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An efficient fully dynamic group signature with message dependent opening from lattice

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Cybersecurity 2021年第1期4卷 208-222页

作者： Yiru Sun yanyan liu State Key Laboratory of Information Security Institute of Information EngineeringChinese Academy of SciencesHaidian DistrictBeijingChina School of Cyber Security University of Chinese Academy of SciencesHuairou DistrictChina State Key Laboratory of Cryptology P.O.Box 515Xicheng DistrictBeijingChina

Message-dependent opening is one of the solutions to solve the problem of the tracing manager owns excessive *** this paper,we present a new lattice-based fully dynamic group signature scheme with message-dependent opening by combining an improved version of the fully dynamic group signature scheme proposed by Ling et al and the double encryption *** addition,we propose an improved underlying zero knowledge protocol,it has a soundness error 1 max(n,p)+1 that is better than the Stern-like protocol,which helps to bring down the communication complexity of the protocol and hence the signature *** scheme constrains the power of group managers by adding an admitter,and the signature size has a logarithmic relationship with the group size.

关键词： Dynamic group signature Message-dependent opening NIZK LWE SIS

Gas-liquid-liquid slug flow and mass transfer in hydrophilic and hydrophobic microreactors

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Chinese Journal of Chemical Engineering 2022年第10期50卷 85-94页

作者： yanyan liu Chaoqun Yao Guangwen Chen Dalian National Laboratory for Clean Energy Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China University of Chinese Academy of Sciences Beijing 100049China

Gas-liquid-liquid three-phase slug flow was generated in both hydrophilic and hydrophobic microreactors with double *** bubble-droplet relative movement and the local mass transfer within the continuous slug and the dispersed droplet were *** was found that bubbles moved faster than droplets under low capillary number(Ca),while droplets moved faster upon the increase of Ca due to the increased *** the first time,we observed that the increased viscosity of droplets fastened the droplet *** mass transfer in the continuous slug was dominated by convection,leading to nearly constant global mass transfer coefficient(k_(L)a);while that in the dispersed droplet was dominated by diffusion,resulting in k_(L) decreasing along the *** features are analogical to the corresponding gas-liquid or liquid-liquid two-phase slug flow,but the formation of bubble-droplet clusters caused by relative movement lowered the absolute mass transfer *** results provide insights for the precise manipulation of gas-liquid-liquid slug flow in microreactors towards process optimization.

关键词： Mass transfer Multiphase flow Slug flow Microreactor Colorimetric method

CONTINUOUS AUXILIARY COVARIATE IN ADDITIVE HAZARDS REGRESSION FOR SURVIVAL DATA

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Journal of Systems Science & Complexity 2014年第6期27卷 1247-1262页

作者： SHI Xiaoping liu yanyan WU Yuanshan School of Mathematics and System Sciences Xinjiang University School of Mathematics and Statistics Wuhan University

This paper considers the additive hazards iliary covariate information to improve the efficiency regression analysis by utilizing continuous aux- of the statistical inference when the primary covariate is ascertained only for a randomly selected subsample. The authors construct a martingale based estimating equation for the regression parameter and establish the asymptotic consistency and normality of the resultant estimators. Simulation study shows that the proposed method can greatly improve the efficiency compared with the estimator which discards the auxiliary covariate information in a variety of settings. A real example is also provided as an illustration.

关键词： Additive hazards regression continuous auxiliary covariate estimating equation kernelsmoothing survival analysis.

Using expansion units to improve CO_(2) absorption for natural gas purification——A study on the hydrodynamics and mass transfer

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Chinese Journal of Chemical Engineering 2021年第1期34卷 35-46页

作者： Kai Zhu Chaoqun Yao yanyan liu Guangwen Chen Dalian National Laboratory for Clean Energy Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China University of Chinese Academy of Sciences Beijing 100049China

The usage of capillary tubes for CO_(2) absorption suffers from small re sidence time,which leads to reduced performance for large *** work presents a method of connecting expansion units to capillary tubes to serve as a residence time *** effect of the expansion unit on gas-liquid hydrodynamics,pressure drop and mass transfer coefficient(k_(L)a) are investigated under various operating pressures up to 4.0 MPa,for both physical and chemical absorption.A novel periodic jetting flow is found in the expansion unit,which can intensify the CO_(2) *** results show that the strategy can significantly decrease the pressure drop while maintaining the absorption performance to a large *** overall k_(L)a for physical and chemical absorption are correlated to pressure drop,***,CO_(2) loading in rich absorbents increases dramatically compared to literature studies with only micromixers or capillary tubes,which is bene ficial to regenerate *** study verifies the concept that pre-treatment with water can largely reduce the usage of amine s,and can also provide a guide for process design in natural gas purification such as biogas recovery.

关键词： Microchannel Microreactor Separation Purification High pressure

Statistical inference methods and applications of outcome-dependent sampling designs under generalized linear models

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Science China Mathematics 2017年第7期60卷 1219-1238页

作者： YAN Shu DING JieLi liu yanyan School of Mathematics and Statistics Wuhan University Wuhan 430072 China

A cost-effective sampling design is desirable in large cohort studies with a limited budget due to the high cost of measurements of primary exposure *** outcome-dependent sampling(ODS) designs enrich the observed sample by oversampling the regions of the underlying population that convey the most information about the exposure-response *** generalized linear models(GLMs) are widely used in many fields,however,much less developments have been done with the GLMs for data from the ODS *** study how to fit the GLMs to data obtained by the original ODS design and the two-phase ODS design,*** asymptotic properties of the proposed estimators are derived.A series of simulations are conducted to assess the finite-sample performance of the proposed *** to a Wilms tumor study and an air quality study demonstrate the practicability of the proposed methods.

关键词： biased-sampling two-phase design generalized linear models empirical likelihood

KSHV strategies for host dsDNA sensing machinery

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Virologica Sinica 2016年第6期31卷 466-471页

作者： Hang Gao yanyan Song Chengrong liu Qiming Liang Department of Nephrology The Second Hospital of Jilin University Changchun 130041 China

The innate immune system utilizes pattern recognition receptors cyclic GMP-AMP synthase(cGAS)to sense cytosolic double-stranded(ds) DNA and initiate type 1 interferon signaling and autophagy pathway, which collaborate to limit pathogen infections as well as alarm the adaptive immune response. The genomes of herpesviruses are large dsDNA, which represent a major class of pathogen signatures recognized by cellular DNA sensor cGAS. However, to successfully establish the persistent infection, herpesviruses have evolved their viral genes to modulate different aspects of host immune signaling. This review summarizes the evasion strategies of host cGAS DNA sensing pathway by Kaposi's Sarcoma-associated Herpesvirus(KSHV) and their contributions to KSHV life cycles.

关键词： dsDNA interferon innate autophagy signaling modulate pathogen alarm initiate contributions

Inhibition of thrombin by functionalized C_(60)nanoparticles revealed via in vitro assays and in silico studies

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Journal of Environmental Sciences 2018年第1期30卷 285-295页

作者： yanyan liu Jianjie Fu Wenxiao Pan Qiao Xue Xian liu Aiqian Zhang State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China College of Resources and Environment University of Chinese Academy of SciencesBeijing 100190China Institute of Environment and Health Jianghan UniversityWuhan 430056China

The studies on the human toxicity of nanoparticles（NPs） are far behind the rapid development of engineered functionalized NPs. Fullerene has been widely used as drug carrier skeleton due to its reported low risk. However, different from other kinds of NPs, fullerene-based NPs（C_（60） NPs） have been found to have an anticoagulation effect, although the potential target is still unknown. In the study, both experimental and computational methods were adopted to gain mechanistic insight into the modulation of thrombin activity by nine kinds of C_（60） NPs with diverse surface chemistry properties. In vitro enzyme activity assays showed that all tested surface-modified C_（60） NPs exhibited thrombin inhibition ability. Kinetic studies coupled with competitive testing using 3 known inhibitors indicated that six of the C_（60） NPs, of greater hydrophobicity and hydrogen bond（HB） donor acidity or acceptor basicity, acted as competitive inhibitors of thrombin by directly interacting with the active site of thrombin. A simple quantitative nanostructure-activity relationship model relating the surface substituent properties to the inhibition potential was then established for the six competitive *** docking analysis revealed that the intermolecular HB interactions were important for the specific binding of C_（60） NPs to the active site canyon, while the additional stability provided by the surface groups through van der Waals interaction also play a key role in the thrombin binding affinity of the NPs. Our results suggest that thrombin is a possible target of the surface-functionalized C_（60） NPs relevant to their anticoagulation effect.

关键词： Thrombin C_(60) nanoparticle(NP) Surface modification Activity inhibition Quantitative nanostructure-activity relationship Molecular docking

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不同来源间充质干细胞治疗卵巢早衰的机制

中国组织工程研究 2025年第13期29卷 2764-2773页

作者：刘艳艳马园园黄向华张敬坤河北医科大学第二医院河北省石家庄市050000

背景:已经有大量细胞及动物实验证实了间充质干细胞具有改善卵巢功能的作用,部分临床试验也已完成并初步证实了其有效性,为卵巢早衰女性带来了希望。目的:总结并分析近年来关于不同来源间充质干细胞治疗卵巢早衰的机制、研究进展及相关... 详细信息

背景:已经有大量细胞及动物实验证实了间充质干细胞具有改善卵巢功能的作用,部分临床试验也已完成并初步证实了其有效性,为卵巢早衰女性带来了希望。目的:总结并分析近年来关于不同来源间充质干细胞治疗卵巢早衰的机制、研究进展及相关临床试验,为间充质干细胞治疗卵巢早衰的进一步研究及临床应用提供理论依据。方法:以“间充质干细胞,卵巢早衰”及“mesenchymal stem cells,premature ovarian failure”分别作为中、英文关键词,在中国知网、万方数据库、中华医学库及PubMed数据库对相关文献进行检索,最终纳入符合要求的72篇文献进行综述。结果与结论:目前常用于治疗卵巢早衰的间充质干细胞种类有7类,分别为脐带间充质干细胞、骨髓间充质干细胞、胎盘间充质干细胞、经血间充质干细胞、羊膜间充质干细胞、羊水间充质干细胞及脂肪间充质干细胞,涉及作用机制主要包括抑制凋亡促进增殖、抗炎及抑制氧化应激、归巢、促血管生成、抗纤维化、旁分泌、免疫调节、自噬及改善微环境。细胞和动物实验均表明不同来源间充质干细胞可以通过各种机制对卵巢早衰有较好的干预效果,一定程度上延缓了卵巢早衰的进展。如果将来能成功运用于临床,能够很大程度上缓解患者来自心理及生理上的痛苦。但目前临床研究因干细胞来源伦理、具体给药方式及剂量、是否引发严重不良反应等方面缺乏全面且准确的证据,故在未来仍需进行深入探讨,同时远期安全性也有待进一步观察。

关键词：卵巢早衰间充质干细胞颗粒细胞卵泡机制作用方式临床试验诊疗

An efficient full dynamic group signature scheme over ring

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Cybersecurity 2018年第1期1卷 617-631页

作者： Yiru Sun yanyan liu Bo Wu State Key Laboratory of Information Security Institute of Information EngineeringChinese Academy of SciencesBeijingChina School of Cyber Security University of Chinese Academy of SciencesBeijingChina

The group signature scheme is an important primitive in cryptography,it allows members in a group to generate signatures anonymously on behalf of the whole *** view of the practical application of such schemes,it is necessary to allow users’registration and revocation when necessary,which makes the construction of dynamic group signature schemes become a significant *** the basis of(Ling et al.,Lattice-based group signatures:achieving full dynamicity with ease,2017),we present the first full dynamic group signature scheme over ring,and under the premise of ensuring security,the efficiency of the scheme is improved mainly from the following three aspects:the size of keys,the dynamic construction of a Merkle hash tree that used to record the information of registered users,and the reuse of the leaves in this *** addition,the public and secret keys of both group manager and trace manager are generated by a trusted third party,which prevents the situation that the two managers generate their respective public key and secret key *** with the counterpart of the scheme in(Ling et al.,Lattice-based group signatures:achieving full dynamicity with ease,2017)over ring,the expected space complexity of the Merkle tree used in our work down almost by half,and the computational complexity of its update has been reduced by a notch because of the dynamic construction of the hash tree.

关键词： Group signature Dynamic Merkle Tree Ring-LWE