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Stability of computed tomography densitometry in patients with otosclerosis:a two-year follow-up

Journal of Otology 2022年第1期17卷 39-45页

作者： yanqing fang Wei Chen Liu-Jie Ren Sebastian Kiehn Yilai Shu Bing Chen ENT Institute and Otorhinolaryngology Department of the Affiliated Eye and ENT Hospital State Key Laboratory of Medical NeurobiologyFudan UniversityShanghai200031China NHC Key Laboratory of Hearing Medicine Fudan UniversityShanghai200031PR China Department of Radiology Eye and ENT HospitalFudan UniversityShanghai200031China Laryngeal Physiology Laboratory University of Wisconsin e MadisonMadisonWIUnited States Institutes of Biomedical Sciences Fudan UniversityNO.83 Fenyang RoadXuhui DistrictShanghai200031China

Objectives:To quantify the progression of otosclerosis in the unoperated ear between two stapedotomy procedures for patients with bilateral otosclerosis which can help to determine whether a HRCT scan should be re-performed before the second surgery for patients who already received HRCT imaging before the initial ***:35 patients who underwent bilateral stapedotomy were *** rounds of HRCT examination and audiometry were performed at the time of the first surgery and second surgery on the ear that was not operated on during the initial *** relationship between the changes in HRCT densitometry and audiometry over time was ***:The second round of HRCT did not add significant information about the changes to the otosclerosis lesions in either the imaging diagnosis or the HRCT density values except for small changes in the HRCT densitometry readings at the area anterior to the inner auditory(P=0.01).While the changes in HRCT manifestation are small,changes near the fissula ante fenestram(FAF)were still positively correlated with the air bone gap(ABG)of patients(p=0.031,r=0.388).Conclusions:The progression of lesions in otosclerosis is slow resulting in small and insignificant changes to the HRCT ***,a repeat HRCT evaluations prior to surgery is not necessary for patients who have had a previous HRCT evaluation within 2 years of the *** small changes in HRCT manifestation near the FAF were still correlated with negative effects on the ABG which could cause worsened hearing thresholds over this timeframe。

关键词： Otosclerosis Fissula ante fenestram(FAF) High reconstruction-computed tomography (HRCT) Auditory CT densitometry

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Assessment of Crop Yield in China Simulated by Thirteen Global Gridded Crop Models

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Advances in Atmospheric Sciences 2024年第3期41卷 420-434页

作者： Dezhen YIN fang LI Yaqiong LU Xiaodong ZENG Zhongda LIN yanqing ZHOU International Center for Climate and Environment Sciences Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China University of Chinese Academy of Sciences Beijing 100049China Institute of Mountain Hazards and Environment Chinese Academy of SciencesChengdu 610041China State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China State Key Laboratory of Desert and Oasis Ecology Xinjiang Institute of Ecology and GeographyChinese Academy of SciencesUrumqi 830011China

Global gridded crop models(GGCMs) have been broadly applied to assess the impacts of climate and environmental change and adaptation on agricultural production. China is a major grain producing country, but thus far only a few studies have assessed the performance of GGCMs in China, and these studies mainly focused on the average and interannual variability of national and regional yields. Here, a systematic national-and provincial-scale evaluation of the simulations by13 GGCMs [12 from the GGCM Intercomparison(GGCMI) project, phase 1, and CLM5-crop] of the yields of four crops(wheat, maize, rice, and soybean) in China during 1980–2009 was carried out through comparison with crop yield statistics collected from the National Bureau of Statistics of China. Results showed that GGCMI models generally underestimate the national yield of rice but overestimate it for the other three crops, while CLM5-crop can reproduce the national yields of wheat, maize, and rice well. Most GGCMs struggle to simulate the spatial patterns of crop yields. In terms of temporal variability, GGCMI models generally fail to capture the observed significant increases, but some can skillfully simulate the interannual variability. Conversely, CLM5-crop can represent the increases in wheat, maize, and rice, but works less well in simulating the interannual variability. At least one model can skillfully reproduce the temporal variability of yields in the top-10 producing provinces in China, albeit with a few exceptions. This study, for the first time, provides a complete picture of GGCM performance in China, which is important for GGCM development and understanding the reliability and uncertainty of national-and provincial-scale crop yield prediction in China.

关键词： global gridded crop model historical crop yield China multi-model evaluation

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新会陈皮产业现状及发展路径研究

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食品安全导刊 2024年第8期 189-192页

作者：方燕青姚华锦巫泽慧姚楷欣郑鹏刘少群华南农业大学经济管理学院广东广州510642 华南农业大学园艺学院广东广州510642

乡村特色产业作为乡村产业的重要组成部分,是“乡村独有”“特色鲜明”的产业。本文以广东特色优势产业--新会陈皮产业为例,分析新会陈皮产业发展的现状和面临的问题,并结合陈皮药食同源产品独特的优势探寻产业发展路径,为推动新会陈皮... 详细信息

乡村特色产业作为乡村产业的重要组成部分,是“乡村独有”“特色鲜明”的产业。本文以广东特色优势产业--新会陈皮产业为例,分析新会陈皮产业发展的现状和面临的问题,并结合陈皮药食同源产品独特的优势探寻产业发展路径,为推动新会陈皮产业高质量发展提供新思路。

关键词：乡村产业新会陈皮产业发展路径研究

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Multi-dimensional multiplexing optical secret sharing framework with cascaded liquid crystal holograms

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Opto-Electronic Advances 2024年第1期7卷 28-35页

作者： Keyao Li Yiming Wang Dapu Pi Baoli Li Haitao Luan Xinyuan fang Peng Chen yanqing Lu Min Gu Institute of Photonic Chips University of Shanghai for Science and TechnologyShanghai 200093China Centre for Artificial-Intelligence Nanophotonics School of Optical-Electrical and Computer EngineeringUniversity of Shanghai for Science and TechnologyShanghai 200093China National Laboratory of Solid State Microstructures and College of Engineering and Applied SciencesNanjing UniversityNanjing 210093China

Secret sharing is a promising technology for information encryption by splitting the secret information into different ***,the traditional scheme suffers from information leakage in decryption process since the amount of available information channels is ***,we propose and demonstrate an optical secret sharing framework based on the multi-dimensional multiplexing liquid crystal(LC)*** LC holograms are used as spatially separated shares to carry secret *** polarization of the incident light and the distance between different shares are served as secret keys,which can significantly improve the information security and ***,the decryption condition is also restricted by the applied external voltage due to the variant diffraction efficiency,which further increases the information *** implementation,an artificial neural network(ANN)model is developed to carefully design the phase distribution of each LC *** the advantage of high security,high capacity and simple configuration,our optical secret sharing framework has great potentials in optical encryption and dynamic holographic display.

关键词： holographic encryption optical secret sharing cascaded liquid crystal hologram multi-dimensional multiplexing

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Atypical manifestations of acute coronary syndrome—throat discomfort:a multi-center observational study

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Frontiers of Medicine 2022年第4期16卷 651-658页

作者： yanqing fang Xiaoting Cheng Wenhui Peng Xueying Chen Chunping Tang Qiusheng Huang Sihai Wu Yibo Huang fanglu Chi Matthew RNaunheim Huawei Li Bing Chen Yilai Shu ENT Institute and Department of Otorhinolaryngology Eye&ENT HospitalState Key Laboratory of Medical NeurobiologyFudan UniversityShanghai 200031China Institutes of Biomedical Sciences Fudan UniversityShanghai 200031China NHC Key Laboratory of Hearing Medicine Fudan UniversityShanghai 200031China Department of Cardiology Shanghai Tenth People’s HospitalSchool of MedicineTongji UniversityShanghai 200072China Department of Cardiology Zhongshan HospitalFudan UniversityShanghai Institute of Cardiovascular DiseasesNational Clinical Research Center for Interventional MedicineShanghai 200032China Department of Cardiology The First Affiliated HospitalNanjing Medical UniversityNanjing 210029China Department of Otolaryngology Affiliated Hospital of Jiangsu UniversityZhenjiang 212001China Department of Otorhinolarynogology The Second People’s Hospital of WuxiNanjing Medical UniversityWuxi 214002China Department of Otolaryngology-Head and Neck Surgery Massachusetts Eye and Ear InfirmaryHarvard Medical SchoolBostonMA 02114USA

To present the clinical characteristics and the misdiagnosis rate of acute coronary syndrome manifested primarily as throat discomfort,we conducted a multicentric and retrospective study in the cardiology and otorhinolaryngology *** of patients with primary complaint of throat discomfort,absence of chest pain at onset,and an ultimate diagnosis of acute coronary syndrome,as well as patients with pharyngitis(as controls)were collected from May 2015 to April *** patients’main manifestations were *** regression results showed that chest tightness,dyspnea,perspiring,and exertional throat symptoms were significantly associated with acute coronary syndrome,with odds ratios of 8.3(95%CI 2.2–31.5),10.9(95%CI 1.8–66.9),25.4(95%CI 3.6–179.9),and 81.2(95%CI 13.0–506.7).A total of 25(56.82%)out of 44 acute coronary syndrome patients,who were first admitted to the otorhinolaryngology department,were misdiagnosed,with a 12%(3/25)mortality *** discomfort can be the principal manifestation of acute coronary *** patients exhibit high misdiagnosis and mortality *** throat symptoms,chest tightness,perspiring,and dyspnea were important indicators of acute coronary syndrome in patients whose main complaint was throat *** awareness of this condition will result in prompt diagnosis and reduce morbidity and mortality.

关键词： acute coronary syndrome(ACS) throat discomfort(TD) throat pain cardiology departments non-cardiologic physicians

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A Generic Strategy to Create Mechanically Interlocked Nanocomposite/Hydrogel Hybrid Electrodes for Epidermal Electronics

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Nano-Micro Letters 2024年第5期16卷 120-133页

作者： Qian Wang Yanyan Li Yong Lin Yuping Sun Chong Bai Haorun Guo Ting fang Gaohua Hu yanqing Lu Desheng Kong College of Engineering and Applied Sciences National Laboratory of Solid State Microstructureand Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210023People’s Republic of China State Key Laboratory of Analytical Chemistry for Life Science and Jiangsu Key Laboratory of Artificial Functional MaterialsNanjing UniversityNanjing 210023People’s Republic of China College of Chemical Engineering and Technology Engineering Research Center of Seawater Utilization Technology of Ministry of EducationState Key Laboratory of Reliability and Intelligence of Electrical EquipmentHebei University of TechnologyTianjin 300130People’s Republic of China Key Laboratory of Intelligent Optical Sensing and Manipulation Nanjing UniversityNanjing 210093People’s Republic of China

Stretchable electronics are crucial enablers for next-generation wearables intimately integrated into the human *** the primary compliant conductors used in these devices,metallic nanostructure/elastomer composites often struggle to form conformal contact with the textured *** electrodes have been consequently developed based on conductive nanocomposite and soft hydrogels to establish seamless skin-device ***,chemical modifications are typically needed for reliable bonding,which can alter their original *** overcome this limitation,this study presents a facile fabrication approach for mechanically interlocked nanocomposite/hydrogel hybrid *** this physical process,soft microfoams are thermally laminated on silver nanowire nanocomposites as a porous interface,which forms an interpenetrating network with the *** microfoam-enabled bonding strategy is generally compatible with various *** resulting interlocked hybrids have a 28-fold improved interfacial toughness compared to directly stacked *** electrodes achieve firm attachment to the skin and low contact impedance using tissue-adhesive *** have been successfully integrated into an epidermal sleeve to distinguish hand gestures by sensing mus-cle *** nanocomposite/hydrogel hybrids reported here offer a promising platform to combine the benefits of both materials for epidermal devices and systems.

关键词： Stretchable electronics Epidermal electronics Silver nanowire Conductive nanocomposites Hydrogel

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Distribution and abundance of krill in various areas of the Southern Ocean: dataset compilation based on samples collected in CHINARE during 2009–2019

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Advances in Polar Science 2024年

作者： fang Xiaoyue HU Shugang WANG yanqing ZHANG Zishang TAO Zhencheng YANG Guang College of Safety and Environmental Engineering Shandong University of Science and Technology Key Laboratory of Marine Ecology and Environmental Sciences Institute of Oceanology Chinese Academy of Sciences Engineering Technology Department Institute of Oceanology Chinese Academy of Sciences Qingdao University of Science and Technology Laboratory for Marine Ecology and Environmental Science Qingdao National Laboratory for Marine Science and Technology University of Chinese Academy of Sciences Center for Ocean Mega-Science Chinese Academy of Sciences

This study investigates the composition, abundance, and basic biological parameters of krill in Prydz Bay, the Antarctic Peninsula and the Amundsen Sea by analyzing samples and environmental data from the Chinese National Antarctic Research Expeditions conducted between 2009/2010 and 2019/2020. The predominant krill species observed were Euphausia superba, Euphausia crystallorophias, and Thysanoessa macrura. T. macrura, although the most widespread, exhibited the lowest mean abundance(9.96 ind·(1000 m–3)) and biomass(0.31 g·(1000 m–3)), predominantly found in low-latitude regions of the Amundsen Sea while E. crystallorophias was most concentrated in polynyas of Prydz Bay. E. superba, with an average abundance of 34.05 ind·(1000 m–3)and biomass of 11.80 g·(1000 m–3), was mainly distributed in the Antarctic Peninsula and Prydz Bay. This study also identified regional variations in mean body length and frequency distributions of krill. The relationship between krill body length and wet weight followed a power-law pattern. Regional differences were observed in the relationship between krill abundance, biomass, and environmental factors with varying correlations. In the Amundsen Sea, no significant correlation was found between krill abundance and environmental factors. Notably, E. crystallorophias in Prydz Bay demonstrated a significant positive correlation with chlorophyll-a concentration,while T. macrura abundance and biomass in the Antarctic Peninsula exhibited a significant negative correlation with ice-free days. The findings contribute valuable regional data on krill distribution, abundance, and biomass in the Southern Ocean, serving as foundational information for the conservation of the Southern Ocean ecosystem and Antarctic krill fishery management on a circumpolar scale.

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耳硬化症镫骨小窗技术后短期与中期听力效果的关系探讨

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中华耳科学杂志 2022年第2期20卷 271-276页

作者：方延青陈兵复旦大学附属眼耳鼻喉科医院国家卫生健康委员会听觉医学重点实验室上海200031

目的探讨临床耳硬化症患者镫骨小窗技术后短期与中期听力效果的关系。方法回顾性分析我院45例耳硬化症并进行镫骨小窗技术的患者,所有患者均在术前1月内、术后1月内(Time-1)及术后1年内(Time-2)进行纯音测听,分析比较三次听力学资料... 详细信息

目的探讨临床耳硬化症患者镫骨小窗技术后短期与中期听力效果的关系。方法回顾性分析我院45例耳硬化症并进行镫骨小窗技术的患者,所有患者均在术前1月内、术后1月内(Time-1)及术后1年内(Time-2)进行纯音测听,分析比较三次听力学资料。结果患者在Time-1及Time-2的气导(AC)阈值、骨导(BC)阈值与术前听力水平有显著相关性(Time-1:AC:P=0.002, BC:P=0.003;Time-2:AC:P=0.012,BC:P=0.0001)。术后Time-1及Time-2两次听力结果之间亦有显著相关性(AC:P=0.001, BC:P=0.001)。AC、BC、气骨导差(ABG)阈值在术后1月显著改善(AC:P<0.001, BC:P<0.001, ABG:P<0.001),在术后1年内仍继续改善(AC:P<0.001, BC:P=0.01, ABG:P=0.04),差异均具有统计学意义。手术成功率从术后1月内84.4%,提高到术后1年内的93.3%。对于单频,术后AC在Time-1及Time-2时改善均以低频优于高频,术后BC改善在2kHz最显著(Time-1改善7dBHL, Time-2改善10.87dBHL)。约1/3患者在Time-1出现了轻微的BC听阈升高,大部分在Time-2改善良好。BC在高频(4kHz)的恢复迟于低频。结论镫骨小窗技术后1年内听力结果有持续改善的趋势,手术成功率亦随时间的延长而继续提高。患者在术后1月内听阈改善值分别为术后1年内的3倍(AC),1.3倍(BC)及4.3倍(ABG)。患者术后1月内的纯音测听结果能预估1年内的听力结果,约1/3患者Time-1时出现了轻微的BC听阈升高,但大部分在Time-2时改善良好。

关键词：纯音测听镫骨小窗技术随访时间

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Activation of the Melanocortin-4 receptor signaling byα-MSH stimulates nervedependent mouse digit regeneration

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Cell Regeneration 2021年第1期10卷 215-225页

作者： Hanqian Xu Hailin Zhang yanqing fang Huiran Yang Ying Chen Chao Zhang Gufa Lin Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education Orthopaedic Department of Tongji HospitalSchool of Life Sciences and TechnologyTongji UniversityShanghaiChina Stem Cell Institute University of MinnesotaMinneapolisMN 55455USA Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalShanghai Key Laboratory of Signaling and Disease ResearchFrontier Science Center for Stem Cell ResearchSchool of Life Sciences and TechnologyTongji UniversityShanghaiChina

Background:Expression of Mc4r in peripheral organs indicates it has broader roles in organ homeostasis and ***,the expression and function of Mc4r in the mouse limb and digit has not been fully *** previous work showed that Mc4r−/−mice fail to regenerate the digit,but whether activation of MC4R signaling could rescue digit regeneration,or stimulate proximal digit regeneration is not ***:We analyzed the expression dynamics of Mc4r in the embryonic and postnatal mouse limb and digit using the Mc4r-gfp *** found that Mc4r-GFP is mainly expressed in the limb nerves,and in the limb muscles that are undergoing secondary *** of Mc4r-GFP in the adult mouse digit is restricted to the nail *** also examined the effect ofα-MSH on mouse digit *** found that administration ofα-MSH in the Mc4r+/−mice rescue the delayed regeneration of distal digit tip.α-MSH could rescue distal digit regeneration in denervated *** addition,α-MSH could stimulate regeneration of the proximally amputated digit,which is ***:Mc4r expression in the mouse limb and digit is closely related to nerve tissues,andα-MSH/MC4R signaling has a neurotrophic role in mouse digit tip regeneration.

关键词： MC4R Mc4r-gfp α-MSH Digit regeneration Distal Proximal Denervation Neurotrophic function

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镫骨小窗技术对耳硬化症患者频率特异性骨导超闭合的影响

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中华耳科学杂志 2022年第1期20卷 88-92页

作者：张坤陈兵方延青复旦大学附属眼耳鼻喉科医院耳鼻喉科上海200031 山东大学齐鲁医院耳鼻咽喉科济南250012

目的评估镫骨小窗技术对耳硬化症患者频率特异性骨导超闭合的影响。方法回顾性分析我院130例诊断为耳硬化症并进行镫骨小窗技术的患者。收集患者术前及术后的纯音测听资料,按照术前骨导(BC)是否≤25 dB HL,把患者分为骨导正常组(normal ... 详细信息

目的评估镫骨小窗技术对耳硬化症患者频率特异性骨导超闭合的影响。方法回顾性分析我院130例诊断为耳硬化症并进行镫骨小窗技术的患者。收集患者术前及术后的纯音测听资料,按照术前骨导(BC)是否≤25 dB HL,把患者分为骨导正常组(normal BC,N-BC)及骨导阈值升高组(increased threshold BC,IT-BC);并根据各频率是否有骨导阈值升高分为亚组。比较术后各频率亚组之间,骨导的超闭合率(Overclosure rate,OR),显著超闭合率(Significant overclosure rate,SOR),骨导恶化率(Deterioration rate,DR),显著恶化率(Significant deterioration rate,SDR)以及相应的阈值的差异是否有统计学意义。结果5例缺乏随访资料被剔除,共纳入125例病人,其中76例为N-BC组,49例为IT-BC组。所有IT-BC亚组的OR、SOR、超闭合阈值、显著超闭合阈值(除外1kHz)优于N-BC亚组(P0.05)。结论小窗技术对于术前骨导阈值升高的临床耳硬化患者仍具有同样的手术效果。在频率相关性听力结果中,骨导超闭合在所有频率的IT-BC亚组均显著优于N-BC亚组;在术前具有骨导阈值升高患者的言语频率,约50%以上的术后骨导改善超过10 dB。

关键词：超闭合骨导镫骨小窗技术

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