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Carbenoxolone pretreatment and treatment of posttraumatic epilepsy

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Neural Regeneration Research 2013年第2期8卷 169-176页

作者： Weiguan Chen Zhiwei Gao yaohui ni Zhenxiang Dai Department of Rehabilitation Medicine Affiliated Hospital of Nantong University Department of Neurology Affiliated Hospital of Nantong University

Gap junction blocking agents can inhibit spontaneous discharge frequency in cells. We established a rat model of posttraumatic epilepsy induced using ferric ions. Rats were intraperitoneally injected with carbenoxolone, 20 mg/kg, prior to and 30 minutes after model establishment, once a day for 14 consecutive days. Immunohistochemistry showed glial cell proliferation around a cortical focus and significantly increased connexin expression in posttraumatic epilepsy. However, carbenoxolone pretreatment or treatment significantly reduced connexin expression in the cortex, inhibited glial fibdllary acidic protein expression and ameliorated seizure degree in rats. These findings indicate that large amounts of glial cell proliferation and abnormal gap junction generation play a role in posttraumatic epilepsy, and that carbenoxolone may prevent and treat this disease.

关键词： neural regeneration brain injury posttraumatic epilepsy ferric ion gap junction carbenoxolone glial fibrillary acidic protein connexin 43 seizure brain injury grant-supported paper photographs-containing paper neuroregeneration

人尿激肽原酶在脑梗死后不同时间窗应用疗效观察

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交通医学 2015年第4期29卷 323-325,332页

作者：倪耀辉季秋虹南通大学附属医院神经内科江苏226001

目的：探讨在脑梗死后不同治疗时间窗应用人尿激肽原酶（尤瑞克林）的疗效差异。方法：将急性脑梗死91例患者随机分为3组，A组30例予阿司匹林和他汀类药物治疗；B组31例，在A组治疗的基础上，发病24h内加用人尿激肽原酶；C组30例，在A... 详细信息

目的：探讨在脑梗死后不同治疗时间窗应用人尿激肽原酶（尤瑞克林）的疗效差异。方法：将急性脑梗死91例患者随机分为3组，A组30例予阿司匹林和他汀类药物治疗；B组31例，在A组治疗的基础上，发病24h内加用人尿激肽原酶；C组30例，在A组治疗的基础上，发病24-48小时予人尿激肽原酶治疗。采用niHSS评分评价患者的神经功能缺损，BI评价患者的日常生活能力，分别比较3组治疗前后及各组间的niHSS评分和BI。结果：治疗前niHSS评分A组为10.23±1.08分，B组为10.94±1.13分，C组为11.37±1.25分，3组比较差异无统计学意义（P＞0.05）；治疗后2周niHSS评分A组为7.98±0.87分，B组为5.78±0.63分，C组为6.02±0.67分，3组niHSS评分与治疗前比显著下降（P＜0.05），B组和C组的niHSS评分明显低于A组（P＜0.05）；B、C两组之间niHSS评分无显著差异（P＞0.05）。治疗前BI评分A组为17.89±1.98分，B组为18.13±1.78分，C组为19.27±2.13分，治疗后3月BI评分A组为51.54±5.94分，B组为68.12±7.83分，C组为66.54±7.68分，3组比较差异无统计学意义（P＞0.05）；治疗后3个月，3组的BI与治疗前比显著增高（P＜0.05），B、C组的BI明显高于A组（P＜0.05）；B、C组之间比较差异均无统计学意义（P＞0.05）。结论：与阿司匹林、他汀类药物联合应用，人尿激肽原酶对急性期脑梗死患者疗效明显，脑梗死后24小时内和24-48小时内使用的疗效相近。

关键词：脑梗死人尿激肽原酶阿托伐他汀时间窗

脑白质疏松与急性脑梗死溶栓后出血转化及临床预后的相关性

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脑与神经疾病杂志 2023年第1期31卷 52-57页

作者：王岩倪耀辉李爱红南通大学附属丹阳医院神经内科江苏212300 南通大学附属医院神经内科

目的探讨脑白质疏松(LA)与急性脑梗死(ACI)溶栓后出血转化及临床预后的相关性。方法选取201例ACI患者,搜集患者临床资料,静脉溶栓前根据Fazekas量表分为无或轻度LA组(n=150)和中重度LA组(n=51)。根据静脉溶栓后否发生出血转化分为出血... 详细信息

目的探讨脑白质疏松(LA)与急性脑梗死(ACI)溶栓后出血转化及临床预后的相关性。方法选取201例ACI患者,搜集患者临床资料,静脉溶栓前根据Fazekas量表分为无或轻度LA组(n=150)和中重度LA组(n=51)。根据静脉溶栓后否发生出血转化分为出血转化组(n=39)和非出血转化组(n=162),根据改良Rankin量表分为预后不良组(n=57)和预后良好组(n=144)。多因素Logistics回归分析ACI溶栓后出血转化及临床预后影响因素。结果中重度LA组出血转化率35.29%和预后不良率49.02%高于无或轻度LA组14.00%和21.33%(均PniHSS)评分、中重度LA是ACI溶栓后出血转化的独立危险因素(均PniHSS评分、出血转化、中重度LA是ACI溶栓后临床预后不良的独立危险因素(均P<0.05)。结论中重度LA是ACI溶栓后出血转化及临床预后不良的独立危险因素,可能作为出血转化及预后评估指标。

关键词：急性脑梗死静脉溶栓出血转化预后脑白质疏松

实验性梗阻性黄疸肠道细菌易位及精氨酸治疗的研究

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中华肝胆外科杂志 2005年第9期11卷 630-632页

作者：周新泽毛勤生倪耀辉南通大学附属医院普外科江苏省226001

目的观察梗阻性黄疸(梗黄)大鼠肠道细菌易位状况及经胃肠道给予精氨酸对肠道细菌易位的影响。方法结扎Wistar大鼠胆管,制成梗黄模型,60只Wistar大鼠随机分为假手术组、梗黄组和梗黄+精氨酸治疗组,每组各20只,于术后21d观察并比较各组血... 详细信息

目的观察梗阻性黄疸(梗黄)大鼠肠道细菌易位状况及经胃肠道给予精氨酸对肠道细菌易位的影响。方法结扎Wistar大鼠胆管,制成梗黄模型,60只Wistar大鼠随机分为假手术组、梗黄组和梗黄+精氨酸治疗组,每组各20只,于术后21d观察并比较各组血浆内毒素、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)的含量及肝功能状况,并对肠系膜淋巴结、胰腺及肺组织行细菌培养,末端小肠做病理检查。结果梗黄组大鼠血浆内毒素、TNF-α、IL-6含量、总胆红素及谷丙转氨酶均明显升高,肠系膜淋巴结、胰及肺组织细菌培养阳性率明显升高,小肠黏膜损伤严重,而精氨酸治疗组以上血清学指标较梗黄组均显著下降,肠系膜淋巴结、胰及肺组织细菌培养阳性率明显降低,小肠黏膜病理损害程度明显减轻。结论梗黄后出现的高内毒素血症与肠道细菌易位关系密切。精氨酸治疗可减轻梗黄时肠道细菌易位,从而降低血浆内毒素水平及细胞因子的过表达。

关键词：胆汁郁积细菌易位精氨酸肠道细菌易位梗阻性黄疸肿瘤坏死因子-α(TNF-α) 治疗组 Wistar大鼠实验性肠系膜淋巴结

颅内静脉窦血栓形成患者D-二聚体、红细胞分布宽度与预后的相关性分析

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交通医学 2017年第2期31卷 121-123,127页

作者：倪耀辉章文季秋虹张元媛南通大学附属医院神经内科江苏226001

目的:探讨颅内静脉窦血栓形成(CVST)患者D-二聚体(D-D)和红细胞分布宽度(RDW)的变化及其与预后的相关性。方法:收集32例CVST患者为观察组,以同期住院的32例青年脑梗死患者为对照组,对两组患者的血红蛋白、D-D、平均红细胞体积、RDW、平... 详细信息

目的:探讨颅内静脉窦血栓形成(CVST)患者D-二聚体(D-D)和红细胞分布宽度(RDW)的变化及其与预后的相关性。方法:收集32例CVST患者为观察组,以同期住院的32例青年脑梗死患者为对照组,对两组患者的血红蛋白、D-D、平均红细胞体积、RDW、平均血小板体积、血小板计数、活化部分凝血活酶时间、凝血酶原时间和国际标准化比值进行比较。采用多变量logistic回归分析CVST发病的危险因素。应用改良Rankin量表将CVST患者分为转归良好组和转归不良组,采用多变量logistic回归分析影响转归的危险因素。结果:与对照组相比,CVST组患者DD(P=0.001)及RDW增高(P=0.002),MCV值降低(P=0.001),差异均有统计学意义。logistic回归分析提示D-D和RDW增高是发生CVST的危险因素。与转归不良组相比,转归良好组D-D(P=0.002)及RDW(P=0.001)均显著减低(P<0.05),差异均有统计学意义。logistic回归分析提示D-D和RDW增高是CVST患者预后不良的危险因素。结论:CVST患者D-D和RDW增高是CVST发生和预后不良的危险因素。

关键词：颅内静脉窦血栓形成 D-二聚体红细胞分布宽度预后

ACTIVE PRODUCTS OF PORCINE TRYPSIN AFTER AUTOLYSIS

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Science in China,Ser.A 1980年第11期 1453-1460页

作者：茹炳根杜锦珠曾耀辉陈濂生倪逸声谭国华张龙翔 Department of Biology Beijing University

Porcine trypsin obtained from pancreas residues subsequent to insulin removal undergoes autolysis when subjected to chromatography and gives rise to new active forms of autolyzed products with intra-chain split at bonds Lys145—Ala146 and Arg105—*** of 1% solutions of porcine trypsin either at pH 5.0 or at pH 9.1 induces autolysis to give active products involving one or two specific cleavages of bonds Lys145—Ala148 and Arg105—Val106 or Lys131—Ser132, as well as inactive degraded products, No evidence has been obtained that on autolysis of porcine trypsin, any active fragment with molecular weight lower than that of the parent molecule was *** active forms of autolyzed products of porcine trypsin have almost the same specific activity as the intact enzyme when assayed against BAEE. They are of the same molecular weight as the parent molecule. These findings indicate that the active forms of autolyzed products maintain the specific three-dimensio

关键词： ACTIVE PRODUCTS OF PORCINE TRYPSIN AFTER AUTOLYSIS very NH

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脑卒中后癫痫发作的发生率及危险因素分析

南通大学学报（医学版） 2024年第4期44卷 358-362页

作者：陈佳妤叶海娇张杰李旭桠李爱红倪耀辉南通大学附属医院神经内科江苏226001 无锡市惠山区人民医院神经内科

目的:探讨脑卒中后癫痫(post-stroke epilepsy,PSE)的发病率及PSE发作的相关危险因素,早期发现PSE发作的危险人群,为癫痫发作早期预防提供依据。方法:收集2019年1—12月在南通大学附属医院神经内科首次因脑卒中住院的既往无癫痫病史的68... 详细信息

目的:探讨脑卒中后癫痫(post-stroke epilepsy,PSE)的发病率及PSE发作的相关危险因素,早期发现PSE发作的危险人群,为癫痫发作早期预防提供依据。方法:收集2019年1—12月在南通大学附属医院神经内科首次因脑卒中住院的既往无癫痫病史的687例患者的人口统计学资料、基线资料、影像学特征等,并通过电话随访的方式将所有患者按是否发生癫痫分为PSE组和非癫痫对照(non-epileptic control,NEC)组,记录癫痫患者首次癫痫发作的时间及癫痫发作形式。分析PSE的发病率,应用多因素Logistic回归分析筛选影响PSE发作的独立危险因素。结果:符合纳入标准获得随访患者共687例,其中诊断为PSE有32例(4.66%)。Logistic回归分析,以PSE发作作为研究结局时,皮层脑卒中、脑卒中病灶最大横截面积、入院格拉斯哥昏迷评分与癫痫发作有相关性(P=0.012、0.026、P<0.001)。结论:皮层脑卒中、大面积脑梗死、入院时昏迷程度重是PSE的独立危险因素,并对PSE的发生有一定的预测作用。

关键词：脑卒中癫痫发作危险因素脑卒中后癫痫

SHRIMP U-Pb zircon dating for lamprophyre from Liaodong Peninsula: Constraints on the initial time of Mesozoic lithosphere thinning beneath eastern China

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Chinese Science Bulletin 2005年第22期50卷 2612-2620页

作者： JIANG yaohui JIANG Shaoyong ZHAO Kuidong ni Pei LING Hongfei LIU Dunyi State Key Laboratory for Mineral Deposits Research Department of Earth Sciences Nanjing University Nanjing 210093 China Beijing SHRIMP Center Beijing 100037 China

It is undebated fact that the lithospheric mantle beneath eastern China was considerably thinned during the Mesozoic time. However, it has no adequate evidence for the exact timing when the lithosphere thinning started. The Liaodong Peninsula is located in the eastern segment of the North China Craton and is one of the important domains to explore the event of lithosphere thinning. SHRIMP U-Pb zircon dating and geochemical study were carried out for the lamprophyre dike swarm that intruded into the magnesite ore-beds in the Dashiqiao Formation of Paleoproterozoic Liaohe Group at the Huaziyu magnesite ore district, Liaodong Peninsula. The results indicate that these lampro- phyre dikes were intruded in late Jurassic (155±4 Ma) and show some geochemical characteristics of potassic magmas. It is now accepted that the lithosphere thinning took place in the late Mesozoic, and the peak thinning stage occurred in early Cretaceous (130―120 Ma). Considering the potassic mafic magmatism marking the onset of the lithospheric thin- ning, we therefore suggest that the studied late Jurassic potassic lamprophyre dike swarm could imply that the late Jurassic is the time that lithosphere thinning started.

关键词：锆石煌斑岩中生代时期岩石圈辽东半岛

RNA viromes of Dermacentor nuttalli ticks reveal a novel uukuvirus in Qinghai Province,China

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Virologica Sinica 2024年第4期39卷 537-545页

作者： yaohui Fang Jun Wang Jianqing Sun Zhengyuan Su Shengyao Chen Jian Xiao Jun ni Zhihong Hu Yubang He Shu Shen Fei Deng Key Laboratory of Special Pathogens and Biosafety and National Virus Resource Center Wuhan Institute of VirologyChinese Academy of SciencesWuhan 430071China University of Chinese Academy of Sciences Beijing 101408China Qinghai Lake National Nature Reserve Administration Xining 810000China Hubei Jiangxia Laboratory Wuhan 430200China Xinjiang Key Laboratory of Vector-borne Infectious Diseases Urumqi830002China

Ticks are a major parasite on the Qinghai-Tibet Plateau,western China,and represent an economic burden to agriculture and animal *** research on tick-borne pathogens that threaten humans and animals,the viromes of dominant tick species in this area remain *** this study,we collected Dermacentor nuttalli ticks near Qinghai Lake and identified 13 viruses belonging to at least six families through metagenomic *** viruses were of high abundance in pools,including Xınjiang tick-associated virus 1(XJTAV1),and three novel viruses:Qinghai Lake virus 1,Qinghai Lake virus 2(QHLV1,and QHLV2,unclassified),and Qinghai Lake virus 3(QHLV3,genus Uukuvirus of family Phenuiviridae in order Bunyavirales),which lacks the M *** minimum infection rates of the four viruses in the tick groups were 8.2%,49.5%,6.2%,and 24.7%,respectively,suggesting the prevalence of these viruses in *** ticks.A putative M segment of QHLV3 was identified from the next-generation sequencing data and further characterized for its signal peptide cleavage site,N-glycosylation,and transmembrane ***,we probed the L,M,and S segments of other viruses from sequencing data of other tick pools by using the putative M segment sequence of *** revealing the viromes of *** ticks,this study enhances our understanding of tick-borne viral communities in highland *** putative M segment identified in a novel uukuvirus suggests that previously identified uukuviruses without M segments should have had the same genome organization as typical *** findings will facilitate virus discovery and our understanding of the phylogeny of tick-borne uukuviruses.

关键词： Dermacentor nuttalli Qinghai Province Virome Uukuvirus M segment