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Casein kinase-2 inhibition promotes retinal ganglion cell survival after acute intraocular pressure elevation

Neural Regeneration Research 2024年第5期19卷 1112-1118页

作者： Meng Wang Shi-Qi yao yao huang Jia-Jian Liang Yanxuan Xu Shaowan Chen Yuhang Wang Tsz Kin Ng Wai Kit Chu Qi Cui Ling-Ping Cen Joint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong ShantouGuangdong ProvinceChina Shantou University Medical College ShantouGuangdong ProvinceChina Beijing Tongren Eye Center Beijing Tongren HospitalCapital Medical UniversityBeijingChina Department of Ophthalmology and Visual Sciences The Chinese University of Hong KongHong Kong Special Administrative RegionChina

Intraocular pressure elevation can induce retinal ganglion cell death and is a clinically reversible risk factor for glaucoma,the leading cause of irreversible *** previously demonstrated that casein kinase-2 inhibition can promote retinal ganglion cell survival and axonal regeneration in rats after optic nerve *** investigate the underlying mechanism,in the current study we increased the intraocular pressure of adult rats to 75 mmHg for 2 hours and then administered a casein kinase-2 inhibitor(4,5,6,7-tetrabromo-2-azabenzimidazole or 2-dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole)by intravitreal *** found that intravitreal injection of 4,5,6,7-tetrabromo-2-azabenzimidazole or 2-dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole promoted retinal ganglion cell survival and reduced the number of infiltrating *** analysis showed that the mitogen activated protein kinase signaling pathway was involved in the response to intraocular pressure elevation but was not modulated by the casein kinase-2 ***,casein kinase-2 inhibition downregulated the expression of genes(Cck,Htrsa,Nef1,Htrlb,Prph,Chat,Slc18a3,Slc5a7,Scn1b,Crybb2,Tsga10ip,and Vstm21)involved in intraocular pressure *** data indicate that inhibition of casein kinase-2 can enhance retinal ganglion cell survival in rats after acute intraocular pressure elevation via macrophage inactivation.

关键词： casein kinase-2 glaucoma intraocular pressure elevation macrophages retinal ganglion cells

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Energy-efficient computation offloading assisted by RIS-based UAV

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The Journal of China Universities of Posts and Telecommunications 2024年第1期31卷 37-48页

作者： Li Linpei Zhao Chuan Su Yu Huo Jiahao huang yao Li Haojin School of Intelligence Science and Technology University of Science and Technology BeijingBeijing 100083China Institute of Artificial Intelligence University of Science and Technology BeijingBeijing 100083China Shunde Innovation School University of Science and Technology BeijingFoshan 528399China School of Computer and Communication Engineering University of Science and Technology BeijingBeijing 100083China Research Department of 5G and Drone China Mobile(Chengdu)Institute of Research and DevelopmentChengdu 610200China College of Communication Engineering Chengdu University of Information TechnologyChengdu 610225China Research and Development Center Sony(China)LimitedBeijing 100027China

The new applications surge with the rapid evolution of the mobile *** explosive growth of the data traffic aroused by the new applications has posed great computing pressure on the local *** is essential to innovate the computation offloading methods to alleviate the local computing burden and improve the offloading *** edge computing(MEC)assisted by reflecting intelligent surfaces(RIS)-based unmanned aerial vehicle(UAV)is a promising method to assist the users in executing the computation tasks in proximity at low *** this paper,we propose an energy-efficient MEC system assisted by RIS-based UAV,where the UAV with RIS mounted relays the computation tasks to the MEC *** energy efficiency maximization problem is formulated by jointly optimizing the UAV's trajectory,the transmission power of all users,and the phase shifts of the reflecting elements placed on the *** that the optimization problem is non-convex,we propose a deep deterministic policy gradient(DDPG)-based *** combining the DDPG algorithm with the energy efficiency maximization problem,the optimization problem can be ***,the numerical results are illustrated to show the performance of the system and the superiority compared with the benchmark schemes.

关键词： mobile edge computing unmanned aerial vehicle reflecting intelligent surface

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A Catalog of ^(13)CO Clumps from the MWISP in l=10°–20°

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Research in Astronomy and Astrophysics 2024年第5期24卷 218-234页

作者： Xiaoyu Luo Sheng Zheng Zhibo Jiang Zhiwei Chen yao huang Shuguang Zeng Xiangyun Zeng Rui Zhang Chen Long Guangrong Zhou Jinbo Hu Center for Astronomy and Space Sciences China Three Gorges UniversityYichang 443000China College of Electrical Engineering and New Energy China Three Gorges UniversityYichang 443000China College of Science China Three Gorges UniversityYichang 443000China Purple Mountain Observatory Chinese Academy of SciencesNanjing 210023China

In this study, we present a catalog of molecular clumps extracted from ^(13)CO(J=1-0) emission data of the Milky Way Imaging Scroll Painting(MWISP) project. The data covers the inner Milky Way within the longitude range10°≤l≤20° and the latitude strip of |b|≤ 5°. 25. The workflow for the extraction of clumps, namely Facet-SS-3DClump, consists of two parts: the identification of clump candidates and their verification. First, Facet-SS-3DClump employs FacetClumps to identify clump candidates. Subsequently, high-confidence clumps are obtained by cross-matching with the clumps detected by other algorithms, such as dendrogram. Second, these high-confidence clumps are used as prior knowledge to train a semi-supervised deep clustering approach, SS-3D-Clump, which is applied to verify clump candidates detected by FacetClumps, providing confidence levels for the molecular clumps. Finally, the catalog comprising 18,757 molecular clumps was obtained using Facet-SS-3D-Clump, and the catalog is 90% complete above 37 K km s^(-1). We observe a significant deviation of the mean Galactic latitude for clumps within |b|≤ 2° from the midplane, with b=-0°.110. We found that 82.3% of the dust clumps correspond to ^(13)CO clumps by matching with Herschel infrared dust clumps. In the future, Facet-SS-3D-Clump will be applied to detect ^(13)CO clumps in the entire MWISP data.

关键词： ISM molecules methods data analysis-stars formation

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Liver stiffness in hepatocellular carcinoma and chronic hepatitis patients:Hepatitis B virus infection and transaminases should be considered

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World Journal of Hepatology 2024年第7期16卷 1018-1028页

作者： Jia-yao huang Jian-Yun Peng Hai-Yi Long Xian Zhong Yu-Hua Xie Lu yao Xiao-Yan Xie Man-Xia Lin Department of Medical Ultrasonics The First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080Guangdong ProvinceChina

BACKGROUND Liver condition is a crucial prognostic factor for patients with hepatocellular carcinoma(HCC),but a convenient and comprehensive method to assess liver condition is *** stiffness(LS)measured by two-dimensional shear wave elastography may help in assessing liver fibrosis and liver *** hepatitis B(CHB)is an important risk factor for HCC progression,but LS was found to be less reliable in assessing liver fibrosis following hepatitis viral *** hypothesize that the status of hepatitis virus infection would affect the accuracy of LS in assessing the liver *** To test the feasibility and impact factors of using LS to assess liver condition in patients with HCC and *** A total of 284 patients were retrospectively recruited and classified into two groups on the basis of serum CHB virus hepatitis B virus(HBV)-DNA levels[HBV-DNA≥100.00 IU/mL as Pos group(n=200)and40 U/L),the correlations between LS and liver condition indices were not significant(P>0.05).CONCLUSION LS was significantly correlated with most liver condition indices in patients with CHB and ***,these correlations varied according to differences in HBV-DNA and transaminase concentrations.

关键词： Liver function Liver stiffness Elastography Chronic hepatitis B Hepatocellular carcinoma

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Influence of liquid film shape on evaporation performance of agitated thin film evaporator

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Chinese Physics B 2024年第8期33卷 305-314页

作者：顾鑫强黄瑶邹鲲彭倚天 College of Mechanical Engineering Donghua UniversityShanghai 201620China

The agitated thin film evaporator(ATFE),which is known for its high efficiency,force the material to form a film through the scraping process of a scraper,followed by evaporation and *** complex shape of the liquid film inside the evaporator can significantly affect its evaporation *** work explores how change in shape of the liquid films affect the evaporation of the materials with non-Newtonian characteristics,achieved by changing the structure of the *** the distribution of circumferential temperature,viscosity,and mass transfer of the flat liquid film shows that the film evaporates rapidly in shear-thinning *** wavy liquid films are developed by using shear-thinning theory,emphasizing the flow condition in the thinning area and the factors contributing to the exceptional evaporation *** exploration is conducted on the spread patterns of the wavy liquid film and flat liquid film on the evaporation wall throughout the *** is noted that breaking the wavy liquid film on the evaporating wall during evaporation is challenging due to its film-forming *** which the fundamental causes are demonstrated by acquiring the data regarding the flow rate and temperature of the liquid *** definitive findings of the analysis reveal a significant improvement in the evaporation capability of the wavy liquid *** enhancement is attributed to increasing the shear-thinning areas and maintaining the overall shape of the film throughout the entire evaporation process.

关键词： liquid film shape shear-thinning fluids flow characteristics evaporative heat transfer

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Pathologically successful conversion hepatectomy for advanced giant hepatocellular carcinoma after multidisciplinary therapy:A case report and review of literature

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1647-1659页

作者： Ju-Hang Chu Lu-yao huang Ya-Ru Wang Jun Li Shi-Long Han Hao Xi Wen-Xue Gao Ying-Yu Cui Ming-Ping Qian Department of General Surgery Shanghai Tenth People's HospitalSchool of MedicineTongji UniversityShanghai 200072China Department of Interventional and Vascular Surgery Shanghai Tenth People's HospitalSchool of MedicineTongji UniversityShanghai 200072China Department of Pathology Shanghai Tenth People's HospitalSchool of MedicineTongji UniversityShanghai 200072China Clinical Research Management Office Shanghai Tenth People’s HospitalShanghai 200072China Department of Cell Biology Institute of Medical GeneticsState Key Laboratory of CardiologyTongji University School of MedicineShanghai 200331China

BACKGROUND Hepatocellular carcinoma(HCC)is one of the leading causes of death due to its complexity,heterogeneity,rapid metastasis and easy recurrence after surgical *** demonstrated that combination therapy with transcatheter arterial chemoembolization(TACE),hepatic arterial infusion chemotherapy(HAIC),Epclusa,Lenvatinib and Sintilimab is useful for patients with advanced *** SUMMARY A 69-year-old man who was infected with hepatitis C virus(HCV)30 years previously was admitted to the hospital with abdominal *** computed tomography(CT)revealed a low-density mass in the right lobe of the liver,with a volume of 12.9 cm×9.4 cm×15 cm,and the mass exhibited a“fast-in/fast-out”pattern,with extensive filling defect areas in the right branch of the portal vein and an alpha-fetoprotein level as high as 657 ng/***,he was judged to have advanced *** treatment,the patient received three months of Epclusa,three TACE treatments,two HAIC treatments,three courses of sintilimab,and twenty-one months of *** the third month of treatment,the patient developed severe side effects and had to stop immunotherapy,and the Lenvatinib dose had to be *** pathological diagnosis indicated a complete *** patient recovered well after the operation,and no tumor recurrence was *** Multidisciplinary conversion therapy for advanced enormous HCC caused by HCV infection has a significant *** drug adjustments should be made during any treatment according to the patient's tolerance to treatment.

关键词： Hepatocellular therapy Conversion hepatectomy Interventional therapy Epclusa Lenvatinib Sintilimab Case report

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地下水排泄河水过程中溶解态铁砷的协同迁移转化机制

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地球科学 2024年第7期49卷 2627-2636页

作者：邓茜予刘慧黄瑶中国地质大学环境学院湖北武汉430078 中国地质大学生物地质与环境地质国家重点实验室湖北武汉430078

地下水排泄河水过程中会将缺氧地下水中的Fe^(2+)与As^(3+)带入含氧的交互带中,本研究旨在探明该过程中Fe^(2+)与As^(3+)随地下水在实际沉积物介质中的协同迁移转化机制.通过室内柱实验和批实验研究地下水排泄河水时Fe^(2+)、As^(3+)的... 详细信息

地下水排泄河水过程中会将缺氧地下水中的Fe^(2+)与As^(3+)带入含氧的交互带中,本研究旨在探明该过程中Fe^(2+)与As^(3+)随地下水在实际沉积物介质中的协同迁移转化机制.通过室内柱实验和批实验研究地下水排泄河水时Fe^(2+)、As^(3+)的迁移转化规律并获取其在交互带不同部位向固相转化(固化)的速率.结果表明:沉积物对Fe^(2+)、As^(3+)具有较强的吸附作用,As^(3+)加快了Fe^(2+)的迁移;Fe^(2+)在流经交互带时发生化学氧化沉淀,形成了Fe-As结合态矿物.从远河处至近河处河处,Fe^(2+)、As^(3+)的固化速率加快.在整个交互带区域Fe^(2+)明显促进了As^(3+)的固化,在离河较近的区域As^(3+)略微抑制了Fe^(2+)的固化.地下水排泄河水过程中,Fe^(2+)、As^(3+)在交互不同部位以不同的速率发生协同化学氧化和吸附固定,从而严重阻碍其向河水方向迁移.

关键词：地下水排泄交互带铁砷迁移水文地质

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Experimental observation of the significant difference between surface and bulk Kondo processes in Kondo lattice YbCu_(2)Si_(2)

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Science China(Physics,Mechanics & Astronomy) 2024年第4期67卷 154-160页

作者： Yin-Zou Zhao Jiao-Jiao Song Qi-Yi Wu Hao Liu Chen Zhang Bo Chen Hong-Yi Zhang Zhen-Hua Chen yao-Bo huang Xue-Qing Ye Ya-Hua Yuan Yu-Xia Duan Jun He Jian-Qiao Meng School of Physics Central South UniversityChangsha 410083China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201204China

Synchrotron-based angle-resolved photoemission spectroscopy was employed to investigate the temperature evolution of the Yb 4 f spectral for surface and bulk in the Kondo lattice YbCu_(2)Si_(2).Our study quantitatively distinguishes between the surface and bulk hybridization processes,revealing that the onset temperatures for both surface and bulk hybridization processes are significantly higher than the Kondo ***,we found that the effective surface Kondo temperature is much lower than that of the *** findings offer valuable insights into the understanding of heavy fermion physics.

关键词： Kondo lattice angle-resolved photoemission spectroscopy electronic structure hybridization surface state

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用于钙离子全光囚禁的离子囚禁装置研究

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仪器仪表学报 2024年第2期45卷 102-111页

作者：陈正王淼黄垚管桦高克林中国科学院精密测量科学与技术创新研究院武汉430071 中国科学院大学北京100049

随着离子光钟技术的飞速发展,由离子光钟中用来囚禁离子的射频场带来的微运动效应对其性能的影响也越来越不可忽略。为彻底消除这一效应,提出了全光囚禁离子光钟的实验方案。针对这一实验方案,设计并搭建了用于钙离子全光囚禁的离子囚... 详细信息

随着离子光钟技术的飞速发展,由离子光钟中用来囚禁离子的射频场带来的微运动效应对其性能的影响也越来越不可忽略。为彻底消除这一效应,提出了全光囚禁离子光钟的实验方案。针对这一实验方案,设计并搭建了用于钙离子全光囚禁的离子囚禁装置。该装置是采用刀片型离子阱设计,能够实现剩余力仅有10^(-20) N量级的高精度的杂散电场补偿;具备6 mm的通关孔径,很好满足了全光囚禁实验中偶极囚禁激光的通过需求;基于改良的螺旋谐振器设计搭建的射频系统能够实现在9.33(1)MHz较低射频频率下的稳定耦合;结合高达10^(-9) Pa的真空制备和装配导电玻窗的真空腔体,可以实现长时间的离子囚禁。为全光囚禁钙离子提供了实验基础,对光学囚禁离子光钟的实现具有重大意义。

关键词：离子光钟全光囚禁离子阱射频真空腔

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数字化转型背景下商业模式创新抗拒路径研究

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科研管理 2024年第4期45卷 42-51页

作者：王炳成孙玉馨黄瑶山东科技大学经济管理学院山东青岛266590 山东科技大学(济南校区) 山东济南250031

商业模式创新是企业数字化转型的关键一环,但实践中却存在诸多商业模式创新抗拒的现象。然而,当前关于创新抗拒的研究多以消费者为主体,企业在转型过程中存在的商业模式创新抗拒问题却鲜有学者涉及,其作用路径与内在机理仍缺乏充分的理... 详细信息

商业模式创新是企业数字化转型的关键一环,但实践中却存在诸多商业模式创新抗拒的现象。然而,当前关于创新抗拒的研究多以消费者为主体,企业在转型过程中存在的商业模式创新抗拒问题却鲜有学者涉及,其作用路径与内在机理仍缺乏充分的理论关注。基于此,论文运用程序化扎根理论,对8家典型的商业模式创新抗拒企业进行了深入剖析,构建了数字化转型背景下企业商业模式创新抗拒的理论模型。研究发现,商业模式创新抗拒不同于产品创新抗拒,其涵盖了企业对改变整体商业模式要素综合逻辑的抗拒。根据情境与主导因素的差异,数字化转型背景下企业的商业模式创新抗拒主要可以分为“抱头缩项型”“画地自限型”“力不从心型”与“安于现状型”四类,并可分别采用风险决策理论、路径依赖理论、资源基础理论与绩效反馈理论予以解释。本研究拓展了商业模式创新的研究视角,并为减少企业在数字化转型背景下的创新抗拒提供了实践启示。

关键词：数字化转型商业模式创新商业模式创新抗拒扎根理论

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