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Virologica Sinica 2015年第1期30卷 45-51页

作者： yanling huang Hang Yang Junping Yu Hongping Wei Key Laboratory of Special Pathogens and Biosafety Center for Emerging Infectious Diseases Wuhan Institute of Virology Chinese Academy of Sciences

The novel phage lysin PlySs2, is reported to be highly active against various bacteria, including staphylococci, streptococci and Listeria. However, the molecular mechanisms underlying its broad lytic spectrum remain to be established. In the present study, the lytic activity of the catalytic domain(CD, PlySc) and binding specificity of the cell wall binding domain(CBD, PlySb) of PlySs2 were examined. Our results showed that PlySc alone maintains very limited lytic activity. Enhanced green fluorescent protein(EGFP)-fused PlySb displayed high binding affinity to the streptococcal strains tested, including ***, ***, and ***, but not staphylococci, supporting its utility as a good CBD donor for streptococcal-targeted lysin engineering. EGFP-fused intact PlySs2 similarly displayed high affinity for streptococci, but not staphylococci. Notably, four truncated PlySb fragments showed no binding capacity. These findings collectively indicate that integrity of the PlySc and PlySb domains is an essential determinant of the broad lytic activity of PlySs2.

关键词： streptococci lysin cell wall binding domain catalytic domain bacterial resistance

Responses of growth performance,antioxidant function,small intestinal morphology and mRNA expression of jejunal tight junction protein to dietary iron in yellow-feathered broilers

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Journal of Integrative Agriculture 2024年第4期23卷 1329-1337页

作者： Kaiwen Lei Hao Wu Jerry W Spears Xi Lin Xi Wang Xue Bai yanling huang Key Laboratory of Animal Science of State Ethnic Affairs Commission Southwest Minzu UniversityChengdu 610041China Key Laboratory of Qinghai-Tibetan Plateau Animal Genetic Resource Reservation and Utilization Southwest Minzu UniversityChengdu 610041China Department of Animal Science North Carolina State UniversityRaleighNC 27695-7621USA

This study aimed to investigate the dose-effect of iron on growth performance,antioxidant *** morphology,and mRNA expression of jejunal tight junction protein in 1-to21-d-old yellow-feathered broilers.A total of 7201-d-old yellow-feathered maleb roilers were allocated to 9 treatments with 8 replicate cages of 10 birds per *** dietary treatments were consisted of a basal diet(contained 79.6 mg Fe kg^(-1))supplemented with 0,20,40,60,80,160,320,640,and 1,280 mg Fe kg^(-1)in the form of FeSO_(4)·7H_(2)*** with the birds in the control group,birds supplemented with 20mg Fe kg^(-1)had higher average daily gain(ADG)(P<0.0001).Adding 640 and 1,280 mg Fe kg^(-1)significantly decreased ADG(P<0.0001)and average daily feed intake(ADFI)(P<0.0001)compared with supplementation of 20mg Fe kg^(-1).Malondialdehyde(MDA)concentration in plasma and duodenum increased linearly(P<0.0001),but MDA concentration in liver and jejunum increased linearly(P<0.05)or quadratically(P<0.05)with increased dietary Fe *** villus height(VH)in duodenum and jejunum,and the ratio of villus height to crypt depth(V/C)in duodenum decreased linearly(P?0.05)as dietary *** dietary Fe increased,the jejunal relative mRNA abundance of claudin-1 decreased linearly(P=0.001),but the jejunal relative mRNA abundance of zona occludens-1(ZO-1)and occludin decreased linearly(P?0.05)or quadratically(P?0.05).Compared with the supplementation of 20 mg Fe kg^(-1),the supplementation of640 mg Fe kg^(-1)or higher increased(P?0.05)MDA concentrations in plasma,duodenum,and jejunum,decreased VH in the duodenum and jejunum,and the addition of 1,280 mg Fe kg^(-1)reduced(P?0.05)the jejunal tight junction protein(claudin-1,ZO-1,occludin)mRNA *** summary,640 mg of supplemental Fe kg^(-1)or greater was associated with decreased growth performance,increased oxidative stress,disrupted intestinal morphology,and reduced mRNA expression of jejunal tight junction protein.

关键词： iron yellow-feathered broiler antioxidant function intestinal morphology tight junction protein

Facile hydrothermal and sol-gel synthesis of novel Sn-Co/C composite as superior anodes for Li-ion batteries

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Chinese Science Bulletin 2014年第23期59卷 2875-2881页

作者： Xiaoli Zou Xianhua Hou Zhibo Cheng yanling huang Min Yue Shejun Hu Laboratory of Quantum Engineering and Quantum Materials School of Physics and Telecommunication EngineeringSouth China Normal University Engineering Research Center of Materials and Technology for Electrochemical Energy Storage (Ministry of Education) BTR New Energy Materials Co.LTD

As an anode material in lithium ion battery,the Sn-Co/C composite electrode materials have been successfully synthesized by hydrothermal and sol-gel methods,*** resultant composites were mainly composed of Sn-based oxides,nanometer Sn-Co alloy and *** and Co,acting as buffer materials,can accommodate to the large volume change of active Sn during the discharge-charge process,thus improving the cycling *** charge/discharge curves revealed the excellent cycle performance for samples synthesized by both methods,composites obtained by the sol-gel showed a better dispersion effect of nanoparticles on the carbon matrix and possessed much more improved stable capacity with*624.9 mAh g-1over 100 cycles and that by hydrothermal method only exhibited*299.3 mAh ***,the Sn-Co/C composites obtained by sol-gel synthesis method could be a perfect candidate for anode material of Li-ion storage battery.

关键词：复合材料锂离子电池合成样品阳极材料凝胶法水热法溶胶循环稳定性

Reactivation of PPARαalleviates myocardial lipid accumulation and cardiac dysfunction by improving fatty acidβ-oxidation in Dsg2-deficient arrhythmogenic cardiomyopathy

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Acta Pharmaceutica Sinica B 2023年第1期13卷 192-203页

作者： Yubi Lin Ruonan Liu yanling huang Zhe Yang Jianzhong Xian Jingmin huang Zirui Qiu Xiufang Lin Mengzhen Zhang Hui Chen Huadong Wang Jiana huang Geyang Xu Department of Physiology School of MedicineJinan UniversityGuangzhou 510632China The First Dongguan Affiliated Hospital Guangdong Medical University Dongguan 523710China The Cardiovascular Center Department of CardiologyInterventional Medical CenterGuangdong Provincial Key Laboratory of Biomedical Imaging and Guangdong Provincial Engineering Research Center of Molecular Imagingthe Fifth Affiliated HospitalSun Yat-sen UniversityZhuhai 519000China Guangdong Provincial Cardiovascular Institute Guangdong Provincial People's HospitalGuangzhou 510080China Biotherapy Center Cell-gene Therapy Translational Medicine Research Centerthe Third Affiliated HospitalSun Yat-sen UniversityGuangzhou 510630China Department of Pathophysiology School of MedicineJinan UniversityGuangzhou 510632China Reproductive Medicine Center the Six Affiliated HospitalSun Yat-sen UniversityGuangzhou 51000China

Arrhythmogenic cardiomyopathy(ACM),a fatal heart disease characterized by fibroadipocytic replacement of cardiac myocytes,accounts for 20%of sudden cardiac death and lacks effective *** is often caused by mutations in desmosome proteins,with Desmoglein-2(DSG2)mutations as a common ***,the mechanism underlying the accumulation of fibrofatty in ACM remains unknown,which impedes the development of curative *** we investigated the fat accumulation and the underlying mechanism in a mouse model of ACM induced by cardiac-specific knockout of Dsg2(CS-Dsg2^(-/-)).Heart failure and cardiac lipid accumulation were observed in CSDsg2^(-/-)*** demonstrated that these phenotypes were caused by decline of fatty acid(FA)β-oxidation resulted from impaired mammalian target of rapamycin(m TOR)*** worsened while overexpression of m TOR and 4EBP1 rescued the FAβ-oxidation pathway in CS-Dsg2^(-/-)*** of PPARa by fenofibrate or AAV9-Ppara significantly alleviated the lipid accumulation and restored cardiac *** results suggest that impaired m TOR-4EBP1-PPARa-dependent FAβ-oxidation contributes to myocardial lipid accumulation in ACM and PPARa may be a potential target for curative treatment of ACM.

关键词： Arrhythmogenic cardiomyopathy Desmosome Desmoglein2 Heart failure Lipid accumulation mTOR PPARa FA oxidation

Key Points of Supervision of Third-Party Payment Business:A Comparative Analysis of China's Mainland and Macao

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Proceedings of Business and Economic Studies 2022年第3期5卷 1-8页

作者： yanling huang Guangzhou Xinhua University Dongguan 523133Guangdong ProvinceChina

China's Mainland has witnessed remarkable achievements in payment innovations based on internet and financial technologies in recent years,whereas Macao has made little progress in financial technologies,especially in payment *** on the concept and types of third-party payment business in China's Mainland and Macao,as well as to investigate the causes for Macao’s lack of innovation in third-party payment,this study compares their differences from two aspects:business licensing authorities and key points of *** comparison,although the classification and methods of third-party payment businesses are different between China's Mainland and Macao,they are all managed and licensed by a unified supervision ***,the key points of supervision in both places are similar,but unlike China's Mainland,which takes financial risk prevention as the principle and financial technology as the means to encourage innovation,Macao showed obvious *** order to further deepen the connection between the financial markets of China's Mainland and Macao as well as boost financial technologies in Macao,this study aims to provide some suggestions and references for the development of cross-border payment systems.

关键词： Third-party payment Authority Key points of supervision Comparative analysis

Advances in Pharmacological Effects of Stevioside

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Journal of Clinical and Nursing Research 2024年第6期8卷 100-104页

作者： Shiqin Fu yanling huang Yiting Xie Jing Zhang Jiangxi University of Chinese Medicine Nanchang 330004Jiangxi ProvinceChina

Stevioside is a low-calorie high-power sweetener with a variety of positive pharmacological *** the growing attention to health,stevia leaf has garnered widespread interest at home and *** article reviews the main pharmacological effects of stevioside and their mechanisms,in order to provide references for the research on the edible and medicinal value of stevioside.

关键词： Stevioside Pharmacological effect Safety

坡面不同截-排水沟布置方式下土壤微团聚体流失特征

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农业工程学报 2017年第13期33卷 151-158页

作者：何丙辉梁艳玲黄欢西南大学资源环境学院/三峡库区生态环境教育部重点实验室重庆400715 国家知识产权局专利局专利审查协作四川中心成都610000

传统坡面水系工程主要在节约工程量的考量下,把截水沟布置成平行于等高线的形式,但为了符合坡面自然排水状况,该研究中考虑用汇流和分流的方式来探究从理论上改变坡面沟道的基本形状是否具有可行性。该研究设计按比例缩小的坡-沟模型,... 详细信息

传统坡面水系工程主要在节约工程量的考量下,把截水沟布置成平行于等高线的形式,但为了符合坡面自然排水状况,该研究中考虑用汇流和分流的方式来探究从理论上改变坡面沟道的基本形状是否具有可行性。该研究设计按比例缩小的坡-沟模型,以无措施坡面为对照,用人工模拟降雨的方法探究在不同坡度、地类坡面上布置汇流型和分流型截排水沟道后,坡面土壤微团聚体的流失变化规律。结果表明:在各个地类和坡度中,布置汇流和分流截排水措施后均出现较小颗粒微团聚体(<5μm)在侵蚀泥沙中富集的现象;在坡耕地中,布设截排水措施能显著稳定土壤小粒径微团聚体(<5μm)比例的稳定性,但分流截排水措施的效果更加明显,但在5°和10°时,汇流截排水措施能更好减缓坡面土壤粗化(250~1 000μm)趋势;汇流措施能减少林地侵蚀泥沙中微团聚体富集的波动性并控制林地坡面较小粒径微团聚体流失(<5μm)的程度,但在荒草地中,总体来看,汇流措施对控制坡面微团聚体流失具有更强的作用。汇流型和分流型截排水措施对不同地类坡面微团聚体的控制保护各有侧重,在布设坡面沟道时,根据坡面、土壤实际情况和土壤保护要求来选择坡面截排水措施是极有必要的。该研究为进一步研究坡面自然排水方式在现实中运用可能性和可行性提供部分基础资料。

关键词：土壤径流侵蚀模拟降雨土地利用微团聚体

自蔓延高温合成钴基Stellite 6合金和铸造HS111合金微观组织(英文)

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稀有金属材料与工程 2009年第8期38卷 1333-1337页

作者：徐仰涛夏天东黄艳灵兰州理工大学甘肃省有色金属新材料省部共建国家重点实验室甘肃兰州730050

运用SEM、XRD和EPMA等分析方法对自蔓延高温合成钴基Stellite 6合金与连续铸造态钴基合金HS111的微观组织进行比较研究。结果表明,运用自蔓延高温合成方法制备的钴基Stellite 6合金与连续铸造态的钴基合金HS111的微观组织结构相似,但连... 详细信息

运用SEM、XRD和EPMA等分析方法对自蔓延高温合成钴基Stellite 6合金与连续铸造态钴基合金HS111的微观组织进行比较研究。结果表明,运用自蔓延高温合成方法制备的钴基Stellite 6合金与连续铸造态的钴基合金HS111的微观组织结构相似,但连铸HS111中的碳化物种类比较单一且均匀。

关键词：自蔓延高温合成钴基Stellite 6合金微观组织

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肉仔鸡锌营养需要量的研究进展

中国饲料 2008年第11期 28-30页

作者：黄艳玲西南民族大学生命科学与技术学院

本文综述了肉仔鸡锌(Zn)营养需要量的主要研究方法、研究结果、影响因素和存在问题。

关键词：锌需要量肉仔鸡

掺化学外加剂水泥净浆的含气量稳定性与流变性能的关系(英文)

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硅酸盐学报 2019年第11期47卷 1593-1604页

作者：黄海元强邓德华彭建伟黄艳玲中南大学土木工程学院高速铁路建设国家工程实验室长沙410075 中铁四局安徽中铁工程材料科技有限公司合肥230023

混凝土中的含气量是影响其新拌与硬化性能的关键因素之一。然而一些混凝土,特别是自密实混凝土(SCC),通常具有较高的含气量,含气量稳定性对混凝土的抗冻性能和混凝土表面外观有重要影响。通过测定水泥净浆中含气量随时间的演化规律,研... 详细信息

混凝土中的含气量是影响其新拌与硬化性能的关键因素之一。然而一些混凝土,特别是自密实混凝土(SCC),通常具有较高的含气量,含气量稳定性对混凝土的抗冻性能和混凝土表面外观有重要影响。通过测定水泥净浆中含气量随时间的演化规律,研究水泥浆中含气量的稳定性。相应地,测试了水泥浆体流变性能的变化规律;研究了超塑化剂、消泡剂、无机和有机增粘剂(VEA)等外加剂对水泥净浆含气量稳定性和流变性能的影响。结果表明:含气量、气泡的大小及其表面特性共同影响着水泥浆体的含气量稳定性;3×10^–4聚氧亚烷基醚型消泡剂与2×10^–4羟丙基甲基纤维素的复掺可达到最高的含气量稳定性和最低的含气量。

关键词：含气量稳定性消泡剂增稠剂水泥