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Association of sleep quality with myopia based on different genetic risk levels

International Journal of Ophthalmology(English edition) 2022年第10期15卷 1657-1664页

作者： Juan He yao-yao lin Jie Chen Bing Sun Yan-Hui Wang Dan-Dan Jiang lin-Jie Liu Shu-Dan lin Yan-Yan Chen School of Optometry and Ophthalmology Wenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina The Eye Hospital Wenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina

AIM: To analyse the association of sleep quality with myopia under different genetic risk(GR) ***: A cross-sectional survey of students aged 9-14 y in Wenzhou, China, was conducted. Refraction without cycloplegia and ocular parameters were measured. Sleep quality was assessed with the Pittsburgh Sleep Quality Index(PSQI). Seventeen single nucleotide polymorphisms(SNPs) were replicated by association analysis and used to compute the GR score(GRS). Possible confounders were assessed by a questionnaire that collected information about the children and their parents. Generalized linear models were used to analyse the sleep quality, the GR, and their interaction effects on the risk of ***: Out of 1354 children included in this study, 353(26.07%) had sleep disturbances. The GRS ranged from 4.49 to 12.89 with a mean of 7.74±1.23, and the participants were divided into a low GR group, a moderate GR group and a high GR group according to the GRS quartile. In the generalized linear model, the children with sleep disturbances and high GR had a higher risk of myopia than those without sleep disturbances and with low GR(OR=1.59, 95%CI: 1.12-2.25;OR=1.88, 95%CI: 1.23-2.88, respectively). Compared to those with low GR and SDs, children with high GR with or without SDs had a higher risk of myopia(OR=4.88, 95%CI: 2.03-11.71;OR=1.70, 95%CI: 1.06-2.72, respectively).CONCLUSION: The prevalence of sleep disturbances in elementary school students in Wenzhou was 26.07%. There is a significant interaction between sleep disturbances and a high GR of myopia, suggesting that a high GR of myopia may increase children’s sensitivity to sleep disturbances. This study indicates that children with a high GR of myopia need to achieve adequate sleep duration and excellent sleep quality.

关键词： sleep quality genetic risk score myopia children

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Posttraumatic stress symptoms among Chinese university students during the COVID-19 pandemic:Prevalence,correlates,and mental health help-seeking

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World Journal of Psychiatry 2025年第1期15卷 145-152页

作者： Rui-yao Wu lin-Feng Ge Bao-Liang Zhong Department of Psychiatry The Affiliated Wuhan Mental Health CenterTongji Medical College of Huazhong University of Science&TechnologyWuhan 430012Hubei ProvinceChina Department of Psychiatry Wuhan Mental Health CenterWuhan 430012Hubei ProvinceChina

BACKGROUND Revisiting the epidemiology of posttraumatic stress symptoms(PTSSs)among university students during the coronavirus disease 2019(COVID-19)pandemic as well as understanding the mental health help-seeking behavior of individuals with PTSSs has critical implications for public mental health strategies in future medical *** To investigate the prevalence and correlates of PTSSs among university students during the first wave of the COVID-19 pandemic in China and to examine mental health help-seeking behaviors among these *** A total of 2507 Chinese university students were recruited via snowball *** students completed the Seven-item Screening Scale for Post-traumatic Stress Disorder during the first wave of the COVID-19 pandemic in ***-graphic characteristics,pandemic-related characteristics,and mental health help-seeking behaviors of students with PTSSs were also *** The prevalence of PTSSs among the participants was 28.0%.Seven significant correlates of PTSSs were identified(odds ratio=1.23-3.65,P≤0.024):Female sex,being 19 years old or older,living with others or alone,a low level of family economic status,fair or poor interpersonal relationships,severe or very severe local pandemic,and having family members diagnosed with ***,only 3.28%of the students with PTSSs reported seeking help from mental health *** the 23 students who sought help from mental health specialists,13 opted for online or telephone-based psychological *** Our data suggest that there was a high risk of PTSSs among university students and a high level of unmet mental health needs during the COVID-19 *** delivery of mental health services online or via telephone is a promising approach to address these unmet needs.

关键词： Posttraumatic stress symptoms University students COVID-19 Mental health help-seeking China

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Infiltration by monocytes of the central nervous system and its role in multiple sclerosis: reflections on therapeutic strategies

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Neural Regeneration Research 2025年第3期20卷 779-793页

作者： Guangyong Zhang Qing yao Chubing Long Pengcheng Yi Jiali Song Luojia Wu Wei Wan Xiuqin Rao Yue lin Gen Wei Jun Ying Fuzhou Hua Department of Anesthesiology the Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi ProvinceChina Key Laboratory of Anesthesiology of Jiangxi Province NanchangJiangxi ProvinceChina

Mononuclear macrophage infiltration in the central nervous system is a prominent feature of neuroinflammation. Recent studies on the pathogenesis and progression of multiple sclerosis have highlighted the multiple roles of mononuclear macrophages in the neuroinflammatory process. Monocytes play a significant role in neuroinflammation, and managing neuroinflammation by manipulating peripheral monocytes stands out as an effective strategy for the treatment of multiple sclerosis, leading to improved patient outcomes. This review outlines the steps involved in the entry of myeloid monocytes into the central nervous system that are targets for effective intervention: the activation of bone marrow hematopoiesis, migration of monocytes in the blood, and penetration of the blood–brain barrier by monocytes. Finally, we summarize the different monocyte subpopulations and their effects on the central nervous system based on phenotypic differences. As activated microglia resemble monocyte-derived macrophages, it is important to accurately identify the role of monocyte-derived macrophages in disease. Depending on the roles played by monocyte-derived macrophages at different stages of the disease, several of these processes can be interrupted to limit neuroinflammation and improve patient prognosis. Here, we discuss possible strategies to target monocytes in neurological diseases, focusing on three key aspects of monocyte infiltration into the central nervous system, to provide new ideas for the treatment of neurodegenerative diseases.

关键词： blood–brain barrier macrophages monocytes multiple sclerosis neuroinflammation review therapy

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Nanostructured ZnO/BiVO4 I-scheme heterojunctions for piezocatalytic degradation of organic dyes via harvesting ultrasonic vibration energy

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International Journal of Minerals,Metallurgy and Materials 2025年第02期 488-497页

作者： Yiling Li Xiaoyao Yu Yingjie Zhou yao lin Ying Wu Key Laboratory of the Ministry of Education for Advanced Catalysis Materials College of Chemistry and Materials ScienceZhejiang Normal University

BiVO4porous spheres modified by ZnO were designed and synthesized using a facile two-step *** resulting ZnO/BiVO4composite catalysts have shown remarkable efficiency as piezoelectric catalysts for degrading Rhodamine B （RhB） unde mechanical vibrations,they exhibit superior activity compared to pure *** 40wt%ZnO/BiVO4heterojunction composite displayed the highest activity,along with good stability and *** enhanced piezoelectric catalytic activity can be attributed to the form ation of an I-scheme heterojunction structure,which can effectively inhibit the electron-hole ***,hole （h+） and superoxide radical （·O2-） are proved to be the primary active ***,ZnO/BiVO4stands as an efficient and stable piezoelectric catalyst with broad potential application in the field of environmental water pollution treatment.

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A Survey on Pre-Processing in Image Matting

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Journal of Computer Science & Technology 2017年第1期32卷 122-138页

作者： Gui-lin yao School of Computer and Information Engineering Harbin University of Commerce Harbin 150028 China

Pre-processing is an important step in digital image matting, which aims to classify more accurate foreground and background pixels from the unknown region of the input three-region mask （Trimap）. This step has no relation with the well-known matting equation and only compares color differences between the current unknown pixel and those known pixels. These newly classified pure pixels are then fed to the matting process as samples to improve the quality of the final matte. However, in the research field of image matting, the importance of pre-processing step is still blurry. Moreover, there are no corresponding review articles for this step, and the quantitative comparison of Trimap and alpha mattes after this step still remains unsolved. In this paper, the necessity and the importance of pre-processing step in image matting are firstly discussed in details. Next, current pre-processing methods are introduced by using the following two categories： static thresholding methods and dynamic thresholding methods. Analyses and experimental results show that static thresholding methods, especially the most popular iterative method, can make accurate pixel classifications in those general Trimaps with relatively fewer unknown pixels. However, in a much larger Trimap, there methods are limited by the conservative color and spatial thresholds. In contrast, dynamic thresholding methods can make much aggressive classifications on much difficult cases, but still strongly suffer from noises and false classifications. In addition, the sharp boundary detector is further discussed as a prior of pure pixels. Finally, summaries and a more effective approach are presented for pre-processing compared with the existing methods.

关键词： image matting pixel classification pre-processing Trimap expansion

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通过灾害脆弱性分析运用PDCA理论改进＂医闹＂应急管理

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中国急救复苏与灾害医学杂志 2017年第2期12卷 150-153页

作者：王笑君沈汉斌李绍刚姚瑶林亮武汉市第五医院质控办湖北430050

采用美国凯撒医疗集团开发的Kaiser模型，在武汉市第五医院开展灾害脆弱性分析，得出的前五位风险事件为：医闹、信息系统功能紊乱、停电、发电机故障和暴发疫情发生；针对目前“医闹”事件频发，笔者运用PDcA循环理论持续质量改进“医... 详细信息

采用美国凯撒医疗集团开发的Kaiser模型，在武汉市第五医院开展灾害脆弱性分析，得出的前五位风险事件为：医闹、信息系统功能紊乱、停电、发电机故障和暴发疫情发生；针对目前“医闹”事件频发，笔者运用PDcA循环理论持续质量改进“医闹”应急管理，做到“医闹”应急预案全员知晓、保安人员限时到位、安保人员携带警具完好、警民联系方式畅通；这些改进后的结果集中体现在启动“医闹”应急预案的院级公众号-“1110”。

关键词：灾害脆弱性分析应急医闹 PDCA 全面质量管理

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Burden of mental disorders and risk factors in the Western Pacific region from 1990 to 2021

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World Journal of Psychiatry 2025年第1期15卷 93-105页

作者： Ya-Xin Xu Xiao-Xuan Niu Wen-Chang Jia Jing Wen Xue-lin Cheng Yan Han Ming-Hui Peng Jing Zhou yao Liu Sun-Fang Jiang Xiao-Pan Li Department of Health Management Centre Zhongshan HospitalFudan UniversityShanghai 200030China Department of General Practice Zhongshan HospitalFudan UniversityShanghai 200030China Department of Nutrition Zhongshan HospitalFudan UniversityShanghai 200032China School of Public Health Fudan UniversityShanghai 200032China

BACKGROUND The burden of mental disorders(MD)in the Western Pacific Region(WPR)re-mains a critical public health concern,with substantial variations across demogra-phics and *** To analyze the burden of MD in the WPR from 1990 to 2021,along with associated risk factors,to reveal changing trends and emerging *** We used data from the Global Burden of Disease 2021,analyzing prevalence,incidence,and disability-adjusted life years(DALYs)of MD from 1990 to *** methods included age-standardisation and uncertainty analysis to address variations in population structure and data *** Between 1990 and 2021,the prevalence of MD rose from 174.40 million cases[95%uncertainty interval(UI):160.17-189.84]to 234.90 million cases(95%UI:219.04-252.50),with corresponding DALYs increasing from 22.8 million(95%UI:17.22-28.79)to 32.07 million(95%UI:24.50-40.68).During this period,the burden of MD shifted towards older age *** and anxiety disorders were predominant,with females showing higher DALYs for depressive and anxiety disorders,and males more affected by conduct disorders,attention-deficit hyperactivity disorder,and autism spectrum ***,New Zealand,and Malaysia reported the highest burdens,whereas Vietnam,China,and Brunei Darussalam reported the ***,childhood sexual abuse and bullying,and intimate partner violence emerged as significant risk *** This study highlights the significant burden of MD in the WPR,with variations by age,gender,and *** coronavirus disease 2019 pandemic has exacerbated the situation,emphasizing the need for a coordinated response.

关键词： Mental disorders Western pacific region Global Burden of Disease Risk factors Disability-adjusted life years

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Influence of coupled characteristics on the internally-staged combustor under low-power operation

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航空动力学报 2017年第1期32卷 42-52页

作者： KANG yao lin Yu-zhen Hunan Aviation Powerplant Research Institute Aero Engine(Group)Corporation of China National Key Laboratory of Science and Technology on Aero-Engine Aero-thermodynamics School of Energy and Power EngineeringBeijing University of Aeronautics and Astronautics

An ultra-low emissions combustor,namely low emission stirred swirl(LESS)combustor was studied,based on a scheme of internally-staged/lean premixed and prevaporized(LPP)*** LESS combustor consists of central pilot stage and outer surrounded coaxially main stage,between which there exists aphysical isolation,namely the step *** existence of step height delayed the pilot and main jets *** and numerical studies were carried out to investigate the influence of the step height on the combustion performance.A single dome rectangular combustor was utilized to conduct the lean lightoff and blowout experiments,and pollutant emission *** experimental results showed that with the increase of step height by 38%,the lean lightoff and blowout fuel air ratio decreased by 57.4% and 37.5%,the NOx emission increased by 35.1%,and the combustion efficiency increased by 1.78%;while the CO,unburned hydrocarbons(UHC)emissions ***,the total pressure loss was kept nearly ***-reacting and reacting flow fields were numerically investigated to analyze the coupled characteristics of pilot and main jets with different step heights.A comparison of flow characteristics,spray structure,and combustion component as well as temperature field with different step heights was *** numerical results showed that the increase of the step height shifted the peak velocity *** enlargement of the primary recirculation zone(PRZ)resulted in the increase of the combustion efficiency and NOx emission,while the CO,UHC emissions decreeased.

关键词：航空动力编辑研究工作

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A fast and precise three-dimensional measurement system based on multiple parallel line lasers

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Chinese Physics B 2021年第2期30卷 276-284页

作者： yao Wang Bin lin State Key Laboratory of Modern Optical Instrumentation CNERC for Optical InstrumentsZhejiang UniversityHangzhou 310027China

This paper conducts a trade-off between efficiency and accuracy of three-dimensional(3 D)shape measurement based on the triangulation principle,and introduces a flying and precise 3 D shape measurement method based on multiple parallel line ***,we establish the measurement model of the multiple parallel line lasers system,and introduce the concept that multiple base planes can help to deduce the unified formula of the measurement system and are used in simplifying the process of the ***,the constraint of the line spatial frequency,which maximizes the measurement efficiency while ensuring accuracy,is determined according to the height distribution of the ***,the simulation analyzing the variation of the systemic resolution quantitatively under the circumstance of a set of specific parameters is performed,which provides a fundamental thesis for option of the four system ***,for the application of the precision measurement in the industrial field,additional profiles are acquired to improve the lateral resolution by applying a motor to scan the 3 D ***,compared with the line laser,the experimental study shows that the present method of obtaining 41220 points per frame improves the measurement ***,the accuracy and the process of the calibration are advanced in comparison with the existing multiple-line laser and the structured light makes an accuracy better than 0.22 mm at a distance of 956.02 mm.

关键词： three-dimensional shape measurement multiple parallel line lasers fast and precise measurement parameter calibration

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Michael addition-based cyclization strategy in the total synthesis of Lycopodium alkaloids

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Science China Chemistry 2016年第9期59卷 1079-1087页

作者： lin-Rui Zhong Zhu-Jun yao State Key Laboratory of Coordination Chemistry Institute of Chemical Biology and Drug Innovation School of Chemistry and Chemical Engineering Collaborative Innovation Center of Chemistry for Life Sciences Nanjing University

Lycopodium alkaloids, a unique family of biologically important natural products isolated and characterized from various species of Lycopodium(sensu lato), have attracted extensive attention from chemists and pharmacists in the past three decades. Michael addition-based cyclization has been successfully employed as an elegant and efficient ring-construction protocol of constructing key cyclohexanone intermediates in the total synthesis of Lycopodium alkaloids. This mini-review chooses and summarizes several representative total syntheses of various Lycopodium alkaloids in which intramolecular Michael addition severed as the key methodology.

关键词： Lycopodium alkaloid Michael addition cyclization total synthesis

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