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Differential gene and protein expression between rat tibial nerve and common peroneal nerve during wallerian degeneration

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Neural Regeneration Research 2019年第12期14卷 2183-2191页

作者： yao-fa lin Zheng Xie Jun Zhou Gang Yin Hao-Dong lin Department of Orthopedic Surgery Changzheng Hospital the Second Military Medical University Shanghai China Department of Orthopedic Surgery Shanghai General Hospital Shanghai Jiao Tong University School of Medicine Shanghai China

Wallerian degeneration and nerve regeneration after injury are complex processes involving many genes, proteins and cytokines. After different peripheral nerve injuries the regeneration rate can differ. Whether this is caused by differential expression of genes and proteins during Wallerian degeneration remains unclear. The right tibial nerve and the common peroneal nerve of the same rat were exposed and completely cut through and then sutured in the same horizontal plane. On days 1, 7, 14, and 21 after surgery, 1–2 cm of nerve tissue distal to the suture site was dissected out from the tibial and common peroneal nerves. The differences in gene and protein expression during Wallerian degeneration of the injured nerves were then studied by RNA sequencing and proteomic techniques. In the tibial and common peroneal nerves, there were 1718, 1374, 1187, and 2195 differentially expressed genes, and 477, 447, 619, and 495 differentially expressed proteins on days 1, 7, 14, and 21 after surgery, respectively. Forty-seven pathways were activated during Wallerian degeneration. Three genes showing significant differential expression by RNA sequencing (Hoxd4, Lpcat4 and Tbx1) were assayed by real-time quantitative polymerase chain reaction. RNA sequencing and real-time quantitative polymerase chain reaction results were consistent. Our findings showed that expression of genes and proteins in injured tibial and the common peroneal nerves were significantly different during Wallerian degeneration at different time points. This suggests that the biological processes during Wallerian degeneration are different in different peripheral nerves after injury. The procedure was approved by the Animal Experimental Ethics Committee of the Second Military Medical University, China (approval No. CZ20160218) on February 18, 2016.

关键词： nerve regeneration peripheral nerves peripheral nerve injuries Wallerian degeneration tibial nerve common peroneal nerve RNA sequencing proteomic real-time quantitative polymerase chain reaction neural regeneration

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Effect of exogenous spastin combined with polyethylene glycol on sciatic nerve injury

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Neural Regeneration Research 2019年第7期14卷 1271-1279页

作者： yao-fa lin Zheng Xie Jun Zhou Hui-Hao Chen Wan-Wan Shao Hao-Dong lin Department of Orthopedics Changzheng Hospitalthe Second Military Medical University Department of Orthopedics the Second People's Hospital of Karamay

Polyethylene glycol can connect the distal and proximal ends of an injured nerve at the cellular level through axonal fusion to avoid Wallerian degeneration of the injured distal nerve and promote peripheral nerve ***,this method can only prevent Wallerian degeneration in 10% of axons because the cytoskeleton is not repaired in a timely *** of the cytoskeletal trunk and microtubule network has been suggested to be the key for improving the efficiency of axonal *** a microtubule-severing protein,spastin has been used to enhance cytoskeletal ***,we hypothesized that spastin combined with polyethylene glycol can more effectively promote peripheral nerve regeneration.A total of 120 male Sprague-Dawley rats were randomly divided into sham,suture,polyethylene glycol,and polyethylene glycol + spastin *** suture group rats,only traditional nerve anastomosis of the end-to-end suture was performed after transection of the sciatic *** polyethylene glycol and polyethylene glycol + spastin groups,50 μL of polyethylene glycol or 25 μL of polyethylene glycol + 25 μL of spastin,respectively,were injected immediately under the epineurium of the distal *** fiber regeneration distance,which was used to assess early nerve regeneration at 1 week after surgery,was shortest in the suture group,followed by polyethylene glycol group and greatest in the polyethylene glycol + spastin *** assessment of motor function recovery in rats showed that limb function was restored in polyethylene glycol and polyethylene glycol + spastin groups at 8 weeks after *** 1,2,4 and 8 weeks after surgery,sciatic functional index values and percentages of gastrocnemius muscle wet weight were highest in the sham group,followed by polyethylene glycol + spastin and polyethylene glycol groups,and lowest in the suture *** staining was utilized to assess the morphology of muscle *** change

关键词： nerve regeneration peripheral nerves Wallerian degeneration polyethylene glycol axonal fusion spastin peripheral nerve injuries Masson staining microtubule neural regeneration

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Nanostructured ZnO/BiVO_(4)I-scheme heterojunctions for piezocatalytic degradation of organic dyes via harvesting ultrasonic vibration energy

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 488-497页

作者： Yiling Li Xiaoyao Yu Yingjie Zhou yao lin Ying Wu Key Laboratory of the Ministry of Education for Advanced Catalysis Materials College of Chemistry and Materials ScienceZhejiang Normal UniversityJinhua 321004China

BiVO_(4)porous spheres modified by ZnO were designed and synthesized using a facile two-step *** resulting ZnO/BiVO_(4)composite catalysts have shown remarkable efficiency as piezoelectric catalysts for degrading Rhodamine B(RhB)unde mechanical vibrations,they exhibit superior activity compared to pure *** 40wt%ZnO/BiVO_(4)heterojunction composite displayed the highest activity,along with good stability and *** enhanced piezoelectric catalytic activity can be attributed to the form ation of an I-scheme heterojunction structure,which can effectively inhibit the electron-hole ***,hole(h+)and superoxide radical(·O_(2)^(-))are proved to be the primary active ***,ZnO/BiVO_(4)stands as an efficient and stable piezoelectric catalyst with broad potential application in the field of environmental water pollution treatment.

关键词： piezoelectric catalytic heterojunction dye degradation ultrasonic vibration

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Mainchain conformation ordering self-assembly tailored room temperature phosphorescence emission

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Science China Chemistry 2025年第01期 329-336页

作者： Yuzhu Li Yumeng Gao Feng Tian Yu Wang Yuan yao Shaoliang lin Xiang Ma Binbin Xu Shanghai Key Laboratory of Advanced Polymeric Materials Key Laboratory for Ultrafine Materials of Ministry of Education School of Materials Science and Engineering East China University of Science and Technology Shanghai Synchrotron Radiation facility Shanghai Advanced Research Institute Chinese Academy of Sciences Key Laboratory for Advance Materials and Feringa Noble Prize Scientist Joint Research Centre Frontiers Science for Materiobiology and Dynamic Chemistry School of Chemistry and Molecular Engineering East China University of Science & Technology

Developing organic room-temperature phosphorescence （RTP） materials with a wide range of tunable-emission is significant in expanding the applications of RTP ***,we rationally designed amphiphilic alternating copolymers poly(1,2-bis（4-alkoxyphenyl）ethane-1,2-dione-alt-（ethylene glycol）x)(P（Bz-alt-EGx）) that combined the advantage of alternating benzil and EGxskeleton,and tunable mainchain *** a mainchain conformation ordering assembly （COA） process,P（Bz-alt-EGx） self-assembled into well-defined platelets,and such assemblies emitted blue RTP at ca.425 nm due to the ordered folded-chain conformation and confined *** contrast,traditional self-assembly （TA） of P（Bz-alt-EGx） obtained less ordered aggregates,such as asymmetric worms,vesicles,and rod-like *** resultant less ordered aggregates exhibited yellow-green RTP at ca.550 *** wide-tuning RTP emission in solution （between blue and yellow-green,over125 nm） is realized using the P（Bz-alt-EGx） alternating copolymers under the treatment of different self-assembly *** study uncovers a new strategy to tailor the RTP emission through different self-assembly pathways and holds great promise for the fabrication of advanced optical materials.

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泥石流防治工程规划的可拓决策技术

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山地学报 2001年第6期19卷 541-545页

作者：汤家法姚令侃王沁西南交通大学土木工程学院西南交通大学土木工程学院四川成都610031

泥石流防治工程规划属于一种半结构化的决策问题。可拓决策是根据物元的可拓性 ,采用定性分析与定量计算相结合的方法解决矛盾问题的一种决策技术。本文根据可拓学的基本理论与方法 ,提出了一种首先基于系统物元相容性评判进行方案比选 ... 详细信息

泥石流防治工程规划属于一种半结构化的决策问题。可拓决策是根据物元的可拓性 ,采用定性分析与定量计算相结合的方法解决矛盾问题的一种决策技术。本文根据可拓学的基本理论与方法 ,提出了一种首先基于系统物元相容性评判进行方案比选 ;再对初选方案通过系统物元变换进行方案优化设计的可拓决策模式 ,并以成昆铁路大田箐沟泥石流防治方案的优化设计为例说明这种可拓决策技术的应用程式。

关键词：泥石流防治相容度评判物元变换可拓决策

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Photoelectron Spectroscopy, Photoionization Mass Spectroscopy, and Theoretical Study on CCl3SSCN

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Chinese Journal of Chemical Physics 2008年第2期21卷 93-98页

作者： lin Du Li yao Mao-fa Ge Beijing National Laboratory for Molecular Sciences State Key Laboratory for Structural Chemistry of Unstable and Stable Species Institute of Chemistry Chinese Academy of Sciences Beijing 100080 China Graduate School of Chinese Academy of Sciences Beijing 100039 China

Trichloromethanesulfenyl thiocyanate, CCl3SSCN, was generated and studied by photoelectron spectroscopy （PES）, photoionization mass spectroscopy （PIMS）, and theoretical calculations. This molecule exhibits a gauche conformation, and the torsional angle around S-S bond is 91.4° due to the sulfur-sulfur lone pair interactions. After ionization, the ground-state cationic-radical form of CCl3SSCN＋ adopts a trans planar main-atom structure with Cs symmetry. The highest occupied molecular orbital （HOMO） of CC13SSCN corresponds to the electrons mainly localized on the sulfur 3p lone pair MO. The first ionization energy is determined to be 10.40 cV.

关键词： Photoelectron spectroscopy Photoionization mass spectroscopy Electronic structure

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Infiltration by monocytes of the central nervous system and its role in multiple sclerosis: reflections on therapeutic strategies

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Neural Regeneration Research 2025年第3期20卷 779-793页

作者： Guangyong Zhang Qing yao Chubing Long Pengcheng Yi Jiali Song Luojia Wu Wei Wan Xiuqin Rao Yue lin Gen Wei Jun Ying Fuzhou Hua Department of Anesthesiology the Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi ProvinceChina Key Laboratory of Anesthesiology of Jiangxi Province NanchangJiangxi ProvinceChina

Mononuclear macrophage infiltration in the central nervous system is a prominent feature of neuroinflammation. Recent studies on the pathogenesis and progression of multiple sclerosis have highlighted the multiple roles of mononuclear macrophages in the neuroinflammatory process. Monocytes play a significant role in neuroinflammation, and managing neuroinflammation by manipulating peripheral monocytes stands out as an effective strategy for the treatment of multiple sclerosis, leading to improved patient outcomes. This review outlines the steps involved in the entry of myeloid monocytes into the central nervous system that are targets for effective intervention: the activation of bone marrow hematopoiesis, migration of monocytes in the blood, and penetration of the blood–brain barrier by monocytes. Finally, we summarize the different monocyte subpopulations and their effects on the central nervous system based on phenotypic differences. As activated microglia resemble monocyte-derived macrophages, it is important to accurately identify the role of monocyte-derived macrophages in disease. Depending on the roles played by monocyte-derived macrophages at different stages of the disease, several of these processes can be interrupted to limit neuroinflammation and improve patient prognosis. Here, we discuss possible strategies to target monocytes in neurological diseases, focusing on three key aspects of monocyte infiltration into the central nervous system, to provide new ideas for the treatment of neurodegenerative diseases.

关键词： blood–brain barrier macrophages monocytes multiple sclerosis neuroinflammation review therapy

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Wear Resistance of CO_2 Corrosion Product Scale Formed at High Temperature

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Journal of Iron and Steel Research International 2006年第5期13卷 47-52页

作者： lin Guan-fa ZHENG Mao-sheng BAI Zhen-quan FENG yao-rong Key Laboratory for Mechanical and Environmental Behavior of Tubular Goods China National Petroleum Corporation Xi＇an 710065 Shaanxi China School of Material Science and Engineering Xi＇an Jiaotong University Xi＇an 710049 Shaanxi China

To investigate the correlation between structure characteristics and wear resistance of CO2 corrosion product scales at high temperature and high pressure, an autoclave was used to prepare CO2 corrosion product scales on N80 steel in carbon dioxide corrosion environment. The correlation between wear resistance of the scales and many other factors, such as temperature, pressure, morphology, structure, velocity of fluid medium, sand grain size, and so on, was comparatively analyzed by a self assembled wear device, and the scale morphologies before or after being worn were observed by scanning electron microscope （SEM）. And then the surface grain size and thickness of scale were measured. The results showed that the cross-section of the corrosion scale was of a double-layer structure, the outer layer of which was composed of regular crystals, whereas the inner layer was a thin scale of fine grains. The outer grain size and thickness of scale varied with temperature, and the initial wear loss was consistent with the surface grain size; at the same time, the total wear loss corresponded to the thickness of scale. Compared to wear resist- ance in different depths of the scale, it was found that the structure of scale was a double-layer structure in cross-section, and the wear resistance of inner layer was better than that of the outer layer; the closer the scale to the matrix, the greater was the wear resistance of scale; and the larger the size or the higher the rotary speed of solid grain in multiphase flowing medium, the more was the wear loss of scale.

关键词： CO2 corrosion corrosion product scale wear N80 steel morphology structure

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Research on Genesis of Pyrite near the Permian-Triassic Boundary in Meishan,Zhejiang,China

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Journal of China University of Mining and Technology 2006年第4期16卷 457-460页

作者： JIANG yao-fa TANG Yue-gang CHOU Chen-lin Department of Resourses and Geoscience China University of Mining ＆ Technology Beijing 100083 China Xuzhou Institute of A rchitectural Technology Xuzhou Jiangsu 221008 China Illinois State Geological Survey Champaign IL 61820 U.S.A

The content and crystal forms of pyrite and sulfur isotope composition of pyrite sulfur as well as its vertical distribution near the Permian-Triassic （P/T） boundary in the Meishan section, Changxing county, Zhejiang province, China were studied using geological, petrological, mineralogical and geochemical methods （techniques）. The result showed that the genesis of abundant pyrites in bed 24e2 at the uppermost part of the Changxing Formation in the Me- ishan section may be related to volcanic activity. In bed 24e2 of the Meishan section, pyrite has its highest content of 1.84% and the sulfur isotope composition has the highest 834S value at ＋2.2%0 which is very similar to that of the average value of volcanic gas, There are some volcanic products such as β-quartz, siliceous cylinders and siliceous spherules which coexisted with pyrites in beds 24e2 and 24f. It can be concluded that a large quantity of volcanic ash fell into the South China Sea and was incorporated into marine sediments during the formation of limestone at the uppermost part of the Changxing Formation. The volcanic eruption with massive amounts of H2S and SO2 gas at the end of the Permian period resulted in the enrichment of HES in the South China Sea areas, The reaction of H2S with reactive iron minerals formed the mass of abundant pyrites.

关键词： pyrites sulfur isotope β-quartz Permian-Triassic boundary volcanism

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Investigation of erosion-corrosion behavior of Q235B steel in liquid-solid flows

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Petroleum Science 2022年第5期19卷 2358-2373页

作者： Yan-lin Zhao Fu-Xiang Ye Ge Zhang Jun yao Yu-fa Liu Shi-Gang Dong International Joint Laboratory on Clean Energy Science and Technology Beijing Key Laboratory of Process Fluid Filtration and SeparationCollege of Mechanical and Transportation EngineeringChina University of PetroleumBeijing102249People’s Republic of China College of Energy Xiamen UniversityXiamen361005People’s Republic of China

This work aims to investigate the erosion-corrosion behavior of Q235B steel in liquid-solid two-phase *** weight loss rate,surface morphology and electrochemical parameters of Q235B steel at different temperatures(20℃,30℃,40℃)and flow velocities(6 m/s,7 m/s,8 m/s,9 m/s,10 m/s)were studied *** results show that the weight loss rate of Q235B steel specimens after erosion-corrosion increases with increasing flow velocity and *** the erosion-corrosion process,the corrosion rates of specimens increase with increasing flow *** results of surface morphology show that the circular pits with clear edges are distributed randomly over specimen surface at low flow velocity,but the pit edge becomes vague at high flow *** temperature increasing,the erosion-corrosion damage became serious as shown by the aggregation of large and small pits on specimen *** working mechanism of erosion-corrosion is found to vary with flow velocity and *** relationships among erosion-corrosion components are quantitatively represented and show that synergy dominates the progress of material *** enhances erosion that is a dominant component in the *** inactions of erosion-corrosion can be described by"synergistic"and"additive"*** results show that"additive"effect becomes more significant with increasing flow velocity but decreases with increasing temperature,while"synergistic"effect is not sensitive to flow velocity and temperature.

关键词： Erosion-corrosion Liquid-solid Synergy Flow velocity Temperature

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