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Probiotic cocktails accelerate baicalin metabolism in the ileum to modulate intestinal health in broiler chickens

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Journal of Animal Science and Biotechnology 2024年第2期15卷 779-794页

作者： Mingkun Gao Chaoyong Liao Jianyang Fu Zhonghua Ning Zengpeng lv Yuming Guo State Key Laboratory of Animal Nutrition and Feeding College of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193China National Engineering Laboratory for Animal Breeding College of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193China

Background Baicalin and probiotic cocktails are promising feed additives with broad application *** probiotic cocktails are known to enhance intestinal health,the potential synergistic impact of combining baicalin with probiotic cocktails on the gut health of broiler chickens remains largely ***,this study aims to investigate the influence of the combined administration of baicalin and probiotic cocktails on the composition of ileal and cecal microbiota in broiler chickens to elucidate the underlying mechanisms responsible for the healthpromoting *** A total of 3201-day-old male Arbor Acres broilers were divided into 4 groups,each with 8 replicates of 10 chicks per *** a period of 42 d,the birds were fed a basal diet or the same diet supplemented with 37.5 g/t baicalin(BC),1,000 g/t probiotic cocktails(PC),or a combination of both BC(37.5 g/t)and PC(1,000 g/t).The results demonstrated that BC+PC exhibited positive synergistic effects,enhancing intestinal morphology,immune function,and barrier *** was evidenced by increased VH/CD ratio,sIgA levels,and upregulated expression of occludin and claudin-1(P<0.05).16S rRNA analysis indicated that PC potentiated the effects of BC,particularly in the ileum,where BC+PC significantly increased theα-diversity of the ileal microbiota,altered itsβ-diversity,and increased the relative abundance of Flavonifractor(P<0.05),a flavonoid-metabolizing ***,Flavonifractor positively correlated with chicken ileum crypt depth(P<0.05).While BC+PC had a limited effect on cecal microbiota structure,the PC group had a very similar microbial composition to BC+PC,suggesting that the effect of PC at the distal end of the gut overshadowed those of *** We demonstrated the synergistic enhancement of gut health regulation in broiler chickens by combining baicalin and probiotic *** cocktails enhanced the effects of baicalin and accelerated its metab

关键词： Baicalin Gut health Ileal microbiota Probiotic cocktails Synergistic effects

Local failure mechanism of sand-blocking fence in latticed dune along desert roads

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Journal of Mountain Science 2024年第2期21卷 526-537页

作者： LI Liangying lv Lele LI Qi WANG Zhenqiang YANG Youhai YIN Wenhua School of Civil Engineering Lanzhou Jiaotong UniversityLanzhou 730070China Ningxia Highway Survey and Design Institute Co Ltd Yinchuan 750001China

The latticed dunes in the Tengger Desert are widely distributed,and the sand-blocking fence placed here are highly susceptible to local failure due to complex wind-sand activities,posing a serious threat to the safe operation of the *** explore the local failure mechanism of sand-blocking fence in the latticed dune area,the local failure of sand-blocking fence in the latticed dune areas along the Wuhai-Maqin Highway in China was *** the first main ridge of the latticed dune as the placement location,the structure of the wind-sand flow field of sand-blocking fence placed at top,the bottom and the middle of windward slope was analyzed by Computational Fluid Dynamics(CFD).The results show that when placed at top of the first main ridge,the wind speed near the sand-blocking fence is the highest,up to 15.23 m/***,the wind load strength on the sand barrier is correspondingly larger,up to 232.61 N∙*** the strength of material continues to decrease,the nylon net is prone to *** roots of the angle steel posts are susceptible to hollowing by vortex action,which can cause sand-blocking fence to fall over in strong wind *** placed at the bottom of windward slope,wind speed drop near sand-blocking fence is greatest,with the decrease of 12.48-14.32 m/s compared to the original wind *** is highly likely to lead to large-scale deposition of sand particles and burial of the sand-blocking *** placed in the middle of windward slope,sand-blocking fence is subjected to less wind load strength(168.61N∙m-2)and sand particles are mostly deposited at the bottom of windward slope,with only a small amount of sand accumulating at the root of sand-blocking *** on field observations and numerical modelling results,when the sand-blocking fence is placed in latticed dune area,it should be placed in the middle of the windward slope of the first main ridge as a matter of *** the sand-blocking fence should be placed

关键词： Latticed dune Sand-blocking fence Local failure Numerical simulation Desert roads

Responses of Nutrients to the Precipitation Variation and Land Use in Subtropical Monsoonal Small Mountainous Rivers:A Case Study of Baixi Watershed

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Journal of Ocean University of China 2024年第2期23卷 383-391页

作者： TIAN Yuan GAO Fei CAO Ke lv Shenghua DUAN Xiaoyong YIN Ping Qingdao Institute of Marine Geology China Geological SurveyMinistry of Natural ResourcesQingdao 266237China Laboratory for Marine Geology Laoshan LaboratoryQingdao 266237China

Small mountainous rivers are characterized by large instantaneous fluxes and susceptible to extreme weather events,which can rapidly transport materials into the sea and have a significant impact on the ecological environment of estuaries and *** order to investigate the seasonal characteristics of nutrients in small mountainous rivers in the subtropical monsoon region and the output pattern to the sea during heavy precipitation,surveys on the mountainous rivers were carried out in Baixi watershed in August 2020(wet season),March 2021(dry season)and June 2021(Meiyu period).The results showed that the dissolved inorganic nitrogen(DIN)of the rivers has an average concentration of 752μg L^(−1)in the wet season and 1472μg L^(−1)in the dry *** concentrations of dissolved inorganic phosphorus(DIP)in wet season and dry season were 63μg L^(−1)and 51μg L^(−1),*** by the changes of land use in sub-watersheds,DIN concentrations in the mainstream increased from 701μg L^(−1)in the upper reaches to 1284μg L^(−1)in the middle *** rainstorms during the Meiyu period in the watershed caused the pulse runoff in the *** maximum daily runoff reached 70 times that before *** maximum daily fluxes of DIN and DIP were 109 and 247 times that before rains,*** view that the watershed experienced several rainstorms in the wet season,the river,with pulse runoff,carries a large amount of nutrients into the sea in a short time,which will have a significant impact on the environment of Sanmen bay and its adjacent sea.

关键词： small mountainous river uneven precipitation rainstorm pulse runoff nitrogen and phosphorus

Protein post-translational modifications in auxin signaling

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Journal of Genetics and Genomics 2024年第3期51卷 279-291页

作者： Xiankui Cui Junxia Wang Ke Li Bingsheng lv Bingkai Hou Zhaojun Ding The Key Laboratory of Plant Development and Environmental Adaptation Biology Ministry of EducationSchool of Life SciencesShandong UniversityQingdaoShandong 266237China Shandong Academy of Grape JinanShandong 250100China College of Horticulture Qingdao Agricultural UniversityQingdaoShandong 266109China

Protein post-translational modifications(PTMs),such as ubiquitination,phosphorylation,and small ubiquitin-like modifier(SUMO)ylation,are crucial for regulating protein stability,activity,subcellular localization,and binding with *** modifications remarkably increase the variety and complexity of proteomes,which are essential for regulating numerous cellular and physiological *** regulation of auxin signaling is finely tuned in time and space to guide various plant growth and *** evidence indicates that PTMs play critical roles in auxin signaling ***,a thorough and systematic review of the functions of PTMs in auxin signal transduction will improve our profound comprehension of the regulation mechanism of auxin signaling and auxin-mediated various *** review discusses the progress of protein ubiquitination,phosphorylation,histone acetylation and methylation,SUMOylation,and S-nitrosylation in the regulation of auxin signaling.

关键词： Arabidopsis thaliana Auxin Auxin signaling Post-translational modifications Protein regulation

Hybridization chain reaction-based DNA nanomaterials for biosensing,bioimaging and therapeutics

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Chinese Chemical Letters 2024年第2期35卷 223-231页

作者： Zhaoyue lv Mengxue Huang Peiran Li Mengdi Xu Chi Yao Dayong Yang Frontiers Science Center for Synthetic Biology Key Laboratory of Systems Bioengineering (MOE)Institute of Biomolecular and Biomedical EngineeringSchool of Chemical Engineering and TechnologyTianjin UniversityTianjin 300350China Zhejiang Institute of Tianjin University Ningbo 315201China

DNA nanomaterials hold great promise in biomedical fields due to its excellent sequence programmability,molecular recognition ability and *** chain reaction(HCR)is a simple and efficient isothermal enzyme-free amplification strategy of DNA,generating nicked double helices with repeated *** the design of HCR hairpins,multiple nanomaterials with desired functions are assembled by DNA,exhibiting great potential in biomedical ***,the recent progress of HCR-based DNA nanomaterials for biosensing,bioimaging and therapeutics are *** works are exemplified to demonstrate how HCR-based DNA nanomaterials are designed and *** challenges and prospects of the development of HCR-based DNA nanomaterials are *** envision that rationally designing HCR-based DNA nanomaterials will facilitate the development of biomedical applications.

关键词： DNA nanotechnology Hybridization chain reaction DNA nanomaterials Biosensing Bioimaging Therapeutics

Blood diagnostic and prognostic biomarkers in amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第9期20卷 2556-2570页

作者： Yongting lv Hongfu Li Department of Neurology Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang ProvinceChina Department of Medical Genetics and Center for Rare disease Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang ProvinceChina Nanhu Brain-Computer Interface Institute HangzhouZhejiang Province

Amyotrophic lateral sclerosis is a devastating neurodegenerative disease for which the current treatment approaches remain severely *** principal pathological alterations of the disease include the selective degeneration of motor neurons in the brain,brainstem,and spinal cord,as well as abnormal protein deposition in the cytoplasm of neurons and glial *** biological markers under extensive scrutiny are predominantly located in the cerebrospinal fluid,blood,and even *** these biomarke rs,neurofilament proteins and glial fibrillary acidic protein most accurately reflect the pathologic changes in the central nervous system,while creatinine and creatine kinase mainly indicate pathological alterations in the peripheral nerves and *** light chain levels serve as an indicator of neuronal axonal injury that remain stable throughout disease progression and are a promising diagnostic and prognostic biomarker with high specificity and ***,there are challenges in using neurofilament light chain to diffe rentiate amyotrophic lateral sclerosis from other central nervous system diseases with axonal *** fibrillary acidic protein predominantly reflects the degree of neuronal demyelination and is linked to non-motor symptoms of amyotrophic lateral sclerosis such as cognitive impairment,oxygen saturation,and the glomerular filtration *** DNA-binding protein 43,a pathological protein associated with amyotrophic lateral sclerosis,is emerging as a promising biomarker,particularly with advancements in exosome-related *** is currently lacking for the value of creatinine and creatine kinase as diagnostic markers;however,they show potential in predicting disease *** the vigorous progress made in the identification of amyotrophic lateral sclerosis biomarkers in recent years,the quest for definitive diagnostic and prognostic biomarke rs remains a formidable *** review summarizes the lat

关键词： amyotrophic lateral sclerosis biomarker blood biomarkers diagnosis glial fibrillary acidic protein neurofilament light chain prognosis TAR DNA-binding protein 43

Effects of fluid therapy combined with a preoperative glucose load regimen on postoperative recovery in patients with rectal cancer

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World Journal of Gastrointestinal Surgery 2024年第8期16卷 2662-2670页

作者： lv-Chi Xia Ke Zhang Chuan-Wen Wang Department of Emergency Medicine Jiujiang First People's HospitalJiujiang 332000Jiangxi ProvinceChina

BACKGROUND Patients with rectal cancer undergoing radical resection often have poor post-operative recovery due to preoperative fasting and water deprivation and the removal of diseased tissue,and have a high risk of ***,it is of great significance to apply appropriate rehydration regimens to patients un-dergoing radical resection of rectal cancer during the perioperative period to improve the postoperative outcomes of *** To analyze the effects of goal-directed fluid therapy(GDFT)with a preoperative glucose load regimen on postoperative recovery and complications in patients undergoing radical resection for rectal *** Patients with rectal cancer who underwent radical resection(n=184)between January 2021 and December 2023 at our hospital were randomly divided into either a control group or an observation group(n=92 in each group).Both groups received a preoperative glucose load regimen,and routine fluid replacement and GDFT were additionally implements in the control and observation groups,*** operative conditions,blood levels of lactic acid and inflammatory markers,postoperative recovery,cognitive status,hemodynamic indicators,brain oxygen metabolism,and complication rates were compared between the *** The colloidal fluid dosage,total infusion,and urine volume,as well as time to first exhaust,time to food intake,and postoperative length of hospital stay,were lower in the observation group(P0.05).Compared with the control group,in the ob-servation group the lactic acid level was lower immediately after the surgery(P<0.05);the Mini-Mental State Examination score was higher on postoperative day 3(P<0.05);the pulse pressure variability(PPV)was lower at 30 min after pneumoperitone

关键词： Radical resection of rectal cancer Goal-directed fluid therapy Preoperative glucose load Cognitive condition Complication

Nanostructured AlFeO_(3) thin films as a novel photoanode for photoelectrochemical water splitting

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Nano Research 2024年第3期17卷 1075-1085页

作者： Xin Sun Min Wang Qi Geng Shuailin Chen Xiaojun lv Xunlei Ding Meicheng Li State Key Laboratory of Alternate Electrical Power System with Renewable Energy Sources School of New EnergyNorth China Electric Power UniversityBeijing 102206China School of Mathematics and Physics North China Electric Power UniversityBeijing 102206China

The earth-abundant and robust aluminum ferrite,AlFeO_(3)(AFO),is mainly studied in the context of ***,we demonstrate that AFO can be used as a stable solar absorber in photoelectrochemical cells for solar water splitting,exhibiting attractive *** is the first report on the photoelectrochemical activity of *** thin-film photoelectrodes prepared by solution-processing methods are composed of vertically oriented thin nanosheets,featuring the rhombohedral symmetry(R3c)and n-type *** as-prepared AFO photoanodes generate a photocurrent density of+0.78 mA·cm^(-2) at 1.23 V *** hydrogen electrode(RHE)with the photocurrent _(onset) potential(U_(onset))close to the flat band potential of 0.5 V *** in the presence of hole ***,the U_(onset) of AFO for solar water splitting coincides with the flat band potential as well,which is rare in n-type inorganic *** also report other properties of AFO associated with photoelectrochemical *** films exhibit a band gap energy of 2.31 eV and positive band edges with low ***,the carrier lifetimes in AFO films are up to millisecond timescales under the mediation of defect *** on the photoelectrochemical behavior and optoelectronic properties,we believe that AFO has great potential for application in photoelectrochemical cells.

关键词： AlFeO_(3) photoanode nanosheets photoelectrochemistry onset potential

Multi-endpoint assays reveal more severe toxicity induced by chloraminated effluent organic matter than chloraminated natural organic matter

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Journal of Environmental Sciences 2024年第1期135卷 310-317页

作者： Hai-Yan Wang De-Xiu Wu Ye Du Xiao-Tong lv Qian-Yuan Wu State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental SciencesBeijing 100012China Environmental Protection Key Laboratory of Microorganism Application and Risk Control Guangdong Provincial Engineering Research Center for Urban Water Recycling and Environmental SafetyTsinghua Shenzhen International Graduate SchoolTsinghua UniversityShenzhen 518055China College of Architecture and Environment Sichuan UniversityChengdu 610000China

Disinfection by chloramination produces toxic byproducts and the difference in toxicity of reclaimed and drinking water treated by chloramination remains *** study investigated cytotoxic effects at the same concentrations of dissolved organic matter and showed that chloraminated effluent organic matter(EfOM)induced 1.7 times higher cytotoxicity than chloraminated natural organic matter(NOM)applied to simulate drinking *** EfOM induced more reactive nitrogen species than chloraminated NOM,and chloraminated EfOM and NOM induced similar and higher levels of reactive oxygen species than the negative control,***,intracellular macromolecule damage indicated by DNA/RNA damage marker 8–hydroxy-(deoxy)guanosine and the intracellular protein carbonyl concentration induced by chloraminated EfOM was higher and slightly more than that induced by chloraminated NOM,*** data were consistent with the effects on cell physiological *** cycle arrest mainly occurred in G2 phase by chloraminated EfOM and *** apoptotic cells,which could return to normal,increased upon exposure to high concentrations of chloraminated EfOM and ***,necrotic cells were significantly increased from 0.5%to 2.5%when the concentration increased from 20-to 60-fold chloraminated EfOM,but were not obviously changed by chloraminated *** results indicated that the comprehensive intracellular changes induced by toxic substances in chloraminated EfOM were more irreversible and induced more cell death than chloraminated NOM.

关键词： Cytotoxicity Intracellular active nitrogen/oxygen Intracellular oxidative damage Cell necrosis Reclaimed water