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Digital pathology-based artificial intelligence models for differential diagnosis and prognosis of sporadic odontogenic keratocysts

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International Journal of Oral Science 2024年第2期16卷 349-358页

作者： Xinjia Cai Heyu Zhang yanjin wang Jianyun Zhang Tiejun Li Department of Oral Pathology Peking University School and Hospital of Stomatology&National Center of Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Research Center of Oral Biomaterials and Digital Medical DevicesBeijingChina Central Laboratory Peking University School and Hospital of StomatologyBeijingChina Department of Oral Pathology Shanghai Stomatological Hospital&School of StomatologyFudan UniversityShanghaiChina Research Unit of Precision Pathologic Diagnosis in Tumors of the Oral and Maxillofacial Regions Chinese Academy of Medical Sciences(2019RU034)BeijingChina

Odontogenic keratocyst(OKC)is a common jaw cyst with a high recurrence *** combined with basal cell carcinoma as well as skeletal and other developmental abnormalities is thought to be associated with Gorlin ***,OKC needs to be differentiated from orthokeratinized odontogenic cyst and other jaw *** of the different prognosis,differential diagnosis of several cysts can contribute to clinical *** collected 519 cases,comprising a total of 2157 hematoxylin and eosinstained images,to develop digital pathology-based artificial intelligence(AI)models for the diagnosis and prognosis of *** Inception_v3 neural network was utilized to train and test models developed from patch-level ***,whole slide imagelevel AI models were developed by integrating deep learning-generated pathology features with several machine learning *** AI models showed great performance in the diagnosis(AUC=0.935,95%CI:0.898–0.973)and prognosis(AUC=0.840,95%CI:0.751–0.930)of *** advantages of multiple slides model for integrating of histopathological information are demonstrated through a comparison with the single slide ***,the study investigates the correlation between AI features generated by deep learning and pathological findings,highlighting the interpretative potential of AI models in the ***,we have developed the robust diagnostic and prognostic models for *** AI model that is based on digital pathology shows promise potential for applications in odontogenic diseases of the jaw.

关键词： diagnosis pathology prognosis

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Comparison of the capacity of biological desulfurization of Thiobacillus ferrooxidans from different sulfur-containing substrates with or without additional ferrous iron

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International Journal of Agricultural and Biological Engineering 2024年第3期17卷 140-143页

作者： yanjin wang Xiaopeng Chang Hongge Tao Zhenfeng wang Quanguo Zhang College of Environment Economics Henan Finance UniversityZhengzhou 450046China College of Mechanical and Electrical Engineering Henan Agricultural UniversityZhengzhou 450002China

Thiobacillus ferrooxidans,abbreviated as *** is one of the important microorganisms in the field of biological *** of ferrous iron and sulfur-containing substrates on biological desulfurization of *** were *** show that in the absence of Fe^(2+),*** can utilize three kinds of sulfur-containing substrates of Na_(2)S_(2)O_(3),elemental S and Na_(2)SO_(3) for growth and *** utilization complexity,Na_(2)S_(2)O_(3) was easiest to use,next was elemental S,and Na_(2)SO_(3) was the worst for *** the utilization of ferrous iron and sulfur-containing substrates by ***,the iron oxidation system was first *** the decrease of the Fe^(2+)concentration,the sulfur oxidation system was started,and then the two systems synergistically *** presence of three sulfur-containing substrates had different effects on Fe^(2+)oxidation,and elemental S did not inhibit the oxidation of Fe^(2+),while Na_(2)S_(2)O_(3) and Na_(2)SO_(3) had some inhibition on the oxidation of Fe^(2+),especially the inhibition of Na_(2)SO_(3) was significant,and complete oxidation of ferrous iron needed more *** isolated *** is applied to the removal of H2S gas,aiming to provide a new technological approach for biological removal of H2S.

关键词： Thiobacillus ferrooxidans ferrous iron sulfur-containing substrate biological desulfurization

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MiR-4465-modified mesenchymal stem cell-derived small extracellular vesicles inhibit liver fibrosis development via targeting LOXL2 expression

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第7期25卷 594-604页

作者： yanjin wang Yifei CHEN Fuji YANG Xiaolong YU Ying CHU Jing ZHOU Yongmin YAN Jianbo XI Department of Laboratory Medicine Wujin Hospital Affiliated with Jiangsu UniversityJiangsu UniversityChangzhou 213017China Department of Laboratory Medicine School of MedicineJiangsu UniversityZhenjiang 212013China Changzhou Key Laboratory of Molecular Diagnostics and Precision Cancer Medicine Wujin Clinical College of Xuzhou Medical UniversityChangzhou 213017China

Liver fibrosis is a significant health burden,marked by the consistent deposition of ***,the currently available treatment approaches for this condition are far from *** oxidase-like protein 2(LOXL2)secreted by hepatic stellate cells(HSCs)is a crucial player in the cross-linking of matrix collagen and is a significant target for treating liver *** stem cell-derived small extracellular vesicles(MSC-sEVs)have been proposed as a potential treatment option for chronic liver *** studies have found that MSC-sEV can be used for microRNA delivery into target cells or *** is currently unclear whether microRNA-4465(miR-4465)can target LOXL2 and inhibit HSC ***,it is uncertain whether MSC-sEV can be utilized as a gene therapy vector to carry miR-4465 and effectively inhibit the progression of liver *** study explored the effect of miR-4465-modified MSC-sEV(MSC-sEVmiR-4465)on LOXL2 expression and liver fibrosis *** results showed that miR-4465 can bind specifically to the promoter of the LOXL2 gene in ***,MSC-sEVmiR-4465 inhibited HSC activation and collagen expression by downregulating LOXL2 expression in ***-sEVmiR-4465 injection could reduce HSC activation and collagen deposition in the CCl4-induced mouse ***-sEVmiR-4465 mediating via LOXL2 also hindered the migration and invasion of HepG2 *** conclusion,we found that MSC-sEV can deliver miR-4465 into HSC to alleviate liver fibrosis via altering LOXL2,which might provide a promising therapeutic strategy for liver diseases.

关键词： Mesenchymal stem cell(MSC) Small extracellular vesicle(sEV) MicroRNA-4465(miR-4465) Hepatic stellate cell(HSC) Liver fibrosis

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孔洞增长层裂模型的改进及其在模拟不同加载波形层裂实验结果方面的应用

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爆炸与冲击 2024年第5期44卷 48-53页

作者：张凤国王裴王言金胡建波北京应用物理与计算数学研究所北京100094 中国工程物理研究院流体物理研究所冲击波物理与爆轰物理全国重点实验室四川绵阳621999

冲击波在靶板自由面反射导致靶板材料内部产生动态拉伸层裂损伤是材料的典型损伤破坏形式之一,材料的初始微结构、冲击加载的强度和应变率、温度等因素直接影响材料内部的损伤演化过程。靶板自由面速度曲线变化间接反映材料内部损伤的... 详细信息

冲击波在靶板自由面反射导致靶板材料内部产生动态拉伸层裂损伤是材料的典型损伤破坏形式之一,材料的初始微结构、冲击加载的强度和应变率、温度等因素直接影响材料内部的损伤演化过程。靶板自由面速度曲线变化间接反映材料内部损伤的演化过程,在层裂损伤物理模型研究方面,目前采用适宜的层裂损伤模型较好地模拟不同冲击加载波形下靶板自由面速度曲线的相关文献很少,主要借助实验手段探讨加载波形与自由面速度曲线变化以及层裂损伤演化过程之间的关联。对于孔洞增长层裂损伤模型,通过解析加载应变率与层裂强度以及损伤模型初始损伤参数之间的相互关系,给出了模型初始损伤参数的计算方法,有效地将损伤模型初始损伤参数与加载应变率关联在一起。该计算方法不仅可以较好地模拟方波、三角波以及泰勒波冲击加载铝材料层裂实验的自由面速度曲线,同时,计算得到的层裂强度和层裂片厚度也与实验结果符合。此外,还进一步分析了靶板内部不同位置的初始损伤、层裂强度的分布与应变率之间的关联,以及其对自由面速度曲线的影响。

关键词：冲击加载波形层裂损伤自由面速度数值分析

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SOX2/DRD2 signaling pathway facilitates astrocytic dedifferentiation in cerebral ischemic mice

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神经解剖学杂志 2024年第3期40卷 277-286页

作者： YI Xuyang KANG Enming wang yanjin ZHANG Kun LIN Wei WU Shengxi wang Yazhou Department of Neurobiology School of Basic Medicine2.Fifth BrigadeSchool of Basic Medicine3.Department of NeurosurgeryXijing HospitalAir Force Medical UniversityXi’an 710032China

Objective:To explore the effects of dopamine receptor D2(DRD2)on astrocytic dedifferentiation based on SOX2-regulated genes in neural stem cells(NSCs)and ***:Immunofluorescence staining and SOX2-GFP mice were used to examine the lineage differentiation of SOX2-positive cells during the development of cerebral *** NSCs/astrocytes culture,ChIP-seq and Western Blot were adopted to analyze and verify the expression of candidate *** manipulation,neurosphere formation,photochemical ischemia,immunofluorescence staining and behavior tests were adopted to evaluate the effects of activating DRD2 signaling on astrocytic ***:Immunofluorescence staining demonstrated the NSC-astrocyte switch of SOX2-expression in the normal development of cerebral ***-seq revealed enrichment of DRD2 signaling by SOX2-bound enhancers in NSCs and SOX2-bound promoters in *** Blot and immunofluorescence staining verified the expression of DRD2 in NSCs and reactive *** of quinagolide hydrocholoride(QH),an agonist of DRD2,significantly promoted astrocytic dedifferentiation both in vitro and in vivo following *** addition,quinagolide hydrocholoride treatment improved locomotion ***:Activating DRD2 signaling facilitates astrocytic dedifferentiation and may be used to treat ischemic stroke.

关键词： cerebral ischemia astrocyte dedifferentiation SOX2 dopamine D2 receptor(DRD2) mouse

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前路手术治疗下颈椎骨折脱位伴关节交锁的研究进展

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中华创伤杂志 2024年第5期40卷 467-474页

作者：王寅王彦金周英杰杨磊河南省洛阳正骨医院(河南省骨科医院)脊柱外科洛阳471002 河南中医药大学研究生院郑州450046

下颈椎骨折脱位伴关节交锁是由屈曲牵张及旋转暴力所造成的一种急性脊柱脊髓损伤,导致患者不同程度的四肢瘫痪和大小便障碍,具有较高的致残率,多需手术治疗。下颈椎骨折脱位伴关节交锁的手术治疗方案包括前路手术、后路手术及联合入路手... 详细信息

下颈椎骨折脱位伴关节交锁是由屈曲牵张及旋转暴力所造成的一种急性脊柱脊髓损伤,导致患者不同程度的四肢瘫痪和大小便障碍,具有较高的致残率,多需手术治疗。下颈椎骨折脱位伴关节交锁的手术治疗方案包括前路手术、后路手术及联合入路手术,但最佳治疗方案尚无定论。前路手术具有入路简单、创伤小、并发症少及矢状位平衡保持好等优点,目前是治疗下颈椎骨折脱位伴关节交锁的首选方案。然而,前路的手术复位及固定方法众多,学者们对前路手术复位及固定方案的选择尚存在争议。对此,笔者对前路手术治疗下颈椎骨折脱位伴关节交锁的研究进展进行综述,旨在为其临床治疗提供参考依据。

关键词：颈椎脊柱骨折脱位椎关节突关节外科手术

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旋转椎弓法显露椎管并回植在椎管内良性肿瘤切除术中的应用

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中华骨科杂志 2024年第10期44卷 669-675页

作者：周英杰王彦金禚汉杰柴旭斌徐铖菡郝宇鹏河南省洛阳正骨医院(河南省骨科医院)脊柱外科洛阳471002

目的探讨旋转椎弓法显露椎管并回植在椎管内良性肿瘤切除术中的有效性和安全性。方法回顾性分析2017年4月至2022年10月于河南省洛阳正骨医院接受旋转椎弓法显露椎管并回植联合肿瘤切除的胸腰椎椎管内良性肿瘤患者17例,男9例、女8例,年龄... 详细信息

目的探讨旋转椎弓法显露椎管并回植在椎管内良性肿瘤切除术中的有效性和安全性。方法回顾性分析2017年4月至2022年10月于河南省洛阳正骨医院接受旋转椎弓法显露椎管并回植联合肿瘤切除的胸腰椎椎管内良性肿瘤患者17例,男9例、女8例,年龄(58.59±13.57)岁(范围29~75岁)。胸椎椎管内肿瘤7例、胸腰段椎管内肿瘤2例、腰椎椎管内肿瘤8例;手术节段为单节段6例、双节段8例、三节段3例。病程(20.35±16.58)个月(范围3~60个月)。组织病理学:神经鞘瘤9例、脊膜瘤5例、畸胎瘤2例、皮样囊肿1例。记录手术时间、术中出血量,观察术后椎管容积、内固定稳定性及椎板愈合情况。比较手术前后Cobb角、美国脊柱损伤协会(American spinal injury association,ASIA)分级和Oswestry功能障碍指数(Oswestry disability index,ODI)的改善情况。结果17例患者均顺利完成手术并获得随访,随访时间为(10.5±2.4)个月(范围6~20个月)。手术时间(156.76±26.81)min(范围120~210 min),术中出血量(338.24±97.68)ml(范围200~600 ml)。术中无一例出现神经及血管损伤,1例因用力过度造成棘突不完全骨折,未特殊处理,术后随访愈合良好。术后引流量(147.06±31.58)ml(范围100~210 ml)。患者术前局部Cobb角为14.15°±6.58°,术后为14.73°±6.34°,差异无统计学意义(t=1.810,P=0.089)。患者术前ODI为63.65%±6.57%,末次随访降低至23.88%±4.21%,差异有统计学意义(t=53.359,P<0.001)。17例患者术前ASIA分级B级2例、C级9例、D级6例,末次随访时ASIA分级B级1例、C级4例、D级8例、E级4例,较术前明显改善,差异有统计学意义(Z=2.587,P=0.010)。所有患者切口均Ⅰ期愈合,无一例发生脑脊液漏、硬膜外血肿等并发症。术后6个月脊柱三维CT示无一例发生椎板移位、内固定松动、感染及断裂。结论旋转椎弓法显露椎管并回植联合肿瘤切除治疗椎管内良性肿瘤术后神经功能恢复良好,并发症发生率低,是治疗椎管内良性肿瘤安全、有效的手术方式。

关键词：椎管肿瘤椎板成形术

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Propagation of Density-Oscillations in Solutions to the Compressible Navier-Stokes-Poisson System

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Chinese Annals of Mathematics,Series B 2008年第5期29卷 501-520页

作者： Zhong TAN yanjin wang Department of Mathematics Xiamen University Xiamen 361005 Fujian China Department of Mathematics Xiamen UniversityXiamen 3610051 Fujian China

Concerning a bounded sequence of finite energy weak solutions to the compressible Navier-Stokes-Poisson system (denoted by CNSP), which converges up to extraction of a subsequence, the limit system may not be the same system. By introducing Young measures as in [6, 15], the authors deduce the system (HCNSP) which the limit functions must satisfy. Then they solve this system in a subclass where Young measures are convex combinations of Dirac measures, to give the information on the propagation of density-oscillations. The results for strong solutions to (CNSP) (see Corollary 6.1) are also obtained.

关键词： Compressible fluids Navier-Stokes-Poisson equations Young measures Propagation of oscillations Strong solutions

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Two-Stage Online Debiased Lasso Estimation and Inference for High-Dimensional Quantile Regression with Streaming Data

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Journal of Systems Science & Complexity 2024年第3期37卷 1251-1270页

作者： PENG yanjin wang Lei School of Statistics and Data Science KLMDASRLEBPS and LPMCNankai UniversityTianjin 300071China

In this paper,the authors propose a two-stage online debiased lasso estimation and statistical inference method for high-dimensional quantile regression(QR)models in the presence of streaming *** the first stage,the authors modify the QR score function based on kernel smoothing and obtain the online lasso smoothed QR estimator through iterative *** estimation process only involves the current data batch and specific historical summary statistics,which perfectly accommodates to the special structure of streaming *** the second stage,an online debiasing procedure is carried out to eliminate biases caused by the lasso penalty as well as the accumulative approximation error so that the asymptotic normality of the resulting estimator can be *** authors conduct extensive numerical experiments to evaluate the performance of the proposed *** experiments demonstrate the effectiveness of the proposed method and support the theoretical *** application to the Beijing PM2.5 Dataset is also presented.

关键词： Adaptive tuning asymptotic normality debiased lasso online updating quantile regres-sion

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直升机共形天线复合材料蜂窝夹层结构成型技术研究

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现代制造技术与装备 2024年第5期60卷 74-76页

作者：汪艳金邱胜唐义号航空工业直升机设计研究所景德镇333001

一方面分析共形天线蜂窝夹层结构的特点和成型难点,另一方面通过铺层优化、辐射体表面处理、蜂窝预固化和共固化工艺参数调整等措施,提升共形天线的质量。产品试制表明,在成型U形结构共形天线时,先对蜂窝进行预成型,再将蜂窝、辐射体和... 详细信息

一方面分析共形天线蜂窝夹层结构的特点和成型难点,另一方面通过铺层优化、辐射体表面处理、蜂窝预固化和共固化工艺参数调整等措施,提升共形天线的质量。产品试制表明,在成型U形结构共形天线时,先对蜂窝进行预成型,再将蜂窝、辐射体和蒙皮进行共固化,能够得到质量良好的共形天线,而且蒙皮、蜂窝和辐射体之间不易脱黏。同时,在共固化过程中设置合理的温度参数,能够有效降低产品的变形量,保证其外观质量。

关键词：共形天线蜂窝夹层辐射体预固化变形控制

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