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“学校离村”与“教育进城”:新时代乡村学校发展的格局转变与治理转型

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湖南师范大学教育科学学报 2023年第6期22卷 76-82页

作者：刘丽群熊燕妮湖南第一师范学院教育学院湖南长沙410205

乡村学校的“离村”表面上看是由于人口进城、人口锐减,深层原因则在于中国的乡村形态正从乡土中国向城乡中国发生巨变。乡村学校在国家极力保留的政策导向下仍逐渐走向自然消失,布点减少、规模小微、村落“退场”并迅速向城镇集聚,教... 详细信息

乡村学校的“离村”表面上看是由于人口进城、人口锐减,深层原因则在于中国的乡村形态正从乡土中国向城乡中国发生巨变。乡村学校在国家极力保留的政策导向下仍逐渐走向自然消失,布点减少、规模小微、村落“退场”并迅速向城镇集聚,教育的重心上移,且乡村学校不再“定居静止”于乡村,而是“迁徙流动”于城乡。乡村学校的问题出在乡村,但治理的向度不只是乡村。构建新时代乡村学校的治理体系,一是治理理念上要从城乡二元对立转向城乡互融共生;二是治理范式上要从立足村庄内部转向着眼于县域整体;三是治理方法上从被动回应性治理转向前瞻科学性研判。

关键词：乡村学校学校离村教育进城教育治理乡村教育

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地铁车站地下空间绿色建筑设计方法探究

城市轨道交通研究 2021年第3期24卷 10-13页

作者：杨艳红赵思源熊燕妮王新瑀天津城建大学城市艺术学院天津300384 天津城建大学建筑学院天津300384 天津市建筑设计研究院有限公司天津300074

结合GB/T 50378—2019《绿色建筑评价标准》,系统地梳理了我国地铁车站地下空间绿色建筑设计研究的发展现状。从宏观场地规划、中观建筑设计、微观空间表达三个维度解构地铁车站绿色建筑设计影响要素。结合客观技术和主观感知层面,提出... 详细信息

结合GB/T 50378—2019《绿色建筑评价标准》,系统地梳理了我国地铁车站地下空间绿色建筑设计研究的发展现状。从宏观场地规划、中观建筑设计、微观空间表达三个维度解构地铁车站绿色建筑设计影响要素。结合客观技术和主观感知层面,提出利用组合赋权法构建相应的评价体系,提出了地铁车站地下空间绿色建筑设计体系中各影响要素的综合权重及总得分的计算公式。系统地归纳了地铁车站绿色建筑设计技术,拓展了地铁车站空间文化表达方式,并探索了地铁车站地下空间绿色建筑设计的理论与方法。

关键词：地铁车站地下空间绿色建筑设计

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乡村公共活动空间优化设计策略研究

城市建筑 2021年第33期18卷 70-72页

作者：熊燕妮潘婷杨艳红天津城建大学建筑学院天津300384 天津城建大学城市艺术学院天津300384

乡村公共空间是乡村中精神文明与社会文明的重要交流场所。本研究基于问卷调研结果分析,通过对当前乡村公共空间相关文献资料的归纳总结,借用威廉·佩纳的问题探究(problem seeking)的方法,构建信息矩阵表,对当前乡村公共空间的现状问... 详细信息

乡村公共空间是乡村中精神文明与社会文明的重要交流场所。本研究基于问卷调研结果分析,通过对当前乡村公共空间相关文献资料的归纳总结,借用威廉·佩纳的问题探究(problem seeking)的方法,构建信息矩阵表,对当前乡村公共空间的现状问题进行分析,明确研究的主要目标人群,确定乡村公共空间从场地设计、功能设计、管理等方面的优化目标并提出理论建议。以期为我国乡村公共空间优化建设提供参考。

关键词：乡村振兴公共空间空间活化公众参与优化设计

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一株豇豆花苞内生不动杆菌的分离鉴定

江汉大学学报（自然科学版） 2015年第5期43卷 398-400页

作者：韩雪熊燕妮江瑞晶曾辰陈禅友江汉大学生命科学学院湖北武汉430056

从武汉豇豆种植基地的豇豆花苞中筛选出花内生菌（命名为wjhb）,其在豇豆花苞中大量存在,在花瓣中为优势内生菌。染色鉴定为革兰阴性杆菌,可以在16~43℃生长。生化试验显示,该菌生化特征符合不动杆菌特征;16Sr DNA扩增产物测序后,经软... 详细信息

从武汉豇豆种植基地的豇豆花苞中筛选出花内生菌（命名为wjhb）,其在豇豆花苞中大量存在,在花瓣中为优势内生菌。染色鉴定为革兰阴性杆菌,可以在16~43℃生长。生化试验显示,该菌生化特征符合不动杆菌特征;16Sr DNA扩增产物测序后,经软件分析其16Sr DNA序列与不动杆菌序列相似度达98%。本试验分离得到的内生不动杆菌（wjhb）,有望成为豇豆基因工程生防菌的理想宿主菌株。

关键词：豇豆花苞内生菌不动杆菌革兰染色序列分析

Effective *** inactivation of core-shell ZnO@ZIF-8 photocatalysis under visible light synergize with peroxymonosulfate:Efficiency and mechanism

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Chinese Chemical Letters 2022年第1期33卷 415-423页

作者： yanni Jiang Zhaokun xiong Jianbo Huang Feng Yan Gang Yao Bo Lai State Key Laboratory of Hydraulics and Mountain River Engineering College of Architecture and EnvironmentSichuan UniversityChengdu 610065China Sino-German Centre for Water and Health Research Sichuan UniversityChengdu 610065China Department of Ultrasound Laboratory of Ultrasound Imaging DrugWest China HospitalSichuan UniversityChengdu 610041China Institute of Environmental Engineering RWTH Aachen UniversityAachen 52072Germany

How to utilize inexhaustible solar light as a means of disinfection technology for its cheap and green remains a *** this work,core-shell ZnO@ZIF-8 was synthesized and used for bacterial inactivation synergizing with peroxymonosulfate(PMS)under visible light *** took 50 min to achieve thorough sterilization for 7.5-log Escherichia coli(***)cells in vis/PMS/ZnO@ZIF-8 system,compared with that 4.5-log reduction completed in vis/PMS/ZnO system under the same *** enhanced photocatalytic disinfection mechanisms of fabricated ZnO@ZIF-8 were investigated by UV-vis diffuse reflectance spectra,electrochemical impedance spectra and Mott-Schottky *** promoted bactericidal efficiency was attributed to higher charge-separation efficiency and stronger oxidation ability of photo-generated ***,it was found that^(1)O_(2)and·OH induced bacterial cell lesion process,and the former was the main active *** external reactive oxygen species(ROS)caused a series of cell wall damage,intercellular ROS up-regulation and genome DNA unwinding,finally resulted in irreversible bacterial death.A two-route mechanism in vis/PMS/ZnO@ZIF-8 system was proposed,in which the generation of^(1)O_(2)was supposed as the product of the oxygen oxidation of photo-generated holes and PMS *** work is expected to provide advanced information about a low-cost water disinfection technology of visible light photocatalysis.

关键词： Bacterial inactivation Photocatalysis Visible light Peroxymonosulfate

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垂直搜索引擎蜘蛛系统的设计与实现

计算机光盘软件与应用 2011年第2期14卷 156-156页

作者：熊燕妮黄凯长江大学计算机科学学院湖北荆州434000

网络信息资源的爆炸式增长使得人们获得有用信息日益困难，随着垂直网站的出现和发展，专业化的垂直搜索引擎成为今后搜索引擎发展的主流。本文介绍了垂直搜索引擎的特点和系统的基本构成，在此基础上采用实证研究的方法，详细介绍了基... 详细信息

网络信息资源的爆炸式增长使得人们获得有用信息日益困难，随着垂直网站的出现和发展，专业化的垂直搜索引擎成为今后搜索引擎发展的主流。本文介绍了垂直搜索引擎的特点和系统的基本构成，在此基础上采用实证研究的方法，详细介绍了基于手机信息检索的垂直搜索引擎的设计与实现。

关键词：垂直搜索网络蜘蛛设计

Exploring the attenuation mechanisms of Dalbergia odorifera leaves extract on cerebral ischemia-reperfusion based on weighted gene co-expression network analysis

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BIOCELL 2023年第7期47卷 1611-1622页

作者： JINFANG HU JIANGEN AO LONGSHENG FU YAOQI WU FENG SHAO TIANTIAN XU MINGJIN JIANG SHAOFENG xiong yanni LV Department of Pharmacy The First Affiliated Hospital of Nanchang UniversityNanchang330006China Department of Pharmacy The Second Affiliated Hospital of Nanchang UniversityNanchang330006China Key Laboratory of Modern Preparation of TCM Ministry of EducationJiangxi University of Traditional Chinese MedicineNanchang330006China Jiangxi Provincial Institute of Translational Medicine The First Affiliated Hospital of Nanchang UniversityNanchang330006China

The attenuation function of Dalbergia odorifera leaves on cerebral ischemia-reperfusion(I/R)is little *** candidate targets for the Chinese herb were extracted from brain tissues through the high-affinity *** molecular mechanism of *** leaves on cerebral I/R was ***:Serial affinity chromatography based on *** leaves extract(DLE)affinity matrices were applied to find specific binding proteins in the brain tissues implemented on C57BL/6 mice by intraluminal middle cerebral artery occlusion for 1 h and reperfusion for 24 *** binding proteins were subjected to mass-spectrometry to search for the differentially expressed proteins between control and DLE-affinity *** hub genes were screened based on weighted gene co-expression network analysis(WGCNA).Then,predictive biology and potential experimental verification were performed for the candidate *** protective role of DLE in blood-brain barrier damage in cerebral I/R mice was evaluated by the leakage of Evans blue,western blotting,immunohistochemistry,and immunofluorescent ***:952 differentially expressed proteins were classified into seven modules based on WGCNA under soft threshold *** on WGCNA,AKT1,PIK3CA,NOS3,SMAD3,SMAD1,IL6,MAPK1,TGFBR2,TGFBR1,MAPK3,IGF1R,LRG1,mTOR,ROCK1,TGFB1,IL1B,SMAD2,and SMAD518 candidate hub proteins were involved in turquoise ***-β,MAPK,focal adhesion,and adherens junction signaling pathway were associated with candidate hub *** ontology analysis demonstrated that candidate hub proteins were related to the TGF-βreceptor signaling pathway,common-partner SMAD protein phosphorylation,*** could significantly reduce the leakage of Evans blue in mice with cerebral I/R,while attenuating the expression of occludin,claudin-5,and zonula *** blotting demonstrated that regulation of TGF-β/SMAD signaling pathway played an essential role in the protective effect of ***:

关键词： Dalbergia odorifera leaves Serial affinity chromatography WGCNA Cerebral ischemia-reperfusion TGF-β SMADS

Nanoparticles (NPs)-mediated Siglec15 silencing and macrophage repolarization for enhanced cancer immunotherapy

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Acta Pharmaceutica Sinica B 2023年第12期13卷 5048-5059页

作者： Xiaodi Liu Qi Zhang Yixia Liang Shiyu xiong Yan Cai Jincheng Cao yanni Xu Xiaolin Xu Ye Wu Qiang Lu Xiaoding Xu Baoming Luo Department of Ultrasound Laboratory of Ultrasound Imaging and DrugWest China HospitalSichuan UniversityChengdu 610041China Department of Ultrasound Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Department of Ultrasound Central People's Hospital of ZhanjiangZhanjiang 524045China

cell infiltration and proliferation in tumor tissues are the main factors that significantly affect the therapeutic outcomes of cancer *** evidence has shown that interferon-gamma(IFN)could enhance CXCL9 secretion from macrophages to recruit T cells,but Siglec15 expressed on TAMs can attenuate T cell ***,targeted regulation of macrophage function could be a promising strategy to enhance cancer immunotherapy via concurrently promoting the infiltration and proliferation of T cells in tumor *** herein developed reductionresponsive nanoparticles(NPs)made with poly(disulfide amide)(PDSA)and lipid-poly(ethylene glycol)(lipid-PEG)for systemic delivery of Siglec15 siRNA(siSiglec15)and IFN for enhanced cancer *** intravenous administration,these cargo-loaded could highly accumulate in the tumor tissues and be efficiently internalized by tumor-associated macrophages(TAMs).With the highly concentrated glutathione(GSH)in the cytoplasm to destroy the nanostructure,the loaded IFN and si-Siglec15 could be rapidly released,which could respectively repolarize macrophage phenotype to enhance CXCL9 secretion for T cell infiltration and silence Siglec15 expression to promote T cell proliferation,leading to significant inhibition of hepatocellular carcinoma(HCC)growth when combining with the immune checkpoint *** strategy developed herein could be used as an effective tool to enhance cancer immunotherapy.

关键词： Nanoparticles Tumor-associated macrophages Macrophage repolarization T cell infiltration T cell proliferation Cancer immunotherapy Siglec15 Hepatocellular carcinoma

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鱼汤风味的形成与调控研究进展

食品科学 2023年第15期44卷 251-260页

作者：武燕霓安玥琦熊善柏华中农业大学食品科学技术学院湖北武汉430070 国家大宗淡水鱼加工技术研发分中心(武汉) 湖北武汉430070

鱼汤是中国传统的一类肉汤食品,其营养组成丰富、消化吸收率高,滋味鲜甜、香气浓郁,深受消费者喜爱。然而,鱼汤在生产加工及贮藏过程中极易产生腥异味,制约了其产业发展。鱼汤的腥异味来源广泛、构成复杂、消减难度较大。因此,亟需了解... 详细信息

鱼汤是中国传统的一类肉汤食品,其营养组成丰富、消化吸收率高,滋味鲜甜、香气浓郁,深受消费者喜爱。然而,鱼汤在生产加工及贮藏过程中极易产生腥异味,制约了其产业发展。鱼汤的腥异味来源广泛、构成复杂、消减难度较大。因此,亟需了解鱼汤风味品质(尤其是腥异味)的形成机理,明确鱼汤风味品质的影响因素,建立鱼汤腥异味的调控措施。基于此,本文综述鱼汤风味的形成途径,系统地探讨影响鱼汤风味品质的加工因素,明确了可通过筛选加工方式有效增强鱼汤特征香气、减弱不良异味的调控措施,总结目前鱼汤去腥脱苦方式并比较其优缺点,以期为鱼汤的风味品质调控、开发鱼汤类便携型食品提供重要理论依据。

关键词：鱼汤风味品质形成机制影响因素调控去腥脱苦