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Epstein-Barr virus infection:the leading cause of multiple sclerosis

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Signal Transduction and Targeted Therapy 2022年第8期7卷 2650-2651页

作者： ruirui He yanyun Du Chenhui Wang The Key Laboratory for Human Disease Gene Study of Sichuan Province and the Department of Laboratory Medicine Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of China611731 ChengduChina Research Unit for Blindness Prevention of the Chinese Academy of Medical Sciences(2019ru026) Sichuan Academy of Medical Sciences and Sichuan Provincial People’s HospitalChengduSichuanChina

In a recent study published in Science,Bjornevik and colleagues demonstrated Epstein-Barr virus(EBV)infection is a trigger for multiple sclerosis(MS)in a longitudinal analysis of more than 10 million US military individuals who were on active duty.1 MS is an autoimmune disease that originates in the central nervous system characterized by inflammatory demyelinating *** is no consensus on the etiology of ***,we all know that MS is a multifactorial disease which can be influenced by genetic and environmental *** factors associated with MS risk are mainly major histocompatibility class Ⅱ(MHC Ⅱ)alleles(e.g.,HLA-DRB1^(*)15:01,the earliest identified and most dominant risk factor in MS)and MHC I alleles(e.g.,HLA-A^(*)02 and HLA B^(*)44,decreasing MS susceptibility).

关键词： infection sclerosis autoimmune

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磷掺杂调控碳纳米管负载的ru促进碱性析氢

山东化工 2024年第1期53卷 1-6,11页

作者：苗红福张燕云王磊赖建平青岛科技大学化学与分子工程学院山东青岛266042 青岛科技大学环境与安全工程学院山东青岛266042

电解水制氢是一种高效清洁的产氢方式,但开发高效稳定的催化剂用于电解水仍面临很大挑战。本文通过磷掺杂策略调节负载于碳纳米管的钌纳米颗粒的电子结构,实现高效促进碱性析氢。经过对反应条件的优化,所得ru-P@CNT(300)(CNT=碳纳米管)... 详细信息

电解水制氢是一种高效清洁的产氢方式,但开发高效稳定的催化剂用于电解水仍面临很大挑战。本文通过磷掺杂策略调节负载于碳纳米管的钌纳米颗粒的电子结构,实现高效促进碱性析氢。经过对反应条件的优化,所得ru-P@CNT(300)(CNT=碳纳米管)催化剂具有最优的碱性析氢反应(HER)催化活性,其达到电流密度10 mA·cm^(-2)时仅需要38 mV的过电位。同时随着电流密度的逐渐增大,ru-P@CNT(300)展现出了优于商用Pt/C的活性,说明随着电流的增大,其具有高于商用Pt/C的催化潜能。同时,该催化剂还表现出良好的催化稳定性。当ru-P@CNT(300)用于碱性海水析氢中时,其表现出的活性与在纯1 mol/L KOH中几乎一致,没有出现明显衰退,10 mA·cm^(-2)处的过电位仅为39 mV,而且在海水中依然保持良好的稳定性。

关键词：掺杂钌基材料磷载体析氢

DOCK2 regulates antifungal immunity by regulating RAC GTPase activity

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Cellular & Molecular Immunology 2022年第5期19卷 602-618页

作者： Xiaojian Ma Xi Tan Bingbing Yu Wanwei Sun Heping Wang Huijun Hu yanyun Du ruirui He ru Gao Qianwen Peng Zhihui Cui Ting Pan Xiong Feng Junhan Wang Chengqi Xu Bin Zhu Wei Liu Chenhui Wang Key Laboratory of Molecular Biophysics of the Ministry of Education National Engineering Research Center for NanomedicineCollege of Life Science and TechnologyHuazhong University of Science and TechnologyWuhan430074China Key Laboratory of Molecular Biophysics the Ministry of EducationCollege of Life Science and Technology and Shenzhen CollegeHuazhong University of Science and TechnologyWuhanHubeiChina The Key Laboratory for Human Disease Gene Study of Sichuan Province and the Department of Laboratory Medicine Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengdu611731China Research Unit for Blindness Prevention of the Chinese Academy of Medical Sciences(2019ru026) Sichuan Academy of Medical Sciences and Sichuan Provincial People’s HospitalChengduSichuanChina University-Affiliated Hospital Huazhong University of Science and TechnologyWuhan430074China Key Laboratory of Molecular Biophysics of the Ministry of Education College of Life Science and TechnologyCenter for Human Genome ResearchCardio-X InstituteHuazhong University of Science and TechnologyWuhan430074PR China

Fungal infections cause~1.5 million deaths each year worldwide,and the mortality rate of disseminated candidiasis currently exceeds that of breast cancer and *** major reasons for the high mortality of candidiasis are the limited number of antifungal drugs and the emergence of drug-resistant ***,a better understanding of antifungal host defense mechanisms is crucial for the development of effective preventive and therapeutic ***,we report that DOCK2(dedicator of cytokinesis 2)promotes indispensable antifungal innate immune signaling and proinflammatory gene expression in ***2-deficient macrophages exhibit decreased RAC GTPase(Rac family small GTPase)activation and ROS(reactive oxygen species)production,which in turn attenuates the killing of intracellular fungi and the activation of downstream signaling ***,after fungal stimulation,activated SYK(spleen-associated tyrosine kinase)phosphorylates DOCK2 at tyrosine 985 and 1405,which promotes the recruitment and activation of RAC GTPases and then increases ROS production and downstream signaling ***,nanoparticle-mediated delivery of in vitro transcribed(IVT)Rac1 mRNA promotes the activity of Rac1 and helps to eliminate fungal infection in *** together,this study not only identifies a critical role of DOCK2 in antifungal immunity via regulation of RAC GTPase activity but also provides proof of concept for the treatment of invasive fungal infections by using IVT mRNA.

关键词： DOCK2 RAC Anti-fungal immunity IVT-mRNA

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润燥止痒胶囊治疗寻常痤疮的系统评价

中国皮肤性病学杂志 2018年第6期32卷 689-696页

作者：郑淇顾云东曹艳云茹意李欣李斌上海中医药大学附属岳阳中西医结合医院皮肤科上海200437 上海市中医药研究院皮肤病研究所上海201203 上海中医药大学附属岳阳中西医结合医院崇明分院皮肤科上海202150 上海市浦东新区人民医院皮肤科上海201200

目的评价润燥止痒胶囊治疗寻常痤疮的疗效及安全性。方法完整检索中国知网(CNKI)、中文科技期刊全文数据库(VIP)、万方数据库(Wan-fang)、中国生物医学文献数据库(Sino Med)、MEDLINE、Cochrane、EMBASE数据库中近10年的相关研究。按照... 详细信息

目的评价润燥止痒胶囊治疗寻常痤疮的疗效及安全性。方法完整检索中国知网(CNKI)、中文科技期刊全文数据库(VIP)、万方数据库(Wan-fang)、中国生物医学文献数据库(Sino Med)、MEDLINE、Cochrane、EMBASE数据库中近10年的相关研究。按照制订的纳入标准及排除标准筛选研究,提取有效数据,评价纳入研究的质量,采用Rev Man 5.2软件进行数据分析。结局效应指标以相对危险度(RR)及其95%可信区间(CI)形式表示。结果共纳入25个研究项目(2 735例患者),其中治疗组1 429例,对照组1 306例。纳入研究的质量均较低。总效应量分析结果显示:润燥止痒胶囊联合西药治疗寻常痤疮的总有效率显著高于纯西药组(RR=1.33,95%CI=1.27~1.39);而润燥止痒胶囊治疗组的总有效率低于联合治疗组(RR=1.30,95%CI=1.04~1.61)。润燥止痒胶囊未发现严重不良反应。结论润燥止痒胶囊联合西药治疗寻常痤疮具有较好的临床疗效,并减少不良反应的发生。但由于纳入研究的质量较低,该疗效需更加严谨的大样本多中心随机对照试验验证。

关键词：润燥止痒胶囊寻常痤疮系统评价 Meta分析

外界膜及椭圆体带完整性与视网膜静脉阻塞黄斑水肿视力预后的相关性

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中华眼视光学与视觉科学杂志 2023年第2期25卷 133-138页

作者：茹月师燕芸孔帆山西医科大学第一临床医学院太原030001 山西省眼科医院眼底病科太原030002

目的:通过视网膜静脉阻塞黄斑水肿(RVO-ME)患者频域光学相干断层扫描(SD-OCT)图像特征,探讨外界膜(ELM)及椭圆体带(EZ)完整性与RVO-ME患者预后视力的相关性。方法:系列病例研究。随机抽取2019年1月至2022年1月就诊于山西省眼科医院的RVO... 详细信息

目的:通过视网膜静脉阻塞黄斑水肿(RVO-ME)患者频域光学相干断层扫描(SD-OCT)图像特征,探讨外界膜(ELM)及椭圆体带(EZ)完整性与RVO-ME患者预后视力的相关性。方法:系列病例研究。随机抽取2019年1月至2022年1月就诊于山西省眼科医院的RVO-ME初发患者30例(30眼),进行最佳矫正视力(BCVA)、眼压、裂隙灯显微镜与SD-OCT检查,并用OCT自带的卡尺对黄斑中心凹视网膜厚度(CMT)、经黄斑中心凹500μm半径以内的ELM、EZ缺损长度进行测量。采用Spearman相关性分析CMT、ELM及EZ缺损长度与治疗后视力改善值的相关性、初始BCVA(LogMAR)与治疗后BCVA(LogMAR)的相关性以及治疗后CMT、ELM及EZ缺损长度与治疗后BCVA的相关性。结果:治疗后视力改善值与初始CMT(r=-0.67,P<0.001)、初始ELM缺损长度(r=-0.82,P<0.001)、初始EZ缺损长度(r=-0.79,P<0.001)均呈负相关,而与发病年龄无相关性(r=-0.18,P=0.540)。初始BCVA与治疗后BCVA呈正相关(r=0.67,P<0.001)。治疗后BCVA与治疗后CMT(r=0.38,P=0.040)、治疗后ELM缺损长度(r=0.54,P=0.002)、治疗后EZ缺损长度(r=0.39,P=0.030)均呈正相关。结论:ELM及EZ的完整性可作为判断RVO-ME患者预后视力的重要指标,初诊视力也是RVO-ME患者水肿消退后预后视力的影响因素。

关键词：视网膜静脉阻塞黄斑水肿外界膜椭圆体带最佳矫正视力

Using Composite Phenotypes to Reveal Hidden Physiological Heterogeneity in High-Altitude Acclimatization in a Chinese Han Longitudinal Cohort

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Phenomics 2021年第1期1卷 3-14页

作者： Yi Li yanyun Ma Kun Wang Menghan Zhang Yi Wang Xiaoyu Liu Meng Hao Xianhong Yin Meng Liang Hui Zhang Xiaofeng Wang Xingdong Chen Yao Zhang Wenyuan Duan Longli Kang Bin Qiao Jiucun Wang Li Jin State Key Laboratory of Genetic Engineering Collaborative Innovation Center for Genetics and DevelopmentSchool of Life Sciences and Human Phenome InstituteFudan UniversityShanghai 200438China Ministry of Education Key Laboratory of Contemporary Anthropology Department of Anthropology and Human GeneticsSchool of Life SciencesFudan UniversityShanghai 200438China Institute for Six‑Sector Economy Fudan UniversityShanghai 200433China Fudan-Taizhou Institute of Health Sciences Taizhou 225300China Key Laboratory of High Altitude Environment and Genes Related To Diseases of Tibet Autonomous Region School of MedicineXizang Minzu UniversityXianyang 712082China Institute of Cardiovascular Disease Shandong Provincial Western HospitalJinanShandong 250022China Research Unit of Dissecting the Population Genetics and Developing New Technologies for Treatment and Prevention of Skin Phenotypes and Dermatological Diseases(2019ru058) Chinese Academy of Medical SciencesBeijing 100730China

Altitude acclimatization is a human physiological process of adjusting to the decreased oxygen *** several physiological processes are involved and their correlations are complicated,the analyses of single traits are insufficient in revealing the complex mechanism of high-altitude *** this study,we examined these physiological responses as the composite phenotypes that are represented by a linear combination of physiological *** developed a strategy that combines both spectral clustering and partial least squares path modeling(PLSPM)to define composite phenotypes based on a cohort study of 883 Chinese Han *** addition,we captured 14 composite phenotypes from 28 physiological traits of high-altitude *** these composite phenotypes,we applied k-means clustering to reveal hidden population physiological heterogeneity in high-altitude ***,we employed multivariate linear regression to systematically model(Models 1 and 2)oxygen saturation(SpO_(2))changes in high-altitude acclimatization and evaluated model fitness *** phenotypes based on Model 2 fit better than single trait-based Model 1 in all measurement *** new strategy of using composite phenotypes may be potentially employed as a general strategy for complex traits research such as genetic loci discovery and analyses of phenomics.

关键词： Altitude acclimatization Composite phenotypes Hypoxia Complex traits Phenomics

The composite phenotype analysis identifies potential concerted responses of physiological systems to high altitude exposure

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National Science Review 2023年第5期10卷 109-111页

作者： Yi Li Meng Hao Zixin Hu yanyun Ma Kun Wang Xiaoyu Liu Xianhong Yin Menghan Zhang Yi Wang Meng Liang Yuan Guo Lei Bao Shixuan Zhang Shiguan Le Chenyuan Wu Dayan Sun Yang Wei Fei Wu rui Zhang Lingxian Zhu Hui Zhang Shuai Jiang Xingdong Chen Xiaofeng Wang Yao Zhang Longli Kang Wenyuan Duan Bin Qiao Jiucun Wang Li Jin State Key Laboratory of Genetic Engineering Collaborative Innovation Center for Genetics and DevelopmentSchool of Life Sciences and Human Phenome InstituteFudan University Institute for Six-sector Economy Fudan University International Human Phenome Institutes Ministry of Education Key Laboratory of Contemporary Anthropology Department of Anthropology and Human GeneticsSchool of Life SciencesFudan University Greater Bay Area Institute of Precision Medicine(Guangzhou) School of Life SciencesFudan University Artificial Intelligence Innovation and Incubation Institute Fudan University Shanghai Pudong Hospital Fudan University Pudong Medical Center Fudan-Taizhou Institute of Health Sciences Key Laboratory of High-Altitude Environment and Genes Related to Diseases of Tibet Autonomous Region School of MedicineXizang Minzu University Institute of Cardiovascular Disease Shandong Provincial Western Hospital Research Unit of Dissecting the Population Genetics and Developing New Technologies for Treatment and Prevention of Skin Phenotypes and Dermatological Diseases (2019ru058) Chinese Academy of Medical Sciences

Environmental stresses,such as temperature,disease and altitude could induce systematic changes of biological systems which manifests as concerted responses across multiple systems within a certain period of time[1].High altitude acclimatization (HAA) refers to a series of adaptive physiological responses to hypoxic *** these processes,

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Studying the Level Properties of ^(16)F via the ^(1)H(^(15)O,p)^(15)O Elastic Scattering

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IMP & HIRFL Annual Report 2018年第1期 38-39页

作者： ru Longhui Hu Jun Liu Enqiang Bai Zhen Duan Fangfang Fang Xiao Hou Suqing Hu Qiang Ji Liancheng Jin Shuya Li Kuoang Li Yiyang Li ruojie Ma Peng Ma Junbing Sun Xinxin Shi Guozhu Tang Xiaodong Wang Xinyu Wang Jiansong Wang Yufeng Wu Jiatong Xu Xiaodong Xu Shiwei Xin Wenyu Yang Kaiping Yang yanyun NMichel 不详

The understanding of open quantum systems in unbound nuclei is a challenge to the nuclear structure research[1].The continuum coupling effect may lead to a reordering of the shells in such systems[2].A way to study this effect is to compare the level schemes of two mirror nuclei involving an unbound and a bound nucleus such as 16F and 16N[3].Here we report an experiment of studying the level properties of 16F using the resonant elastic scattering with an 15O radioactive beam delivered by the Radioactive Ion Beam Line at Lanzhou(RIBLL)[4].

关键词： Elastic resonant shells

基于集对分析偏联系数研究银屑病皮损对疗效的影响

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中华中医药学刊 2019年第5期37卷 1042-1045页

作者：徐蓉卢怡蒯仂茹意柴媛媛曹艳云迮侃李欣李斌赵克勤上海中医药大学附属岳阳中西医结合医院上海200437 上海市中医药研究院皮肤病研究所上海201203 上海市浦东新区人民医院上海200000 诸暨市联系数学研究所浙江诸暨311811

目的:探讨用集对分析中的偏联系数研究银屑病患者皮损程度与部位对疗效的影响。方法:首先把皮损状况分成红斑、鳞屑、浸润、面积、部位5个大类12个子类,统计202例患者在各子类上的痊愈、显效、有效、无效百分比,令其依次对应于四元联系... 详细信息

目的:探讨用集对分析中的偏联系数研究银屑病患者皮损程度与部位对疗效的影响。方法:首先把皮损状况分成红斑、鳞屑、浸润、面积、部位5个大类12个子类,统计202例患者在各子类上的痊愈、显效、有效、无效百分比,令其依次对应于四元联系数中的同一度a,偏同度b,偏反度c,对立度d;计算各子类疗效的四元联系数的全偏联系数,根据全偏联系数值的大小做出排序,全偏联系数值大的疗效好于全偏联系数值小的疗效,据此确定皮损状况对疗效的影响性质与影响程度。结果:浸润积分0～1.46的患者疗效最好(排序1),鳞屑积分>2.04的患者疗效最差(排序12);相对于皮损状况来说,皮损发生在何部位对治疗后的预期影响不大,但所有的皮损状况项目都不利于疗效的提高(反映在三阶全偏联系数上的值全部为负值),这与临床实际一致。结论:利用四元联系数的全偏联系数研究银屑病皮损状况对中西医结合治疗银屑病疗效的影响,在临床中根据皮损部位及皮损程度作出统计学意义上的疗效预期,从而为临床治疗提供一种新的决策支持技术。

关键词：银屑病皮损疗效四元联系数全偏联系数集对分析