Effect of HbA_(1c) combined FPG on screening diabetes in health checkup

作     者：Li-Juan Li Jing-Xia Zhou Guang-Tao Chen Yan-Ling Song Yao-Ming Xue 

作者机构：Department of Endocrinology and Metabolic DiseaseNanfang HospitalSouthern Medical University Department of GeriatricsAffiliated Hospital of Hainan Medical University Department of MedicineHainan General Hospital of Armed Police Department of NeurologyHainan Agricultural Reclamation Hospital 

出 版 物：《Asian Pacific Journal of Tropical Medicine》 (亚太热带医药杂志（英文版）)

年 卷 期：2012年第5卷第6期

页      面：472-475页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：HbA_(1c) Diabetes Screening Health checkup 

摘      要：Objective:To appraise the effectiveness of HbA_(1c) and fasting plasma glucose(FPG) on screening diabetes in health ***:A total of 1 337 individuals(male 850,female 487),aged 27 to 91 years with HbA_(1c) test were *** with HbA_(1c)≥6.0%or FPG≥6.1 mmol/ L underwent oral glucose tolerance test(OGTT).Diabetes mellitus was diagnosed according to the criteria of WHO in 1999,FPG≥7.0 mmol/L and/or OGTT 2 h-postload plasm glucose(2 h-PG)≥11.1 mmol/*** sensitivity and specificity of HbA_(1c) thresholds and FPG or combination test on screening of diabetes were ***:A total of 842 subjects had HbA_(1c)6.0%,in which 32 had isolated FPG≥6.1 mmol/L,of 495 had HbA_(1c)≥6.0%.Subjects with HbA_(1c)≥6.0% had significant increased disorder indexes than those with HbA_(1c)6.0%.527 subjects who had HbA_(1c)≥6.0%or FPG≥6.1 mmol/L underwent OGTT.A total of 234 subjects were newly diagnosed diabetes,including 123(123/234,52.56%) with FPG≥7.0 mmol/L,and 111 subjects(111/234, 47.43%) with isolated 2 h-PG≥11.1 mmol/*** 234 new diabetes,91.88%(215 subjects) had HbA_(1c)≥6.3%,and 77.40%(181 subjects) had HbA_(1c)≥6.5%.HbA_(1c)≥6.3%combined FPG≥7.0 mmol/L increased the positive rate of newly diagnosed diabetes from 91.88%to 96.58%. Conclusions:HbA_(1c) is a practical and convenient tool for screening undiagnosed diabetes in routine health check-up of a large *** use of HbA_(1c)≥6.3%and/or FPG≥7.0 mmol/L is efficient for early detection of diabetes.