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Mechano-active biomaterials for tissue repair and regeneration

Journal of Materials Science & Technology 2020年第24期59卷 227-233页

作者： Xiao Lin yanjie bai Huan Zhou Lei Yang Orthopaedic Institute and Department of Orthopaedics The First Affiliated HospitalSoochow UniversitySuzhou 215006China School of Public Health Soochow UniversitySuzhou 215123China Center for Health Science and Engineering(CHSE) School of Materials Science and EngineeringTianjin Key Laboratory of Materials Laminating Fabrication and Interface Control TechnologyHebei University of TechnologyTianjin 300401China

There is a lack of effective tissue repair and regeneration strategies in current clinical *** studies have suggested that smart or responsive biomaterials possessing the ability to respond to endogenous stimuli in vivo may positively mediate the tissue micro-environment towards a tissue repair or *** stimuli,which constantly exist in a wide range of biological systems and are involved in almost all the physiological processes,belong to such stimuli to which responsive biomaterials can *** recent studies,a new type of smart biomaterials,which can dynamically adapt to the mechanical stimuli in vivo and thus has specific functionality consistently mediated by such mechanical stimuli,has *** contrast to common biomaterials that passively react to the mechanical environment of an implantation site,such mechano-active biomaterials have enabled various active or automatic strategies for tissue repair or regeneration,such as providing precise spatial-temporal controls on delivery of drugs or cells in the organs of the musculoskeletal and the circulatory systems;in situ reconstructing the original or a favorable mechanical environment at a lesion site;and accelerating the tissue remodeling or healing process via a mechanobiological *** article elucidates a perspective of perfecting tissue repair or regeneration using mechano-active biomaterials,especially highlighting the rationale behind the concept of mechano-active biomaterials and their potential in the repair or regeneration of musculoskeletal and cardiovascular *** outstanding challenges and unknowns,the emergence of mechano-active biomaterials has become a new avenue for tissue engineering and regenerative medicine.

关键词： Mechano-active Smart biomaterials Tissue engineering and regeneration Mechanobiology Gel-point adhesive hydrogel

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Effect of surgical factors on the augmentation of cementinjectable cannulated pedicle screw fixation by a novel calcium phosphate-based nanocomposite

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Frontiers of Medicine 2019年第5期13卷 590-601页

作者： Haolin Sun Chun Liu Shunlun Chen yanjie bai Huilin Yang Chunde Li Lei Yang Department of Orthopedics Peking University First Hospital Beijing 100034China Orthopedic Institute Department of OrthopedicsFirst Affiliated HospitalSoochow UniversitySuzhou 215006China School of Public Health Medical CollegeSoochow UniversitySuzhou 215100China International Research Center for Translational Orthopedics Suzhou 215006China School of Materials Science and Engineering Hebei University of TechnologyTianjin 300130China

Bone cement-augmented pedicle screw system demonstrates great efficacy in spinal disease treatments. However, the intrinsic drawbacks associated with clinically used polymethylmethacrylate (PMMA) cement demands for new bone cement formulations. On the basis of our previous studies, a novel injectable and biodegradable calcium phosphate-based nanocomposite (CPN) for the augmentation of pedicle screw fixation was systematically evaluated for its surgical feasibility and biomechanical performance by simulated and animal osteoporotic bone models, and the results were compared with those of clinical PMMA cement. ASTM-standard solid foam and open-cell foam models and decalcified sheep vertebra models were employed to evaluate the augmentation effects of CPN on bone tissue and on the cement-injected cannulated pedicle screws (CICPs) placed in osteoporotic bone. Surgical factors in CICPs application, such as injection force, tapping technique, screw diameter, and pedicle screw loosening scenarios, were studied in comparison with those in PMMA. When directly injected to the solid foam model, CPN revealed an identical augmentation effect to that of PMMA, as shown by the similar compressive strengths (0.73 ± 0.04 MPa for CPN group vs. 0.79 ± 0.02 MPa for PMMA group). The average injection force of CPN at approximately 40-50 N was higher than that of PMMA at approximately 20 N. Although both values are acceptable to surgeons, CPN revealed a more consistent injection force pattern than did PMMA. The dispersing and anti-pullout ability of CPN were not affected by the surgical factors of tapping technique and screw diameter. The axial pullout strength of CPN evaluated by the decalcified sheep vertebra model revealed a similar augmentation level as that of PMMA (1351.6 ± 324.2 N for CPN vs. 1459.7 ± 304.4 N for PMMA). The promising results of CPN clearly suggest its potential for replacing PMMA in CICPs augmentation application and the benefits of further study and development for

关键词： bone cement pedicle screw degenerative spinal diseases calcium phosphate injectable

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Starch-based adhesive hydrogel with gel-point viscoelastic behavior and its application in wound sealing and hemostasis

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Journal of Materials Science & Technology 2021年第4期63卷 228-235页

作者： Yuxuan Mao Peng Li Jiewei Yin yanjie bai Huan Zhou Xiao Lin Huilin Yang Lei Yang College of Chemistry Chemical Engineering and Materials ScienceOrthopaedic InstituteSoochow UniversitySuzhou215000China Department of Orthopaedics The First Affiliated HospitalSoochow UniversitySuzhou215000China School of Public Health Soochow UniversitySuzhou215000China Center for Health Science and Engineering(CHSE) School of Materials Science and EngineeringHebei University of TechnologyTianjin300000China School of Mechanical Engineering Jiangsu University of TechnologyChangzhou213000China

Hydrogels with tissue adhesiveness have demonstrated great promise for wearable electronics,artificial skin,soft robotics,and tissue ***,adhesive hydrogels that are capable of sealing and hemostasis of wound with severe hemorrhage still *** this purpose,a series of ionically crosslinked starch hydrogels were developed *** viscoelastic properties and tissue adhesiveness of the starch hydrogels were *** is shown that the starch and cross linkers had significant influence on the viscoelastic properties of the starch hydrogels,which further resulted in varied tissue *** the starch gels,there was one exhibiting a unique and stable"Gel Point"viscoelastic characteristic and it was named as gel-point adhesive hydrogel(GPAH).GPAH showed electrical conductivity,high tissue adhesiveness,high stretch-ability,self-healing capability,injectability,and *** GPAH also exhibited high cytocompatibility,low hemolysis risk,and strong antibacterial *** wound sealing and hemostatic performance of GPAH was further evaluated by a rat femoral artery injury *** blood loss after the sealing of GPAH(2.4±1.3 g)was significantly decreased compared to the group using gauze for sealing(6.3±1.5 g).Meanwhile,GPAH did not cause pathological changes of the soft tissues surrounding the *** above results indicate that GPAH,with high tissue adhesiveness,suitable viscoelastic property,strong antibacterial capacity,as well as electro-conductivity,bears great potential for the applications in smart wound management.

关键词： sealing viscoelastic hydrogel

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Research progress in rehabilitation treatment of stroke patients A bibliometric analysis

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Neural Regeneration Research 2013年第15期8卷 1423-1430页

作者： Xiaodong Feng Chengmei Liu Qingchuan Guo yanjie bai Yafeng Ren Binbin Ren Junmin bai Lidian Chen Rehabilitation Center the First Affiliated Hospital of Henan University of Traditional Chinese Medicine Fujian University of Traditional Chinese Medicine

BACKGROUND： Stroke presents as a transient or chronic brain dysfunction and is associated with high morbidity and high mortality. The doctors and scientists would like to argue how to enhance the validity of the rehabilitation treatment and how to further improve the level of treatment on stroke. OBJECTIVE： The aim of this study was to quantitatively analyze the current worldwide progress in research on stroke rehabilitation treatment based on Web of Science database and *** in the past 10 years. METHODS： We conducted a quantitative analysis of clinical trial articles regarding stroke rehabilitation published in English from 2003 to 2013 and indexed in the National Institutes of Health Clinical Trials registry and Web of Science databases. Data were downloaded on March 15, 2013. RESULTS：（1） From 2003 to 2013, 2 654 clinical trials investigating stroke were indexed in ***. There were only 58 clinical trials registered in 2003, and there was a marked increase from 2005. A total of 605 clinical trials on the rehabilitation of stroke were conducted in the past 10 years. （2） The analysis showed that most of the trials in the field were registered by North American institutions. With respect to the Asian countries, China and Taiwan Region of China also published a reasonable proportion of the trials, but comparatively speaking, the number of trials is really rare. Most of the interventions were drugs, followed by the devices, and behavioral interventions were ranked third. （3） In the past 10 years, there were 4 052 studies on stroke indexed by Web of Science database. CONCLUSION： From perspective of research progress, we found that the number of clinical trials and papers on stroke rehabilitation has increased significantly in the past 10 years, between them a remarkable positive correlation exists.

关键词： neural regeneration reviews stroke rehabilitation treatment Web of Science National Institutes ofHealth Clinical Trials registry database bibliometric analysis neuroregeneration

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针刺调节BDNF/TrkB信号通路改善中枢神经系统疾病的研究进展

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中山大学学报（医学科学版） 2024年第4期45卷 530-538页

作者：栗文静白艳杰河南中医药大学河南郑州450046 河南中医药大学第一附属医院河南郑州450000

BDNF/TrkB信号通路作为神经元生长、发育和突触可塑性的关键调节器,广泛参与中枢神经系统疾病的发生发展,如缺血性脑卒中、阿尔茨海默病、帕金森病和脊髓损伤等。研究表明针刺能调节BDNF/TrkB信号通路的活性,对以上疾病具有显著的治疗潜... 详细信息

BDNF/TrkB信号通路作为神经元生长、发育和突触可塑性的关键调节器,广泛参与中枢神经系统疾病的发生发展,如缺血性脑卒中、阿尔茨海默病、帕金森病和脊髓损伤等。研究表明针刺能调节BDNF/TrkB信号通路的活性,对以上疾病具有显著的治疗潜力,其作用机制与参与突触结构重塑,抑制神经细胞凋亡,促进神经发生和突触再生等有关。本文综述了BDNF/TrkB相关信号通路在中枢神经系统疾病中的作用以及针刺对该通路的调控机制,以期为临床治疗提供新思路。未来研究应深入探究针刺对BDNF/TrkB信号通路的精准调控,以开发更高效安全的治疗策略。

关键词：针刺 BDNF/TrkB信号通路中枢神经系统疾病缺血性脑卒中阿尔茨海默病帕金森病脊髓损伤作用机制

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型煤与原煤全应力–应变过程渗流特性对比研究

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岩石力学与工程学报 2010年第5期29卷 899-906页

作者：曹树刚李勇郭平白燕杰刘延保重庆大学西南资源开发及环境灾害控制工程教育部重点实验室重庆400044

利用自主研制的自压式三轴渗流装置对型煤和原煤试样进行三轴压缩渗流试验,得到不同围压下2种煤样的全应力–应变曲线,并利用流量计和环向引伸计自动采集整个试验过程中煤样的渗流速度和横向变形。从细观损伤力学的观点分析2种煤样不同... 详细信息

利用自主研制的自压式三轴渗流装置对型煤和原煤试样进行三轴压缩渗流试验,得到不同围压下2种煤样的全应力–应变曲线,并利用流量计和环向引伸计自动采集整个试验过程中煤样的渗流速度和横向变形。从细观损伤力学的观点分析2种煤样不同的破坏形式以及煤样的变形破坏对渗流速度的影响;讨论渗流速度对外部变量的敏感性和煤与瓦斯突出的突发性。研究结果表明,2种煤样的全应力–应变曲线都可以分为5个阶段,并与渗流速度–轴向应变曲线具有良好的对应关系。由于型煤与原煤的结构特性不同,致使2种煤样受力以后具有不同的损伤机制,渗流速度–轴向应变曲线差异较大,尤其在破坏阶段。型煤变形主要在前2个阶段影响煤的渗流特性,而原煤在整个试验过程中都受影响;型煤的渗流速度对轴向压力和轴向变形最敏感,而原煤的渗流速度对体积变形和横向变形比较敏感。原煤全应力–应变–渗流试验的5个阶段可以较好地解释煤与瓦斯突出过程的准备、发动、发展和终止4个阶段,可以间接地利用煤体瓦斯渗流速度变化进行煤与瓦斯突出预测预报。研究结果对探索煤层真实的瓦斯运移规律具有一定的参考价值。

关键词：采矿工程含瓦斯煤三轴试验全应力–应变过程渗透性对比分析煤与瓦斯突出

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富血小板纤维蛋白和浓缩生长因子对施万细胞影响的比较

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中国医科大学学报 2016年第12期45卷 1089-1093页

作者：吴晶洋白艳洁王稚英锦州医科大学附属第二医院口腔种植中心辽宁锦州121001 中国医科大学附属盛京医院集团抚顺医院口腔科辽宁抚顺113000

目的以施万细胞作为周围神经模型，比较富血小板纤维蛋白（PRF）与浓缩生长因子（CGF）对其的影响。方法随机选取18-55岁身体健康志愿者10人，无菌条件下采集静脉血10mL，制备PRF和CGF。将细胞随机分为对照组、PRF组和CGF组。倒置相差... 详细信息

目的以施万细胞作为周围神经模型，比较富血小板纤维蛋白（PRF）与浓缩生长因子（CGF）对其的影响。方法随机选取18-55岁身体健康志愿者10人，无菌条件下采集静脉血10mL，制备PRF和CGF。将细胞随机分为对照组、PRF组和CGF组。倒置相差显微镜下观察细胞形态；MTF比色法测定细胞增殖能力；酶联免疫吸附法检测细胞上清液中神经生长因子的分泌量；流式细胞仪检测细胞周期。结果倒置相差显微镜下观察各组细胞形态无明显差异；MTT结果显示PRF组和CGF组与对照组相比光密度值明显升高（P〈0．05），细胞上清液中神经生长因子分泌量均明显升高（P〈0．05），处于S＋G2M期的细胞数明显增多（P〈0．01），而PRF组与CGF组相比各项指标的差异无统计学意义。结论PRF和CGF均可以促进施万细胞增殖并增加神经生长因子的分泌量，但就改善细胞增殖能力、促进神经生长因子分泌来看，二者无明显差异。

关键词：富血小板纤维蛋白浓缩生长因子施万细胞神经生长因子细胞周期

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基于CEEMDAN和SVM的混凝土破坏状态声发射信号识别

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水利水电科技进展 2023年第1期43卷 93-98页

作者：宿辉栾亚伟胡宝文白延杰河北工程大学水利水电学院河北邯郸056038 河北省智慧水利重点实验室河北邯郸056038

针对混凝土破坏状态复杂多变、声发射(AE)信号难以从背景噪声中分离的问题,将自适应噪声完备集合经验模态分解(CEEMDAN)方法与支持向量机(SVM)方法耦合,对混凝土破坏状态声发射信号进行识别与预测。利用CEEMDAN方法对采集的声发射信号... 详细信息

针对混凝土破坏状态复杂多变、声发射(AE)信号难以从背景噪声中分离的问题,将自适应噪声完备集合经验模态分解(CEEMDAN)方法与支持向量机(SVM)方法耦合,对混凝土破坏状态声发射信号进行识别与预测。利用CEEMDAN方法对采集的声发射信号进行分解,获取一定数量的自适应特征模态(IMF)分量,并计算各分量与原声发射信号之间的相关系数,优选出包含原声发射信号主要频域信息的IMF分量。计算各分量的特征参数能量系数和波形系数,并将其分别输入SVM中对混凝土不同破坏状态进行分类识别,结果表明能量系数作为特征参数的预测率为92.39%,波形系数作为特征参数的预测率为91.30%。

关键词：混凝土破坏自适应噪声完备集合经验模态分解支持向量机能量系数波形系数声发射

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大开口升降式光电吊舱设计技术研究

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航空工程进展 2021年第2期12卷 157-162页

作者：苗志桃李建平白艳洁航空工业西安飞机工业(集团)有限责任公司设计院西安710089

机身大开口存在结构刚度急剧变化、变形不连续等问题,使得机身大开口加强设计成为飞机设计改装的重点和难点。以国外某飞机为例,通过对开口加强区设计研究,采用单力素对比方法验证加装升降式光电吊舱结构强度;通过梳理载荷设计思路,自... 详细信息

机身大开口存在结构刚度急剧变化、变形不连续等问题,使得机身大开口加强设计成为飞机设计改装的重点和难点。以国外某飞机为例,通过对开口加强区设计研究,采用单力素对比方法验证加装升降式光电吊舱结构强度;通过梳理载荷设计思路,自主设计光电吊舱及升降机构,并对改装前后各工况应力进行对比。结果表明:在机身气密压力、机身切面载荷及光电吊舱载荷作用下,该结构能够实现升降功能,载荷计算方法及结果量级合理,结构满足强度设计要求;采用单力素对比方法作为强度合格的评价指标能够指导同类型飞机改装设计。

关键词：光电吊舱大开口升降机构单力素对比方法气密压力机身切面载荷

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煤体吸附瓦斯膨胀变形效应的试验研究

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岩石力学与工程学报 2010年第12期29卷 2484-2491页

作者：刘延保曹树刚李勇王军郭平徐健白燕杰重庆大学西南资源开发及环境灾害控制工程教育部重点实验室重庆400044 煤炭科学研究总院重庆研究院重庆400037 博洛尼亚大学结构力学系意大利博洛尼亚40136

为了探讨煤体吸附瓦斯产生膨胀变形效应这一特有的力学行为,利用自行研发的含瓦斯煤岩细观力学试验系统,进行不同瓦斯压力下的吸附膨胀变形试验。试验结果表明:(1)同一煤样在不同瓦斯压力下随时间的变形曲线具有相同的变化规律,煤样的... 详细信息

为了探讨煤体吸附瓦斯产生膨胀变形效应这一特有的力学行为,利用自行研发的含瓦斯煤岩细观力学试验系统,进行不同瓦斯压力下的吸附膨胀变形试验。试验结果表明:(1)同一煤样在不同瓦斯压力下随时间的变形曲线具有相同的变化规律,煤样的应变变化率随时间逐渐减小,直至一个相对稳定值;(2)煤样的吸附膨胀变形呈各向异性,垂直于层理方向和平行于层理方向的应变整体变化趋势呈现一致性,但由于煤体内部裂隙分布差异,垂直层理方向的变形值明显大于平行层理方向;(3)煤体瓦斯吸附量与体应变量呈现较好的线性关系,以此建立考虑温度、水分、灰分和各向异性等因素的吸附膨胀变形计算方程;(4)利用吸附变形应力与制约吸附变形量的线性关系,以及吸附变形量与瓦斯压力的关系得出吸附膨胀应力计算方法;(5)煤体的吸附膨胀变形具有不可逆性,且吸附气体压力越大,其残余变形值也越大。煤体的膨胀变形效应具有重要的工程应用价值,可作为煤层突出危险性测定的辅助指标,以及应用于煤层透气性的研究。

关键词：采矿工程煤与瓦斯突出含瓦斯煤瓦斯吸附膨胀效应透气性

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