检索结果-南通市图书馆

Phase I clinical trial of intracerebral injection of lentiviral-ABCD1 for the treatment of cerebral adrenoleukodystrophy

在线全文

学校读者我要写书评

暂无评论

Science Bulletin 2024年第16期69卷 2596-2603页

作者： Qiu-Hong Wang Jing Wanga zhi-Pei Ling zhi-Qiang cui Jie Gong Rui Zhang Shi-Jun Li Yang-Yang Wang Rui Yang De-hui huang Wen He Jing Gao Chen Feng Pei-Li hu Li-Ying Liu Lung-Ji Chang Li-Ping Zou Senior Department of Pediatrics Chinese PLA General HospitalBeijing 100853China Medical School of Chinese PLA Beijing 100853China Department of Neurosurgery Hainan Hospital of PLA General HospitalSanya 572013China Department of Neurosurgery The First Medical Center of Chinese PLA General HospitalBeijing 100853China Chengdu Women’s and Children’s Central Hospital School of MedicineUniversity of Electronic Science and Technology of ChinaChengdu 611731China School of Medicine University of Electronic Science and Technology of ChinaChengdu 610054China Beijing meikang Biotechnology Co. LTD.Beijing 100085China Department of Radiology The First Medical Center of Chinese PLA General HospitalBeijing 100853China Department of Neurology The First Medical Center of Chinese PLA General HospitalBeijing 100853China Department of Pediatrics Xuanwu HospitalCapital Medical UniversityBeijing 100053China Shenzhen Geno-Immune Medical Institute Shenzhen 518057China Beijing Institute for Brain Disorders Center for Brain Disorders Research Capital Medical UniversityBeijing 100069China

This was a single-arm,multicenter,open-label phase I *** vectors(LV)carrying the ABCD1 gene(LV-ABCD1)was directly injected into the brain of patients with childhood cerebral adrenoleukodystrophy(CCALD),and multi-site injection was *** injection dose increased from 200 to 1600 lL(vector titer:1×10^(9) transduction units per mL(TU/mL)),and the average dose per kilogram body weight ranges from 8 to 63.6 lL/*** primary endpoint was safety,dose-exploration and immunogenicity and the secondary endpoint was initial evaluation of efficacy and the expression of ABCD1 protein.A total of 7 patients participated in this phase I study and were followed for 1 *** injectionrelated serious adverse event or death *** adverse events associated with the injection were irritability(71%,5/7)and fever(37.2-38.5℃,57%,4/7).Adverse events were mild and selflimited,or resolved within 3 d of symptomatic *** maximal tolerable dose is 1600 *** 5 cases(83.3%,5/6),no lentivirus associated antibodies were *** overall survival at 1-year was 100%.The ABCD1 protein expression was detected in neutrophils,monocytes and *** study suggests that the intracerebral injection of LV-ABCD1 for CCALD is safe and can achieve successful LV transduction in vivo;even the maximal dose did not increase the risk of adverse ***,the direct LV-ABCD1 injection displayed low *** addition,the effectiveness of intracerebral LV-ABCD1 injection has been preliminarily demonstrated while further investigation is *** study has been registered in the Chinese Clinical Trial Registry(https://***/,registration number:ChiCTR1900026649).

关键词： Adrenoleukodystrophy Lentiviral vectors ABCD1 Intracerebral injection

中国典型城市群碳排放的影响机制研究——以长三角城市群为例

在线全文

学校读者我要写书评

暂无评论

China City Planning Review 2024年第2期33卷 30-40页

作者：魏猛徐建刚戚红年 Cai zhi cui Hao Liu Jinxin Liu Jiayan School of Architecture and Urban Planning Nanjing UniversityNanjingP.R.China School of Architecture and Urban Planning Nanjing UniversityNanjingP.R.Chin National Registered Planner School of HistoryNanjing UniversityNanjingP.R.China. School of Tourism and Urban-Rural Planning Zhejiang Gongshang UniversityHangzhouP.R.China Jiangsu Oriental Architectural Design Company NanjingP.R.China 不详

Urban agglomeration plays a vital role in fostering high-quality and sustainable development in China,where urbanization rates signifi-cantly influence both urban and rural environments,generating different economic and socio-spatial impacts that,in turn,influence carbon emissions in *** delve into the influencing mechanisms of carbon emissions,this paper examines the spatio-temporal pattern of carbon emissions across 41 cities in the Yangtze River Delta urban agglomeration in *** utilizes data on economic,social,and spatial factors from 2012 to 2019 and employs a spatial econometric regression model for *** results indicate that carbon emissions of cities in the urban agglomeration exhibited strong spatial correlation from 2012 to 2019,characterized by relatively stable cold and hot spots,along with continuous outward spread of high-value *** and social factors demonstrate a significant positive spatial correlation with carbon emissions of a city,with weak spatial spillover *** factors exhibit correlations with carbon emissions in both the city and neighboring cities,with strong spatial spillover ***,the spatial layout and functional division of cities in the urban agglomeration also significantly impact the spatio-temporal pattern of carbon emissions.

关键词： economic and social factor urban spatial factor carbon emissions spatial econometric analysis urban agglomeration

Frontiers in high entropy alloys and high entropy functional materials

在线全文

学校读者我要写书评

暂无评论

Rare Metals 2024年第10期43卷 4639-4776页

作者： Wen-Tao Zhang Wen huang Fu-Jie Yu Qi Zhao Xin-Dong Zhu Tao Feng Yao Jiang Xiao-Ming Li Xue-Fei Miao He Zhu Si Lan Xue-Qian Wang Bao-Long Shen Zhe Jia Feng-Qi Zhang Wei Wang Qi Liu Yang Ren Xun-Li Wang Xiao-Ya cui Xiao-Yang Wang Ya-Nan Chen Bing-Bing Fan Meng-Ru Li Qi-Long Gao Jia-Ming Guo Zeng-Bao Jiao zhi-Min Guo Yu-Ping Zhao Qian Yu Rui huang Ling-kun Zhang Yi-Ping Lu Xu-Bo Li huai-Jun Lin Yan Ma Wei-Ming Yang zhi-hua Shen Hai-Yan He Yong-Gang Sun Yong-Jiang huang De-Zhuang Wang Qing-Feng Liu Fei-Yang Wang hui Liu Hong-hui Wu Li-Qiang Wang Yang Lu Nan Wang Tian-Li Wang Wei-Bing Liao Yi-Han Wang Yuan Wu Yu-Zhen Yin Jie Pan Yi Zhang Qing Wang Jian-Yang Zhang Tao Yang Yasir Sohail Jin-Yu Zhang hua Ji Qiang Li Wei-Di Liu zhi-Gang Chen xiong-Jun Liu Wen Ma Liang Mao Zhen-Duo Wu School of Materials Science and Engineering Nanjing University of Science and Technology Jiangsu Key Laboratory for Advanced Metallic Materials School of Materials Science and Engineering Southeast University Department of Physics City University of Hong Kong School of Materials Science and Engineering Tianjin University School of Physics and Microelectronics Zhengzhou University Department of Mechanical Engineering Research Institute for Advanced Manufacturing The Hong Kong Polytechnic University Center of Electron Microscopy and State Key Laboratory of Silicon Materials School of Materials Science and Engineering Zhejiang University Key Laboratory of Solidification Control and Digital Preparation Technology (Liaoning Province) School of Materials Science and Engineering Dalian University of Technology Institute of Advanced Wear & Corrosion Resistance and Functional Materials Jinan University School of Mechanics and Civil Engineering China University of Mining and Technology School of Physical Sciences Great Bay University School of Materials Science andEngineering Harbin Institute of Technology State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical Engineering Nanjing Tech University Beijing Advanced Innovation Center for Materials Genome Engineering Research Institute for Carbon Neutrality University of Science and Technology Beijing Department of Mechanical Engineering The University of Hong Kong School of Computing Macquarie University Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Physics and Optoelectronic Engineering Shenzhen University State Key Laboratory for Advanced Metals and Materials University of Science and Technology Beijing State Key Laboratory of Materials Processing and Die & Mould Technology School of Materials Science and Engineering Huazhong University of Science and Technology Institute of materials Shanghai University Department of Materials Science and Engineering C

Owing to their exceptional properties, high-entropy alloys(HEAs) and high-entropy materials have emerged as promising research areas and shown diverse applications. Here,the recent advances in the field are comprehensively reviewed,organized into five sections. The first section introduces the background of HEAs, covering their definition, significance,application prospects, basic properties, design principles, and microstructure. The subsequent section focuses on cutting-edge high-entropy structural materials, highlighting developments such as nanostructured alloys, grain boundary engineering,eutectic systems, cryogenic alloys, thin films, micro-nano-lattice structures, additive manufacturing, high entropy metallic glasses, nano-precipitate strengthened alloys, composition modulation, alloy fibers, and refractory systems. In the following section, the emphasis shifts to functional materials, exploring HEAs as catalysts, magneto-caloric materials, corrosion-resistant alloys, radiation-resistant alloys, hydrogen storage systems, and materials for biomedicine. Additionally, the review encompasses functional high-entropy materials outside the realm of alloys, including thermoelectric, quantum dots, nanooxide catalysts, energy storage materials, negative thermal expansion ceramics,and high-entropy wave absorption materials. The paper concludes with an outlook, discussing future directions and potential growth areas in the field. Through this comprehensive review,researchers, engineers, and scientists may gain valuable insights into the recent progress and opportunities for further exploration in the exciting domains of high-entropy alloys and functional materials.

关键词： Cutting-edge structural materials Cutting-edgefunctional materials High entropy alloys

Review of prevention and mitigation technologies for thermal runaway in lithium-ion batteries

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Aerospace Traffic and Safety 2024年第1期1卷 55-72页

作者： Maoyong zhi Quanyi Liu Qinrou Xu zhiheng Pan Qiang Sun Bingjian Su Haihui Zhao huajian cui Yuanhua He College of Civil Aviation Safety Engineering Civil Aviation Flight University of ChinaGuanghan 618307China Civil Aircraft Fire Science and Safety Engineering Key Laboratory of Sichuan Province Civil Aviation Flight University of ChinaGuanghan 618307China

Lithium-ion batteries have been widely used in transportation,power equipment,aerospace,and other ***,the complex electrochemical reactions inside the battery cause excessive heat generation rate due to thermal,mechanical,and electrical abuse conditions,and even lead to thermal *** problem of thermal runaway has become an important factor limiting its *** review summarizes the intrinsic safety of batteries,thermal management,early monitoring and warning for thermal runaway,fire prevention and fire suppression *** intrinsic safety technologies were summarized from the aspects of electrolyte flame retardancy,improvement of thermal stability of battery materials,and ceramic *** effectively control battery temperature,thermal management technologies were elaborated from the perspectives of air cooling,liquid cooling,heat pipes,phase change materials,and coupled thermal *** parameter detection,multi parameter composite detection,and new detection technologies were also ***-situ monitoring of batteries based on fiber optic sensors helps to achieve early warning of thermal *** thermal runaway occurs,fire prevention and fire extinguishing technology can effectively reduce the harm of thermal runaway,which should be given sufficient *** work provides important references value and research ideas for the prevention and mitigation of thermal runaway in lithium-ion batteries.

关键词： Lithium-ion battery Thermal runaway Thermal management Early warning Fire prevention

Diagnosis,treatment and prevention of severe acute respiratory syndrome coronavirus 2 infection in children:experts'consensus statement updatedforthe Omicron variant

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Pediatrics 2024年第3期20卷 272-286页

作者： Rong-Meng Jiang Zheng-De Xie Yi Jiang Xiao-Xia Lu Run-Ming Jin Yue-Jie Zheng Yun-Xiao Shang Bao-Ping Xu zhi-Sheng Liu Gen Lu Ji-Kui Deng Guang-hua Liu Xiao-Chuan Wang Jian-She Wang Lu-Zhao Feng Wei Liu Yi Zheng Sai-Nan Shu Min Lu Wan-Jun Luo Miao Liu Yu-Xia cui Le-Ping Ye A-Dong Shen Gang Liu Li-Wei Gao Li-Juan xiong Yan Bai Li-Kai Lin Zhuang Wei Feng-Xia Xue Tian-You Wang Dong-Chi Zhao Jian-Bo Shao Daniel Kwok-keung Ng Gary Wing-kin Wong Zheng-Yan Zhao Xing-Wang Li Yong-Hong Yang kun-Ling Shen Diagnosis and Treatment Center of Infectious Diseases Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Beijing Key Laboratory of Pediatric Respiratory Infection Diseases Key Laboratory of Major Diseases in ChildrenMinistry of EducationNational Clinical Research Center for Respiratory DiseasesResearch Unit of Critical Infection in ChildrenChinese Academy of Medical Sciences2019RU016Laboratory of Infection and VirologyBeijing Pediatric Research InstituteBeijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthBeijing 100045China Department of Pediatrics Renmin Hospital of Wuhan UniversityWuhan 430060China Department of Respiratory Wuhan Children's HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430016China Department of Pediatrics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Respiratory Shenzhen Children's HospitalShenzhen 518038China Department of Pediatric Respiratory Shengjing Hospital Affiliated to China Medical UniversityShenyang 110004China Department of Respiratory Beijing Children's HospitalCapital Medical UniversityNational Clinical Research Center for Respiratory DiseasesNational Center for Children's HealthBeijing 100045China Department of Neurology Wuhan Children's HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430016China Department of Respiratory Guangzhou Women and Children's Medical CenterGuangzhou 510623China Department of Infectious Diseases Shenzhen Children's HospitalShenzhen 518038China Department of Pediatrics Fujian Branch of Shanghai Children's Medical CenterFujian Children's HospitalFuzhou350005China Department of Clinical Immunology and Allergy Children's Hospital of Fudan UniversityNational Center for Children's HealthShanghai 201102China Department of Infectious Diseases Children's Hospital of Fudan UniversityNational Center for Children's Health.Shanghai

It has been more than 3 years since the novel coronavirus(SARS-CoV-2)pandemic raged *** coronavirus disease 2019(COVID-19)has greatly influenced human *** to data from the World Health Organization(WHO),there were ove... 详细信息

关键词： prevention infection statement

超高性能混凝土单轴拉、压循环作用下力学性能及其本构模型研究

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

工程力学 2024年第4期41卷 81-93页

作者：赵继之辛公锋陶慕轩崔文涛清华大学土木工程系土木工程安全与耐久教育部重点实验室北京100084 山东高速集团有限公司创新研究院山东济南250000 山东高速基础设施建设有限公司山东济南250000

超高性能混凝土(ultra-high performance concretre,UHPC)是一种新型材料,具有抗拉、抗压强度高、开裂后应变硬化等特点,在装配式结构领域具有较为广阔的应用前景。为了明确UHPC在单轴循环荷载下的受力性能并提出适合的本构关系,通过大... 详细信息

超高性能混凝土(ultra-high performance concretre,UHPC)是一种新型材料,具有抗拉、抗压强度高、开裂后应变硬化等特点,在装配式结构领域具有较为广阔的应用前景。为了明确UHPC在单轴循环荷载下的受力性能并提出适合的本构关系,通过大量的试验建立循环荷载下UHPC的本构模型,设计具有不同钢纤维掺量的棱柱体和狗骨直拉试件,开展不同加载制度的单轴压缩试验,分析试验结果以明确钢纤维掺量、养护方式和加载制度对UHPC单轴拉压力学性能的影响情况。试验结果表明,在受压方面,钢纤维体积含量为2%的UHPC峰值压应变明显高于钢纤维体积含量为1%和3%的UHPC峰值压应变。各UHPC试件的弹性模量明显大于普通混凝土的弹性模量。在受拉方面,UHPC呈现出一定的应变硬化现象,且达到峰值后拉应力下降较为缓慢,展现出一定的受拉延性。钢纤维体积含量和蒸养处理对UHPC试件的抗拉强度有明显的提高作用。最后,在试验数据的基础上,提出了UHPC受压和受拉的骨架曲线和滞回准则,并拟合了卸载(再加载)的计算公式,可用于有限元计算中UHPC的基本本构方程。

关键词：本构模型循环荷载拉伸试验压缩试验超高性能混凝土

长庆气田净化厂CO_(2)捕集与液化技术优选

在线全文

学校读者我要写书评

暂无评论

石油化工应用 2024年第9期43卷 117-121页

作者：熊小伟王智胡建国范君来崔雪琳长庆工程设计有限公司陕西西安710000 中国石油长庆油田分公司陕西西安710000 中国石油长庆油田分公司第三采气厂陕西西安710000

减少CO_(2)排放是控制碳排放的重要手段,气田净化厂捕集到的CO_(2)可以用于CO_(2)驱油等领域。针对长庆气田净化厂需要开展尾气捕集回收CO_(2)的实际情况,本文探讨了净化厂捕集CO_(2)的可行性,并提出了正压焚烧加氢氧化钠碱洗尾气处理... 详细信息

减少CO_(2)排放是控制碳排放的重要手段,气田净化厂捕集到的CO_(2)可以用于CO_(2)驱油等领域。针对长庆气田净化厂需要开展尾气捕集回收CO_(2)的实际情况,本文探讨了净化厂捕集CO_(2)的可行性,并提出了正压焚烧加氢氧化钠碱洗尾气处理工艺及胺液捕集+丙烷制冷的CO_(2)捕集、液化工艺,同时得到长庆气田各个净化厂的CO_(2)回收率及回收能耗,对下步开展CO_(2)回收具有重要意义。

关键词： CO_(2)捕集 CO_(2)液化净化厂尾气回收流程模拟

Roadmap for rechargeable batteries:present and beyond

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2024年第1期67卷 13-42页

作者： Sen Xin Xu Zhang Lin Wang Haijun Yu Xin Chang Yu-Ming Zhao Qinghai Meng Pan Xu Chen-Zi Zhao Jiahang Chen huichao Lu Xirui Kong Jiulin Wang Kai Chen Gang huang Xinbo Zhang Yu Su Yao Xiao Shu-Lei Chou Shilin Zhang Zaiping Guo Aobing Du Guanglei cui Gaojing Yang Qing Zhao Liubing Dong Dong Zhou Feiyu Kang hu Hong Chunyi zhi zhizhang Yuan Xianfeng Li Yifei Mo Yizhou Zhu Dongfang Yu Xincheng Lei Jianxiong Zhao Jiayi Wang Dong Su Yu-Guo Guo Qiang Zhang Jun Chen Li-Jun Wan CAS Key Laboratory of Molecular Nanostructure and Nanotechnology CAS Research/Education Center for Excellence in Molecular SciencesBeijing National Laboratory for Molecular Sciences(BNLMS)Institute of ChemistryChinese Academy of Sciences(CAS)Beijing 100190China University of Chinese Academy of Sciences.Beijing 100049 China Institute of Advanced Battery Materials and Devices Faculty of Materials and ManufacturingBeijing University of TechnologyBeijing 100124China Key Laboratory of Advanced Functional Materials Ministry of EducationBeijing University of TechnologyBeijing 100124China Beijing Key Laboratory of Green Chemical Reaction Engineering and Technology Department of Chemical EngineeringTsinghua UniversityBeijing 100084China State Key Laboratory of Chemistry and Utilization of Carbon-Based Energy Resources College of ChemistryXinjiang UniversityUrumqi 830046China Department of Chemical Engineering Shanghai Jiao Tong UniversityShanghai 200240China State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied ChemistryChangchun 130022China Institute for Carbon Neutralization College of Chemistry and Materials EngineeringWenzhou UniversityWenzhou 325035China School of Chemical Engineering and Advanced Materials The University of AdelaideAdelaide 5000Australia Qingdao Industrial Energy Storage Research Institute Qingdao Institute of Bioenergy and Bioprocess TechnologyChinese Academy of SciencesQingdao 266101China Frontiers Science Center for New Organic Matter Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education)College of ChemistryNankai UniversityTianjin 300071China College of Chemistry and Materials Science Jinan UniversityGuangzhou 511443China Tsinghua Shenzhen International Graduate School Tsinghua UniversityShenzhen 518055China Department of Materials Science and Engineering City University of Hong KongHong Kong 999077China Division of Energy Storage Dalian National Laboratory for Clean Energy(DNL)Dalian Institute of Chem

Rechargeable batteries currently hold the largest share of the electrochemical energy storage market,and they play a major role in the sustainable energy transition and industrial decarbonization to respond to global climate *** to the increased popularity of consumer electronics and electric vehicles,lithium-ion batteries have quickly become the most successful rechargeable batteries in the past three decades,yet growing demands in diversified application scenarios call for new types of rechargeable *** efforts are made to developing the next-generation post-Li-ion rechargeable batteries,which include,but are not limited to solid-state batteries,lithium–sulfur batteries,sodium-/potassium-ion batteries,organic batteries,magnesium-/zinc-ion batteries,aqueous batteries and flow *** the great achievements,challenges persist in precise understandings about the electrochemical reaction and charge transfer process,and optimal design of key materials and interfaces in a *** roadmap tends to provide an overview about the current research progress,key challenges and future prospects of various types of rechargeable *** computational methods for materials development,and characterization techniques will also be discussed as they play an important role in battery research.

关键词： energy storage rechargeable batteries battery materials electrochemistry

在线全文

学校读者我要写书评

暂无评论

聚四氟乙烯材料切削工艺和应用研究进展

中国机械工程 2024年第3期35卷 498-514页

作者：倪敬崔智何利华付新朱泽飞杭州电子科技大学机械工程学院杭州310018 浙江大学流体动力与机电系统国家重点实验室杭州310027

聚四氟乙烯(polytetrafluoroethylene,PTFE)因其优异的物理化学性能而成为生产制造电子通信、航空航天等领域关键零部件的重要材料。相比模压烧结工艺,切削工艺能够更高效地加工结构较为复杂的PTFE零部件。然而,PTFE材料具有韧性强、回... 详细信息

聚四氟乙烯(polytetrafluoroethylene,PTFE)因其优异的物理化学性能而成为生产制造电子通信、航空航天等领域关键零部件的重要材料。相比模压烧结工艺,切削工艺能够更高效地加工结构较为复杂的PTFE零部件。然而,PTFE材料具有韧性强、回弹性高、导热性差和线膨胀系数大等特点,使得其切削加工质量难以保证,在一些特殊领域,对PTFE零部件的表面洁净度更是有极高的要求,这些都对PTFE材料的切削工艺提出了新的挑战。从PTFE材料的基础力学和物理化学等特性出发,总结了PTFE材料的切削加工性;结合聚合物切削理论及其研究方法分析了PTFE材料的切削去除机理;阐述了PTFE及其复合材料的车、铣、钻等切削加工工艺;最后概述了PTFE材料切削工艺在相关重要领域的应用现状,并从材料性能研究、基础切削理论研究、切削工艺探索等方面总结了现有研究和应用中存在的问题,对未来研究的发展趋势和研究重点进行了展望。

关键词：聚四氟乙烯切削机理切削工艺力学性能