.152 s。研究液滴在CPG电场中的聚结特性能够为CPG电场在工业中的应用提供理论依据。

关键词：油包水乳液混沌脉冲组聚结特性液滴电场参数数值分析

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Tea polyphenol-gut microbiota interactions:hints on improving the metabolic syndrome in a multi-element and multi-target manner

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Food Science and human Wellness 2022年第1期11卷 11-21页

作者： hui Ma yaozhong hu Bowei Zhang Zeping Shao Eugeni Roura Shuo Wang a Tianjin Key Laboratory of Food Science and Health School of MedicineNankai UniversityTianjin 300071China Centre for Nutrition and Food Sciences Queensland Alliance for Agriculture and Food InnovationThe University of QueenslandBrisbaneQLD 4072Australia

The metabolic syndrome(MS)has become one of the main problems in public *** polyphenols(TPs),the main bioactive components of tea,has been claimed to have the potential to regulate metabolism and effectively prevent or mitigate the ***,many studies into the effects of TPs on MS have provided conflicting findings and the underlying mechanism has been *** predominant TPs in unfermentedand and fermented tea are catechins and oxidized polyphenols(theaflavins and thearubigins),both of which have low bioavailability and reach the colon where most gut microbes *** microbiota has been demonstrated to be tightly associated with host *** interactions between TPs and gut microbiota will lead to the alterations of gut microbiota composition and the production of metabolites including short chain fatty acids,bile acids,amino acids and TPs derived metabolites,accordingly exerting their biological effects both locally and *** review highlighted the contribution of metabolites and specific gut bacteria in the process of TPs intervention on the MS and further discuss how TPs impact the MS via gut microbiota from the viewpoint of gut organ/tissue axis.

关键词： Tea polyphenols Gut microbiota Metabolic syndrome Metabolites Gut organ/tissue axis

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OPTIMAL TRACKING FOR BILINEAR STOCHASTIC SYSTEM DRIVEN BY FRACTIONAL BROWNIAN MOTIONS

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Journal of Systems Science & Complexity 2012年第2期25卷 238-248页

作者： yaozhong hu Changli YANG College of Science Wuhan University of Science and Technology Department of Mathematics University of Kansas School of Information Science and Technology East China Normal University

This paper discusses a problem of optimal tracking for a linear control system driven by fractional Brownian *** equation is obtained for the linear Markov feedback *** existence and uniqueness of the solution to the ... 详细信息

关键词：分数布朗运动驱动系统双线性最优跟踪随机线性控制系统解的存在性跟踪问题

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Stochastic quantization and ergodic theorem for density of diffusions

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Science China Mathematics 2012年第11期55卷 2285-2296页

作者： hu yaozhong Department of Mathematics University of Kansas Lawrence KS 66045 USA

For a given probability density function ρ(x) on Rd,we construct a(non-stationary) diffusion process xt,starting at any point x in Rd,such that 1/T∫T0 δ(xt-x)dt converges to ρ(x) almost *** rate of this convergence is also *** find this rate,we mainly use the Clark-Ocone formula from Malliavin calculus and the Girsanov transformation technique.

关键词：概率密度函数扩散过程遍历定理随机量化改造技术融合率微积分

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Slippery hydrogel with desiccation-tolerant‘skin’for high-precision additive manufacturing

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International Journal of Extreme Manufacturing 2024年第2期6卷 486-500页

作者： Desheng Liu Pan Jiang Yue hu yaozhong Lu Yixian Wang Jiayu Wu Danli hu Tao Wu Xiaolong Wang State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000People’s Republic of China CAS Key Laboratory of Chemistry of Northwestern Plant Resources Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000People’s Republic of China Shandong Laboratory of Advanced Materials and Green Manufacturing at Yantai Yantai Zhongke Research Institute of Advanced Materials and Green Chemical EngineeringYantai 264006People’s Republic of China Key Laboratory of Materials-Oriented Chemical Engineering of Xinjiang Uygur Autonomous Region School of Chemistry and Chemical EngineeringShihezi UniversityShihezi 832003People’s Republic of China

Hydrogels inevitably undergo dehydration,structural collapse,and shrinkage deformation due to the uninterrupted evaporation in the atmosphere,thereby losing their flexibility,slipperiness,and manufacturing ***,we propose a novel bioinspired strategy to construct a spontaneously formed‘skin’on the slippery hydrogels by incorporating biological stress metabolites trehalose into the hydrogel network,which can generate robust hydrogen bonding interactions to restrain water *** contents of trehalose in hydrogel matrix can also regulate the desiccation-tolerance,mechanical properties,and lubricating performance of slippery hydrogels in a wide *** vat photopolymerization three-dimensional printing and trehalose-modified slippery hydrogels enables to achieve the structural hydrogels with high resolution,shape fidelity,and sophisticated architectures,instead of structural collapse and shrinkage deformation caused by *** thus,this proposed functional hydrogel adapts to manufacture large-scale hydrogels with sophisticated architectures in a long-term *** a proof-of-concept demonstration,a high-precision and sophisticated slippery hydrogel vascular phantom was easily fabricated to imitate guidewire ***,the proposed protocol is universally applicable to diverse types of hydrogel *** strategy opens up a versatile methodology to fabricate dry-resistant slippery hydrogel for functional structures and devices,expanding their high-precision processing and broad applications in the atmosphere.

关键词： slippery hydrogel trehalose desiccation tolerance vat photopolymerization 3D printing hydrogen bonding

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Selection of specific nanobodies against peanut allergen through unbiased immunization strategy and the developed immuno-assay

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Food Science and human Wellness 2023年第3期12卷 745-754页

作者： yaozhong hu Chuan Zhang Jing Lin Yi Wang Sihao Wu Ying Sun Bowei Zhang huan Lv Xuemeng Ji Yang Lu Shuo Wang Tianjin Key Laboratory of Food Science and Health School of MedicineNankai UniversityTianjin 300071China College of Food Science and Engineering Tianjin University of Science and TechnologyTianjin 300457China

Peanut allergy is considered to be a major health issue with global *** date,no effective curative approach has been applied for the therapy of the anaphylaxis resulting from the peanut *** accurate and effective detection methods for the surveillance of allergens in food are still the primary strategies to avoid allergic *** this study,nanobodies(Nbs)derived from the Heavy-Chain only Antibodies(HCAbs)were selected against the general peanut protein extract through the unbiased strategy to facilitate the development of the sandwich ELISA for the detection and surveillance of peanut allergen *** target antigen of the selected Nb was identified as peanut allergen Ara h 3,and a cross-reaction was observed with the member of Gly 1 from the Ara h 3 *** applicability of the self-paired Nb P43 on the establishment of the immuno-assay was verified.A sandwich ELISA against peanut allergen was developed,which reached a linear range of 0.2-10.6μg/mL,and a limit of detection of 53.13 ng/mL.

关键词： Peanut allergen Ara h 3 Nanobody Sandwich ELISA Gly 1

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SOME RECENT PROGRESS ON STOCHASTIC HEAT EQUATIONS

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Acta Mathematica Scientia 2019年第3期39卷 874-914页

作者：胡耀忠 Department of Mathematical and Statistical Sciences University of Alberta

This article attempts to give a short survey of recent progress on a class of elementary stochastic partial differential equations (for example, stochastic heat equations) driven by Gaussian noise of various covariance structures. The focus is on the existence and uniqueness of the classical (square integrable) solution (mild solution, weak solution). It is also concerned with the Feynman-Kac formula for the solution;Feynman-Kac formula for the moments of the solution;and their applications to the asymptotic moment bounds of the solution. It also briefly touches the exact asymptotics of the moments of the solution.

关键词： Gaussian random field Gaussian noise stochastic partial differential equation(stochastic heat equation) Feynman-Kac formula for the solution FeynmanKac formula for the moments of the solution chaos expansion hypercontractivity moment bounds Holder continuity joint Holder continuity asymptotic behaviour Trotter-Lie formula Skorohod integral

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JOINT HOLDER CONTINUITY OF PARABOLIC ANDERSON MODEL

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Acta Mathematica Scientia 2019年第3期39卷 764-780页

作者：胡耀忠 Khoa Lê Department of Mathematical and Statistical Sciences University of Alberta Department of Mathematics South Kensington Campus Imperial College London

We obtain the Holder continuity and joint Holder continuity in space and time for the random field solution to the parabolic Anderson equation(■t-1/2△)u=u◇Win d-dimensional space, where W is a mean zero Gaussian noise with temporal covariance γo and spatial covariance given by a spectral density μ(ζ).We assume that γo(t)≤c|t|^-α0 and |μ(ζ)|≤c ∏di=1|ζi|^-αi or|μ(ζ)|≤c|ζ|^-α, where α,α1,…,αd can take both positive and negative values.

关键词： Gaussian process stochastic heat equation parabolic Anderson model multiplicative noise chaos expansion hypercontractivity Holder continuity joint Holder continuity

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