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Photocatalytic vinyl radical-mediated multicomponent 1,4-/1,8-carboimination across alkynes and olefins/(hetero)arenes

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Science China Chemistry 2024年第2期67卷 558-567页

作者： Shan-Shan Li Yu-Shi Jiang Xue-ling luo Xuming Ran Yuqiang Li Dong Wu Cheng-Xue Pan Peng-Ju Xia School of Chemistry and Pharmaceutical Sciences Guangxi Normal UniversityGuilin541004China Shanghai Artificial Intelligence Laboratory Shanghai200433China The Institute for Advanced Studies Wuhan UniversityWuhan430064China

We developed a highly selective and efficient multicomponent transformation by utilizing alkynes and olefins/(hetero)arenes through photoinduced energy-transfer *** reaction involves the formation of three distinct chemical bonds,namely C(sp~3)–C(sp~2),C(sp~2)–C(sp~3),and C(sp~3)–N,in a single coordinated *** strategy used a vinyl radical-mediated radical relay approach under mild conditions,exhibiting a broad substrate scope(>70 examples),excellent functional-group tolerance,and remarkable regio-and *** the utilization of a combination of experimental techniques and density functional theory(DFT),we delved deeper into the mechanistic intricacies of this distinctive *** revealed that the selective radical addition to electron-deficient alkynes,rather than olefins,was governed by the inherent reactivity of alkyl *** discovery presented a highly effective approach for the synthesis of stereodefined multisubstituted alkenes.

关键词： alkyne-olefin coupling DFT studies regio-and anti-stereoselectivity multisubstituted alkenes

Design,synthesis,and biological evaluation of novel chrysin derivatives as poly(ADP-ribose)polymerase 1(PARP1)inhibitors for the treatment of breast cancer

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Chinese Journal of Natural Medicines 2024年第5期22卷 455-465页

作者： YANG yao TONG Jing XIE Xianshun CAO Hong FU Yong luo Yong LIU Shan CHEN Wen YANG Ning Hengyang Medical School University of South ChinaHengyang 421200China Emergency Department Hengyang Medical SchoolThe Second Affiliated HospitalUniversity of South ChinaHengyang 421200China Hengyang Medical School The Second Affiliated HospitalUniversity of South ChinaHengyang 421200China Hemato-oncology Department Hengyang Medical SchoolThe Second Affiliated HospitalUniversity of South ChinaHengyang 421200China Department of Breast and Thyroid Surgery Hengyang Medical SchoolThe Second Affiliated HospitalUniversity of South ChinaHengyang 421200China

In this study,we reported the discovery and structure-activity relationship analysis of chrysin derivatives as a new class of inhibitors targeting poly(ADP-ribose)polymerase 1(PARP1).Among these derivatives,compound 5d emerged as the most effective chrysin-based inhibitor of PARP1,with an IC50 value of 108 nmol·L^(-1).This compound significantly inhibited the proliferation and migration of breast cancer cell lines HCC-1937 and MDA-MB-436 by inducing DNA ***,5d induced apoptosis and caused an extended G1/S-phase in these cell *** docking studies revealed that 5d possesses a strong binding affinity toward *** vivo,in a xenograft model,5d effectively reduced tumor growth by downregulating PARP1 ***,compound 5d shows promise as a potential therapeutic agent for the treatment of BRCA wild-type breast cancer.

关键词： Chrysin derivatives PARP1 Antitumor DNA damage Small molecules

Efficient hydrogenolysis of fructose to 1,2-propanediol over bifunctional Ru-WO_(x)-MgO_(y) catalysts under mild reaction conditions via enhancing the chemoselective cleavage of C-C bonds

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Journal of Energy Chemistry 2024年第5期92卷 311-321页

作者： Shuang luo Tie Shu Min Mao Haijie Yu Yuxin Zheng Daqian Ding lingmei Liu Kexin yao Jianjian Wang School of Chemistry and Chemical Engineering State Key Laboratory of Coal Mine Disaster Dynamics and ControlInstitute of Advanced Interdisciplinary StudiesMulti-scale Porous Materials CenterChongqing UniversityChongqing 401331China Key Laboratory for Efficient Conversion and Circular Economy of Coal Chemical Engineering CollegeInner Mongolia University of TechnologyHohhot 010051Inner MongoliaChina

Selective conversion of fructose to 1,2-propanediol(1,2-PDO)is considered as a sustainable and cost-effective alternative to petroleum-based processes,however,this approach still faces challenges associated with low efficiency and harsh reaction ***,we have successfully synthesized a novel bifunctional Ru-WO_(x)-MgO_(y) catalyst through a facile'one-pot'solvothermal ***,this catalyst exhibits exceptional catalytic performances in the conversion of fructose to 1,2-PDO under mild reaction *** yield of 1,2-PDO is up to 56.2%at 140°C for 4 h under an ultra-low hydrogen pressure of only 0.2 MPa,surpassing the reported results in recent literature(below 51%).Comprehensive characterizations and density functional theory(DFT)calculations reveal that the presence of oxygen vacancies in the Ru-WO_(x)-MgO_(y) catalyst,serving as active acidic sites,facilitates the chemoselective cleavage of C-C bonds in fructose,which leads to the generation of active intermediates and ultimately resulted in the high yield of 1,2-PDO.

关键词： Biomass Fructose 1,2-Propanediol Retroaldol condensation Heterogenous catalysis

Antihypertensive effects of whey protein hydrolysate involve reshaping the gut microbiome in spontaneously hypertension rats

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Food Science and Human Wellness 2024年第4期13卷 1974-1986页

作者： Peipei Dou Xiaoyi Li Xiaoxiao Zou Kai Wang Lei yao Zhuo Sun Hui Hong Yongkang luo Yuqing Tan Key Laboratory of Functional Dairy College of Food Science and Nutritional EngineeringChina Agricultural UniversityBeijing 100083China Hebei Dongkang Dairy Co. Ltd.Shijiazhuang 052160China

Novel angiotensin-converting enzyme(ACE)inhibitory peptides were identified from whey protein hydrolysates(WPH)in vitro in our previous study and the antihypertensive abilities of WPH in vivo were further investigated in the current *** indicated that WPH significantly inhibited the development of high blood pressure and tissue injuries caused by *** inhibited ACE activity(20.81%,Pling pathway and Apelin signaling pathway were altered after WPH ***,WPH alleviated serum oxidative stress,indicated by the decreased malondialdehyde content(P<0.01),enhanced total antioxidant capacity(P<0.01)and superoxide dismutase activity(P<0.01).The current study suggests that WPH exhibit promising antihypertensive abilities in vivo and could be a potential alternative for antihypertensive dietary supplements.

关键词： Whey protein hydrolysate Antihypertension Short chain fatty acids Gut microbiome

Laser-assisted synthesis of PtPd alloy for efficient ethanol oxidation

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Nano Research 2024年第7期17卷 6032-6037页

作者： Zihang Chen Tong Liu Huijuan Zhang Beibei Pang Yuanhua Sun Longfei Hu Qiquan luo Xiaokang Liu Linlin Cao Tao yao School of Nuclear Science and Technology National Synchrotron Radiation LaboratoryUniversity of Science and Technology of ChinaHefei 230029China Institutes of Physical Science and Information Technology Anhui UniversityHefei 230601China

The inefficiency of ethanol oxidation reaction(EOR)presents a significant obstacle in harnessing renewable biofuels with high energy density into *** efforts,most Pt-based catalysts still suffer from drawbacks such as poor activity and susceptibility to CO poisoning,particularly in acidic ***,we employed a physical laser-assisted approach to synthetize a PtPd alloy with a 1:1 atomic *** alloy demonstrates remarkable performance in acidic EOR,boasting a high mass activity of 1.86 A·mgPt^(−1)and competitive resistance to *** in situ synchrotron radiation infrared spectroscopy with theoretical calculations,we reveal that the synergic interaction between Pt and Pd enhances both the adsorption of OH*intermediate and the dehydrogenation ability of *** work will prove the feasibility of synthesizing bimetallic alloys by a physical laser-assisted strategy and promote the development of advanced alloy electrocatalysts.

关键词： laser-assisted strategy Pt-based alloy in situ synchrotron radiation infrared spectroscopy ethanol oxidation reaction synergic interaction

Lower extremity peripherally inserted central catheter placement ectopic to the ascending lumbar vein:A case report

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World Journal of Clinical Cases 2024年第8期12卷 1430-1436页

作者： Xiao-Ju Zhu ling Zhao Na Peng Jia-Min luo Shui-Xia Liu Cancer Center Daping HospitalArmy Medical UniversityChongqing 400042China

BACKGROUND Peripherally inserted central catheters(PICCs)are an essential infusion route for oncology patients receiving intravenous treatments,but lower extremity veni-puncture is the preferred technique for patients with superior vena cava syndrome(SVCS).We report the case of a patient with a lower extremity PICC ectopic to the ascending lumbar vein,to indicate and verify PICC catheterisation in the lower extremity is safe and *** hope to provide different per-spectives for clinical PICC venipuncture to get the attention of *** SUMMARY On 24 August 2022,a 58-year-old male was admitted to our department due to an intermittent cough persisting for over a month,which worsened 10 d *** and laboratory investigations suggested the patient with pulmonary malignancy and *** was not an absolute contraindication in this *** extremity venipuncture is the preferred technique because administering upper extremity venous transfusion to patients with SVCS can exacerbate oedema in the head,neck,and upper *** patient and his family were informed about the procedure,and informed consent was *** successful puncture and prompt treatment,the patient was discharged,experiencing some relief from *** Inferior vena cava catheterisation is rare and important for cancer patients with SVCS,particularly in complex situations involving ectopic placement.

关键词： Superior vena cava syndrome Peripherally inserted central catheter Ascending lumbar vein Complications Case report

Protective layer for stable lithium-metal anodes at 60 mA·h/cm^(2) and 60 mA/cm^(2) with ion channel and inductive effect

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Journal of Materiomics 2024年第6期10卷 1252-1260页

作者： Xiao Zhang Zhiwei Chen Jiaojiao Han Qiang Wang Jinshan Wang Juhua luo Jianguang Xu Chi Chen Wei yao School of Materials Science and Engineering Jiangsu Provincial Key Laboratory of Eco-Environmental MaterialsYancheng Institute of TechnologyYancheng 224051China School of Materials and Energy Shanghai Key Laboratory of Engineering Materials Application and EvaluationShanghai Polytechnic UniversityShanghai 201209China CAS Key Laboratory of Design and Assembly of Functional Nanostructures and Fujian Provincial Key Laboratory of NanomaterialsFujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China Xiamen Key Laboratory of Rare Earth Photoelectric Functional Materials and Xiamen Institute of Rare Earth MaterialsHaixi InstituteChinese Academy of SciencesXiamen 361021China

Contradiction between ultrafast nucleation and deposition rates of lithium(Li)crystals at high rate and heterogeneity of Li^(+)flux resulting from concentration polarization has compromised the performance of Li metal anodes especially at high areal capacity and current ***,multifunctional protective layer consisting of MoO_(3) nanobelt films(MoO_(3)-NF)is introduced on the surface of Li by a simple rolling *** strong binding energy between Li and MoO_(3) guides the homogeneous nucleation and deposition of Li,while the nanobelt networks provide effective ion channels for uniform distribution of the Li+*** of the novel multifunctional protective layer,the MoO_(3)-NF@Li anodes demonstrate a remarkable stability for 800 h with ultralow overpotential of 159 mV at extreme harsh conditions of 60 mA·h/cm^(2) and 60 mA/cm^(2).MoO_(3)-NF@Li||LiNi_(0.6)Co_(0.2)Mn_(0.2)O_(2) full-cells can run 100 cycles with a superior capacity retention of 84.2%under practical test conditions,demonstrating great potential for high output and energy-density metal batteries.

关键词： Multifunctional protective layer Ion channel Inductive effect High areal capacity Li metal anodes

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Blossoms Shanghai

今日中国（西文版） 2024年第3期 70-71页

作者： luo yao 不详

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If You Are the One Ⅲ

今日中国（西文版） 2024年第2期 70-71页

作者： luo yao 不详