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Effect of mechanical stresses on degradation behavior of high-purity magnesium in bone environments

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Journal of Materials Science & Technology 2024年第4期171卷 252-261页

作者： yan yao Jie Xia Lizhen Wang Yuanming Gao Xili Ding Chao Wang Yubo Fan Key Laboratory of Biomechanics and Mechanobiology(Beihang University) Ministry of EducationBeijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringSchool of Engineering MedicineBeihang UniversityBeijing 100083China

High-purity(HP)magnesium(Mg)has emerged as a promising biomaterial for supporting functional bone *** previous study found that mechanical stresses and the surrounding fibrotic tissue(subcuta-neous)both play crucial roles in the degradation of HP ***,due to challenges in the degradation and regeneration process in vivo,it remains unclear how stress affects HP Mg degradation in bone en-vironments,limiting its further *** this study,novel loading devices were designed and the effects of tensile and compressive stresses on HP Mg degradation in vivo and in vitro bone environments were quantitatively *** addition,bone osteointegration around HP Mg was explored *** stress increases the degradation rate of HP Mg in vivo and in *** Mg degradation in vivo is more sensitive to stress factors than in vitro,but the sensitivity decreases with corrosion *** volume loss rate of HP Mg is multilinear with the applied stress and degradation *** volume of bone tissue surrounding HP Mg is larger in the no-stress group compared to the stressed groups,which is more pronounced with increasing implantation *** results provide valuable insights for optimiz-ing the design of HP Mg-based implants considering load *** will help to achieve a balance between the degradation rate of the implant and the regeneration rate of the surrounding bone.

关键词： High-purity magnesium Quantitative stresses Degradation Bone environments In vivo and in vitro

Atomic tailoring-induced deficiency in tungsten oxides for high-performance energy-related devices

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Tungsten 2024年第2期6卷 269-277页

作者： Jing-Huang Lin yao-Tian yan Jun-Lei Qi Chen-yang Zha Institute of Applied Physics and Materials Engineering Zhuhai UM Science and Technology Research InstituteUniversity of MacaoTaipaMacao SAR 999078China State Key Laboratory of Advanced Welding and Joining Harbin Institute of TechnologyHarbin 150001China Jiangmen Laboratory of Carbon Science and Technology Hong Kong University of Science and Technology(Guangzhou)Jiangmen 529199China Key Laboratory of Flexible Electronics School of Flexible Electronics(Future Technologies)Institute of Advanced MaterialsNanjing Tech UniversityNanjing 211816China

Nowadays,tungsten oxides,as a typical transition metal oxide,are widely and intensively investigated owing to their excellent material properties and device *** oxygen defi ciency in tungsten oxides is typically the key to enhance their performances for a variety of critical technological *** a gradual increase of oxygen defi ciency,various non-stoichiometric tungsten oxides can be formed by re-adjustment of the atomic arrangement,which exhibits superior performances than their traditional stoichiometric *** review mainly focuses on the recent advances in oxygen-defi cient tungsten oxides from the point of atomic structures,including the forming mechanism of non-stoichiometric tungsten oxides and the superiority of these oxygen-defi cient tungsten oxides in energy-related ***,the challenge and perspective of oxygen-defi cient tungsten oxides are also discussed.

关键词： Oxygen defi ciency Tungsten oxide Atomic structures Catalyst Storage

Urinary exosomal microRNA-145-5p and microRNA-27a-3p act as noninvasive diagnostic biomarkers for diabetic kidney disease

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World Journal of Diabetes 2024年第1期15卷 92-104页

作者： Lu-Lu Han Sheng-Hai Wang Ming-yan yao Hong Zhou Department of Endocrinology The Second Hospital of Hebei Medical UniversityShijiazhuang 050000Hebei ProvinceChina Department of Endocrinology Baoding No.1 Central HospitalBaoding 071000Hebei ProvinceChina Department of Critical Care Medicine The Affiliated Hospital of Hebei UniversityBaoding 071000Hebei ProvinceChina

BACKGROUND Diabetic kidney disease(DKD),characterized by increased urinary microalbumin levels and decreased renal function,is the primary cause of end-stage renal *** pathological mechanisms are complicated and multifactorial;Therefore,sensitive and specific biomarkers are *** exosome originate from diverse renal cells in nephron segments and partially mirror the pathological changes in the *** microRNAs(miRNAs)in urinary exosome are remark-ably stable and highly tissue-specific for the *** Type 2 diabetic mellitus(T2DM)patients were recruited from the Second Hospital of Hebei Medical University and were divided into two groups:DM,diabetic pa-tients without albuminuria[urinary albumin to creatinine ratio(UACR)<30 mg/g]and DKD,diabetic patients with albuminuria(UACR≥30 mg/g).Healthy subjects were the normal control(NC)*** exosomal miR-145-5p,miR-27a-3p,and miR-29c-3p,were detected using real-time quantitative polymerase chain *** correlation between exosomal miRNAs and the clinical in-dexes was *** diagnostic values of exosomal miR-145-5p and miR-27a-3p in DKD were determined using receiver operating characteristic(ROC)*** functions of miR-145-5p were investigated by performing RESULTS Urinary exosomal expression of miR-145-5p and miR-27a-3p was more upregulated in the DKD group than in the DM group(miR-145-5p:4.54±1.45 vs 1.95±0.93,P<0.001;miR-27a-3p:2.33±0.79 vs 1.71±0.76,P<0.05)and the NC group(miR-145-5p:4.54±1.45 vs 1.55±0.83,P<0.001;miR-27a-3p:2.33±0.79 vs 1.10±0.51,P<0.001).The exosomal miR-145-5p and miR-27a-3p positively correlated with albuminuria and serum creatinine and negatively correlated with the estimated glomerular filtration ***-27a-3p was also closely related to blood glucose,gly-cosylated hemoglobin A1c,and low-density lipoprotein *** analysis revealed that miR-145-5p had a better area under the curve of 0.88[95%confidence interval(CI):0.784-0.985

关键词： Urinary exosome MicroRNA-145-5p MicroRNA-27a-3p Diabetic kidney disease Diagnostic biomarkers

Active sites and reaction mechanisms of COhydrogenation on zinc-based mixed oxide catalysts

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Science China Chemistry 2024年

作者： Zhuo-yan yao Si-Cong Ma Zhi-Pan Liu Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Key Laboratory of Computational Physical ScienceDepartment of Chemistry Fudan University State Key Laboratory of Metal Organic Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of Sciences Shanghai Qi Zhi Institution

The conversion of C1 molecules, COx（CO and CO2）, to valuable chemical products has garnered ever-increasing *** many routes, the hydrogenation via thermal catalysis is particularly promising as a key clean energy technology with the increasing supply of green H2. Zinc-based mixed oxide catalysts exhibit exceptional catalytic performance in the COxhydrogenation to value-added hydrocarbons, especially in combination with zeolite. This review overviews the recent achievements in understanding the active sites and reaction mechanisms of COxhydrogenation on zinc-based mixed oxide catalysts, focusing on three most-studied zinc-based mixed oxide catalysts, namely ZnCrOx, ZnAlOxand ZnZrOx. The challenges and future directions are also discussed.

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Exploring the therapeutic potential of Qi Teng Mai Ning recipe in ischemic stroke and vascular cognitive impairment

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Traditional Medicine Research 2024年第10期9卷 21-35页

作者： Jia-yan yao Yue-Lan yang Wei-Jian Chen Hai-Ying Fan Department of Neurosurgery Changxing People’s HospitalChangxing 313100China Department of Ultrasound Medicine Changxing People’s HospitalChangxing 313100China Department of Orthopedics The Fifth Clinical College of Guangzhou University of Chinese MedicineGuangzhou 510095China

Background:This study aims to explore the therapeutic effects of the Qi Teng Mai Ning recipe on ischemic stroke and vascular cognitive impairment through its potential to modulate cellular autophagy,with a focus on identifying its active ingredients and their target ***:The study began with the identification of active ingredients in the Qi Teng Mai Ning *** proceeded to screen the gene expression omnibus database for ischemic stroke and vascular cognitive impairment-associated differentially expressed mRNAs and to identify cellular autophagy-related proteins via the Human Autophagy *** proteins were annotated with Gene Ontology and Kyoto Encyclopedia of Genes and Genomes functions and subjected to molecular docking with the recipe’s core active *** vitro cell experiments were conducted on hypoxic HT22 cells,involving CCK8 assay,lentiviral transfection to silence autophagy related 9B(ATG9B),immunofluorescence staining,and qPCR validation to investigate the effects of the recipe on ***:The analysis identified 104 active ingredients targeting 408 proteins and forming a complex ingredient-target *** 55 ischemic stroke-related and 909 vascular cognitive impairment-related differentially expressed mRNAs revealed 14 co-expressed *** docking showed quercetin,kaempferol,myrcene,and conferone as key ingredients targeting autophagy-related *** experiments indicated that the recipe significantly enhanced cell viability under hypoxic conditions,reduced apoptosis,and modulated the expression of autophagy-related factors,thereby decreasing apoptosis rates in HT22 ***:The Qi Teng Mai Ning recipe offers protective effects against ischemic stroke and vascular cognitive impairment by modulating autophagy-related *** efficacy highlights the potential of traditional Chinese medicine in treating these conditions,though further research is needed to fully understand its

关键词： Qi Teng Mai Ning recipe autophagy ischemic stroke vascular cognitive impairment traditional Chinese medicine

Effectiveness of cardioneuroablation in different subtypes of vasovagal syncope

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Journal of Geriatric Cardiology 2024年第6期21卷 651-657页

作者： Bin TU Zi-Hao LAI Ai-Yue CHEN Zhi-Yuan WENG Si-Min CAI Zhu-Xin ZHANG Li-Kun ZHOU Li-Hui ZHENG yan yao Arrhythmia Center Fuwai HospitalNational Center for Cardiovascular DiseasesNational Key LaboratoryChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Cardiac Center Beijing Chaoyang HospitalCapital Medical UniversityBeijingChina Cardiovascular Department The First Affiliated HospitalFujian Medical UniversityFujian Institute of HypertensionFujianChina Department of Cardiovascular The Second Affiliated Hospital of Zhejiang University School of MedicineZhejiangChina

BACKGROUND Cardioneuroablation(CNA)has shown encouraging results in patients with vasovagal syncope(VVS).However,data on different subtypes was *** This observational study retrospectively enrolled 141 patients[mean age:40±18 years,51 males(36.2%)]with the diagnosis of *** characteristics among different types of VVS and the outcomes after CNA were *** After a mean follow-up of 4.3±1.5 years,41 patients(29.1%)experienced syncope/pre-syncope events after ***/pre-syncope recurrence significantly differed in each subtype(P=0.04).The cardioinhibitory type of VVS had the lowest recurrence rate after the procedure(n=6,16.7%),followed by mixed(n=26,30.6%)and vasodepressive(n=9,45.0%).Additionally,a significant difference was observed in the analyses of the Kaplan-Meier survival curve(P=0.02).Syncope/pre-syncope burden was significantly reduced after CNA in the vasodepressive type(P<0.01).Vasodepressive types with recurrent syncope/pre-syncope after CNA have a lower baseline deceleration capacity(DC)level than those without(7.4±1.0 ms vs.9.0±1.6 ms,P=0.01).Patients with DC<8.4 ms had an 8.1(HR=8.1,95%CI:2.2-30.0,P=0.02)times risk of syncope/pre-syncope recurrence after CNA compared to patients with DC≥8.4 ms,and this association still existed after adjusting for age and sex(HR=8.1,95%CI:2.2-30.1,P=0.02).CONCLUSIONS Different subtypes exhibit different event-free *** vasodepressive type exhibited the lowest event-free rate,but those patients with DC≥8.4 ms might benefit from CNA.

关键词： syncope subtypes diagnosis

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北魏均田制与土地兼并问题再探

史学集刊 2024年第5期 97-107页

作者：严耀中上海师范大学人文学院上海200234

北魏均田制包含着同一等级内之均平和等级之间分田不均的两面性,这体现着以权力为背景的土地之身份占有权,也是土地被多层次兼有在制度上之反映。其结果之一是导致大土地合法占有的同时,在一定程度上抑制了土地兼并。谴责土地兼并,在历... 详细信息

北魏均田制包含着同一等级内之均平和等级之间分田不均的两面性,这体现着以权力为背景的土地之身份占有权,也是土地被多层次兼有在制度上之反映。其结果之一是导致大土地合法占有的同时,在一定程度上抑制了土地兼并。谴责土地兼并,在历史上一向被视为政治正确,也令均田制往往获得赞扬。其实,均田制的推行,一方面容纳了以权力为后盾的直接或间接占有大土地现象在中国的延续,另一方面也阻碍了通过生产要素流转而使资源得到优化配置,并加重了行政操作成本。因此,均田制是一个效费比很低的制度。由此亦可发现其中一些所谓的“地主”往往只是一种权位所附带的身份。

关键词：北魏均田制土地兼并

Diagnosis and management of benign recurrent intrahepatic cholestasis and psychosocial stressors in an adolescent:A case report

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World Journal of Clinical Cases 2024年第20期12卷 4427-4433页

作者： Ya-Xin Xu Xiao-Xuan Niu Bei-Li Xu Yuan Ji Qun-yan yao Department of General Practice Zhongshan HospitalFudan UniversityShanghai 200032China Department of Nutrition Zhongshan HospitalFudan UniversityShanghai 200032China Department of Gastroenterology and Hepatology Zhongshan HospitalFudan UniversityShanghai 200032China Department of Pathology Zhongshan HospitalFudan UniversityShanghai 200032China

BACKGROUND Benign recurrent intrahepatic cholestasis(BRIC)is a rare autosomal recessive disorder,characterized by episodes of intense pruritus,elevated serum levels of alkaline phosphatase and bilirubin,and near-normal-glutamyl *** episodes may persist for weeks to months before spontaneously resolving,with patients typically remaining asymptomatic between *** entails the evaluation of clinical symptoms and targeted genetic *** BRIC is recognized as a benign genetic disorder,the triggers,particularly psychosocial factors,remain poorly *** SUMMARY An 18-year-old Chinese man presented with recurrent jaundice and pruritus after a cold,which was exacerbated by self-medication involving vitamin B and *** and laboratory evaluations revealed elevated levels of bilirubin and liver enzymes,in the absence of viral or autoimmune liver *** excluded biliary and pancreatic abnormalities,and liver biopsy demonstrated centrilobular cholestasis,culminating in a BRIC diagnosis confirmed by the identification of a novel ATP8B1 gene *** assessment of the patient unveiled stress attributable to academic and familial pressures,regarded as potential triggers for *** relief was observed with ursodeoxycholic acid and cetirizine,followed by an adjustment of the treatment regimen in response to elevated liver *** patient's condition significantly improved following a stress-related episode,thanks to a comprehensive management approach that included psychosocial support and medical *** Our research highlights genetic and psychosocial influences on BRIC,emphasizing integrated diagnostic and management strategies.

关键词： Benign recurrent intrahepatic cholestasis Genetic testing Psychosocial factors ATP8B1 gene mutation Cholestasis Jaundice Pruritus Case report

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论习近平文化思想的原创性贡献

新疆师范大学学报（哲学社会科学版） 2024年第4期45卷 25-36页

作者：姚金艳柳颖华中师范大学马克思主义学院湖北武汉430079

习近平文化思想高屋建瓴、精辟深邃,是内涵丰富、逻辑严密、论述深刻的理论体系,是新时代党领导文化建设实践经验的理论总结,是马克思主义文化理论中国化时代化的最新成果。习近平文化思想创造性提出“建设中华民族现代文明”这一时代命... 详细信息

习近平文化思想高屋建瓴、精辟深邃,是内涵丰富、逻辑严密、论述深刻的理论体系,是新时代党领导文化建设实践经验的理论总结,是马克思主义文化理论中国化时代化的最新成果。习近平文化思想创造性提出“建设中华民族现代文明”这一时代命题,赋予中华文明新的文化内涵和发展活力;高度重视中国特色社会主义文化建设,把文化建设摆在治国理政的突出位置,将意识形态工作和宣传思想文化工作视为极端重要的工作,对建设文化强国作出新的判断和战略部署。同时,习近平文化思想鲜明提出文化使命、文化自信、“两个结合”“又一次思想解放”、中国共产党人精神谱系等一系列原创性理论,从政治保证、制度保障、价值引领、文化底蕴和国际建设五个方面为新时代文化建设谋划新方略,为中国特色社会主义文化建设提供强大思想武器和科学行动指南。

关键词：习近平文化思想中华文化文化强国 “两个结合”