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Tumor-infiltrating Myeloid-derived Suppressor Cells in Patients with Bladder Cancer

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Gemcitabine promoting CCL2 secretion by Bladder cancer cell recruited MDSCs into tumor microenvironment

第十三届全国免疫学学术大会

作者： Ke Wu Ren-jie Wang Zhi-xian yao Zhong Zheng Zhi-hong Liu Shanghai General Hospital

Background: Both cancer-related inflammation and tumor-induced immune suppression are associated with number of myeloid cell subsets including myeloid-derived suppressor cells(MDSCs). But which kind of myeloid cells play a more important role and the mechanism of tumor promoting is not very *** of Study: For tumor tissues, we tested the proportion of MDCSs in bladder cancer(BC) tissues(n=81) and normal bladder tissues(n=39) by flow cytometry assay. For blood immune environment, we analyzed the proportion of MDCSs of healthy people(n=116) and BC patients(n=226). The biomarker of granulocytic MDSC are CD11 b(violet1), CD45(PEcy7), CD33(PE), CD14-(FITC) and CD15(PE-cy5). The biomarker of monocyte MDSC are CD11 b(violet1), CD45(PE-cy7), CD33(PE), CD14(FITC) and CD15-(PE-cy5). The tumor promoting mechanism was analyzed by gene chip after BC cells and MDSC ***: Our results demonstrated that immune cells from bladder cancer tissues and bladder normal tissues contain two major CD11 b myeloid cell subsets: granulocyte-type and monocyte-type MDSCs. The number of tumor-infiltrating granulocytic but not monocytic myeloid cells in cancer tissues was markedly increased when compared to normal bladder tissues. Granulocyte-type MDSCs can promote progression of BC cells directly, which regulated by many gene ***: We demonstrate that these Granulocyte-type MDSCs is a major kind of immune suppression cells and may contribute to inflammation and immune dysfunction in bladder cancer.

关键词： MDSCs Bladder cancer Immune environment Immune suppression

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Gemcitabine promoting CCL2 secretion by Bladder cancer cell ...

基于Kohonen神经网络的燃气轮机故障诊断

第十三届全国免疫学学术大会

作者： Ke Wu Ren-jie Wang Zhi-xian yao Zhong Zheng Zhi-hong Liu Shanghai General Hospital

Background: Bladder cancer(BC) is one of the most common malignant tumors of the urinary tract in China, 75% to 85% of which are grouped as non-muscle invasive bladder ***(GEM), mainly known as chemotherapeutic drug, is known to enhance the resistance potential of cancer cells to ***, the mechanism of that remains *** of study: In this study, 5637 and T24 bladder cancer cell lines were divided into control groups and GEM treated *** cells treated drug concentration was tested by CCK-8 *** chemotaxis of MDSC from peripheral blood was evaluated by flow cytometry *** mRNA and protein level of CCL2 in BC cells was analyzed by qRT-PCR, ELISA and flow cytometry *** expression of the key molecules in GEM treated BC cells was assessed by in-cell Western *** effects of MDSCs on the proliferation of BC cells in vitro were assessed using flow cytometry ***: We have found that though GEM treatment can kill and wound BC cells, which leads to higher expression of CCL2 in the GEM treated groups than the control *** level of CCL2 significantly enhances the chemotaxis of MDSCs in the microenvironment of BC *** accumulation of MDSCs can promote the progression of BC, such as the proliferation, invasion and migration of the BC *** phenomenon can be inhibited by using CCR2 ***: GEM can enhance BC cells generate much more CCL2, which can recruit MDSC to tumor *** phenomenon can partly explain the mechanism of GEM related chemotherapy resistance.

关键词： MDSCs Gemcitabine CCL2 Tumor microenvironment

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热能动力工程 2005年第6期20卷 562-564页

作者：田质广董振东孟宪尧大连海事大学自动化所辽宁大连116026 济南钢铁设计院山东济南250002

针对基于热力参数的燃气轮机8种典型常见故障,根据Kohonen神经网络诊断的工作原理、诊断特征,研究了基于Kohonen神经网络方法在燃气轮机故障诊断中的应用方法,得出了Kohonen模型具有自学习功能,运算速度快,类型识别能力强的优点,是一种... 详细信息

针对基于热力参数的燃气轮机8种典型常见故障,根据Kohonen神经网络诊断的工作原理、诊断特征,研究了基于Kohonen神经网络方法在燃气轮机故障诊断中的应用方法,得出了Kohonen模型具有自学习功能,运算速度快,类型识别能力强的优点,是一种适合于燃气轮机分类故障较好的具有特色的神经网络。

关键词：燃气轮机 Kohonen神经网络故障诊断

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线性查询的一种近似最优差分隐私机制

软件学报 2017年第9期28卷 2309-2322页

作者：武跟强贺也平夏娴瑶中国科学院软件研究所基础软件国家工程研究中心北京100190 兰州财经大学信息工程学院甘肃兰州730020 计算机科学国家重点实验室(中国科学院软件研究所) 北京100190

在差分隐私保护程度确定的条件下使数据的有用性最大化的问题,称为差分隐私的最优机制问题.最优机制问题是差分隐私理论中的一个重要问题,与差分隐私模型的理论基础及应用前景有直接联系.与已有的研究不同,提出一种不基于敏感度的分析... 详细信息

在差分隐私保护程度确定的条件下使数据的有用性最大化的问题,称为差分隐私的最优机制问题.最优机制问题是差分隐私理论中的一个重要问题,与差分隐私模型的理论基础及应用前景有直接联系.与已有的研究不同,提出一种不基于敏感度的分析方法来寻找最优机制:首先,将最优机制问题构造为一个多目标函数优化问题,并提出了一种差分隐私机制构造方法,在此基础上,对线性查询问题给出了一种近似最优差分隐私机制,该机制达到了差分隐私不等式的边界.此外,大部分分析方法也可对非线性查询的最优机制问题进行分析.该研究揭示了敏感度方法的不足之处,发现其无法刻画数据集的邻居集合对应的查询函数值集合的特性,而该集合包含了差分隐私的一些深层特征.

关键词：线性查询差分隐私最优机制多目标优化非敏感度方法

因子von Neumann代数上的非线性混合Lie三重可导映射

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数学学报（中文版） 2019年第1期62卷 13-24页

作者：梁耀仙张建华陕西师范大学数学与信息科学学院西安710062

本文通过经典的可导映射,运用矩阵分块的方法,证明了因子von Neumann代数■上的每一个非线性混合Lie三重可导映射都是可加的*-导子.

关键词：混合Lie三重可导映射 von Neumann代数 *-导子

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干细胞治疗疾病及安全性的研究进展

中国新药杂志 2015年第5期24卷 509-512,544页

作者：许冰洁宣尧仙浙江省医学科学院安全性评价研究中心杭州310013

近年来,干细胞治疗疾病是一个新的研究热点,在治疗心血管疾病、糖尿病、骨髓及软骨损伤、神经系统疾病以及恶性肿瘤等方面有广泛的应用。它是通过干细胞移植并迁移到损伤部位修复受损的细胞或组织的一种疗法,主要应用在因细胞或组织损... 详细信息

近年来,干细胞治疗疾病是一个新的研究热点,在治疗心血管疾病、糖尿病、骨髓及软骨损伤、神经系统疾病以及恶性肿瘤等方面有广泛的应用。它是通过干细胞移植并迁移到损伤部位修复受损的细胞或组织的一种疗法,主要应用在因细胞或组织损伤引起的疾病,而且自体移植干细胞避免了免疫排斥和伦理道德问题。利用干细胞治疗这些疾病有一定的发展前景,为很多难以治愈的疾病提供了新的治疗途径和技术方法。然而,随着干细胞治疗疾病这项新技术的发展,安全性问题也引起了广泛的关注。因此,在干细胞应用到临床前,进行严格的安全性评价是很有必要的,这样才能保证干细胞治疗安全、稳定的造福于人类。

关键词：干细胞干细胞移植疾病安全性

PAHs removal by soil washing with thiacalix[4]arene tetrasulfonate

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Environmental Science and Ecotechnology 2024年第5期21卷 256-267页

作者： Le-yao Xing Guan-Han Meng Ji-xian Yang Ming-Han Xu Yi-Ming Xu Hai-Xiao Xie Ai-Jie Wang Yi-Lu Sun State Key Laboratory of Urban Water Resource and Environment School of EnvironmentHarbin Institute of TechnologyHarbin150090China Key Laboratory of Environmental Biotechnology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing100085China Hangzhou Yanqu Information Technology Co. Ltd.Y2Hangzhou310003China

Remediating soil contaminated with polycyclic aromatic hydrocarbons(PAHs)presents a significant environmental challenge due to their toxic and carcinogenic *** PAHs remediation methodsdchemical,thermal,and bioremediationdalong with conventional soil-washing agents like surfactants and cyclodextrins face challenges of cost,ecological harm,and *** we show an effective and environmentally friendly calixarene derivative for PAHs removal through soil ***[4]arene tetrasulfonate(TCAS)has a unique molecular structure of a sulfonate group and a sulfur atom,which enhances its solubility and facilitates selective binding with *** forms host-guest complexes with PAHs through p-p stacking,OH-p interactions,hydrogen bonding,van der Waals forces,and electrostatic *** interactions enable partial encapsulation of PAH molecules,aiding their desorption from the soil *** results show that a 0.7%solution of TCAS can extract approximately 50%of PAHs from contaminated soil while preserving soil nutrients and minimizing adverse environmental *** research unveils the pioneering application of TCAS in removing PAHs from contaminated soil,marking a transformative advancement in resource-efficient and sustainable soil remediation strategies.

关键词： Calixarenes Soil-washing Host-guest interaction PAHs

Cisplatin Inhibits the Progression of Bladder Cancer by Selectively Depleting G-MDSCs:A Novel Chemoimmunomodulating Strategy

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Cisplatin Inhibits the Progression of Bladder Cancer by Sele...

职业隔离的经济效应——对我国城市就业人口职业性别歧视的分析

第十二届全国免疫学学术大会

作者： Wu Ke Mu Xing-Yu Wang Ren-Jie yao Zhi-xian Liu Zhi-hong Shanghai General Hospital

Myeloid-derived suppressor cells(MDSCs) expand broadly and have strong immunosuppressive activities in the cancer ***-MDSCs(G-MDSCs),which constitute one of the two types of MDSCs,are the absolutely predominant subset in bladder cancer(BC) *** found that G-MDSCs were significantly increased in BC tissues compared with those in the adjacent bladder tissues,but the number of CD8 T cells in the BC tissues was significantly lower than in the adjacent bladder tissues;there was a robust negative correlation between the G-MDSCs and the CD8 T cells in the BC *** this study,we attempted to identify pharmacological approaches to eliminate MDSCs and restore the T cell anti-tumor *** is a chemotherapy medication used to treat *** not only rapidly kills proliferating cancer cells but also affects the tumor immune *** mechanism underlying this phenomenon is largely *** this study,we found that cisplatin directly inhibited the proliferation and induced the apoptosis of T24 cells(a BC cell line) and,decreased the percentage of the G-MDSCs in peripheral blood mononuclear cells(PBMCs),which restored the expansion of the CD8 T *** the C57 mouse BC model,cisplatin treatment inhibited the progression of BC and effectively decreased the percentage of *** results suggest that cisplatin treatment enhances the anti-tumor function of CD8 T cells by decreasing *** finding provides a new perspective for cisplatin treatment to prevent the progression of BC,particularly in patients with abnormally high levels of G-MDSCs.

关键词： Cisplatin Bladder cancer Myeloid-derived suppressor cells CD8+ T cells Immunomodulation

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浙江大学学报（人文社会科学版） 2006年第2期36卷 73-79页

作者：姚先国谢嗣胜浙江大学公共管理学院浙江杭州310027 南京航空航天大学经济与管理学院江苏南京210016

劳动力市场中的性别歧视是较普遍的现象,其中职业隔离是性别歧视的主要形式之一。为了分析我国城市就业人口中的职业性别隔离问题,我们使用差异指数法对当前职业隔离的程度进行了测量,并且通过CES生产函数和C D生产函数对假定消除职业... 详细信息

劳动力市场中的性别歧视是较普遍的现象,其中职业隔离是性别歧视的主要形式之一。为了分析我国城市就业人口中的职业性别隔离问题,我们使用差异指数法对当前职业隔离的程度进行了测量,并且通过CES生产函数和C D生产函数对假定消除职业隔离后,各种职业的劳动力性别构成比例、工资水平及经济总产出变化情况做出估计,以期对打破职业隔离提供一些理论依据和政策建议。

关键词：职业隔离性别歧视差异指数法生产函数