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REDH:A database of RNA editome in hematopoietic differentiation and malignancy

Chinese Medical Journal 2024年第3期137卷 283-293页

作者： Jiayue Xu Jiahuan He Jiabin Yang Fengjiao Wang Yue Huo Yuehong Guo yanmin si Yufeng Gao Fang Wang Hui Cheng Tao Cheng Jia Yu Xiaoshuang Wang Yanni Ma State Key Laboratory of Common Mechanism Research for Major Diseases Haihe Laboratory of Cell EcosystemInstitute of Basic Medical SciencesChinese Academy of Medical SciencesBeijing 100005China Key Laboratory of RNA and Hematopoietic Regulation Chinese Academy of Medical SciencesBeijing 100005China Department of Biochemistry and Molecular Biology Chinese Academy of Medical SciencesSchool of Basic Medicine Peking Union Medical CollegeBeijing 100005China State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood DiseasesInstitute of Hematology and Blood Diseases HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeTianjin 300020China Institute of Blood Transfusion Chinese Academy of Medical SciencesChengduSichuan 610052China

Background:The conversion of adenosine(A)to inosine(I)through deamination is the prevailing form of RNA editing,impacting numerous nuclear and cytoplasmic transcripts across various eukaryotic *** of high-confidence RNA editing sites have been identified and integrated into various RNA databases,providing a convenient platform for the rapid identification of key drivers of cancer and potential therapeutic ***,the available database for integration of RNA editing in hematopoietic cells and hematopoietic malignancies is still ***:We downloaded RNA sequencing(RNA-seq)data of 29 leukemia patients and 19 healthy donors from National Center for Biotechnology Information(NCBI)Gene Expression Omnibus(GEO)database,and RNA-seq data of 12 mouse hematopoietic cell populations obtained from our previous research were also *** performed sequence alignment,identified RNA editing sites,and obtained characteristic editing sites related to normal hematopoietic development and abnormal editing sites associated with hematologic ***:We established a new database,"REDH",represents RNA editome in hematopoietic differentiation and *** is a curated database of associations between RNA editome and *** integrates 30,796 editing sites from 12 murine adult hematopoietic cell populations and systematically characterizes more than 400,000 edited events in malignant hematopoietic samples from 48 cohorts(human).Through the Differentiation,Disease,Enrichment,and knowledge modules,each A-to-I editing site is systematically integrated,including its distribution throughout the genome,its clinical information(human sample),and functional editing sites under physiological and pathological ***,REDH compares the similarities and differences of editing sites between different hematologic malignancies and healthy ***:REDH is accessible at http://***/.This user-friendly database

关键词： RNA editing Hematopoietic differentiation Hematopoietic malignancy Database management systems

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KHSRP combines transcriptional and posttranscriptional mechanisms to regulate monocytic differentiation

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Blood Science 2022年第3期4卷 103-115页

作者： Jiayue Xu Dongsheng Wang Hongliu Ma Xueying Zhai Yue Huo Yue Ren Weiqian Li Le Chang Dongxu Lu Yuehong Guo yanmin si Yufeng Gao Xiaoshuang Wang Yanni Ma Fang Wang Jia Yu State Key Laboratory of Medical Molecular Biology Haihe Laboratory of Cell EcosystemInstitute of Basic Medical SciencesChinese Academy of Medical SciencesSchool of Basic Medicine Peking Union Medical CollegeBeijing 100005China Key Laboratory of RNA and Hematopoietic Regulation Chinese Academy of Medical SciencesBeijing 100005China Department of Clinical Laboratory Sichuan Cancer Hospital and InstituteSichuan Cancer CenterSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengdu 610041China Department of Gynecology Dian Jiang People’s Hospital of Chong QingChongqing 408300China Medical Epigenetic Research Center Chinese Academy of Medical SciencesBeijing 100005China

RNA-binding proteins(RBPs)are widely involved in the transcriptional and posttranscriptional regulation of multiple biological *** transcriptional regulatory ability of RBPs was indicated by the identification of chromatin-enriched RBPs(Che-RBPs).One of these proteins,KH-type splicing regulatory protein(KHSRP),is a multifunctional RBP that has been implicated in mRNA decay,alternative splicing,and miRNA biogenesis and plays an essential role in myeloid differentiation by facilitating the maturation of *** this study,we revealed that KHSRP regulates monocytic differentiation by regulating gene transcription and RNA ***-occupied specific genomic sites in promoter and enhancer regions to regulate the expression of several hematopoietic genes through transcriptional activation and bound to pre-mRNA intronic regions to modulate alternative splicing during monocytic *** note,KHSRP had co-regulatory effects at both the transcriptional and posttranscriptional levels on MOGOH and *** together,our analyses revealed the dual DNA-and RNA-binding activities of KHSRP and have provided a paradigm to guide the analysis of other functional Che-RBPs in different biological systems.

关键词： KHSRP Monocytic differentiation RNA-binding proteins Transcriptional regulation

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C包覆Ni磁性载体负载Pt催化硝基苯加氢性能

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金属学报 2024年第8期60卷 1141-1149页

作者：武逸司阳黄彦民刁江勇孟繁敬刘增刘洪阳中国科学院金属研究所沈阳材料科学国家研究中心沈阳110016 沧州大化股份有限公司河北省改性异氰酸酯技术创新中心沧州061000

苯胺是一种重要的基础化工原料,在医药、染料、橡胶等领域被广泛应用。以硝基苯为原料通过液相催化加氢制备苯胺是目前主要工业生产方法之一,然而,如何从液相加氢反应体系中将催化剂高效分离和回收仍然是该领域的一个重要挑战。本工作... 详细信息

苯胺是一种重要的基础化工原料,在医药、染料、橡胶等领域被广泛应用。以硝基苯为原料通过液相催化加氢制备苯胺是目前主要工业生产方法之一,然而,如何从液相加氢反应体系中将催化剂高效分离和回收仍然是该领域的一个重要挑战。本工作开发了一种具有磁可分的C包覆Ni磁性载体负载Pt金属催化剂,用于高效催化硝基苯加氢制苯胺。以乙二胺四乙酸和Ni(OH)_(2)为原料成功合成了N掺杂石墨烯包覆Ni纳米颗粒磁性载体(Ni@NG),采用沉积-沉淀法制备Ni@NG负载Pt金属催化剂(Pt/Ni@NG),通过Raman光谱、TEM、XRD和XPS对制备的Pt/Ni@NG催化剂进行结构表征。结果表明,这种Ni@NG载体具有典型的核壳结构(纳米Ni颗粒为核,石墨烯为壳层)。XPS结果表明Ni@NG载体表面N掺杂石墨烯壳含有3.64%N (原子分数)。当Pt负载量(质量分数)从0.1%增加到0.5%时,Pt在石墨烯壳层表面的分散状态经历了单原子、团簇、颗粒的转变过程。当Pt负载量为0.3%时,以Pt团簇形式分散为主的Pt/Ni@NG催化硝基苯加氢显示出最高的活性,在反应压力为1 MPa和反应温度为30℃时,硝基苯加氢的周转频率为27239.2 h^(-1),硝基苯在60 min内完全转化为苯胺。此外,由于Pt/Ni@NG催化剂具有优异的液相磁可分性能,催化剂经5 cyc使用后加氢活性未明显降低。

关键词：核壳结构硝基苯加氢磁可分载体 N掺杂C材料

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From illite/smectite clay to mesoporous silicate adsorbent for efficient removal of chlortetracycline from water

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Journal of Environmental Sciences 2017年第1期29卷 31-43页

作者： Wenbo Wang Guangyan Tian Li Zong yanmin Zhou Yuru Kang Qin Wang Aiqin Wang Center of Eco-materials and Green Chemistry Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000China University of the Chinese Academy of Sciences Beijing 100049China Key Laboratory of Clay Mineral Applied Research of Gansu Province Lanzhou 730000China College of Animal Science and Technology Nanjing Agricultural UniversityNanjing 210095China

A series of mesoporous silicate adsorbents with superior adsorption performance for hazardous chlortetracycline（CTC） were sucessfully prepared via a facile one-pot hydrothermal reaction using low-cost illite/smectite（IS） clay,sodium silicate and magnesium sulfate as the starting *** this process,IS clay was ＂teared up＂ and then ＂rebuilt＂ as new porous silicate adsorbent with high specific surface area of 363.52 m^2/g（about 8.7 folds higher than that of IS clay） and very negative Zeta potential（- 34.5 mV）.The inert si- O- si（Mg,Al） bonds in crystal framework of IS were broken to form si（Al）- O^- groups with good adsorption activity,which greatly increased the adsorption sites served for holding much CTC *** evaluation on adsorption properties reveals the optimal silicate adsorbent can adsorb 408.81 mg/g of CTC（only 159.7 mg/g for raw IS clay） and remove 99.3%（only 46.5%for raw IS clay） of CTC from 100 mg/L initial solution（pH 3.51;adsorption temperature 30℃;adsorbent dosage,3 g/L）.The adsorption behaviors of CTC onto the adsorbent follows the Langmuir isotherm model,Temkin equation and pseudo second-order kinetic *** mesopore adsorption,electrostatic attraction and chemical association mainly contribute to the enhanced adsorption *** a whole,the high-efficient silicate adsorbent could be candidates to remove CTC from the wastewater with high amounts of CTC.

关键词： Illite/smectite clay Hybrid silicate adsorbent Chlortetracycline Removal

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Synthesis of(HfZrTiNbTa)N powders via nitride thermal reduction with soft mechano-chemical assistance

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Journal of Advanced Ceramics 2023年第3期12卷 565-577页

作者： Xiang Liu Youjun Lu Qian Xu Lutong Yang Hongfang Shen Wenzhou Sun Xiao Zhang yanmin Wang School of Materials Science&Engineering North Minzu UniversityYinchuan 750021China College of Materials Science&Engineering South China University of TechnologyGuangzhou 510641China

High-entropy nitride powders are one of prerequisite materials for the preparation of high-performance high-entropy nitride *** this paper,high-entropy(HfZrTiNbTa)N powders were synthesized via nitride(i.e.,silicon nitride(si_(3)N_(4)))thermal reduction with soft mechanochemical *** results show that metal oxides like hafnium dioxide(HfO_(2)),zirconium dioxide(ZrO_(2)),titanium dioxide(TiO_(2)),niobium pentoxide(Nb_(2)O_(5)),and tantalum pentoxide(Ta_(2)O_(5))can all be transformed into the corresponding metal nitrides in the presence of si_(3)N_(4)at 1700℃,and solid solution of the metal nitrides can be formed as the temperature increases to 2100℃.The high-entropy(HfZrTiNbTa)N powders with submicron-sized particles,a narrower size distribution,and a single face-centered cubic(fcc)structure are obtained from raw material mixtures ground for 10 h and subsequently sintered at 1800℃.In addition,the high-entropy bulk nitride ceramics with relative density(Rw)of 94.31%±0.76%,Vickers hardness of 21.00±0.94 GPa,and fracture toughness(KIC)of 3.18±0.16 MPa·m1/2 are obtained with submicron-sized powders,which are superior to those obtained with micron-sized powders.

关键词： soft mechanochemistry thermal reduction high-entropy nitride powders high-entropy nitrideceramics

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单细胞长链非编码RNA图谱绘制结合功能筛选揭示H19对于造血干细胞发育至关重要

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科学新闻 2020年第2期 63-63页

作者：刘兵余佳兰雨周杰徐嘉悦张琳琳刘思琪马艳妮 Xin Wen Junkai Hao Zongcheng Li Yanli Ni Xianlong Li Fan Zhou Qingqing Li Fang Wang Xiaoshuang Wang yanmin si Pengcheng Zhang Chen Liu Marisa Bartolomei Fuchou Tang 军事医学科学院附属医院(现为解放军总医院第五医学中心) 中国医学科学院基础医学研究所暨南大学医学部基础医学院

文章简介小鼠胚胎发育早期,第一个造血干细胞(Hematopoietic stem cell,HSC)出现于胚胎发育中期的主动脉—性腺—中肾(AGM)区。其起源于一群特化的血管内皮细胞,通过内皮-造血转化,历经pre-HSC阶段,最终成熟。既往关于HSC发育调控机制... 详细信息

文章简介小鼠胚胎发育早期,第一个造血干细胞(Hematopoietic stem cell,HSC)出现于胚胎发育中期的主动脉—性腺—中肾(AGM)区。其起源于一群特化的血管内皮细胞,通过内皮-造血转化,历经pre-HSC阶段,最终成熟。既往关于HSC发育调控机制的研究多集中在信号通路以及转录因子,然而非编码RNA在HSC发育中的动态表达全貌和生理功能仍一无所知。

关键词： HSC lncRNA H19 RNA 功能筛选细胞发育单细胞长链非编码

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含水率对土壤有机质含量高光谱估算的影响

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农业工程学报 2015年第9期31卷 114-120页

作者：司海青姚艳敏王德营刘影农业部农业信息技术重点实验室北京100081 中国农业科学院农业资源与农业区划研究所北京100081

土壤含水率对有机质（soil organic matter，SOM）含量高光谱估算精度有很大的影响。为了探讨SOM高光谱估算中土壤含水率的影响，该文对烘干土、风干土和质量含水率为5%～40%（按5%递增）的土壤样本进行了室内高光谱测量，对光谱数据进... 详细信息

土壤含水率对有机质（soil organic matter，SOM）含量高光谱估算精度有很大的影响。为了探讨SOM高光谱估算中土壤含水率的影响，该文对烘干土、风干土和质量含水率为5%～40%（按5%递增）的土壤样本进行了室内高光谱测量，对光谱数据进行了反射率、反射率一阶导数和反射率倒数对数3种光谱数据变换，运用偏最小二乘回归法（partial least squares regression，PLSR）建立了相应的SOM估算模型。结果表明，风干土的SOM高光谱估算精度较好；当含水率水平小于25%时，SOM估算模型精度受含水率的影响较大，光谱数据进行反射率倒数对数变换后的模型精度最高；当含水率水平大于等于25%时，水分对土壤光谱反射率的影响要大于SOM，不适宜利用土壤光谱数据进行SOM含量高光谱估算。该研究可为大田环境不同含水率情况下光谱估算SOM提供参考。

关键词：土壤土壤含水率回归有机质高光谱偏最小二乘

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不同含水量土壤高光谱二向性反射特征研究

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中国农业资源与区划 2017年第1期38卷 51-58页

作者：刘影姚艳敏司海青农业部农业信息技术重点实验室北京100081 中国农业科学院农业资源与农业区划研究所北京100081

【目的】探讨高光谱遥感土壤含水量对土壤二向性反射分布函数(bidirectional reflectance distribution function,BRDF)的影响,可为改进土壤含水量高光谱遥感反演机理模型,提高反演精度奠定重要基础。【方法】该研究在室内条件下对含水... 详细信息

【目的】探讨高光谱遥感土壤含水量对土壤二向性反射分布函数(bidirectional reflectance distribution function,BRDF)的影响,可为改进土壤含水量高光谱遥感反演机理模型,提高反演精度奠定重要基础。【方法】该研究在室内条件下对含水量为5%~45%(按5%递增)的土样进行多角度光谱测定,分析光源天顶角、观测天顶角、观测方位角及含水量不同对土壤二向性反射特征的影响。【结果与结论】由于土壤表面颗粒之间的相互遮蔽,土壤BRDF随光源天顶角的增加而增大,随观测天顶角的减小而降低,且土壤BRDF随观测天顶角的变化与波长有关。后向散射方向的土壤BRDF最高,前向散射方向的土壤BRDF最小。在400~1 400nm波段范围内,当土壤含水量小于田间持水量时,土壤BRDF值随含水量的增加而降低;大于田间持水量时,土壤BRDF值随含水量的增加而增加。但在波长1 400~2 400nm范围内,不同的观测位置下,土壤含水量不同引起土壤BRDF的变化没有明显规律。

关键词：高光谱 BRDF 多角度土壤含水量

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飞秒激光整形脉冲激发金膜的超快热弛豫特性

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中国激光 2014年第5期41卷 23-28页

作者：杨青杜广庆陈烽吴艳敏司金海侯洵西安交通大学电子信息工程学院机械制造系统工程国家重点实验室陕西省信息光子技术重点实验室陕西西安710049

在传统双温模型中引入傅里叶热扩散机制,提出了一种时间序列热弛豫模型。数值研究获得了飞秒激光整形脉冲与金膜作用的跨时间尺度(飞秒纳秒)热弛豫特性及温度场时空进化规律,并获得了双温弛豫周期与整形冲间隔的依赖关系。该研究对于澄... 详细信息

在传统双温模型中引入傅里叶热扩散机制,提出了一种时间序列热弛豫模型。数值研究获得了飞秒激光整形脉冲与金膜作用的跨时间尺度(飞秒纳秒)热弛豫特性及温度场时空进化规律,并获得了双温弛豫周期与整形冲间隔的依赖关系。该研究对于澄清飞秒激光与金属作用的超快热弛豫机制,调控飞秒激光微纳加工中的超快加热过程具有重要意义。

关键词：超快光学飞秒激光整形脉冲热弛豫双温模型

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Effect of Fabrication Process Parameters on Microstructure Evolution and Spectral Characteristics of silicon Carbide Quantum Dots

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Journal of the Chinese Ceramic Society 2014年第2期 93-98页

作者： SONG Yuepeng KANG Jie ZHU yanmin GAO Dongsheng GUO Jing KIM Hyoungseop Mechanical and Electronic Engineering College Shandong Agricultural University Shandong Province Key Laboratory of Horticultural Machineries and Equipments Shandong Agricultural University College of Horticulture Science and Engineering Shandong Agricultural University Department of Materials Science and Engineering Pohang University of Science and Technology

silicon carbide（siC） quantum dots（QDs） in aqueous suspension were produced via corrosion in a mixture of chemical etchants（i.e.,HNO;and HF）,ultrasonic dispersion and *** microstructural evolution of rawβ-siC particles during the etching process was *** porous structure of the β-siC raw particles obtained due to the hydrofluoric-acid-induced dissociation of si—O bonding and oxidation by nitric acid was *** hollow and grid-like structures formed in the corrosion process were broken due to the cavitation and crushing of ultrasonic treatment,forming *** homogeneous siC-QDs in aqueous suspension were obtained in a *** of preparation parameters on the spectral characteristics of the siC-QDs was *** results show that the maximum photo-luminescence（PL） intensity of the siC-QDs can be obtained at excitation wavelengths of 340 *** PL intensity and emission wavelength are affected by the volume ratio of the mixture of chemical etchants and the duration of ultrasonic ***,the color of the fluorescence is related to the size of the siC-QDs.

关键词： chemical etching silicon carbide quantum dots microstructure evolution etching components sonification

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