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Screening and regulatory network analysis of survival-related genes of patients with colorectal cancer

Science China(Life Sciences) 2014年第5期57卷 526-531页

作者： QI Lu ding yanqing Department of Pathology School of Basic Medical SciencesSouthern Medical University Department of Pathology Nanfang HospitalSouthern Medical University

The purpose of this study was to screen key survival-related genes from patients with colorectal cancer and explore signal transduction network of the involved *** a previous study,survival-related genes of patients with colorectal cancer were selected by colorectal cancer-related expression data GSE17538 using the Significance Analysis of Microarrays(SAM3.01)software,and 235 genes related to the survival of patients with colorectal cancer were ***,the following screening and analysis were conducted on these 235 genes in this ***,the enrichment analysis of transcription factor binding sites was conducted on the 235 *** with more than seven transcription factor binding sites were ***,these genes and upregulated genes in colorectal cancer were ***,survival analysis and regulatory network analysis were conducted on the screened *** allowed clarification of the relationship between these genes and the survival of patients with colorectal cancer and the signaling network involving these genes in the cell signal transduction network of colorectal *** the above analysis,six upregulated genes in colorectal cancer related to the survival of colorectal cancer patients and highly regulated by transcription factors were selected,namely STX2,PODXL,KLK6,GRB10,EHBP1 and *** genes are involved in signal regulatory networks related to colorectal cancer metastasis-related signaling ***,the survival of patients with colorectal cancer is closely correlated with colorectal cancer *** six survival-related genes affect the survival of patients by regulating colorectal cancer metastasis-associated signaling pathways.

关键词： survival time colorectal cancer transcription factor bioinformatics

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Variation in Short-term Temperature Fluctuations Across China During the Past 60 Years

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Chinese Geographical Science 2022年第4期32卷 563-579页

作者： HE Yunchuan DENG Jianming ZHANG Yunlin ding yanqing QIN Boqiang Taihu Lake Laboratory Ecosystem Research Station State Key Laboratory of Lake Science and EnvironmentNanjing Institute of Geography and LimnologyChinese Academy of SciencesNanjing 210008China School of Resource and Geosciences China University of Mining and TechnologyXuzhou 221116China

Short-term temperature fluctuations(STFs),including amplitude and frequency fluctuations,are one of the main features of weather and play vital roles in determining the type of ecosystem *** temperature fluctuations at different time scales have been extensively discussed,the research on week-scale STFs is *** this study,we developed a method,that can quantify the amplitude and frequency of STFs by the thresholds from all *** used this method to quantify the amplitude and frequency of the 7-d STFs from 1951 to 2019 across *** results indicate that the amplitude of the STF was much higher in the eastern part of China than in the western part,while the frequency of the STF was higher in the middle part than in the southern and northern parts;further-more,the STF was highly dependent on internal factors such as *** long-term STF mainly showed a decreasing trend before 1990,which implies that temperature became increasingly stable from the 1950s to the *** main influencing factors were related to topography since the trends were relatively consistent in space.A case study in Taihu Lake showed that an unstable STF in winter and summer resulted in a smaller bloom area in the following spring and *** method could eliminate seasonal effects and is capable of analyzing STFs at scales ranging from days to *** of the amplitude and frequency also make the STF indicators more ***,the STF increased significantly across most of China after 1990,which implies that temperature is becoming increasingly *** drivers of these STFs are related to human impacts since the trends are different in space.

关键词： short-term temperature fluctuation altitude effect global warming climate change China

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Traditional Dietary Habits and Interprovincial Migration in College Choice: Evidence From Ningxia in China

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ECNU Review of Education 2020年第2期3卷 310-337页

作者： Le Kang Xiaoyang Ye yanqing ding Institute of Economics of Education&Graduate School of Education Peking UniversityBeijing 100871China Princeton University Peking University

Purpose:Every September,millions of students—elite human resources—enter higher education in *** large-scale college-induced migration has substantial impacts on China’s national and local labor *** study examines the migration pattern in college choice and admission among the Hui students in *** doing so,we extend the existing interprovincial migration model by identifying and measuring the role of traditional dietary habits in college migration ***/Approach/Methods:This study uses college entrance examination(Gaokao)admission data for 10 high school graduation cohorts from 2001 to 2010 in the Ningxia Hui Autonomous *** data are used to study the interprovincial migration of the Hui students following their college entrance *** least squares and logit regressions are used to control for other confounding factors,while the method of instrumental variables and placebo group comparison were used to rule out other ***:Results demonstrate that traditional dietary habits produce geographic inequalities in terms of college opportunities for Hui and other minority group ***,after controlling for variables such as college entrance examination scores and personal characteristics,results show that the Hui students are more likely to choose an institution closer to their hometown and preferred institutions located in Ningxia and the northwestern provinces rather than the Yangtze/Pearl River Delta regions and coastal ***,this migration pattern is shaped by the dietary habits of the ***,the Hui students were more likely to choose institutions in underdeveloped areas,resulting in corresponding welfare ***/Value:This study supplements classic college choice literature by documenting a special impact factor of geography previously overlooked by researchers,demonstrating the need to examine the underlying mechanisms of proximity and its significance in college c

关键词： College admissions demographical welfare dietary habits interprovincial migration Ningxia

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Potential antitumor mechanisms of phenothiazine drugs

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Science China(Life Sciences) 2013年第11期56卷 1020-1027页

作者： QI Lu ding yanqing Department of Pathology School of Basic Medical Sciences Southern Medical University Department of Pathology Nanfang Hospital Southern Medical University

In this study,three kinds of phenothiazine drugs were analyzed to explore their potential antitumor ***,target proteins that could interact with chlorpromazine,fluphenazine and trifluoperazine were ***,the target proteins of the three drugs were *** signaling pathway enrichment and related disease enrichment were conducted for the intersected proteins to extract the enrichment categories associated with *** regulation network analysis of the protein interactions,the mechanisms of action of these target proteins in tumor tissue were clarified,thus confirming the potential antitumor mechanisms of the phenothiazine *** final results of cell signaling pathway enrichment and related disease enrichment showed that the categories with the highest score were all found in *** proteins belonging to the tumor category included signaling pathway members such as Wnt,MAPK and retinoic acid ***,another target protein,MAPK8,could indirectly act on target proteins CDK2,IGF1R,GSK3B,RARA,FGFR2 and MAPK10,thereby affecting tumor cell division and ***,phenothiazine drugs may have potential antitumor effects,and tumorassociated target proteins play important roles in the process of cell signaling transduction cascades.

关键词： phenothiazines antitumor bioinformatics target proteins

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MicroRNA-34c-5p provokes isoprenaline-induced cardiac hypertrophy by modulating autophagy via targeting ATG4B

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Acta Pharmaceutica Sinica B 2022年第5期12卷 2374-2390页

作者： Yuhong Zhang yanqing ding Min Li Jing Yuan Youhui Yu Xueying Bi Huiqi Hong Jiantao Ye Peiqing Liu Department of Pharmacology and Toxicology School of Pharmaceutical SciencesNational and Local United Engineering Lab of Druggability and New Drugs EvaluationSun Yat-sen UniversityGuangzhou 510006China State Key Laboratory of Oncology in Southern China Collaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhou 510006China

Pathological cardiac hypertrophy serves as a significant foundation for cardiac dysfunction and heart failure. Recently, growing evidence has revealed that microRNAs(miRNAs) play multiple roles in biological processes and participate in cardiovascular diseases. In the present research, we investigate the impact of miRNA-34 c-5 p on cardiac hypertrophy and the mechanism involved. The expression of miR-34 c-5 p was proved to be elevated in heart tissues from isoprenaline(ISO)-infused mice. ISO also promoted miR-34 c-5 p level in primary cultures of neonatal rat cardiomyocytes(NRCMs). Transfection with miR-34 c-5 p mimic enhanced cell surface area and expression levels of foetal-type genes atrial natriuretic factor(Anf) and β-myosin heavy chain(β-Mhc) in NRCMs. In contrast, treatment with miR-34 c-5 p inhibitor attenuated ISO-induced hypertrophic responses. Enforced expression of miR-34 c-5 p by tail intravenous injection of its agomir led to cardiac dysfunction and hypertrophy in mice, whereas inhibiting miR-34 c-5 p by specific antagomir could protect the animals against ISO-triggered hypertrophic abnormalities. Mechanistically, miR-34 c-5 p suppressed autophagic flux in cardiomyocytes, which contributed to the development of hypertrophy. Furthermore, the autophagy-related gene 4 B(ATG4 B) was identified as a direct target of miR-34 c-5 p, and miR-34 c-5 p was certified to interact with 3’untranslated region of Atg4 b mRNA by dual-luciferase reporter assay. miR-34 c-5 p reduced the expression of ATG4 B, thereby resulting in decreased autophagy activity and induction of hypertrophy. Inhibition of miR-34 c-5 p abolished the detrimental effects of ISO by restoring ATG4 B and increasing autophagy. In conclusion, our findings illuminate that miR-34 c-5 p participates in ISO-induced cardiac hypertrophy, at least partly through suppressing ATG4 B and autophagy. It suggests that regulation of miR-34 c-5 p may offer a new way for handling hypertrophy-related cardiac dysfuncti

关键词： Pathological cardiac hypertrophy Isoprenaline miR-34c-5p ATG4B LC3 Autophagy Autophagic flux Neonatal rat cardiomyocytes Mice

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Forming Mechanism of Gaseous Defect in Ti-48Al-2Cr-2Nb Exhaust Valves Formed with Permanent Mold Centrifugal Casting Method

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Journal of Materials Science & Technology 2001年第5期17卷 569-571页

作者： Research Notes Wenbin SHENG, Jingjie GUO, yanqing SU, Hongsheng ding and Jun JIA School of Materials Science and Engineering, Harbin Institute of Technology. Harbin 150001, China Inst. of Metal Res. Chinese Acad. of Sci. Shenyang 110016 China

A method combining theoretical analysis with experiment is adopted and the flowing process of Ti-48A1-2Cr-2Nb alloy melt poured in a permanent mould during the centrifugal casting process has been analyzed. A mathematical model of the filling process is established and the forming mechanism of internal gaseous defect is summarized. The results of calculation show that the melt fills the mould with varying cross-section area and inclined angle. The filling speed of the cross-section is a function of filling time. The cross-section area is directly proportional to the filling speed and the inclined angle is inversely proportional to the filling speed at a given rotating speed of the platform. Both of them changes more obvious near the mould entrance. The gaseous defect can be formed in several ways and the centrifugal field has an important influence on the formation of the defect. In addition, the filling process in centrifugal field has been verified by wax experiments and the theoretical analysis are consistent with experimental results.

关键词： Forming Mechanism of Gaseous Defect in Ti-48Al-2Cr-2Nb Exhaust Valves Formed with Permanent Mold Centrifugal Casting Method Mold Ti Al Cr

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Effect of Traveling Magnetic Field on Mould-Filling Length of the A357 Melt during Casting Thin Walled Plate

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Journal of Materials Science & Technology 2003年第1期19卷 43-46页

作者： Tiejun ZHANG, Jingjie GUO, yanqing SU, Hongsheng ding, Weisheng BI, Jim JIA and Hengzhi FUSchool of Materials Science and Engineering, Harbin Institute of Technology, Harbin 150001, China Sch. of Mat. Sci. and Eng. Harbin Inst. of Technol. Harbin 150001 China

In order to improve the mould filling ability, the method for production of thin-walled castings in the travelingmagnetic field was applied. The relationship between magnetic field density and input voltage as well as distancewas investigated, and the mould filling length of A357 melt has been studied. The electromagnetic forces appliedon the melt were also analyzed. The result shows that the mould-filling length of the melt increase rapidly with theincrease of magnetic flux density. The mould filling lengths in gypsum upper mould and magnetic material uppermould were compared from the standpoint of application. It demonstrated that the steel upper mould is superior togypsum mould.

关键词： Mould filling Traveling magnetic field A357 melt

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Coarsening Manner and Microstructure Evolution of Al-In Hypermonotectic Alloy during Rapidly Cooling Process

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Journal of Materials Science & Technology 2002年第3期18卷 241-244页

作者： Yuan LIU, Jingjie GUO, Jun JIA, yanqing SU, Hongsheng ding, Jiuzhou ZHAO and Xiang XUESchool of Materials Science and Engineering, Harbin Institute of Technology, Harbin 150001, China [ Manuscript received April 13, 2001, in revised form June 2,5, 2001] Sch. of Mat. Sci. and Eng. Harbin Inst. of Technol. Harbin 150001 China

A numerical model reflecting the real physical processes well has been developed to predict the coarsening manner of the second phase droplets and the microstructural evolution under the common action of nucleation, diffusional growth, colliding coagulation during rapid cooling Al-ln hypermonotectic alloys. The model reflects the real physical processes well and is also applicable to other immiscible alloys.

关键词： Al-In immiscible alloy Coarsening Microstructure

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A telomere-to-telomere genome assembly of Hongyingzi,a sorghum cultivar used for Chinese Baijiu production

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The Crop Journal 2024年第2期12卷 635-640页

作者： yanqing ding Yilin Wang Jianxia Xu Feng Jiang Wenzhen Li Qiaoling Zhang Longping Yang Zhenyu Zhao Bin Cheng Ning Cao Xu Gao Xin Zhang Guihua Zou Fan Yang Liyi Zhang Guizhou Institute of Upland Crops Guizhou Academy of Agricultural SciencesGuiyang 550006GuizhouChina Kweichow Moutai Co. Ltd.Maotai TownRenhuai 564501GuizhouChina Kweichow Moutai Distillery(Group)Hongyingzi Agricultural Technology Development Co. Ltd.Maotai TownRenhuai 564501GuizhouChina Wuhan GrandOmics Biosciences Co. Ltd.Grandomics BiosciencesWuhan 430000HubeiChina Institute of Crop and Nuclear Technology Utilization Zhejiang Academy of Agricultural SciencesZhejiang

Sorghum(Sorghum bicolor(L.)Moench)is a world cereal crop used in China for producing Baijiu,a distilled *** report a telomere-to-telomere genome assembly of the Baijiu cultivar Hongyingzi,HYZ-T2T,using ultralong *** 10 chromosome pairs contained 33,462 genes,of which 93%were functionally *** 20 telomeres and 10 centromeric regions on the HYZ-T2T chromosomes were predicted and two consecutive large inversions on chromosome 2 were characterized.A 65-gene reconstruction of the metabolic pathway of tannins,the flavor substances in Baijiu,was performed and may advance the breeding of sorghum cultivars for Baijiu production.

关键词： Sorghum Telomere-to-telomere assembly Hongyingzi(HYZ) Chinese Baijiu-making cultivar

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中国民族自治地区和非民族自治地区义务教育生均支出分析

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北京大学教育评论 2008年第1期6卷 154-166页

作者：丁延庆北京大学教育学院北京100871

本研究利用2000年全国教育财政基层报表数据,对全国民族自治地区和非民族自治地区义务教育阶段的生均支出进行了简要分析。研究发现,民族自治地区义务教育阶段的生均教育支出水平低于非民族自治地区;在民族自治地区比较集中的"二片"和"... 详细信息

本研究利用2000年全国教育财政基层报表数据,对全国民族自治地区和非民族自治地区义务教育阶段的生均支出进行了简要分析。研究发现,民族自治地区义务教育阶段的生均教育支出水平低于非民族自治地区;在民族自治地区比较集中的"二片"和"三片"地区,特别是在小学层次,民族自治地区和非民族自治地区的生均支出水平并无明显差距;在初中阶段,两类民族地区的生均支出水平也非本片地区最低的。研究的描述性统计分析还发现,在义务教育阶段,民族自治地区学校相对于非民族自治地区学校,总支出中来自预算内的比重较大(即民族自治地区的教育支出相对于非民族自治地区来说,更依赖预算内收入,而较少从学生家庭和社区汲取教育资源)。多元回归分析发现,中国义务教育财政并不满足"财富中立性"或"财政中立性"的原则;但在其他条件相同的情况下,民族自治地区的生均支出(收入)水平高于非民族地区。

关键词：义务教育生均教育支出民族地区非民族地区

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