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Effect of HbA_(1c) combined FPG on screening diabetes in health checkup

Asian Pacific Journal of Tropical Medicine 2012年第6期5卷 472-475页

作者： Li-Juan Li Jing-Xia Zhou Guang-Tao Chen Yan-Ling Song yao-ming xue Department of Endocrinology and Metabolic Disease Nanfang HospitalSouthern Medical University Department of Geriatrics Affiliated Hospital of Hainan Medical University Department of Medicine Hainan General Hospital of Armed Police Department of Neurology Hainan Agricultural Reclamation Hospital

Objective:To appraise the effectiveness of HbA_(1c) and fasting plasma glucose(FPG) on screening diabetes in health ***:A total of 1 337 individuals(male 850,female 487),aged 27 to 91 years with HbA_(1c) test were *** with HbA_(1c)≥6.0%or FPG≥6.1 mmol/ L underwent oral glucose tolerance test(OGTT).Diabetes mellitus was diagnosed according to the criteria of WHO in 1999,FPG≥7.0 mmol/L and/or OGTT 2 h-postload plasm glucose(2 h-PG)≥11.1 mmol/*** sensitivity and specificity of HbA_(1c) thresholds and FPG or combination test on screening of diabetes were ***:A total of 842 subjects had HbA_(1c)<6.0%,in which 32 had isolated FPG≥6.1 mmol/L,of 495 had HbA_(1c)≥6.0%.Subjects with HbA_(1c)≥6.0% had significant increased disorder indexes than those with HbA_(1c)<6.0%.527 subjects who had HbA_(1c)≥6.0%or FPG≥6.1 mmol/L underwent OGTT.A total of 234 subjects were newly diagnosed diabetes,including 123(123/234,52.56%) with FPG≥7.0 mmol/L,and 111 subjects(111/234, 47.43%) with isolated 2 h-PG≥11.1 mmol/*** 234 new diabetes,91.88%(215 subjects) had HbA_(1c)≥6.3%,and 77.40%(181 subjects) had HbA_(1c)≥6.5%.HbA_(1c)≥6.3%combined FPG≥7.0 mmol/L increased the positive rate of newly diagnosed diabetes from 91.88%to 96.58%. Conclusions:HbA_(1c) is a practical and convenient tool for screening undiagnosed diabetes in routine health check-up of a large *** use of HbA_(1c)≥6.3%and/or FPG≥7.0 mmol/L is efficient for early detection of diabetes.

关键词： HbA_(1c) Diabetes Screening Health checkup

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Turner syndrome with positive SRY gene and non-classical congenital adrenal hyperplasia: A case report

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World Journal of Clinical Cases 2021年第10期9卷 2259-2267页

作者： Mei-Nan He Shan-Chao Zhao Ji-Min Li Lu-Lu Tong Xin-Zhao Fan yao-ming xue Xiao-Hong Lin Ying Cao Department of Endocrinology and Metabolism Nanfang HospitalSouthern Medical UniversityGuangzhou 510515Guangdong ProvinceChina Department of Urology Nanfang HospitalSouthern Medical UniversityGuangzhou 510515Guangdong ProvinceChina Guangzhou KingMed Center for Clinical Laboratory Co. Ltd.Guangzhou 510005Guangdong ProvinceChina

BACKGROUND Co-morbidity of SRY gene turner syndrome(TS)with positive SRY gene and nonclassical congenital adrenal hyperplasia(NCAH)is extremely rare and has never been reported to *** SUMMARY In this article,we present a 14-year-old girl who was referred to our hospital with short stature(weight of 43 kg and height of 143 cm,<-2 SD)with no secondary sexual characteristics(labia minora dysplasia).Laboratory tests indicated hypergonadotropic hypogonadism with significantly increased androstenedione and 17-hydroxyprogesterone(17-OHP)*** was accompanied by the thickening of the extremity of the left adrenal medial *** patient’s karyotype was 45,X/46,X,+mar,and cytogenetic analysis using multiplex ligation-dependent probe amplification and high-throughput sequencing indicated that the SRY gene was positive with compound heterozygous mutations in CYP21A2 as the causative gene for congenital adrenal *** sites of the suspected candidate mutations were amplified and verified using Sanger *** patient was finally diagnosed as having SRY positive TS with *** patient and her family initially refused medical *** her most recent follow-up visit(age=15 years old),the patient presented facial hair,height increase to 148 cm,and weight of 52 kg,while androstenedione and 17-OHP levels remained *** patient was finally willing to take small doses of hydrocortisone(10 mg/d).CONCLUSIONIn conclusion, upon evaluation of the patient mentioned in the report, we feel that17-OHP measurement and cytogenetic analysis are necessary for TS patients evenin the absence of significant virilization signs. This will play a significant role inguiding diagnosis and treatment.

关键词： Turner syndrome SRY gene Congenital adrenal hyperplasia Tumor Diagnosis Endocrinology and metabolism Case report

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Efficacy and Safety of Avandamet or Uptitrated Metformin Treatment in Patients with Type 2 Diabetes Inadequately Controlled with Metformin Alone： A Multicenter, Randomized,Controlled Trial

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Chinese Medical Journal 2015年第10期128卷 1279-1287页

作者： Xiao-Ling Cai Ying-Li Chen Jia-Jun Zhao Zhong-Yan Shan ming-Cai Qiu Cheng-Jiang Li Wei Gu Hao-ming Tian Hua-Zhang Yang yao-ming xue Jin-Kui Yang Tian-Pei Hong Li-Nong Ji Department of Endocrinology and Metabolism Peking University People's HospitalBeijing 100044China Department of Endocrinology and Metabolism Shandong Provincial HospitalJinanShandong 250021China Department of Endocrinology and Metabolism First Hospital of China Medical UniversityShenyangLiaoning 110001China Department of Endocrinology and Metabolism Tianjin Medical University General HospitalTianjin 300070China Department of Endocrinology and Metabolism First Affiliated Hospital of School of MedicineZhejiang UniversityHangzhouZhejiang 310003China Department of Endocrinology and Metabolism Second Affiliated Hospital of School of MedicineZhejiang UniversityHangzhouZhejiang 310009China Department of Endocrinology and Metabolism West China Hospital Sichuan University Chengdu Sichuan 610041 China Department of Endocrinology and Metabolism Guangdong General Hospital Guangzhou Guangdong 510080 China Department of EndocrinoLogy and Metabolism South Hospital Guangzhou Guangdong 510515 China Department of Endocrinology and Metabolism Beijing Tongren Hospital Beijing 100730 China Department of Endocrinology and Metabolism Peking University Third Hospital Beijing 100191 China

Background：At present,China has listed the compound tablet containing a fixed dose ofrosiglitazone and metformin,Avandamet,which may improve patient *** aim of this study was to evaluate the efficacy and safety of Avandamet or uptitrated metformin treatment in patients with type 2 diabetes inadequately controlled with metformin ***：This study was a 48-week,multicenter,randomized,open-labeled,active-controlled *** with inadequate glycaemic control （glycated hemoglobin [HbA1c] 7.5-9.5%） receiving a stable dose of metformin （≥1500 mg） were recruited from 21 centers in China （from 19 November,2009 to 15 March,2011）.The primary objective was to compare the proportion of patients who reached the target of HbA1c ≤7% between Avandamet and metformin ***：At week 48,83.33% of patients reached the target of HbA 1 c ≤7% in Avandamet treatment and 70.00% in uptitrated metformin treatment,with significantly difference between *** target of HbAlc ≤6.5% was reached in 66.03% of patients in Avandamet treatment and 46.88% in uptitrated metformin *** target of fasting plasma glucose （FPG） ≤6.1 mmol/L was reached in 26.97% of patients in Avandamet treatment and 19.33% in uptitrated metformin *** target of FPG ≤7.0 mmol/L was reached in 63.16% of patients in Avandamet treatment and 43.33% in uptitrated metformin *** insulin decreased 3.24 ±0.98 μU/ml from baseline in Avandamet treatment and 0.72 ＆#177; 1.10 μU/ml in uptitrated metformin *** adverse event （AE） rates and serious AE rates were similar between *** occurred rarely in both ***：Compared with uptitrated metformin,Avandamet treatment provided significant improvements in key parameters ofglycemic control and was generally well *** number：ChiCTR-TRC-13003776.

关键词： Avandamet Efficacy Type 2 Diabetes

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基于UHPLC-Q-Exactive Orbitrap-MS技术分析土茯苓苯丙素类化学成分及其对类风湿关节炎特征基因的干预

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科学技术与工程 2024年第27期24卷 11586-11593页

作者：杨欣黄聪姚血明贵州中医药大学基础医学院贵阳550025 贵州中医药大学第二附属医院贵阳550025

通过超高效液相色谱-四极杆-静电场轨道阱高分辨质谱联用技术(UHPLC-Q Exactive Orbitrap-MS)鉴定土茯苓苯丙素类化合物,筛选与特定免疫细胞浸润相关的类风湿关节炎(rheumatoid arthritis,RA)诊断标志物及苯丙素类化合物。以正离子和负... 详细信息

通过超高效液相色谱-四极杆-静电场轨道阱高分辨质谱联用技术(UHPLC-Q Exactive Orbitrap-MS)鉴定土茯苓苯丙素类化合物,筛选与特定免疫细胞浸润相关的类风湿关节炎(rheumatoid arthritis,RA)诊断标志物及苯丙素类化合物。以正离子和负离子模式采集数据分析土茯苓苯丙素类化学成分。通过GEO(gene expression omnibus)数据库获取RA基因芯片,基于“一致性聚类”进行共识聚类且区分RA不同的分子亚型。通过R软件绘制特征基因受试者工作特征曲线(receiveroperating characteristic curve,ROC),并计算ROC曲线下的面积。通过单样本基因集富集分析特征基因与免疫细胞的相关性。基于SYBYL2.1.1分子对接分析苯丙素类化合物与特征基因的结合情况。对RA差异表达基因进行过滤,获得5个特征基因,其中RAC2、ITGB7、CD52、ITGB2基因的ROC曲线面积通过验证,4特征基因能影响8种免疫细胞(活化的CD4+T细胞,活化的CD8+T细胞,中央记忆CD4+T细胞,效应记忆CD4+T细胞,骨髓源性抑制细胞,单核细胞,调节性T细胞,效应记忆CD8+T细胞),且呈正相关(P<0.05,P<0.01,P<0.001)。土茯苓苯丙素类化合物26个,能共同干预4个免疫特征基因。基于免疫细胞浸润的模型可用于预测RA的发病机制,土茯苓苯丙素类化合物对免疫特征基因具有干预作用,研究结果为RA免疫调节治疗和早期诊断提供科学依据。

关键词： UHPLC-Q-Exactive Orbitrap-MS 类风湿关节炎土茯苓苯丙素免疫细胞浸润分析分子对接

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白血病K562/A02细胞MDR1、NF-κB的表达及解毒化瘀中药的调控作用研究

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中国药理学通报 2011年第7期27卷 1031-1032页

作者：马武开李玉莹姚血明王莹黄礼明贵阳中医学院第二附属医院血液风湿科贵州贵阳550003

在白血病细胞的耐药机制中,核周因子NF-κB与肿瘤细胞的发生、增殖、分化、凋亡及耐药有密切关系,是多药耐药（multidrug resistance,MDR1）信号转导途径中的主要信号分子,在白血病细胞表达与耐药有关的因素中可能起关键的调控作用。本... 详细信息

在白血病细胞的耐药机制中,核周因子NF-κB与肿瘤细胞的发生、增殖、分化、凋亡及耐药有密切关系,是多药耐药（multidrug resistance,MDR1）信号转导途径中的主要信号分子,在白血病细胞表达与耐药有关的因素中可能起关键的调控作用。本研究采用血清药理学方法和分子生物学技术研究解毒化瘀药含药血清对人白血病耐药细胞系K562/A02细胞NF-κB信号的影响,探讨解毒化瘀药对K562/A02耐药逆转机制。

关键词：白血病多药耐药 K562/A02细胞 NF-κB 解毒化瘀药

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Müller cells are activated in response to retinal outer nuclear layer degeneration in rats subjected to simulated weightlessness conditions

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Neural Regeneration Research 2025年第7期20卷 2116-2128页

作者： Yuxue Mu Ning Zhang Dongyu Wei Guoqing Yang Lilingxuan yao Xinyue Xu Yang Li Junhui xue Zuoming Zhang Tao Chen Aerospace Clinical Medical Center School of Aerospace MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina Department of Aviation Medicine Xijing HospitalAir Force Medical UniversityXi’anShaanxi ProvinceChina Department of Emergency Medicine Wuhan No.1 HospitalWuhanHubei ProvinceChina Third Regiment School of Basic MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina Fourth Regiment School of Basic MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina

A microgravity environment has been shown to cause ocular damage and affect visual acuity,but the underlying mechanisms remain ***,we established an animal model of weightlessness via tail suspension to examine the pathological changes and molecular mechanisms of retinal damage under *** 4 weeks of tail suspension,there were no notable alterations in retinal function and morphology,while after 8 weeks of tail suspension,significant reductions in retinal function were observed,and the outer nuclear layer was thinner,with abundant apoptotic *** investigate the mechanism underlying the degenerative changes that occurred in the outer nuclear layer of the retina,proteomics was used to analyze differentially expressed proteins in rat retinas after 8 weeks of tail *** results showed that the expression levels of fibroblast growth factor 2(also known as basic fibroblast growth factor)and glial fibrillary acidic protein,which are closely related to Müller cell activation,were significantly *** addition,Müller cell regeneration and Müller cell gliosis were observed after 4 and 8 weeks,respectively,of simulated *** findings indicate that Müller cells play an important regulatory role in retinal outer nuclear layer degeneration during weightlessness.

关键词： glial fibrous acidic protein gliosis Müller cells nerve growth factor neural differentiation neurodegeneration proteomic retinal degeneration retinal outer nuclear layer simulated weightlessness

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解毒化瘀药含药血清对白血病HL60/ADR耐药细胞NF-κB信号靶向干预研究

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中国实验方剂学杂志 2011年第18期17卷 154-157页

作者：马武开姚血明王莹黄颖黄礼明贵阳中医学院第二附属医院贵阳550003

目的:探讨解毒化瘀药含药血清对白血病HL60/ADR细胞核周因子κB(NF-κB)信号基因表达的影响。方法:将HL60/ADR耐药细胞分为牛血清组、兔血清组、含药血清高、中、低剂量处理组和干扰素对照组,用Western blot法检测各组细胞NF-κB/p65,NF... 详细信息

目的:探讨解毒化瘀药含药血清对白血病HL60/ADR细胞核周因子κB(NF-κB)信号基因表达的影响。方法:将HL60/ADR耐药细胞分为牛血清组、兔血清组、含药血清高、中、低剂量处理组和干扰素对照组,用Western blot法检测各组细胞NF-κB/p65,NF-κB/p50,IκBα的表达情况。结果:流式细胞仪检测结果显示非细胞毒作用的解毒化瘀药血清能够增加HL60/ADR细胞内柔红霉素的浓度。HL60/ADR耐药细胞NF-κB信号基因呈高表达,HL60敏感细胞未见表达,加用不同浓度解毒化瘀含药血清处理后,p65,p50和IKBa的表达均有不同程度下降,以高、中剂量组对p65的下调作用更明显。结论:解毒化瘀药对HL60/ADR细胞的耐药逆转作用是通过阻断NF-κB信号通路实现的。

关键词：白血病多药耐药 HL60/ADR细胞 NF-κB信号解毒化瘀药

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完全■-单半群

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数学学报（中文版） 2011年第4期54卷 643-650页

作者：马思遥任学明袁莹西安建筑科技大学数学系西安710055

完全g-单半群是完全单半群和完全g-单半群在U-半富足半群类中的一个自然推广．本文证明了半群S是完全g-单半群，当且仅当S同构于幺半群T上的正规Rees矩阵半群M（T；I，A；P）．这一结果不仅推广了完全单半群的著名Rees定理，而且推广了... 详细信息

完全g-单半群是完全单半群和完全g-单半群在U-半富足半群类中的一个自然推广．本文证明了半群S是完全g-单半群，当且仅当S同构于幺半群T上的正规Rees矩阵半群M（T；I，A；P）．这一结果不仅推广了完全单半群的著名Rees定理，而且推广了任学明和岑嘉评在2004年建立的完全g-单半群的一个结构定理．

关键词： U-超富足半群完全g-单半群正规Rees矩阵半群

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基于流固耦合的液压缸碰撞研究

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液压气动与密封 2012年第5期32卷 13-16页

作者：姚雪明权辉第二炮兵工程学院陕西西安710025

针对经典碰撞模型的局限性,通过采用缸筒弹簧模型,建立了新型液压缸碰撞模型;通过构建描述液压缸碰撞的流固耦合方程组,利用有限元软件ADINA分析了有无流体及不同负载力对液压缸碰撞位移、速度和应力的影响,分析结果表明流体对于液压缸... 详细信息

针对经典碰撞模型的局限性,通过采用缸筒弹簧模型,建立了新型液压缸碰撞模型;通过构建描述液压缸碰撞的流固耦合方程组,利用有限元软件ADINA分析了有无流体及不同负载力对液压缸碰撞位移、速度和应力的影响,分析结果表明流体对于液压缸碰撞具有明显的阻尼作用。

关键词：液压缸流固耦合碰撞 ADINA

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中国药理学通报 2024年第10期40卷 1937-1944页

作者：李浩姚血明姚晓玲娄华勇潘卫东马武开贵州中医药大学第二附属医院风湿免疫科贵州贵阳550001 贵州中医药大学第二临床医学院贵州贵阳550001 贵州省天然产物研究中心贵州贵阳550014

目的探讨漆黄素对人类风湿关节炎滑膜成纤维细胞(human fibroblast-like synoviocytes of rheumatoid arthritis, HFLS-RA)增殖、迁移、周期阻滞及焦亡相关炎症因子调控机制。方法采用细胞迁移及侵袭实验研究细胞增殖、迁移及侵袭;流... 详细信息

目的探讨漆黄素对人类风湿关节炎滑膜成纤维细胞(human fibroblast-like synoviocytes of rheumatoid arthritis, HFLS-RA)增殖、迁移、周期阻滞及焦亡相关炎症因子调控机制。方法采用细胞迁移及侵袭实验研究细胞增殖、迁移及侵袭;流式细胞术检测细胞周期;ELISA法、RT-qPCR法和Western blot法检测焦亡相关炎症因子IL-1β、IL-18、caspase-1和caspase-3的表达。结果迁移与侵袭实验表明,漆黄素低、中、高剂量组细胞增殖率较空白对照组降低(P<0.05)。细胞周期分析显示,在G_(0)/G_(1)期,漆黄素中、高剂量组DNA表达量升高(P<0.05),G_(2)、S期,漆黄素中、高剂量组DNA表达量降低(P<0.05)。ELISA、RT-qPCR和Western blot检测结果显示,与IL-1β+caspase-3抑制剂组比较,漆黄素低、中、高剂量组IL-1β、IL-18、caspase-1、caspase-3表达降低(P<0.05)。结论漆黄素能够抑制HFLS-RA增殖,在G_(1)期发挥明显阻滞作用,其通过调控caspase-1/IL-1β焦亡通路,抑制caspase-1活化,从而减少通路下游IL-1β、IL-18等炎症因子的生成与释放,这可能是漆黄素治疗RA潜在的作用机制之一。

关键词：漆黄素类风湿关节炎细胞周期炎性细胞因子焦亡机制民族医药

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