检索结果-南通市图书馆

Chinese Journal of Polymer Science 2000年第1期18卷 25-31页

作者： Yan-feng li Jun-rong li lian-di Fu yao-zeng li department of chemistry, lanzhou university, lanzhou 73.000, china gansu natural energy research institute, lanzhou 73.000, china gansu provincial institute of drug control, lanzhou 73.000, china 兰州大学甘肃兰州甘肃自然能源所甘肃兰州 730000 甘肃省药检所甘肃兰州 730000

A kind of macroporous bead carrier of copolymer containing monomer units of N-aminoethyl acrylamide and vinylalcohol was synthesized, i.e. the MR-AA carrier. Papain was immobilized on the carrier using glutaraldehyde as the couplingagent. The enzymatic activity of the immobilized papain was compared with free papain using casein as a substrate, and theeffects of glutaraldehyde concentration, pH, temperature, time and papain amount added on the activity recovery were alsoinvestigated. The results show that the MR-AA carrier contains reactive primary amine groups, hydrophilic amido links andhydroxyl groups, as well as macroporous structures based on its matrix (MR-AV matrix), furthermore, the activity recoveryof papain in the immobilization could reach 48%/～58%. In comparison with free papain, the resulting immobilized papainexhibits a remarkable thermostability and better reusability.

关键词： Immobilization Papain Proteolytic enzyme Macroporous bead carrier

Achieving strength-ductility synergy in novel paramagnetic Fe-based medium-entropy alloys through deep cryogenic deformation

在线全文

学校读者我要写书评

暂无评论

Rare Metals 2024年第9期43卷 4493-4507页

作者： Hu-Wen Ma Yan-Chun Zhao li Feng Tian-zeng liu Zhi-Qi Yu Bo Jin Wang-Chun Duan Peter K.liaw Dong Ma State Key Laboratory of Advanced Processing and Recycling of Non-Ferrous Metals Lanzhou University of TechnologyLanzhou 730050China Wenzhou Pump and Valve Engineering research institute Lanzhou University of TechnologyWenzhou 325105China Iron and Steel research institute Jiuquan Iron and Steel CorporationJiayuguan 735100China lanzhou Resources and Environment Voc-Tech university Lanzhou 730123China department of Materials Science and Engineering The University of TennesseeKnoxvilleTN 37996-2200USA Neutron Science Center Songshan Lake Materials LaboratoryDongguan 523808China

Cryogenic pre-deformation treatment has been widely used to effectively improve the comprehensive mechanical properties of steels and novel ***,the dislocation evolution and phase transformation induced by different degrees of deep cryogenic deformation are not yet fully *** this study,the effects of multiple cryogenic pre-treatments on the mechanical properties and deformation mechanisms of a paramagnetic Fe_(63.3)Mn_(14-)Si_(9.1)Cr_(9.8)C_(3.8)medium-entropy alloy(MEA)were investigated,leading to the discovery of a pretreated MEA that exhibits exceptional mechanical properties,including a fracture strength of 3.0 GPa,plastic strain of 26.1%and work-hardening index of *** addition,X-ray diffraction(XRD)and transmission electron microscopy(TEM)analyses revealed that multiple cryogenic pre-deformation treatments significantly increased the dislocation density of the MEA(from 9×10^(15)to 4×10^(16)m^(-2)after three pretreatments),along with a transition in the dislocation type from predominantly edge dislocations to mixed dislocations(including screw-and edge-type dislocations).Notably,this pretreated MEA retained its paramagnetic properties(μ_(r)energy of the MEA by a factor of approximately four(i.e.,from 9.7 to2.6 m J·m^(-2)),thereby activating the synergistic effects of transformation-induced plasticity,twinning-induced plasticity and dislocation strengthening *** synergistic effects lead to simultaneous strength and ductility enhancement of the MEA.

关键词： Deep cryogenic transformation Iron-based medium-entropy alloys Dislocation evolution Phase transformation Stacking fault energy

Porous ultrathin-shell microcapsules designed by microfluidics for selective permeation and stimuli-triggered release

在线全文

学校读者我要写书评

暂无评论

Frontiers of Chemical Science and Engineering 2022年第11期16卷 1643-1650页

作者： li Chen yao Xiao Zhiming Zhang Chun-Xia Zhao Baoling Guo Fangfu Ye Dong Chen department of Oncology Longyan First Affiliated Hospital of Fujian Medical UniversityLongyan 364000China Zhejiang Key Laboratory of Smart Biomaterials College of Chemical and Biological EngineeringZhejiang UniversityHangzhou 310027China Wenzhou institute University of Chinese Academy of SciencesWenzhou 325001China Faculty of Engineering Computerand Mathematical SciencesThe University of AdelaideAdelaideSA 5005Australia Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China College of energy Engineering and State Key Laboratory of Fluid Power and Mechatronic Systems Zhejiang UniversityHangzhou 310027China

Microcapsules are versatile delivery vehicles and widely used in various ***,microcapsules with solid shells lack selective permeation and only exhibit a simple release ***,we use ultrathin-shell water-in-oil-in-water double emulsions as templates and design porous ultrathin-shell microcapsules for selective permeation and multiple stimuli-triggered *** preparation of double emulsions by microfluidic devices,negatively charged shellac nanoparticles dispersed in the inner water core electrostatically complex with positively charged telechelicα,ω-diamino functionalized polydimethylsiloxane polymers dissolved in the middle oil shell at the water/oil interface,thus forming a porous shell of shellac nanoparticles cross-linked by telechelic ***,the double emulsions become porous microcapsules upon evaporation of the middle oil *** porous ultrathin-shell microcapsules exhibit excellent properties,including tunable size,selective permeation and stimuli-triggered *** molecules or particles can diffuse across the shell,while large molecules or particles are encapsulated in the core,and release of the encapsulated cargos can be triggered by osmotic shock or a pH *** to their unique performance,porous ultrathin-shell microcapsules present promising platforms for various applications,such as drug delivery.

关键词： microcapsule emulsion microfluidics selective permeation stimuli-triggered release

Neurological recovery and antioxidant effects of resveratrol in rats with spinal cord injury: a meta-analysis

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration research 2020年第3期15卷 482-490页

作者： Bao-Ping Xu Min yao Zhen-Jun li Zi-Rui Tian Jie Ye Yong-Jun Wang Xue-Jun Cui Spine Disease institute Longhua HospitalShanghai University of Traditional Chinese MedicineShanghaiChina Lu’an Hospital of Traditional Chinese Medicine Lu’anAnhui ProvinceChina Key Laboratory of Theory and Therapy of Muscles and Bones Ministry of Education(Shanghai University of Traditional Chinese Medicine)ShanghaiChina gansu provincial Hospital of Traditional Chinese Medicine LanzhouGansu ProvinceChina department of Orthopedics and Traumatology Longhua HospitalShanghai University of Traditional Chinese MedicineShanghaiChina

Objective:To critically assess the neurological recovery and antioxidant effects of resveratrol in rat models of spinal cord *** sources:Using“spinal cord injury”,“resveratrol”and“animal experiment”as the main search terms,all studies on the treatment of spinal cord injury in rats by resveratrol were searched for in PubMed,EMBASE,MEDliNE,Web of Science,Science Direct,china National Knowledge Infrastructure,Wanfang,VIP,and SinoMed databases by *** search was conducted from their inception date to April *** language restriction was used in the literature *** selection:The methodological quality of each study was assessed by the initial Stroke Therapy Academic Industry Roundtable *** reviewers independently selected studies according to the title,abstract and full *** risk of bias in the included studies was also ***-analyses were performed with Review Manager 5.3 *** measures:Neurological function was assessed by the Basso,Beattie,and Bresnahan scale score,inclined plane score and Gale’s motor function ***-biological analysis of antioxidative effects was conducted to determine superoxide dismutase levels,malondialdehyde levels,nitric oxide synthase activity,nitric oxide levels,xanthine oxidase and glutathione levels in spinal cord ***:The methodological quality of the 12 included studies was *** results of meta-analysis showed that compared with the control group,resveratrol significantly increased the Basso,Beattie,and Bresnahan scale scores after spinal cord injury(n=300,mean difference(MD)=3.85,95%confidence interval(CI)[2.10,5.59],Pcontrol group,superoxide dismutase levels were significantly elevated(n=138,standardized mean difference(SMD)=5.22,95%CI[2.98,7.45],P<0.00001),but malondialdehyde levels were significantly diminished(n=84,SMD=–3.64,95%CI[–5.84,–1.43],P=0.001)in the spinal cord of the resveratrol treatment ***:Re

关键词： antioxidation meta-analysis neurological recovery pharmacotherapy rats resveratrol spinal cord injury systematic review

Visible light-Driven Catalyst-Free Amination of Indoles Initiated by Electron Donor-Acceptor Complexes

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of chemistry 2023年第12期41卷 1485-1490页

作者： Jiahong Sui Zhonglie Yang Shuangqiao li Xueqin Chen Xiaobin Zhang Qing Shen Hezhong Jiang Jiahong li School of life Science and Engineering Sichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs Southwest Jiaotong University Chengdu Sichuan 610031 China department of Pharmacy Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital/Personalized Drug Therapy Key Laboratory of Sichuan Province School of Medicine University of Electronic Science and Technology of China Chengdu Sichuan 610072 China

The visible light-driven C2 or C3 amination of indoles without any additives was initiated via electron donor-acceptor (EDA) complex formed by indole and N-aminopyridinium *** method was compatible with a wide range of substrates and could proceed smoothly without the addition of any photocatalysts,transition-metal catalysts,or bases.A variety of studies were carried out to examine the presence of EDA complex.

关键词： Photochemistry Amination C-N bond formation Green chemistry N-Heterocycles Donor-acceptor systems

Molecular imaging of advanced atherosclerotic plaques with folate receptor-targeted 2D nanoprobes

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano research 2020年第1期13卷 173-182页

作者： Zhide Guo liu Yang Mei Chen Xuejun Wen Huanhuan liu Jingchao li Duo Xu Yuanyuan An Changrong Shi Jindian li Xinhui Su Zijing li Ting liu Rongqiang Zhuang Nanfeng Zheng Haibo Zhu Xianzhong Zhang State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics&Center for Molecular Imaging and Translational Medicine School of Public HealthXiamen UniversityXiamen361102China State Key Laboratory for Bioactive Substances and Functions of natural Medicines Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation StudyInstitute of Materia MedicaChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing100050China College of Materials Science and Engineering Hunan UniversityChangsha410082China The State Key Laboratory for Physical chemistry of Solid Surfaces Collaborative Innovation Center of Chemistry for Energy MaterialsDepartment of ChemistryXiamen UniversityXiamen361005China Zhongshan Hospital Affiliated to Xiamen university Xiamen361004China

Vulnerable atherosclerotic plaques are responsible for most cardiovascular diseases(CVDs).Folate receptor(FR)positive activated macrophages were thought to be a prominent component in the development of vulnerable *** objective of this study is to develop folate conjugated two-dimensional(2D)Pd@Au nanomaterials(Pd@Au-PEG-FA)for targeted multimodal imaging of the FRs in advanced atherosclerotic *** and imaging studies(single photon emission computed tomography(SPECT),computed tomography(CT)and photoacoustic(PA)imaging)were performed to confirm the prolonged blood half-life and enrichment of radioactivity in atherosclerotic *** signals were detected in vivo with SPECT,CT and PA imaging in heavy atherosclerotic plaques,which were significantly higher than those of the normal aortas after injection of Pd@*** studies with preinjection of excess FA could effectively reduce the targeting ability of Pd@Au-PEG-FA in atherosclerotic plaques,further demonstrating the specific binding of Pd@Au-PEG-FA for plaque *** characterization revealed that the signal of probe was in accordance with the high-risk *** summary,the Pd@Au-PEG-FA has favorable pharmacokinetic properties and provides a valuable approach for detecting high-risk plaques in the presence of FRs in atherosclerotic plaques.

关键词： 2D material folate receptor multifunctional imaging activated macrophages atherosclerosis

Digital light processing (DLP)-based (bio)printing strategies for tissue modeling and regeneration

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

聚集体(英文)

聚集体(英文) 2023年第2期4卷 42-61页

作者： Hongbin li Jiliang Dai Zixuan Wang Heshan Zheng Wanlu li Mian Wang Feng Cheng MIIT Key Laboratory of Critical Materials Technology for New energy Conversion and Storage School of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbinP.R.China College of light Industry and Textile Qiqihar UniversityQiqiharP.R.China Biomanufacturing Center department of Mechanical Engineering Tsinghua UniversityBeijingP.R.China School of Biomedical Engineering and Med-X research institute Shanghai Jiao Tong UniversityShanghaiP.R.China institute for Regenerative Medicine Shanghai East HospitalFrontier Science Center for Stem Cell ResearchSchool of Life Science and TechnologyTongji UniversityShanghaiP.R.China

Digital light processing(DLP)-based bioprinting technology has recently aroused considerable concerns as a strategy to deliver biomedical materials and/or specific cells to create sophisticated structures for various tissue modeling and *** this review,we display a concise introduction of DLP bioprinting,and a further discussion on the design and manufacture of DLP(bio)printer with varied bioinks and their biomedical applications toward drug screening,disease modeling,tissue repair,and regenerative ***,the advantages,challenges,and perspectives of the DLP printing platforms are *** is believed that DLP bioprinting will play a decisive role in the field of tissue model and regenerative medicine,mainly due to its time-efficient,higher resolution,and amenability to automation for various tissue needs.

关键词： disease modeling DLP bioprinting drug screening tissue modeling

Metagenomic analysis reveals oropharyngeal microbiota alterations in patients with COVID-19

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2021年第6期6卷 1822-1832页

作者： Shengli Ma Fan Zhang Fengxia Zhou Hui li Wenyu Ge Rui Gan Huan Nie Biao li Yindong Wang Meng Wu Duo li Dongmei Wang Zheng Wang Yuhong You Zhiwei Huang Heilongjiang provincial Hospital Harbin Institute of TechnologyHarbinChina School of life Science and Technology Harbin Institute of TechnologyHarbinChina School of energy Science and Engineering Harbin Institute of TechnologyHarbinChina department of Stomatology Zhongshan HospitalFudan UniversityShanghaiChina

COVID-19 remains a serious emerging global health problem,and little is known about the role of oropharynx commensal microbes in infection susceptibility and ***,we present the oropharyngeal microbiota characteristics identified by shotgun metagenomic sequencing analyses of oropharynx swab specimens from 31 COVID-19 patients,29 influenza B patients,and 28 healthy *** results revealed a distinct oropharyngeal microbiota composition in the COVID-19 patients,characterized by enrichment of opportunistic pathogens such as Veillonella and Megasphaera and depletion of Pseudopropionibacterium,Rothia,and *** on the relative abundance of the oropharyngeal microbiome,we built a microbial classifier to distinguish COVID-19 patients from flu patients and healthy controls with an AUC of 0.889,in which Veillonella was identified as the most prominent biomarker for COVID-19 *** members of the genus Veillonella,especially Veillonella parvula which was highly enriched in the oropharynx of our COVID-19 patients,were also overrepresented in the BALF of COVID-19 patients,indicating that the oral cavity acts as a natural reservoir for pathogens to induce co-infections in the lungs of COVID-19 *** also found the increased ratios of Klebsiella sp.,Acinetobacter sp.,and Serratia *** correlated with both disease severity and elevated systemic inflammation markers(neutrophil-lymphocyte ratio,NLR),suggesting that these oropharynx microbiota alterations may impact COVID-19 severity by influencing the inflammatory ***,the oropharyngeal microbiome of COVID-19 patients exhibited a significant enrichment in amino acid metabolism and xenobiotic biodegradation and *** addition,all 26 drug classes of antimicrobial resistance genes were detected in the COVID-19 group,and were significantly enriched in critical *** conclusion,we found that oropharyngeal microbiota alterations and functional differences were associated

关键词： alterations patients severity

Three-year Follow-up on the Safety and Effectiveness of Rituximab Plus Chemotherapy as First-line Treatment of Diffuse Large B-Cell Lymphoma and Follicular Lymphoma in Real-World Clinical Settings in china： A Prospective, Multicenter, Noninterventional Study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Medical Journal 2018年第15期131卷 1767-1775页

作者： Jian-Qiu Wu Yong-Ping Song li-Ping Su Ming-Zhi Zhang Wei li Yu Hu Xiao-Hong Zhang Yu-Huan Gao Zuo-Xing Niu Ru FengTM Wei Wang Jie-Wen Peng Xiao-lin li Xue-Nong Ouyang Chang-Ping Wu Wei-Jing Zhang Yun zeng Zhen Xiao Ying-Min liang Yong-Zhi Zhuang Ji-Shi Wang Zi-Min Sun Hai Bai Tong-Jian Cui Ji-Feng Feng department of Oncology Jiangsu Cancer Hospital ＆ Jiangsu Institute of Cancer Research ＆ Nanjing Medical University Affiliated Cancer HospitalNanjing Jiangsu 210008China department of Hematology Henan Cancer HospitalZhengzhouHenan 450000China department of Hematology Shanxi Cancer HospitalTaiyuanShanxi 030013China department of Oncology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan 450000China department of Oncology Jilin University First Affiliated HospitalChangchunJilin 130000China department of Hematology Union Hospital Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430072China department of Hematology The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhouZhejiang 310009China department of Hematology Fourth Hospital of Hebei Medical UniversityShijiazhuangHebei 050000China department of Oncology Affiliated Hospital of Shandong Academy of Medical SciencesJinanShandong 250000China department of Hematology Medical University Nanfang HospitalGuangzhouGuangdong 510000China department of Oncology Guangdong Foshan First HospitalFoshanGuangdong 528000China department of Oncology Guangdong Zhongshan People＇s HospitalZhongshanGuangdong 528403China department of Hematology Xiangya Hospital Central South UniversityChangshaHunan 410008China department of Oncology Fuzhou General Hospital of Nanjing Military CommandFuzhouFujian 350001China department of Oncology Changzhou First People＇s HospitalChangzhouJiangsu 213000China department of Oncology 307 Hospital of Chinese People＇s Liberation ArmyBeijing 100070China Tdepartment of Hematology First Affiliated Hospital of Kunming Medical UniversityKunmingYunnan 650221China department of Hematology Affiliated Hospital of Neimenggu Medical CollegeHohhotHuhehaoteInner Mongolia 010050China department of Hematology The Fourth Military Medical University Affiliated Tangdu HospitalXi＇anShaanxi 710038China department of Oncology Daqing General Hospital Grou

Background： Prospective real-life data on the safety and effectiveness of rituximab in Chinese patients with diffuse large B-cell lymphoma （DLBCL） or follicular lymphoma （FL） are limited. This real-world study aimed to evaluate long-term safety and effectiveness outcomes ofrituximab plus chemotherapy （R-chemo） as first-line treatment in Chinese patients with DLBCL or FL. Hepatitis B virus （HBV） reactivation management was also investigated. Methods： A prospective, multicenter, single-arm, noninterventional study of previously untreated CD20-positive DLBCL or FL patients receiving first-line R-chemo treatment at 24 centers in china was conducted between January 17, 2011 and October 31, 2016. Enrolled patients underwent safety and effectiveness assessments after the last rituximab dose and were followed up for 3 years. Effectiveness endpoints included progression-free survival （PFS） and overall survival （OS）. Safety endpoints were adverse events （AEs）, serious AEs, drug-related AEs, and AEs of special interest. We also reported data on the incidence of HBV reactivation. Results： In total, 283 previously untreated CD20-positive DLBCL and 31 FL patients from 24 centers were enrolled. Three-year PFS was 59% （95% confidence interval [CI]： 50-67%） for DLBCL patients and 46% （95% CI： 20-69%） for FL patients. For DLBCL patients, multivariate analyses showed that PFS was not associated with international prognostic index, tumor maximum diameter, HBV infection status, or number ofrituximab treatment cycles, and OS was only associated with age 〉60 years （P 〈 0.05）. R-chemo was well tolerated. The incidence of HBV reactivation in hepatitis B surface antigen （HBsAg）-positive and HBsAg-negative/hepatitis B core antibody-positive patients was 13% （3/24） and 4% （3/69）, respectively. Conclusions： R-chemo is effective and safe in real-world clinical practice as first-line treatment for DLBCL and FL in china, and that HBV reactivation during R-chemo is manageable with preventive measur

关键词： Asian Hematopoietic Malignancy Hepatitis B Virus Observational Study Rituximab

在线全文

学校读者我要写书评

暂无评论

官能团导向立体选择性的糖苷化反应研究进展

有机化学 2022年第11期42卷 3506-3529页

作者：孙阳星李彦芝曹燕来王能中向少华刘明国姚辉三峡大学生物与制药学院、中国轻工业功能酵母重点实验室天然产物研究与利用湖北省重点实验室湖北宜昌443002 湖北广辰药业有限公司湖北宜昌443002 南方科技大学、深圳格拉布斯研究院化学系、广东省催化重点实验室广东深圳518055

糖类化合物不仅是生命活动的能量来源,还在许多细胞信号传导和药物研发中发挥着至关重要的作用.糖化学的核心是糖苷化反应,而开发一种通用、高效的立体选择性糖苷化方法仍是一大挑战.目前主要从糖供体、催化条件以及糖受体三个方面进行... 详细信息

糖类化合物不仅是生命活动的能量来源,还在许多细胞信号传导和药物研发中发挥着至关重要的作用.糖化学的核心是糖苷化反应,而开发一种通用、高效的立体选择性糖苷化方法仍是一大挑战.目前主要从糖供体、催化条件以及糖受体三个方面进行立体选择性糖苷化反应研究,其中研究最多的是糖供体的开发.主要综述了近十年来糖供体的官能团对糖苷化立体选择性调控的发展,根据官能团参与糖苷化反应的方式可将其分为五大类:邻基参与型官能团、远程参与型官能团、分子内苷元传递型官能团、与催化剂配位型官能团及氢键作用型官能团.

关键词：糖类化合物糖苷化反应官能团立体选择性合成