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Highly-efficient CoRuO_(x)nanocatalysts for acidic oxygen evolution:The merit of optimum ordering degree of carbon nanotube support

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Particuology 2024年第7期90卷 470-477页

作者： Wenwen Li yanni wang Zhenzhen Zhao Meiqi Liu Qing Liang Yuhua Liu Fuxi Liu Zhou Jiang Xu Zou Bingsen Zhang Wei Zhang Key Laboratory of Automobile Materials MOE School of Materials Science&EngineeringJilin Provincial International Cooperation Key Laboratory of High-Efficiency Clean Energy MaterialsElectron Microscopy CenterInternational Center of Future ScienceJilin UniversityChangchun 130012China Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of Sciences110016ShenyangChina

Hydrogen production from proton exchange membrane water electrolysis is constrained by the sluggish kinetics of the anodic oxygen evolution reaction.RuO_(2)has attracted considerable attention due to its low reaction overpotential,but its inferior stability remains a major challenge.Herein,a strategy is proposed to enhance the catalytic activity and stability of CoRuOx nanoparticles by doping Co and regulating the ordering degree of carbon nanotubes(CNTs)by air annealing.It was found that the CoRuOx@CNTs-300 catalyst exhibited the best catalytic activity and stability when the annealing temperature was 300°C.At the current density of 10 mA cm−2,the overpotential of this catalyst was only 201 mV,which was nearly 100 mV lower than that of commercial RuO_(2)(300 mV).Surprisingly,there was no significant increase in the overpotential when tested at a current density of 10 mA cm−2 for 50 h.The density functional theory calculations indicate that the high activity of the catalyst is due to the electronic coupling of CoRuOx nanoparticles and CNTs,and that the introduction of Co and CNTs improves the electronic structure and solvation energies of the Ru in the active site,dramatically increasing the structural stability.

关键词： Electrocatalysis RuO_(2) CNTs Oxygen evolution reaction

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The clinical characteristics and risk factors for necrotizing soft tissue infection in children

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儿科学研究(英文) 2024年第1期8卷 21-26页

作者： Liu Jing Chen Jigang wang yanni Qi Hongyan Yu Jing Department of Burn and Plastic Surgery Beijing Children’s Hospital Capital Medical University National Center for Children’s Health Beijing China

Importance: Necrotizing soft tissue infection (NSTI) is a serious infectious disease. However, the early clinical manifestations and indicators of NSTI in children are still unclear.Objective: The purpose of this study was to analyze the clinical characteristics and risk factors of NSTI in pediatric patients.Methods: A total of 127 children with skin and soft tissue infection (SSTI) were treated at our hospital and divided into two groups: the NSTI group and the non-NSTI group, based on their discharge diagnosis from January 2011 to December 2022. Then, we collected and analyzed the clinical characteristics and risk factors of all patients, including sex and age, disease inducement, admission temperature, local skin manifestations, infection site, the presence of sepsis, bacterial culture, and laboratory indicators.Results: In our study, there was a statistical difference in the age distribution and disease inducement between NSTI and non-NSTI groups. The occurrence of local skin manifestations (blisters/bullae and ecchymosis) and the presence of sepsis significantly increased in the NSTI group compared to the non-NSTI group. Additionally, only the platelet count on laboratory tests was statistically different between the NSTI and non-NSTI groups. Finally, the logistic regression analysis suggested that local skin manifestations such as blisters/bullae, and ecchymosis, as well as the presence of sepsis, were identified as risk factors for NSTI.Interpretation: Children with SSTI and skin manifestations such as blisters/bullae, ecchymosis, and the presence of sepsis are at a higher risk of developing NSTI. These symptoms serve as useful indicators for early detection of NSTI.

关键词： Clinical characteristics Risk factors Necrotizing soft tissue infection Skin and soft tissue infection

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A Concentric Array for Generating Multimode OAM Waves

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Journal of Communications and Information Networks 2022年第3期7卷 333-348页

作者： yanni wang Xuehong Sun Liping Liu School of Physics and Electronic-Electrical Engineering Ningxia UniversityYinchuan 750021China Ningxia Key Laboratory of Intelligent Sensing of Desert Information Ningxia UniversityYinchuan 750021China

For the problem of multiplexing multimodal vortex electromagnetic waves,a double-ring concentric uniform circular array(CUCA)consisting of 12 circularly polarized antennas(4 inner rings and 8 outer rings)is proposed in this paper.A complex feeding network is solved by rotating the circularly polarized antennas at a certain angle.The antennas are rotationally symmetric and point to the center,generating orbital angular momentum(OAM)waves by feeding the same amplitude and phase signals.In addition,this paper combines millimeter wave(mm-wave)and ultra-wideband(UWB)with OAM.The proposed antenna array can generate OAM beams at 30∼40 GHz with l=−1,−2.When l=−1 the relative bandwidth is 25.2% and the gain is 8.03 dBi;when l=−2 the relative bandwidth is 27.7% and the gain is 9.43 dBi.The analysis of simulation results shows that the antenna array has UWB performance,good gain,and a standard spiral phase distribution,which can provide some practical significance for modal multiplexing of mm-wave band OAM.

关键词： orbital angular momentum(OAM) concentric uniform circular array(CUCA) millimeter wave(mm-wave) ultra-wideband(UWB) modal multiplexing

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Bioimaging of Dissolvable Microneedle Arrays: Challenges and Opportunities

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Research 2022年第4期2022卷 633-655页

作者： yanni wang Gehua Ma Guangzhi Gao Ji Tao Wenzhao Cao Haohao Sun Fengsen Ma Yilong Zhang Yen Wei Mei Tian Laboratory of Biologics and Biomaterials Collge of PharmacyZhejiang University of TechnologyHangzhou 310014China Cllge of Computer Science and Technology Zhejiang UniversityHangzhou 310027China Human Phenome Institute Fudan UniversityShanghai 201203China College of Information Engineering Zhejiang University of TechnologyHangzhou 310023China Life Science Research Center Frontier Crossing InstituteZhejiang University of TechnologyHangzhou 310023China Engineering Research Center of Intelligent Sensing and System Ministry of EducationHangzhou 310023China College of Computer Science and Technology Zhejiang University of TechnologyHangzhou 310023China Department of Chemistry and the Tsinghua Center for Frontier Polymer Research Tsinghua UniversityBeijing 100084China

The emergence of microneedle arrays(MNAs)as a novel,simple,and minimally invasive administration approach largely addresses the challenges of traditional drug delivery.In particular,the dissolvable MNAs act as a promising,multifarious,and well-controlled platform for micro-nanotransport in medical research and cosmetic formulation applications.The effective delivery mostly depends on the behavior of the MNAs penetrated into the body,and accurate assessment is urgently needed.Advanced imaging technologies offer high sensitivity and resolution visualization of cross-scale,multidimensional,and multiparameter information,which can be used as an important aid for the evaluation and development of new MNAs.The combination of MNA technology and imaging can generate considerable new knowledge in a cost-effective manner with regards to the pharmacokinetics and bioavailability of active substances for the treatment of various diseases.In addition,noninvasive imaging techniques allow rapid,receptive assessment of transdermal penetration and drug deposition in various tissues,which could greatly facilitate the translation of experimental MNAs into clinical application.Relying on the recent promising development of bioimaging,this review is aimed at summarizing the current status,challenges,and future perspective on in vivo assessment of MNA drug delivery by various imaging technologies.

关键词： needle mostly formulation

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Cytokine storm promoting T cell exhaustion in severe COVID-19 revealed by single cell sequencing data analysis

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Precision Clinical Medicine 2022年第2期5卷 87-99页

作者： Minglei Yang Chenghao Lin yanni wang Kang Chen Yutong Han Haiyue Zhang Weizhong Li Zhongshan School of Medicine Sun Yat-sen UniversityGuangzhou 510080China Center for Precision Medicine Sun Yat-sen UniversityGuangzhou 510080China Key Laboratory of Tropical Disease Control of Ministry of Education Sun Yat-Sen UniversityGuangzhou 510080China

Background:Evidence has suggested that cytokine storms may be associated with T cell exhaustion(TEX)in COVID-19.However,the interaction mechanism between cytokine storms and TEX remains unclear.Methods:With the aim of dissecting the molecular relationship of cytokine storms and TEX through single-cell RNA sequencing data analysis,we identified 14 cell types from bronchoalveolar lavage fluid of COVID-19 patients and healthy people.We observed a novel subset of severely exhausted CD8 T cells(Exh T_CD8)that co-expressed multiple inhibitory receptors,and two macrophage subclasses that were the main source of cytokine storms in bronchoalveolar.Results:Correlation analysis between cytokine storm level and TEX level suggested that cytokine storms likely promoted TEX in severe COVID-19.Cell–cell communication analysis indicated that cytokines(e.g.CXCL10,CXCL11,CXCL2,CCL2,and CCL3)released by macrophages acted as ligands and significantly interacted with inhibitory receptors(e.g.CXCR3,DPP4,CCR1,CCR2,and CCR5)expressed by Exh T_CD8.These interactions formed the cytokine–receptor axes,which were also verified to be significantly correlated with cytokine storms and TEX in lung squamous cell carcinoma.Conclusions:Cytokine storms may promote TEX through cytokine-receptor axes and be associated with poor prognosis in COVID19.Blocking cytokine-receptor axes may reverse TEX.Our finding provides novel insights into TEX in COVID-19 and new clues for cytokine-targeted immunotherapy development.

关键词： COVID-19 immune exhaustion cytokine storm single-cell sequencing data analysis T cell immune checkpoint

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Alterations in DNA damage response and repair genes as potential biomarkers for immune checkpoint blockade in gastrointestinal cancer

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Cancer Biology & Medicine 2022年第8期19卷 1139-1149页

作者： Yujiao wang Xi Jiao Shuang Li Huan Chen Xin Wei Chang Liu Jifang Gong Xiaotian Zhang Xicheng wang Zhi Peng Changsong Qi Zhenghang wang yanni wang Na Zhuo Jianling Zou Henghui Zhang Jian Li Lin Shen Zhihao Lu Department of Gastrointestinal Oncology Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education)Peking University Cancer Hospital&InstituteBeijing 100142China Department of Gastric&Colorectal Surgery The First Hospital of Jilin UniversityChangchun 130021China Genecast Precision Medicine Technology Institute Beijing 100192China Life Sciences Institute Zhejiang UniversityHangzhou 310058China Institute of Infectious Diseases Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China

Objective:Immune checkpoint inhibitors(ICIs)have achieved remarkable results in cancer treatments.However,there is no effective predictive biomarker for gastrointestinal(GI)cancer.Methods:We conducted integrative analyses of the genomic and survival data of ICI-treated GI cancer patients from the Memorial Sloan Kettering Cancer Center cohort(MSK-GI,n=227),the Janjigian cohort(n=40),and the Peking University Cancer Hospital&Institute cohort(PUCH,n=80)to determine the possible associations between DNA damage response and repair(DDR)gene mutations and clinical outcomes.Data from The Cancer Genome Atlas database were analyzed to determine the possible correlations between DDR gene mutations and the tumor microenvironment.Results:In the MSK cohort,the presence of≥2 DDR gene mutations was correlated with prolonged overall survival(OS).The Janjigian and PUCH cohorts further confirmed that subgroups with≥2 DDR gene mutations displayed a prolonged OS and a higher durable clinical benefit.Furthermore,the DDR gene mutation load could be considered as an independent prognostic factor,and exhibited a potential predictive value for survival in GI cancer patients treated with ICIs.Mechanistically,we showed that the presence of≥2 DDR gene mutations was correlated with higher levels of tumor mutation burden,neoantigen,and T cell infiltration.Conclusions:The DDR gene mutation status was correlated with favorable clinical outcomes in GI cancer patients receiving ICIs,which could serve as a potential biomarker to guide patient selection for immunotherapy.

关键词： Gastrointestinal cancer DDR gene mutation immunotherapy biomarker

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Restricted dispersal determines fine-scale spatial genetic structure of Mongolian gerbils

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Current Zoology 2017年第6期63卷 687-691页

作者： Guiming wang Wei LIU yanni wang Xinrong WAN Wenqin ZHONG Department of Wildlife Fisheries and Aquaculture Mississippi State University Mail Stop 9690 Mississippi State MS 39762 USA Institute of Zoology Chinese Academy of Sciences State Key Laboratory of Integrated Management of Pest Insects and Rodents 1 Beichen West Road Chaoyang District Beijing 100101 China University of Chinese Academy of Sciences Beijing 100190 China College of Chemistry and Life Sciences Zhejiang Normal University 688 Yingbin Road Jinhua Zhejiang 321004 China

Restricted gene flow may cause positive spatial genetic autocorrelation of animal populations at fine spatial scales. The Mongolian gerbil is a territorial, social rodent. Territoriality may create social fences to restrict dispersal or gene flow of Mongolian gerbils to a short distance. Restricted dispersal may differentiate fine-scale spatial genetic structure of populations with increasing distances (i.e., isolation by distance [IBD]). Competition for mates and inbreeding avoidance may result in equal dispersal propensity and subsequently similar spatial genetic autocorrelation between males and females of monogamous gerbils. We genotyped 327 gerbils, live captured from 26 burrow systems on a 9-ha plot in northcentral Inner Mongolia, China, using seven microsatellite loci. Spatial genetic autocorrelation was positive within 80 m and became negative from 80 m to 200 m, suggesting restricted gene flow. Inter-group genetic and geographic distances were related positively, supporting the IBD model. Live trapping data demonstrated equal dispersal propensities of male and female gerbils. Restricted dispersal and social organization may determine fine-scale spatial population genetic structure of social rodents.

关键词： Meriones unguiculatus dispersal isolation by distance microsatellite analysis social rodents spatial genetic autocorrelation

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群众文化视角下中华民族故事叙事策略研究

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现代出版 2024年第6期 9-17页

作者：周建新王燕妮中国传媒大学科学研究处中国传媒大学铸牢中华民族共同体意识研究基地中国传媒大学经济与管理学院

中华民族故事的内涵丰富,呈现出多元性与一体性、依存性与独立性、继承性与创新性的复杂特征。讲好中华民族故事具有鲜明的政治属性、文化属性和艺术属性,是我国民族工作的重大理论和实践命题,要在准确理解并把握其内涵的基础上,寻找与... 详细信息

中华民族故事的内涵丰富,呈现出多元性与一体性、依存性与独立性、继承性与创新性的复杂特征。讲好中华民族故事具有鲜明的政治属性、文化属性和艺术属性,是我国民族工作的重大理论和实践命题,要在准确理解并把握其内涵的基础上,寻找与之高度契合的叙事逻辑和叙事策略。凝结各族群众智慧的群众文化与中华民族故事同源同脉、共促共进,二者在叙事上不仅互为基础还可以彼此成就。讲好中华民族故事,要立足各民族群众对故事的文化需求,传承并创造性使用民族文化资源,加大讲述民族故事的理论阐释,共奏全民族叙事大合唱,持续铸牢中华民族共同体意识,维护中华民族共有精神家园。

关键词：群众文化中华民族故事叙事策略

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Effect of Case Management for Patients with Gestational Diabetes

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Journal of Clinical and Nursing Research 2023年第4期7卷 195-200页

作者： yanni wang Duomei Ren Shue wang Chunrong Yang Meirong wang Obstetrics Department Shaanxi Provincial People’s HospitalXi’an 710068China

Objective:To explore the effect of allocating case managers for gestational diabetes patients.Methods:200 patients with gestational diabetes mellitus from December 2021 to December 2022 were included in this study,and the collection period.They were divided into groups according to the interventions received.Each patient in the observation group was managed by a case manager,while the control group were managed with conventional methods without the supervision of a case manager.There were 100 cases in each group,and the curative effects of the two groups were compared.Results:The fasting blood glucose and 2-hour postprandial blood glucose in the observation group were significantly lower than those of the control group(P<0.05).The re-admission rate of patients due to poor blood sugar control in the observation group was lower than that in the control group(P<0.05).The pregnancy outcome of the observation group was better than that of the control group(P<0.05).Conclusion:Case management of gestational diabetes can not only control the blood glucose of pregnant women,but also improve pregnancy outcomes.

关键词： Gestational diabetes mellitus Case management Blood glucose Pregnancy outcome

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Research on the Different Frequencies of Transcutaneous Electrical Acupoint Stimulation for Postpartum Pelvic Girdle Pain

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Journal of Clinical and Nursing Research 2023年第2期7卷 65-72页

作者： Chunrong Yang Feng Yuan yanni wang Duomei Ren Obstetrics Department Shaanxi Provincial People’s HospitalXi’an 710068China

Objective:To observe the clinical effect of different frequencies of transcutaneous electrical acupoint stimulation in treating postpartum pelvic girdle pain and promoting postpartum rehabilitation.Methods:From January to September 2022,300 patients with pelvic girdle pain after spontaneous delivery in a hospital in Shaanxi Province were selected and randomly divided into three groups,low frequency,high frequency,and alternating frequency,with 100 cases in each group.In addition to routine postpartum care and psychological counseling,the three groups received transcutaneous electrical acupoint stimulation at low-frequency(2 Hz,)high-frequency(100 Hz),and alternating frequency(2/100 Hz),respectively.The differences in initial pain,pain scores before and after treatment,satisfaction with analgesic effect,and postpartum rehabilitation effect were evaluated among the three groups of patients.Results:There was a significant correlation between maternal age and postpartum pelvic girdle pain(P0.05).After 1d/2d of treatment,the pain scores and rehabilitation effect of patients in the alternating-frequency group and low-frequency group were significantly better than those in the high-frequency group,and the postpartum curative effect of patients in the alternating-frequency group was the best,followed by the low-frequency group,and the high-frequency group;the differences were statistically significant(P<0.001).Among the three groups,the alternating-frequency group had the highest satisfaction with the analgesic effect and the highest rate of selecting the same analgesic regimen the next time;the differences were statistically significant(P<0.001).Conclusion:Transcutaneous electrical acupoint stimulation at different frequencies is safe and effective in treating postpartum pelvic girdle pain and beneficial to postpartum rehabilitation.Sparse-dense wave stimulation is effective in treating postpartum pelvic girdle pain.

关键词： Transcutaneous electrical acupoint stimulation Pelvic girdle pain Postpartum rehabilitation Frequency

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