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Nanocarrier-mediated siRNA delivery:a new approach for the treatment of traumatic brain injury-related Alzheimer's disease

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Neural Regeneration Research 2025年第9期20卷 2538-2555页

作者： Jie Jin Huajing Zhang Qianying Lu Linqiang Tian Sanqiao yao Feng Lai Yangfan Liang Chuanchuan Liu Yujia Lu Sijia Tian Yanmei Zhao Wenjie Ren Institute of Disaster and Emergency Medicine Tianjin UniversityTianjinChina Key Laboratory for Disaster Medicine Technology TianjinChina Henan Medical Key Laboratory for Research of Trauma and Orthopedics The Third Affiliated Hospital of Xinxiang Medical UniversityXinxiangHenan ProvinceChina Clinical Medical Center of Tissue Engineering and Regeneration Xinxiang Medical UniversityXinxiangHenan ProvinceChina Institutes of Health Central Plain Xinxiang Medical UniversityXinxiangHenan ProvinceChina School of Public Health Xinxiang Medical UniversityXinxiangHenan ProvinceChina

Traumatic brain injury and Alzheimer's disease share pathological similarities,including neuronal loss,amyloid-βdeposition,tau hyperphosphorylation,blood-brain barrier dysfunction,neuroinflammation,and cognitive ***,traumatic brain injury can exacerbate Alzheimer's disease-like pathologies,potentially leading to the development of Alzheimer's *** offer a potential solution by facilitating the delive ry of small interfering RNAs across the blood-brain barrier for the targeted silencing of key pathological genes implicated in traumatic brain injury and Alzheimer's disease.U nlike traditional approaches to neuro regeneration,this is a molecula r-targeted strategy,thus avoiding non-specific drug *** review focuses on the use of nanocarrier systems for the efficient and precise delive ry of siRNAs,discussing the advantages,challenges,and future *** principle,siRNAs have the potential to target all genes and non-targetable protein s,holding significant promise for treating various *** the various therapeutic approaches currently available for neurological diseases,siRNA gene silencing can precisely"turn off"the expression of any gene at the genetic level,thus radically inhibiting disease progression;however,a significant challenge lies in delivering siRNAs across the blood-brain *** have received increasing attention as an innovative drug delive ry tool fo r the treatment of brain *** are considered a potential therapeutic strategy with the advantages of being able to cross the blood-brain barrier,targeted drug delivery,enhanced drug stability,and multifunctional *** use of nanoparticles to deliver specific modified siRNAs to the injured brain is gradually being recognized as a feasible and effective *** this strategy is still in the preclinical exploration stage,it is expected to achieve clinical translation in the future,creating a new field of molecular tar

关键词： blood-brain barrier cognitive dysfunction exosomes gene silencing immunotherapy inorganic nanomaterials liposome nanoparticles neuroinflammation polymer nanoparticles stem cells

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An Efficient Boron Source Activation Strategy for the Low‑Temperature Synthesis of Boron Nitride Nanotubes

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Nano-Micro Letters 2025年第1期17卷 548-558页

作者： Ying Wang Kai Zhang Liping Ding Liyun Wu Songfeng E Qian He Nanyang Wang Hui Zuo Zhengyang Zhou Feng Ding Yue Hu Jin Zhang Yagang yao National Laboratory of Solid State Microstructures College of Engineering and Applied SciencesJiangsu Key Laboratory of Artificial Functional Materialsand Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093People’s Republic of China School of Electronic Information and Artificial Intelligence Shaanxi University of Science&TechnologyXian 710000People’s Republic of China College of Bioresources Chemical and Materials Engineering Shaanxi University of Science&TechnologyXian 710000People’s Republic of China Key Laboratory of Carbon Materials of Zhejiang Province College of Chemistry and Materials EngineeringWenzhou UniversityWenzhou 325000People’s Republic of China Shenzhen Institutes of Advanced Technology Chinese Academy of SciencesShenzhen 518000People’s Republic of China College of Chemical and Molecular Engineering Peking UniversityBeijing 100871People’s Republic of China

Lowering the synthesis temperature of boron nitride nanotubes(BNNTs)is crucial for their *** primary reason for adopting a high temperature is to enable the effective activation of highmelting-point solid *** this study,we developed a novel approach for efficiently activating boron by introducing alkali metal compounds into the conventional MgO–B *** approach can be adopted to form various low-melting-point AM–Mg–B–O growth *** growth systems have improved catalytic capability and reactivity even under low-temperature conditions,facilitating the synthesis of BNNTs at temperatures as low as 850℃.In addition,molecular dynamics simulations based on density functional theory theoretically demonstrate that the systems maintain a liquid state at low temperatures and interact with N atoms to form BN *** findings offer novel insights into the design of boron activation and are expected to facilitate research on the low-temperature synthesis of BNNTs.

关键词： Boron nitride nanotubes Low-temperature Boron activation Density functional theory

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Anlotinib-induced sick sinus syndrome:Two case reports

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World Journal of Clinical Cases 2025年第6期13卷 30-34页

作者： Cheng-Feng Fu Li-Fen Yang Lei Tian Song Deng Qi Zhang Biao yao Department of Oncology Tongren People’s HospitalTongren 554300Guizhou ProvinceChina Department of Oncology Guizhou Provincial People’s HospitalGuiyang 550000Guizhou ProvinceChina

BACKGROUND This manuscript describes the first known cases of sick sinus syndrome(SSS)associated with the use of anlotinib in non-small cell lung cancer patients,highlighting the need for increased vigilance and cardiac *** SUMMARY Two patients with non-small cell lung cancer developed SSS after 15 months and 5 months of anlotinib treatment,respectively,presenting with syncope and *** confirmed SSS,and different treatment approaches were taken for each *** patient received a dual-chamber permanent pacemaker,while the other discontinued the medication and experienced symptom *** Anlotinib can induce SSS,suggesting that cardiac monitoring is crucial during anlotinib *** management strategies are necessary for affected individuals.

关键词： Lung cancer Anlotinib Sick sinus syndrome Cardiac pacemaker Adverse drug reaction Case report

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Repairable,Recyclable,and Regenerable Macrocycle Organic Polymer

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Chinese Journal of Chemistry 2023年第12期41卷 1497-1503页

作者： Yifan Liu Yuanyuan Chen Huacan Wu Xiaowei Chen Donghui Wang xiaocheng Zhang Shiya Zheng yao Ling Baoshuai Liang Jiamao Chen Yu Dong Weiguo Huang College of Chemistry and Materials Science Fujian Normal University Fuzhou Fujian 350007 China State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences 155 Yangqiao West Road Fuzhou Fujian 350002 China Fujian Science & Technology Innovation Laboratory for Optoelectronic Information of China Fuzhou Fujian 350002 China University of Chinese Academy of Sciences 19A Yuquan Road Beijing 100049 China

Covalent/metal organic frameworks are highly attractive due to their tunable structure and properties,and broad applications in multiple ***,they still suffer from numbers of drawbacks including low solubility,harsh synthesis and fabrication,and low mechanical ***,we report a new organic framework consisting of macrocycles and organic frames in its periodic structure,and denote it as macrocycle organic polymer(MOP).The size-tunable macrocycles containing peripheral furan units are synthesized by anionic ring-opening polymerization,which undergo a reversible Diels-Alde reaction with bismaleimide to generate/degrade MOPs at given *** on above features,MOPs exhibit excellent flexibility,healable ability and recycle ***,owing to the“living”nature of anionic ring-opening polymerization,MOPs can self-grow into bigger sizes in the presence of monomer and catalysis,analogs to the living ***,their high porosity and rich thioether structure enable them as good metal ion absorbers and promising applications in wearable electronics.

关键词： Macrocycle organic polymer Healable Recyclable Regenerable Wearable electronics Ring-opening polymerization Adsorption

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3D Printing of Tough Hydrogel Scaffolds with Functional Surface Structures for Tissue Regeneration

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Nano-Micro Letters 2025年第2期17卷 18-45页

作者： Ke yao Gaoying Hong Ximin Yuan Weicheng Kong Pengcheng Xia Yuanrong Li Yuewei Chen Nian Liu Jing He Jue Shi Zihe Hu Yanyan Zhou Zhijian Xie Yong He State Key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China Liangzhu Laboratory Zhejiang UniversityHangzhou 310027People’s Republic of China Key Laboratory of 3D Printing Process and Equipment of Zhejiang Province College of Mechanical EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China Stomatology Hospital School of StomatologyZhejiang University School of MedicineHangzhou 310027People’s Republic of China State Key Laboratory of Advanced Welding and Joining Harbin Institute of TechnologyHarbin 150001People’s Republic of China Institute of Digital Medicine Nanjing First HospitalNanjing Medical UniversityNanjing 210006People’s Republic of China

Hydrogel scaffolds have numerous potential applications in the tissue engineering ***,tough hydrogel scaffolds implanted in vivo are seldom reported because it is difficult to balance biocompatibility and high mechanical *** by Chinese ramen,we propose a universal fabricating method(printing-P,training-T,cross-linking-C,PTC&PCT)for tough hydrogel scaffolds to fill this ***,3D printing fabricates a hydrogel scaffold with desired structures(P).Then,the scaffold could have extraordinarily high mechanical properties and functional surface structure by cycle mechanical training with salting-out assistance(T).Finally,the training results are fixed by photo-cross-linking processing(C).The tough gelatin hydrogel scaffolds exhibit excellent tensile strength of 6.66 MPa(622-fold untreated)and have excellent ***,this scaffold possesses functional surface structures from nanometer to micron to millimeter,which can efficiently induce directional cell ***,this strategy can produce bionic human tissue with mechanical properties of 10 kPa-10 MPa by changing the type of salt,and many hydrogels,such as gelatin and silk,could be improved with PTC or PCT *** experiments show that this scaffold can effectively promote the new generation of muscle fibers,blood vessels,and nerves within 4 weeks,prompting the rapid regeneration of large-volume muscle loss injuries.

关键词： 3D printing Tough hydrogel scaffold Functional surface structure Tissue regeneration Biomaterials

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Mediating role of health literacy in the relationship between social isolation and psychological distress among pre-frail older adults

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World Journal of Psychiatry 2025年第1期15卷 137-144页

作者： Juan Fang Li-Hui Li Ming-Qian He Yue Ji Dong-Yan Lu Li-Bing Zhang Jin-Lan yao School of Medicine Huzhou UniversityHuzhou 313000Zhejiang ProvinceChina

BACKGROUND Frailty has become a significant public health *** recent increase in the number of frail older adults has led to increased attention being paid to psycho-logical care services in *** social isolation of pre-frail older adults can impact their psychological *** To explore the mediating effect of health literacy between social isolation and psychological distress among communitydwelling older adults with *** This descriptive cross-sectional study was conducted with 254 pre-frail older individuals aged 60 years and *** isolation,health literacy,and psycholo-gical distress were comprehensively measured using the Lubben Social Network Scale-6,12-item Short-Form Health Literacy Questionnaire,and the Kessler Psy-chological Distress *** were evaluated using the SPSS 27.0 package program and the PROCESS macro *** statistical analyses,correlation analyses,and bootstrap mediation tests were used to assess associations between the *** The results showed that social isolation had an effect on health literacy among pre-frail older adults(β=0.240,P<0.001),social isolation impact on psycho-logical distress pre-frail older adults(β=-0.415,P<0.001);health literacy was identified effect on psychological distress among pre-frail older persons(β=-0.307,P<0.001).Health literacy partially mediated the relationship between social isolation and psychological distress among community-dwelling older adults with pre-frailty,with a mediation effect of-0.074,accounting for 17.83%of the total effect.

关键词： Frail Ageing Psychological distress Health literacy Social isolation

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Unified Control Strategy of Heterogeneous Thermostatically Controlled Loads with Market-based Mechanism

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Journal of Modern Power Systems and Clean Energy 2020年第6期8卷 1231-1239页

作者： yao yao Peichao Zhang Key Laboratory of Control of Power Transmission and Conversion of Ministry of Education Department of Electrical EngineeringShanghai Jiao Tong UniversityShanghai 200240China

This paper studies the coordination of heterogeneous thermostatically controlled loads(TCLs)to provide the real-time ancillary services.A market-based control framework is adopted for its *** first advantage is that the demand curve-oriented approach makes it possible to form a unified control scheme for heterogeneous loads without identifying their different *** second one is that the broadcast price signal helps simplify the downlink control and reduce the implementation ***,the separate demand curve construction strategies based on a virtual price for different types of TCLs are *** flexibility of each TCL is reflected through the curve,and its practical constraints,i.e.,comfort requirements of users and operation constraints of devices,are satisfied *** ensure the control fairness and full utilization for the regulation ability of TCL cluster,a comfort-levelequality principle is applied in demand curve *** are carried out to verify the effectiveness of the proposed method in providing frequency regulation services,for which a regulation capacity estimation method is ***,a series of case studies are conducted considering the practical situations,e.g.,model errors,imperfect communication and sudden load change after the end of services.

关键词： Thermostatically controlled load(TCL) market-based control coordination control frequency regulation

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Interior-collapsing mechanism by hydrothermal process of the MgAl_(2)O_(4)/MgO porous ceramic

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Journal of Advanced Ceramics 2022年第5期11卷 814-824页

作者： yao yao Yue ZHANG Key Laboratory of Aerospace Materials and Performance(Ministry of Education) School of Materials Science and EngineeringBeihang UniversityBeijing 100191China

Ceramic core is a critical component in the super-alloy turbine blade *** our previous work,a novel multi-phase MgAl_(2)O_(4)/MgO porous ceramic was prepared for this *** most important property was that it crumbled completely after hydrothermal treatment in just pure water,due to the hydration of *** this work,the hydration process of the MgO embedded in the inert matrix was investigated in *** collapse behaved as an interior destruction without any bulk expansion of the *** hydration percentage was the only factor related to the *** morphology of hydration product indicated that the reaction advanced in particular *** on the finite element analysis for the expansion effect on the porous structure,the interiorcollapsing mechanism was *** the hydration process,the MgO grains exerted pressure to the surrounding matrix and induced the collapse in the adjacent *** process took place throughout the ***,the sample crumbled completely to the *** bulk dilatation was detected before the powdering,indicating that the collapse process would not exert pressure *** the alloy blade would not be damaged during the removal of the ceramic *** was also predicted that the decrease in the MgO grain size was beneficial to the water-collapsibility.

关键词： ceramic cores porous structure MgO hydration interior-collapsing mechanism

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论健康数据科学研究合法性基础的证成与适用

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科技与法律（中英文） 2025年第1期 57-67页

作者：姚旭鑫华东政法大学卫生健康法治与政策研究院上海200042 安特卫普大学法学院安特卫普2000

现有的个人信息处理合法性基础框架难以满足健康数据科学研究的需要。将科学研究作为健康数据处理的合法性基础,是国家促进、实现科学研究自由和健康权的要求,并可通过对“公共利益”的解释得到证成。科学研究主体应当隶属于以科学研究... 详细信息

现有的个人信息处理合法性基础框架难以满足健康数据科学研究的需要。将科学研究作为健康数据处理的合法性基础,是国家促进、实现科学研究自由和健康权的要求,并可通过对“公共利益”的解释得到证成。科学研究主体应当隶属于以科学研究为主要目的范围的组织机构。科学研究不排斥商业目的,但商业程度的不同,决定了研究主体是否需要向数据主体付酬。科学研究主体对健康数据的访问需要依托健康数据协调机构加以实现。在适用科学研究这一合法性基础对健康数据进行处理时,应将对数据主体的影响控制在最小范围。原则上对健康数据去标识化,对科学研究有重要意义的标识符可依申请予以保留。标识符的保留和健康数据科学研究的黑箱属性,决定了要对健康数据科学研究课以更高标准的公开透明要求。同时相关规则具有较大自由裁量空间,自由裁量应以风险收益平衡原则为基本遵循。科学研究和其他合法性基础可能存在重合或冲突,只有在数据主体未明示反对的前提下,才可适用科学研究这一合法性基础。当科学研究与其他法定数据处理情形相重合时,科学研究作为特别情形,应优先于一般情形的适用。

关键词：健康数据科学研究合法性基础适用规则

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A theoretical analysis of the electromigration-induced void morphological evolution under high current density

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Acta Mechanica Sinica 2017年第5期33卷 868-878页

作者： Yuexing Wang yao yao School of Mechanics and Civil Engineering Northwestern Polytechnical University

In this work, analysis of electromigration-induced void morphological evolution in solder interconnects is performed based on mass diffusion theory. The analysis is conducted for three typical experimentally observed void shapes: circular, ellipse, and cardioid. Void morphological evolution is governed by the competition between the electric field and surface capillary force. In the developed model, both the electric field and capillary force on the void's surface are solved analytically. Based on the mass conversation principle, the normal velocity on the void surface during diffusion is obtained. The void morphological evolution behavior is investigated, and a physical model is developed to predict void collapse to a crack or to split into sub-voids under electric current. It is noted that when the electric current is being applied from the horizontal direction, a circular void may either move stably along the electric current direction or collapse to a finger shape, depending on the relative magnitude of the electric current and surface capillary force. However, the elliptical-shaped void will elongate along the electric current direction and finally collapse to the finger shape. On the other hand, the cardioid-shaped void could bifurcate into two sub-voids when the electric current reaches a critical value. The theoretical predictions agree well with the experimental observations.

关键词： Electromigration Analytical solution Void evolution High current density Mass diffusion

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