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Comparison of concomitant and subsequent cholangiocarcinomas associated with hepatolithiasis:Clinical implications

World Journal of Gastroenterology 2013年第3期19卷 375-380页

作者： Chia-cheng lin Ping-Yi lin yao-li chen Department of Surgery Changhua Christian Hospital Transplant Medicine and Surgery Research Centre Changhua Christian Hospital School of Medicine Chung Shan Medical University

AIM:To compare the outcomes of concomitant cholangiocarcinoma(C-CCA)and subsequent cholangiocar-cinoma(S-CCA)associated with hepatolithiasis. METHODS:From December 1987 to December 2007, 276 patients underwent hepatic resection for hepa-tolithiasis in Changhua Christian ***-five patients were excluded due to incomplete medical records and the remaining 211 patients constituted our study population *** patients were diag-nosed with C-CCA based on the preoperative biopsy or postoperative *** the follow-up period, 12 patients developed *** diagnosis of S-CCA was made by image-guided biopsy or by pathology if surgical intervention was carried *** charts were reviewed to collect clinical *** such as CCA incidence,interval from operation to CCA diagnosis,interval from CCA diagnosis to disease-related death,follow-up time,and mortality rate were calculated for both the C-CCA and S-CCA *** outcomes of the C-CCA and S-CCA groups were math-ematically compared and analysed. RESULTS:Our study demonstrates the clinical implications and the survival outcomes of C-CCA and S-CCA. Among the patients with unilateral hepatolithiasis,the incidence rates of C-CCA and S-CCA were fairly similar (4.8%vs 4.5%,respectively,P=0.906).However,for the patients with bilateral hepatolithiasis,the incidence rate of S-CCA(12.2%)was higher than that of C-CCA (4.7%),although the sample size was limited and the difference between two groups was not statistically sig-nificant(P=0.211).The average follow-up time was 56 mo for the C-CCA group and 71 mo for the S-CCA *** to the average time intervals from operation to CCA diagnosis,S-CCA was diagnosed after 67 mo from the initial *** average time intervals from the diagnoses of CCA to disease-related death was 41 mo for the C-CCA group and 4 mo for the S-CCA group,this difference approached statistical sig-nificance(P=0.075).Regarding the rates of overall and disease-

关键词： Hepatolithiasis Intrahepatic duct stones Recurrent pyogenic cholangitis Cholangiocarcinoma Concomitant cholangiocarcinoma Subsequent cholangio-carcinoma

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A New xanthene from Blumea riparia

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Chinese Chemical Letters 2007年第3期18卷 303-305页

作者： Jia Qing Cao yao yao Huan chen li Qiao Yu Zhi Zhou Yue Hu Pei School of Traditional Chinese Materia Medica Shenyang Pharmaceutical University Shenyang 110016 China

A new xanthene, named blumeaxanthene, was isolated from Blumea riparia DC. The structure was elucidated on the basis of the data of NMR, MS, IR.

关键词： Blumea riparia DC. Compositae Blumeaxanthene

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Role of doublecortin-like kinase 1 and leucine-rich repeat-containing G-protein-coupled receptor 5 in patients with stage Ⅱ/Ⅲ colorectal cancer:Cancer progression and prognosis

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World Journal of Gastroenterology 2020年第43期26卷 6853-6866页

作者： Xue-ling Kang li-Rui He yao-li chen Shu-Bin Wang Department of Oncology Peking University Shenzhen HospitalShenzhen-Peking University-Hong Kong University of Science and Technology Medical CenterShenzhen 518036Guangdong ProvinceChina Department of Gastrointestinal Surgery Peking University Shenzhen HospitalShenzhen 518036Guangdong ProvinceChina Department of Pathology Peking University Shenzhen HospitalShenzhen 518036Guangdong ProvinceChina Department of Oncology Peking University Shenzhen HospitalShenzhen Key Laboratory of Gastrointestinal Cancer Translational ResearchChina Cancer Institute of Shenzhen-Peking University-Hong Kong University of Science and Technology Medical CenterShenzhen 518036Guangdong ProvinceChina

BACKGROUND Cancer stem cells(CSCs)are a subpopulation of cancer cells with the potential of self-renewal and *** play critical roles in tumorigenesis,recurrence,metastasis,radiation tolerance and *** To assess the expression patterns and clinical potential of doublecortin-like kinase 1(DCLK1)and leucine-rich repeat-containing G-protein-coupled receptor 5(Lgr5),as prognostic CSC markers of colorectal cancer(CRC).METHODS The expression of DCLK1 and Lgr5 in CRC tissue sections from 92 patients was determined by *** case was evaluated using a combined scoring method based on signal intensity staining(scored 0-3)and the proportion of positively stained cancer cells(scored 0-3).The final staining score was calculated as the intensity score multiplied by the proportion *** expression of DCLK1 and Lgr5 was defined as a score of 0-3;high expression of DCLK1 and Lgr5 was defined as a score of≥*** were categorized as either high or low expression,and the correlation between the expression of DCLK1 or Lgr5 and clinicopathological factors was *** DCLK1 and Lgr5 expression levels were significantly positively *** patients with high DCLK1,Lgr5 and DCLK1/Lgr5 expressions had poorer progression-free survival and overall ***,high expression of DCLK1 was an independent prognostic factor for recurrence and overall survival in patients with CRC by multivariate analysis(P=0.026 and P=0.049,respectively).CONCLUSION DCLK1 may be a potential CSC marker for the recurrence and survival of CRC patients.

关键词： Colorectal cancer Cancer stem cells Doublecortin-like kinase 1 Leucine-rich repeat-containing G-protein-coupled receptor 5 Cancer prognosis Cancer progression

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Differentiation between dysplastic nodule and early-stage hepatocellular carcinoma: The utility of conventional MR imaging

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World Journal of Gastroenterology 2013年第42期19卷 7433-7439页

作者： chen-Te Chou Jung-Mao Chou Ting-An Chang Shiu-Feng Huang Chia-Bang chen yao-li chen Ran-Chou chen Department of Biomedical Imaging and Radiological Science National Yang-Ming Medical University Department of Radiology Chang-Hua Christian Hospital Department of Pathology Taipei City Hospital Transplant Medicine and Surgery Research Centre Chang-Hua Christian Hospital Department of Radiology Taipei City Hospital

AIM:To elucidate the variety of ways early-stage hepatocellular carcinoma(HCC)can appear on magnetic resonance(MR)imaging by analyzing T1-weighted,T2-weighted,and gadolinium-enhanced dynamic ***:Seventy-three patients with well-differentiated HCC(wHCC)or dysplastic nodules were retrospectively identified from medical records,and new histological sections were prepared and *** tumor nodules were categorized into three groups:dysplastic nodule(DN),wHCC compatible with Edmondson-Steiner grade I HCC(w1-HCC),and wHCC compatible with Edmondson-Steiner gradeⅡHCC(w2-HCC).The signal intensity on pre-contrast MR imaging and the enhancing pattern for each tumor were recorded and compared between the three tumor ***:Among the 73 patients,14 were diagnosed as having DN,40 were diagnosed as having w1-HCC,and 19 were diagnosed as having *** measurements on T2-weighted axial images(T2WI)were statistically significant between DNs and wHCC(P=0.006)and between DN and w1-HCC(P=0.02).The other imaging features revealed no significant differences between DN and wHCC or between DN and *** on both T1W out-phase imaging(P=0.007)and arterial enhancement on dynamic study(P=0.005)showed statistically significant differences between w1-HCC and *** other imaging features revealed no significant differences between w1-HCC and ***:In the follow-up for a cirrhotic nodule,increased signal intensity on T2WI may be a sign of malignant ***,a noted loss of hyperintensity on T1WI and the detection of arterial enhancement might indicate further progression of the histological grade.

关键词： Dysplastic nodule Hepatocellular carcinoma Histological grading Magnetic resonance imaging Well-differentiated hepatocellular carcinoma

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CAPILLARY ZONE ELECTROPHORESIS OF NONOSACCHARIDES

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Chinese Chemical Letters 1993年第4期4卷 343-346页

作者： RuiFeng yao Yi chen li Wen CHANG Institute of Chemistry,Academia Sinica,Beijing 100080

A method for the analysis of monosaccharides derived from glycoproteins and glycolipids was described using the newly developed technique of capillary zone electrophoresis(CZE).It is found that,at ca.0.5-5 nL in- jection,CZE can offer a high resolution of most monoses from glycoprotein and glycolipids.A mixture of amino-and non-aminomonosaccharides,which is difficult to separate with chromatographic methods,was separated complet- ely by CZE in borate buffer after the monosaccharides were derivatized with 1-naphthylamine.

关键词： CZE chen CAPILLARY ZONE ELECTROPHORESIS OF NONOSACCHARIDES

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胰岛素瘤合并继发性肾上腺皮质功能不全一例

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浙江大学学报（医学版） 2017年第6期46卷 662-665页

作者：李瑶陈慧兰州大学第二医院内分泌代谢科甘肃兰州730030

一例中年男性反复发生低血糖的患者,经过各项相关检查诊断为胰岛素瘤。患者促肾上腺皮质激素和皮质醇水平低,推测存在继发性肾上腺皮质功能不全,补充糖皮质激素后行胰岛素瘤切除术。术后停激素替代疗法,患者促肾上腺皮质激素和皮质醇水... 详细信息

一例中年男性反复发生低血糖的患者,经过各项相关检查诊断为胰岛素瘤。患者促肾上腺皮质激素和皮质醇水平低,推测存在继发性肾上腺皮质功能不全,补充糖皮质激素后行胰岛素瘤切除术。术后停激素替代疗法,患者促肾上腺皮质激素和皮质醇水平正常,生理节律恢复。

关键词：胰岛素瘤/外科学低血糖症肾上腺功能减退/并发症病例报告

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Building of hFⅨ transgenic mice by spermatogenic cells

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Chinese Science Bulletin 2003年第19期48卷 2061-2063页

作者： WANG Ning, chen Xiaoguang, chen li, yao Jihua, chen Haoming, SHEN Qi & XUE Jinglun State Key Laboratory of Genetic Engineering, Institute of Genetics, School of life Sciences, Fudan University, Shanghai 200433, China Correspondence should be addressed to Xue Jinglun (e-mail: jlxue @***) State Key Laboratory of Genetic Engineering Institute of Genetics School of Life Sciences Fudan University Shanghai 200433 China

Human FⅨ expression vector pCMVⅨ was packaged by EffecteneTM reagent and injected into mice seminiferous tubules with glass pipettes. The expressional frame of pCMVⅨ was examined by PCR and Southern blotting among 41 progenies. There were 2 (4%) mice being integrated with hFⅨ gene into chromosomes. 4.6 ng/mL of hFⅨ protein was expressed in plasma of one mouse, which was tested by EliSA. We demonstrated that building of transgenic animals by spermatogonial stem cells is an efficient method. Meanwhile, it has also been proved to be an alternative choice for mammary gland bioreactor.

关键词：基因转录老鼠精子生成细胞抗血友病因子 FⅨ 表达载体 pCMVⅨ 乳腺生物反应器

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Recent progress in the applications of presynaptic dopaminergic positron emission tomography imaging in parkinsonism

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Neural Regeneration Research 2025年第1期20卷 93-106页

作者： Yujie Yang Xinyi li Jiaying Lu Jingjie Ge Mingjia chen Ruixin yao Mei Tian Jian Wang Fengtao liu Chuantao Zuo Key Laboratory of Arrhythmias Ministry of EducationDepartment of Medical GeneticsShanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina Department of Neurology National Research Center for Aging and MedicineNational Center for Neurological Disordersand State Key Laboratory of Medical NeurobiologyHuashan HospitalFudan UniversityShanghaiChina Department of Nuclear Medicine&PET Center National Center for Neurological Disordersand National Clinical Research Center for Aging and MedicineHuashan HospitalFudan UniversityShanghaiChina International Human Phenome Institutes(Shanghai) ShanghaiChina Human Phenome Institute Fudan UniversityShanghaiChina

Nowadays,presynaptic dopaminergic positron emission tomography,which assesses deficiencies in dopamine synthesis,storage,and transport,is widely utilized for early diagnosis and differential diagnosis of *** review provides a comprehensive summary of the latest developments in the application of presynaptic dopaminergic positron emission tomography imaging in disorders that manifest *** conducted a thorough literature search using reputable databases such as PubMed and Web of *** criteria involved identifying peer-reviewed articles published within the last 5 years,with emphasis on their relevance to clinical *** findings from these studies highlight that presynaptic dopaminergic positron emission tomography has demonstrated potential not only in diagnosing and differentiating various Parkinsonian conditions but also in assessing disease severity and predicting ***,when employed in conjunction with other imaging modalities and advanced analytical methods,presynaptic dopaminergic positron emission tomography has been validated as a reliable in vivo *** validation extends to screening and exploring potential neuropathological mechanisms associated with dopaminergic *** summary,the insights gained from interpreting these studies are crucial for enhancing the effectiveness of preclinical investigations and clinical trials,ultimately advancing toward the goals of neuroregeneration in parkinsonian disorders.

关键词： aromatic amino acid decarboxylase brain imaging dopamine transporter Parkinson’s disease parkinsonism positron emission tomography presynaptic dopaminergic function vesicle monoamine transporter type 2

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Müller cells are activated in response to retinal outer nuclear layer degeneration in rats subjected to simulated weightlessness conditions

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Neural Regeneration Research 2025年第7期20卷 2116-2128页

作者： Yuxue Mu Ning Zhang Dongyu Wei Guoqing Yang lilingxuan yao Xinyue Xu Yang li Junhui Xue Zuoming Zhang Tao chen Aerospace Clinical Medical Center School of Aerospace MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina Department of Aviation Medicine Xijing HospitalAir Force Medical UniversityXi’anShaanxi ProvinceChina Department of Emergency Medicine Wuhan No.1 HospitalWuhanHubei ProvinceChina Third Regiment School of Basic MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina Fourth Regiment School of Basic MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina

A microgravity environment has been shown to cause ocular damage and affect visual acuity,but the underlying mechanisms remain ***,we established an animal model of weightlessness via tail suspension to examine the pathological changes and molecular mechanisms of retinal damage under *** 4 weeks of tail suspension,there were no notable alterations in retinal function and morphology,while after 8 weeks of tail suspension,significant reductions in retinal function were observed,and the outer nuclear layer was thinner,with abundant apoptotic *** investigate the mechanism underlying the degenerative changes that occurred in the outer nuclear layer of the retina,proteomics was used to analyze differentially expressed proteins in rat retinas after 8 weeks of tail *** results showed that the expression levels of fibroblast growth factor 2(also known as basic fibroblast growth factor)and glial fibrillary acidic protein,which are closely related to Müller cell activation,were significantly *** addition,Müller cell regeneration and Müller cell gliosis were observed after 4 and 8 weeks,respectively,of simulated *** findings indicate that Müller cells play an important regulatory role in retinal outer nuclear layer degeneration during weightlessness.

关键词： glial fibrous acidic protein gliosis Müller cells nerve growth factor neural differentiation neurodegeneration proteomic retinal degeneration retinal outer nuclear layer simulated weightlessness

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Highly conductive and stable iodine doped argyrodite electrolyte for all-solid-state lithium batteries

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Journal of Energy Chemistry 2025年第1期100卷 50-58页

作者： Gaozhan liu Jing Zhang Jing Yang Jinghui chen Xingyue Xiao Xiayin yao Ningbo Institute of Materials Technology and Engineering Chinese Academy of Sciences Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences

lithium argyrodites with high ionic conductivity and low cost are considered as one of the most prospective solid electrolytes for all-solid-state lithium ***,the poor chemical stability and compatibility with lithium metal limit their ***,li5.4PS4.4Cl1.4I0.2solid electrolyte with high ionic conductivity of 11.49 m S cm-1and improved chemical stability is synthesized by iodine *** ultra-thin li5.4PS4.4Cl1.4I0.2membrane with thickness of 10μm can be obtained by wet coating process,exhibiting a high ionic conductivity of 2.09 mS cm-1and low areal resistance of 1.17Ω***,iodine doping could in-situ form liI at the lithium/electrolyte interface and improve the critical current density of li5.4PS4.4Cl1.6from 0.8 to 1.35 mA *** resultant liCoO2/li5.4PS4.4Cl1.4I0.2/li battery shows excellent cycling stability at 1 C,with a reversible specific capacity of 110.1 mA h g-1and a retention of 80.5% after 1000 *** addition,the assembled liCoO2/li5.4PS4.4Cl1.4I0.2membrane/li pouch cell delivers an initial discharge capacity of 110.4 mA h g-1and 80.5% capacity retention after 100 cycles.

关键词： Solid-State Batteries

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