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长江流域氧氟沙星和金霉素的人体健康水质基准研究

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生态环境学报 2024年第1期33卷 92-100页

作者：高尧峰段艳平陈昱如涂耀仁高峻上海师范大学环境与地理科学学院上海200234 上海长三角城市湿地生态系统国家野外科学观测研究站上海200234

抗生素因其潜在的生态和健康风险而引起全球关注。目前,中国长江流域抗生素的人体健康水质基准研究尚处于空白阶段,不利于国家进一步开展抗生素新污染物的管控和风险评估工作。为促进长江流域抗生素污染物的人体健康水质基准研究和人体... 详细信息

抗生素因其潜在的生态和健康风险而引起全球关注。目前,中国长江流域抗生素的人体健康水质基准研究尚处于空白阶段,不利于国家进一步开展抗生素新污染物的管控和风险评估工作。为促进长江流域抗生素污染物的人体健康水质基准研究和人体健康风险评估工作的开展,分别在长江流域宜宾段(上游)、重庆段(上游)、宜昌段(上游)、武汉段(中游)和上海段(下游)采集并分析了表层水样和不同营养级鱼样中氧氟沙星(OFL)和金霉素(CTC)的含量(采样点涉及长江干流、支流、沿江水库以及沿江城镇密集区)。通过分析长江流域OFL和CTC在第2、3、4营养级鱼类的最终营养级生物累积系数(Afi),结合抗生素毒理参数和人群暴露参数,在饮水和消费水产品两种暴露途径下,推导出了长江流域OFL和CTC的人体健康水质基准(AWQC)。结果表明,长江流域水体中OFL和CTC的质量浓度分别为ND-1.55×10^(-4)、ND-4.17×10^(-4)mg·L^(-1),鱼体中OFL和CTC的质量分数分别为ND-4.94×10^(-2)、ND-0.108 mg·kg^(-1);OFL在第2、3、4营养级鱼类中的Afi分别为1.40×10^(3)、79.0、172 L·kg^(-1),CTC在第2、3、4营养级鱼类中的Afi分别为755、9.19×10^(4)、744 L·kg^(-1);OFL和CTC的AWQC分别为3.04、0.250μg·L^(-1)。该结果显示长江流域OFL的人体健康风险暂时处于可接受水平,但长江流域宜宾段局部水体CTC浓度高于推导出的水质基准则表明仍需重点关注长江流域CTC的浓度变化情况及其可能会带来的人体健康风险。研究结果可为科学制定长江流域抗生素的水环境质量标准和评估其人体健康风险提供参考依据。

关键词：氧氟沙星金霉素人体健康水质基准长江流域

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老年睡眠障碍的研究进展

中国临床保健杂志 2024年第2期27卷 172-177页

作者：胡汝锐康琳段艳平中国医学科学院北京协和医学院北京协和医院老年医学科北京100730 中国医学科学院北京协和医学院北京协和医院心理医学科北京100730

随着年龄的增长,老年人睡眠质量呈下降趋势。统计显示,40%~70%的老年人存在睡眠障碍,其中失眠症是最为常见的一种睡眠障碍,通常是患者对睡眠时间或睡眠质量不满意并影响日间社会功能的一种主观体验。长期失眠会导致老年人社会功能下降... 详细信息

随着年龄的增长,老年人睡眠质量呈下降趋势。统计显示,40%~70%的老年人存在睡眠障碍,其中失眠症是最为常见的一种睡眠障碍,通常是患者对睡眠时间或睡眠质量不满意并影响日间社会功能的一种主观体验。长期失眠会导致老年人社会功能下降、认知功能受损、跌倒风险提高以及其他慢性疾病发病率与病死率的增加,对老年人的生活质量具有重要影响。因此,及时诊断并干预睡眠障碍,对于促进健康老龄化具有重要意义。

关键词：睡眠障碍生活质量健康老龄化老年人

维普期刊数据库博看期刊

高龄剖宫产史合并妊娠期糖尿病双胎孕妇多学科管理1例

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中华健康管理学杂志 2024年第3期18卷 222-224页

作者：刘利崔姝宜刘燕萍平凡段艳平张素菡王亚新杨萱瑾朱灿马良坤中国医学科学院北京协和医学院护理学院北京100144 北京心宜韵健康管理有限公司北京102445 中国医学科学院北京协和医院营养科北京100730 中国医学科学院北京协和医院内分泌科北京100730 中国医学科学院北京协和医院心理科北京100730 中国医学科学院北京协和医院妇产科北京100730

双胎妊娠孕期合并症与并发症的发生率较单胎妊娠高,做好双胎妊娠的围孕期管理至关重要。本文描述并总结了多学科联合管理的1例高龄剖宫产史合并妊娠期糖尿病(GDM)双胎孕妇的临床相关资料,包括产后出血的预防、营养干预、运动指导、心理... 详细信息

双胎妊娠孕期合并症与并发症的发生率较单胎妊娠高,做好双胎妊娠的围孕期管理至关重要。本文描述并总结了多学科联合管理的1例高龄剖宫产史合并妊娠期糖尿病(GDM)双胎孕妇的临床相关资料,包括产后出血的预防、营养干预、运动指导、心理支持等,并结合文献探讨了多学科管理在优化母婴健康中的重要性,为围产保健管理提供参考经验。

关键词：双胎妊娠期糖尿病多学科管理

Bird specimen number linked with species trait and climate niche breadth

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Avian Research 2024年第1期15卷 108-115页

作者： Xiaoyu duan Xiongwei Huang Jingya Zhang Shuo Lv Gang Song yanping Wang Gang Feng Ministry of Education Key Laboratory of Ecology and Resource Use of the Mongolian Plateau&Inner Mongolia Key Laboratory of Grassland Ecology School of Ecology and EnvironmentInner Mongolia UniversityHohhot010020China Key Laboratory of Marine Biotechnology of Fujian Province Institute of OceanologyCollege of Marine SciencesFujian Agriculture and Forestry UniversityFuzhou350002China Key Laboratory of Zoological Systematics and Evolution Institute of ZoologyChinese Academy of SciencesBeijing100101China Laboratory of Island Biogeography and Conservation Biology College of Life SciencesNanjing Normal UniversityNanjing210023China

Biological specimens are fundamental for taxonomy and flora/fauna *** importantly,they also play crucial roles in recording environmental impacts on morphology and behavior,which is vital for biodiversity research and ***,there are few systematic studies on the patterns and drivers of bird specimen number at regional *** study is the first attempt to examine the relationships between bird specimen number and species traits as well as climate niche breadth in China,aiming to answer two questions:1)how do species’temperature niche breadth and precipitation niche breadth influence specimen number?2)which trait is most associated with bird specimen number?The associations between bird specimen number and explanatory variables were examined using ordinary least squares,generalized linear models,phylogenetic generalized linear mixed models,and multiple *** results showed that Muscicapidae was the family with the highest specimen number,and Passeriformes was the order with the highest specimen *** specimen number significantly increased with larger temperature niche breadth and precipitation niche *** number was also positively associated with geographic range size,habitat specificity,hunting vulnerability and clutch size,but negatively associated with body *** findings suggest that future bird specimen collection should pay more attention to birds with limited ecological niches,large body sizes,and small clutch *** research enhances the use of bird specimen data to study and preserve biodiversity.

关键词： Biodiversity conservation Biological specimens Bird traits Scientific collection Specimen number Temperature and precipitation

工程教育认证背景下“化工原理实验”课程体系优化的思考与探索

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四川化工 2024年第2期27卷 56-60页

作者：刘军海李志洲季晓晖雷霄云段延萍王伟邵先钊陕西理工大学化学与环境科学学院陕西汉中723000

工程教育认证是衡量高校工程教育质量的重要标准,也对“化工原理实验”课程体系提出了新的要求和更大的挑战。为促进“化工原理实验”课程教学质量的提升、推动工程教育认证工作的开展,探讨在工程教育认证背景下“化工原理实验”课程的... 详细信息

工程教育认证是衡量高校工程教育质量的重要标准,也对“化工原理实验”课程体系提出了新的要求和更大的挑战。为促进“化工原理实验”课程教学质量的提升、推动工程教育认证工作的开展,探讨在工程教育认证背景下“化工原理实验”课程的实验内容、教学方法、课程设置和评价机制等方面的优化策略与建议。多项优化策略在某高等院校化学工程与工艺专业实施后,实现了课程体系的不断优化,建立起了完善的实验教学管理机制和质量控制体系,从学生成绩和大赛表现来看取得了良好的成效。

关键词：工程教育认证化工原理实验课程体系存在的问题教学改革优化策略与建议成效

Associations between the physical environment and park-based physical activity:A systematic review

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Journal of Sport and Health Science 2019年第5期8卷 412-421页

作者： Ru Zhang Hagen Wulff yanping duan Petra Wagner Department of Sport and Physical Education Faculty of Social SciencesHong Kong Baptist UniversityHong Kong 999077China Institute of Exercise and Public Health Faculty of Sport SciencesUniversity of LeipzigLeipzig 04109Germany

Background:With an increase in the evidence for the associations between park-based physical activity(PA)and physical environments(especially park and neighborhood environments),researchers face an important challenge in interpreting and summarizing the evidence to develop environ?mental change *** updated review is needed to better inform policymaking and environmental *** current study aimed to systematically review the research on the associations of park-based PA with park and neighborhood environmental ***:We targeted English peer-reviewed articles from 5 electronic databases using keywords related to park-based PA,park environments,and neighborhood *** the 4071 identified papers,25 studies published between 2008 and 2016 met all the eligibility criteria and were included in this ***:The characteristics of physical environment that received consistent support included paths/trails,lighting,and incivilities(e.g.,broken glasses and litter).Mixed findings were revealed for 6 park environmental factors(unspecified active facilities,playgrounds and skating areas,fit?ness stations,picnic areas,greenness,and park size)and 2 neighborhood environmental factors(park density and park proximity).Conclusion:It can be concluded that paths/trails,lighting,and incivilities are 3 key physical environmental attributes of park-based *** the inconsistent findings on park and neighborhood environmental factors,more robust designs such as prospective investigation are required.

关键词： Neighborhood Park-based physical activity Park environment Physical environment Systematic review

Experimental and density functional theory computational evaluation of poly(N-vinyl caprolactam-co-butyl methacrylate) kinetic hydrate inhibitors

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Chinese Journal of Chemical Engineering 2021年第12期34卷 237-244页

作者： yanping duan Pengfei Wang Wenge Yang Xia Zhao Hong Hao Ruijie Wu Jie Huang School of Chemical Engineering Northwest UniversityXi’an 710069China Luoyang JALON Micro-Nano New Materials Co. LtdLuoyang 471000China

Natural gas hydrate inhibitor has been serving the oil and gas industry for many years. The development and search for new inhibitors remain the focus of research. In this study, the solution polymerization method was employed to prepare poly(N-vinyl caprolactam-co-butyl methacrylate)(P(VCap-BMA)), as a new kinetic hydrate inhibitor(KHI). The inhibition properties of P(VCap-BMA) were investigated by tetrahydrofuran(THF) hydrate testing and natural gas hydrate forming and compared with the commercial KHIs. The experiment showed that PVCap performed better than copolymer P(VCap-BMA). However,low doses of methanol or ethylene glycol are compounded with KHIs. The compounding inhibitors show a synergistic inhibitory effect. More interesting is the P(VCap-BMA)-methanol system has a better inhibitory effect than the PVCap-methanol system. 1% P(VCap-BMA) + 5% methanol presented the best inhibiting performance at subcooling 10.3 °C, the induction time of natural gas hydrate was 445 ***, the interaction between water and several dimeric inhibitors compared by natural bond orbital(NBO) analyses and density functional theory(DFT) indicated that inhibitor molecules were able to form the hydrogen bond with the water molecules, which result in gas hydrate inhibition. These exciting properties make the P(VCap-BMA) compound hydrate inhibitor promising candidates for numerous applications in the petrochemical industry.

关键词： Kinetic hydrate inhibitors Synthesis Poly(N-vinylcaprolactam-co-butyl methacrylate) Natural gas Hydrate Computer simulation

Neurofilament 200 expression in a rat model of complete spinal cord injury following growth-associated protein-43 treatment

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Neural Regeneration Research 2009年第11期4卷 827-831页

作者： yanping duan Dongkui Zhang Yingchun Ba Yun Yuan Jun Sun Dengli Fu Ran Zhang Jinde Wang Department of Histology and Embryology Kunming Medical University Kunming 650031 Yunnan Province China Yunnan Medical College Kunming Medical University Kunming 650031 Yunnan Province China Department of Anatomy Kunming Medical University Kunming 650031 Yunnan Province China Second Affiliated Hospital Kunming Medical University Kunming 650031 Yunnan Province China

BACKGROUND： Growth-associated protein-43 （GAP-43） expression in the nervous system has been demonstrated to promote neural regeneration, neuronal growth and development, as well as synaptic reconstruction. Neurofilament 200 （NF200） expression could reflect degree of injury and repair in injured spinal axons. OBJECTIVE： To observe NF200 expression changes in a rat model of complete spinal cord injury following GAP-43 treatment and to explore the effects of GAP-43 following spinal cord injury. DESIGN, TIME AND SETTING： A randomized, controlled, animal experiment was performed at the Laboratory of Histology and Embryology of Kunming Medical University between March 2007 and October 2008. MATERIALS： GAP-43 and GAP-43 antibody were provided by Beijing Boao Biology, China; mouse anti-rat NF200 antibody was purchased from Chemicon, USA. METHODS： Female, 8-week-old, Sprague Dawley rats were randomly assigned into three groups following complete spinal cord injury, with 20 animals in each group： GAP-43 antibody, GAP-43, and model groups. In addition, each group was subdivided into four subgroups according to sampling time after modeling, Le., 3-, 5-, 9-, and 15-day groups, with 5 rats in each group. GAP-43 antibody or GAP-43 was injected into injury sites of the spinal cord, 5 μg/0.2 mL, respectively, twice daily for three consecutive days, followed by three additional days of injection, once daily. The model group did not receive any treatment following injury. MAIN OUTCOME MEASURES： NF200 expression in the damaged spinal area at different stages was detected by immunohistochemistry; lower limb motion function following injury was evaluated using the Basso, Beattie and Bresnahan （BBB） locomotor rating scale. RESULTS： NF200 expression was significantly reduced in the GAP-43 antibody group, compared with GAP-43 and model groups, at 3 and 5 days after spinal cord injury （P 〈 0.05）. In addition, the model group expressed significantly less NF200 than the GAP-43 group （P 〈 0.05）

关键词： spinal cord injury growth-associated protein-43 neurofilament 200 Basso, Beattie and Bresnahan locomotor rating scale

“以期管业”与“遵额纳粮”:清代云南乡村社会秩序建构中的官民互动

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思想战线 2023年第5期49卷 93-103页

作者：吴晓亮段艳萍云南大学历史与档案学院云南昆明650091 云南民族大学文学与传媒学院云南昆明650091

管业执照在云南的实行,是清王朝国家治理深入边疆地区的重要标志。清代云南管业执照规范化与制度化的过程,深藏了边疆与内地一体化的制度设计和边疆社会秩序构建中官民互动协作的现实选择,官民合作“给照管业”满足了国家“遵额纳粮”... 详细信息

管业执照在云南的实行,是清王朝国家治理深入边疆地区的重要标志。清代云南管业执照规范化与制度化的过程,深藏了边疆与内地一体化的制度设计和边疆社会秩序构建中官民互动协作的现实选择,官民合作“给照管业”满足了国家“遵额纳粮”与业户“以期管业”的双重需求,是国家力量与乡村社会力量相互渗透、相互影响的结果,呈现了清中央王朝政治制度及其边疆治理政策在云南地方社会调和、适应的样态。云南乡村社会秩序的建构与清王朝的边疆治理也在这种联结与互动中共塑“边疆与内地一体化”的基本格局,并将云南社会经济发展推向新的历史阶段。

关键词：管业执照 “以期管业” “遵额纳粮” 乡村秩序