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Compression Algorithm for Implicit 3D B-Spline Solids

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Communications in Mathematics and Statistics 2018年第2期6卷 119-140页

作者： yanzhi song Yixin Luo Yuan Liu Jiansong Deng Zhouwang Yang School of Mathematical Sciences University of Science and Technology of ChinaHefeiChina School of Mathematics HeFei University of TechnologyHefeiChina

Due to advantages in solid modeling with complex geometry and its ideal suitability for 3D printing,the implicit representation has been widely used in recent *** demand for free-form shapes makes the implicit tensor-product B-spline representation attract more and more ***,it is an important challenge to deal with the storage and transmission requirements of enormous coefficient *** this paper,we propose a new compression framework for coefficient tensors of implicit 3D tensor-product B-spline *** proposed compression algorithm consists of four steps,i.e.,preprocessing,block splitting,using a lifting-based 3D discrete wavelet transform,and coding with 3D set partitioning in hierarchical trees ***,we manage to lessen the criticism of the implicit tensor-product B-spline representation of surface for its redundancy store of 3D coefficient *** results show that the proposed compression framework not only achieves satisfactory reconstruction quality and considerable compression ratios,but also sup-ports progressive transmissions and random access by employing patch-wise coding strategy.

关键词： Implicit tensor-product B-spline Compression 3D discrete wavelet transform 3D SPIHT Progressive transmission Additive manufacturing

The accelerated blood clearance phenomenon of PEGylated nanoemulsion upon cross administration with nanoemulsions modified with polyglycerin

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Asian Journal of Pharmaceutical Sciences 2018年第1期13卷 44-53页

作者： Yuqing Su Lirong Wang Kaifan Liang Mengyang Liu Xinrong Liu yanzhi song Yihui Deng Shenyang Pharmaceutical University

For investigating the accelerated blood clearance(ABC) phenomenon of polyglycerin modified nanoemulsions upon cross administration with polyethylene glycol(PEG) covered nanoemulsion, we used the 1,2-distea-royl-sn-glycero-3-phosphoethanolamine-npolyglycerine-610 and the 1,2-distearoyl-n-glycero-3-phosphoethanolamine-n-[methoxy(polyethylene glycol)-2000] as modify materials, the dialkylcarbocyanines as fluorescence indicator. Exhausted macrophages rat model was established and new material containing polycarboxyl structure was synthesized. The microplate reader and the in vivo optical imaging system were applied to measure the concentration of nanoemulsions in *** results show that the first dose of polyglycerin modified nanoemulsion can induce the ABC phenomenon of the second dose of PEGylated nanoemulsion. With the increase in the amount of the surface polyglycerin, the extent of the ABC phenomenon decreases. Liver accumulation has positive relationship with the ABC phenomenon. Furthermore, kupffer cells in liver can get more immune information from polyhydroxy structure than polycarboxyl group in the modify compound. The results of our work imply that the polycarboxyl structure has advantages to eliminate the ABC phenomenon.

关键词： ABC phenomenon Nanoemulsion Liver accumulation Kupffer cells Polyglycerin Polycarboxyl

The effect of monosialylganglioside mix modifying the PEGylated liposomal epirubicin on the accelerated blood clearance phenomenon

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Asian Journal of Pharmaceutical Sciences 2017年第2期12卷 134-142页

作者： Ting Zhang songlei Zhou Le Kang Xiang Luo Yang Liu yanzhi song Xinrong Liu Yihui Deng College of Pharmacy Shenyang Pharmaceutical University

PEGylated liposomes are potential candidates to improve the pharmacokinetic characteristics of encapsulated drugs, to extend their circulation half-life and facilitate their passive accumulation at tumour sites. However, PEG-modified liposomes can induce accelerated blood clearance(ABC) upon repeated administration, and the extent of ABC phenomenon on the cytotoxic drugs-containing PEGylated liposomes is related to the dose of the cytotoxic *** this study, EPI served as a model cytotoxic drug, a hydrophilic surfactant molecule,monosialylganglioside(GM1) was chosen and modified on the liposomes together with *** was shown that upon mixed modification, when GM1 contents reached 10% or 15% mol,the ABC phenomenon of the PEGylated liposomal EPI significantly reduced. We also found that GM1 played an important role in abrogating the ABC phenomenon in both the induction phase and the effectuation phase. The results suggested that GM1 incorporation unfortunately did not avoid occurrence of ABC phenomenon completely, but GM1 modification on PEGylated liposomes may provide a significant improvement in clinical practice of PEGylated liposomes. Further study must be necessary.

关键词： PEGylated liposomes Epirubicin Monosialylganglioside(GM1) Mixed modification Accelerated blood clearance (ABC) phenomenon

Preparation and toxicity evaluation of a novel nattokinase-tauroursodeoxycholate complex

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Asian Journal of Pharmaceutical Sciences 2018年第2期13卷 173-182页

作者： Rui Feng Jing Li Jiepeng Chen Lili Duan XinRong Liu Donghua Di Yihui Deng yanzhi song College of Pharmacy Shenyang Pharmaceutical University Sungen Biotech Co. Ltd.

Nattokinase(NK), which has been identified as a potent fibrinolytic protease, has remarkable potential in treatment of thrombolysis, and even has the ability to ameliorate chronic vein thrombosis. To reduce the hemorrhagic risk from an intravenous injection of NK,nattokinase-tauroursodeoxycholate(NK-TUDCA) complex was prepared at different pH values and with different ratios of NK and TUDCA. When assessing survival time, survival state,tail injury, and the body weight of mice, it was found that the NK-TUDCA complex(NK: 10 k IU/ml; TUDCA: 10 mg/ml; pH 5.0) had a lower toxicity when administered at an NK dosage of 130 kIU/kg in the acute toxicity test and 13 kIU/kg in the repeated low-dose challenge. From the results of the in vitro thrombolytic test and characterization of NKTUDCA, we speculated that the delayed release of NK-TUDCA might be the main cause of toxicity reduction by the complex. This study described the preparation of an NK complex with low toxicity following intravenous administration, which could be utilized for further clinical study of NK.

关键词： Nattokinase Tauroursodeoxycholate Complex Toxicity test In vitro thrombolytic test

Blockade of neutrophil recruitment to tumor sites based on sialic acid-modified nanoplatforms enhances the efficacy of checkpoint blockade immunotherapy

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Asian Journal of Pharmaceutical Sciences 2023年第2期18卷 94-105页

作者： Meng Chen Zhaowei Qi Xianmin Meng Shuo Wang Xueying Zheng Miao Hu Xinrong Liu yanzhi song Yihui Deng School of Pharmacy Shenyang Pharmaceutical UniversityShenyang 110016China

Checkpoint inhibitors are designed to rejuvenate depleted or suppressed T cells in the tumor microenvironment,relying on the immune system to control and kill ***,accumulating evidence indicates that tumor-infiltrating neutrophils impede the proliferation and activation of T cells and determine the resistance to checkpoint blockade and *** this study,sialic acid ligand-modified colchicine derivative phospholipid complexes specifically targeted tumor-associated neutrophils in the peripheral blood,blocked neutrophil accumulation in tumors,and attenuated the inhibitory effect of infiltrating neutrophils on T *** blocking therapy enhanced the immunotherapy effect of the PD-L1 antibody in S180 advanced tumors and 4T1 breast *** study found that PD-L1 antibody monotherapy increased the tumor infiltration of immunosuppressive *** therapy with neutrophil blocking can greatly reduce tumor-infiltrating neutrophils and increase the proliferation of cytotoxic CD8^(+) T lymphocytes in the *** combination therapy significantly improved the survival rate of mice with advanced S180 tumors and increased the sensitivity of immune checkpoint inhibitors to 4T1 cold tumors.

关键词： Neutrophil blockade Combination immunotherapy Sialic acid

Effects of complement inhibition on the ABC phenomenon in rats

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Asian Journal of Pharmaceutical Sciences 2017年第3期12卷 250-258页

作者： Lirong Wang Yuqing Su Xuling Wang Kaifan Liang Mengyang Liu Wenya Tang yanzhi song Xinrong Liu Yihui Deng Shenyang Pharmaceutical University

Researchers reported that intravenously injected PEGylated colloidal drug carriers lose their long-circulating characteristic and accumulated extensively in liver when they are administrated twice in the same animal with certain intervals. This phenomenon was referred to as the 'accelerated blood clearance(ABC) phenomenon'. Some former studies had found that complement-mediated phagocytosis, activated by antigen–antibody complex, was responsible for inducing the phenomenon. According to the theory, we have used cobra venom factor to deplete complement in vivo and to investigate the effect of complement inhibition on the ABC phenomenon. Rats were administered by injection of cobra venom factor solution to build up the model of complement exhaustion/inhibition, and the effect of the inhibition of complement on ABC phenomenon was carried out. It seemed that inhibition of complement didn’t affect the pharmacokinetic of the first infection. By contrast, in rats of which complement had been depleted, the second dose of PEGylated nanoemulsions showed enhanced circulation time compared with normal rats in a complement inhibition-independent manner, but the ABC phenomenon was not completely eliminated. It indicated that complement inhibition could certainly weaken the accelerated clearance;meanwhile, there were other factors causing the ABC *** findings provide novel insights into the attenuating of ABC phenomenon and lay foundation for further study of immune mechanism.

关键词： ABC phenomenon PEGylated nanoemulsions Complement inhibition Cobra venom factor

Phyto-phospholipid complexes(phytosomes): A novel strategy to improve the bioavailability of active constituents

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Asian Journal of Pharmaceutical Sciences 2019年第3期14卷 265-274页

作者： Mei Lu Qiujun Qiu Xiang Luo Xinrong Liu Jing Sun Cunyang Wang Xiangyun Lin Yihui Deng yanzhi song College of Pharmacy Shenyang Pharmaceutical UniversityShenyang110016China College of Pharmaceutical Engineering Shenyang Pharmaceutical UniversityShenyang110016China

Although active constituents extracted from plants show robust in vitro pharmacological effects, low in vivo absorption greatly limits the widespread application of these compounds. A strategy of using phyto-phospholipid complexes represents a promising approach to increase the oral bioavailability of active constituents, which is consist of ‘‘label-friendly'phospholipids and active constituents. Hydrogen bond interactions between active constituents and phospholipids enable phospholipid complexes as an integral part. This review provides an update on four important issues related to phyto-phospholipid complexes: active constituents, phospholipids, solvents, and stoichiometric ratios. We also discuss recent progress in research on the preparation, characterization, structural verification, and increased bioavailability of phyto-phospholipid complexes.

关键词： Phyto-phospholipid complexes Active constituents Hydrogen bonds Bioavailability

Effect of Kupffer cells depletion on ABC phenomenon induced by Kupffer cells-targeted liposomes

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Asian Journal of Pharmaceutical Sciences 2019年第4期14卷 455-464页

作者： Chaoyang Lai Cong Li Mengyang Liu Qiujun Qiu Xiang Luo Xinrong Liu Ling Hu Yihui Deng yanzhi song Shenyang Pharmaceutical University

Accelerated blood clearance(ABC) phenomenon is common in many PEGylated nanocarriers, whose mechanism has not been completely elucidated yet. In this study, the correlation between Kupffer cells(KCs) and ABC phenomenon has been studied by KCs-targeted liposomes inducing ABC phenomenon and KCs depletion. In other words, the 4-aminophenyl-α-D-mannopyranoside(APM) lipid derivative DSPE-PEG 2000-APM(DPM), and 4-aminophenyl-β-L-fucopyranoside(APF) lipid derivative DSPE-PEG 2000-APF(DPF) were conjugated and modified on alendronate sodium(AD) liposomes to specifically target and deplete KCs. The dualligand modified PEGylated liposomes(MFPL) showed stronger ability to damage KCs in vitro and in vivo, which also could indirectly illustrate that dual-ligand modification could better target KCs. Besides, the hepatic biodistribution and pharmacokinetics could directly prove that MFPL had a stronger targeting ability to KCs. In addition, in depletion rats, plasma concentration and splenic biodistribution of MFPL and PEGylated liposomes(PL) were significantly elevated and hepatic biodistribution was significantly reduced, which demonstrated that KCs played an important role on elimination of nanoparticles. What’s more, ABC phenomenon of the secondary injection of PL was stronger in KCs depletion rats than that in normal rats, which indicated that depletion of KCs prolonged the circulation of PL in the first injection repeatedly stimulating B-cells in the marginal region of the spleen and causing it to secrete more IgM antibodies. This could also illustrate that anti-PEG IgM takes up a major station compared with KCs. Most important of all, KCs-targeted liposomes could induce a stronger ABC phenomenon than PL in normal rats, which declared that based on the same IgM concentration, the more the KCs were stimulated, the stronger ABC phenomenon was induced. However, in depletion rats, this difference of ABC phenomenon between PL and MFPL could no more exist, further demonstrating tha

关键词： Accelerated blood clearance (ABC) phenomenon Kupffer cells Depletion Liposomes Bio-distribution

Sialic acid-mediated photochemotherapy enhances infiltration of CD8^(+)T cells from tumor-draining lymph nodes into tumors of immunosenescent mice

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Acta Pharmaceutica Sinica B 2023年第1期13卷 425-439页

作者： Dezhi Sui Changzhi Li Xueying Tang Xianmin Meng Junqiang Ding Qiongfen Yang Zhaowei Qi Xinrong Liu Yihui Deng yanzhi song College of Pharmacy Shenyang Pharmaceutical UniversityShenyang 110016China

Immunoscenescence plays a key role in the initiation and development of ***,immunoscenescence also impacts drug delivery and cancer therapeutic *** reduce the impact of immunosenescence on anti-tumor therapy,this experimental plan aimed to use neutrophils with tumor tropism properties to deliver sialic acid(SA)-modified liposomes into the tumor,kill tumor cells via SA-mediated photochemotherapy,enhance infiltration of neutrophils into the tumor,induce immunogenic death of tumor cells with chemotherapy,enhance infiltration of CD8^(+)T cells into the tumordraining lymph nodes and tumors of immunosenescent mice,and achieve SA-mediated *** found that CD8^(+)T cell and neutrophil levels in 16-month-old mice were significantly lower than those in 2-and 8-month-old mice;16-month-old mice exhibited *** anti-tumor efficacy of SA-mediated non-photochemotherapy declined in 16-month-old mice,and tumors recurred after ***-mediated photochemotherapy enhanced tumor infiltration by CD8^(+)T cells and neutrophils,induced crusting and regression of tumors in 8-month-old mice,inhibited metastasis and recurrence of tumors and eliminated the immunosenescence-induced decline in antitumor therapeutic efficacy in 16-month-old mice via the light-heat-chemical-immunity conversion.

关键词： Immunosenescence Sialic acid Photochemotherapy CD8^(+)T cells Doxorubicin Neutrophils Indocyanine green Liposomes