检索结果-南通市图书馆

Ru-Ni alloy nanosheets as tandem catalysts for electrochemical reduction of nitrate to ammonia

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Nano Research 2024年第6期17卷 4815-4824页

作者： Xingchao You Jiawei Xu Zechao Zhuang Junkai Xia Suwen wang Haiyan Wei Yongfu Li yanjiang Cai Hai Xiang Bing Yu State Key Laboratory of Subtropical Silviculture Zhejiang A&F UniversityHangzhou 311300China Ecological-Environment&Health College(EEHC) Zhejiang A&F UniversityHangzhou 311300China Jiangsu Key Laboratory of Numerical Simulation of Large Scale Complex Systems and School of Chemistry and Materials Science Nanjing Normal UniversityNanjing 210023China Department of Chemistry Tsinghua UniversityBeijing 100084China Department of Chemical Engineering Columbia UniversityNew YorkNY 10027USA

Developing electrocatalysts that exhibit both high activity and ammonia selectivity for nitrate reduction is a significant and demanding challenge,primarily due to the complex nature of the multiple-electron reduction process involved.An encouraging approach involves coupling highly active precious metals with transition metals to enhance catalytic performance through synergy.Here,we report a ruthenium-nickel alloy catalyst with nanosheets(Ru-Ni NSs)structure that achieves a remarkable ammonia Faradaic efficiency of approximately 95.93%,alongside a yield rate of up to 6.11 g·h^(−1)·cm^(−2).Moreover,the prepared Ru-Ni NSs exhibit exceptional stability during continuous nitrate reduction in a flow reactor for 100 h,maintaining a Faradaic efficiency of approximately 90%and an ammonia yield of 37.4 mg·L^(−1)·h^(−1)using 0.05 M nitrate alkaline electrolyte.Mechanistic studies reveal that the catalytic process follows a two-step pathway,in which HONO serves as a migration intermediate.The presence of a partially oxidized Ru(002)surface enhances the adsorption of nitrate and facilitates the release of the migration intermediate by adjusting the strength of the electrostatic and covalent interactions between the adsorbate and the surface,respectively.On the other hand,the Ni(111)surface promotes the utilization of the migration intermediate and requires less energy for NH_(3)desorption.This tandem process contributes to a high catalytic activity of Ru-Ni NSs towards nitrate reduction.

关键词： alloy catalyst nitrate reduction ammonia synthesis Faradaic efficiency

Precise genome-editing in human diseases:mechanisms,strategies and applications

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2024年第3期9卷 1065-1085页

作者： yanjiang Zheng Yifei Li Kaiyu Zhou Tiange Li Nathan J.VanDusen Yimin Hua Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE Department of PediatricsWest China Second University HospitalSichuan UniversityChengduSichuan 610041China Department of Cardiovascular Surgery West China HospitalSichuan UniversityChengduSichuan 610041China Department of Pediatrics Herman B Wells Center for Pediatric ResearchIndiana University School of MedicineIndianapolisIN 46202USA

Precise genome-editing platforms are versatile tools for generating specific,site-directed DNA insertions,deletions,and substitutions.The continuous enhancement of these tools has led to a revolution in the life sciences,which promises to deliver novel therapies for genetic disease.Precise genome-editing can be traced back to the 1950s with the discovery of DNA’s doublehelix and,after 70 years of development,has evolved from crude in vitro applications to a wide range of sophisticated capabilities,including in vivo applications.Nonetheless,precise genome-editing faces constraints such as modest efficiency,delivery challenges,and off-target effects.In this review,we explore precise genome-editing,with a focus on introduction of the landmark events in its history,various platforms,delivery systems,and applications.First,we discuss the landmark events in the history of precise genome-editing.Second,we describe the current state of precise genome-editing strategies and explain how these techniques offer unprecedented precision and versatility for modifying the human genome.Third,we introduce the current delivery systems used to deploy precise genome-editing components through DNA,RNA,and RNPs.Finally,we summarize the current applications of precise genome-editing in labeling endogenous genes,screening genetic variants,molecular recording,generating disease models,and gene therapy,including ex vivo therapy and in vivo therapy,and discuss potential future advances.

关键词： precise generating editing

Dual active sites over Cu-ZnO-ZrO_(2) catalysts for carbon dioxide hydrogenation to methanol

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2023年第9期131卷 162-172页

作者： Xiucheng Sun Yifei Jin Zaizhe Cheng Guojun Lan Xiaolong wang Yiyang Qiu yanjiang wang Huazhang Liu Ying Li Institute of Industrial Catalysis Zhejiang University of TechnologyHangzhou 310014China

CO_(2) hydrogenation to methanol is a significant approach to tackle the problem of global warming and simultaneously meet the demand for the portable fuel.Cu-ZnO catalysts with various kinds of promoters have received wide attention.However,the role of promoter and the form of active sites in CO_(2) hydrogenation are still in debate.Here,various molar ratios of ZrO_(2) were added into the Cu-ZnO catalysts to tune the distributions of Cu^(0) and Cu+species.A volcano-like trend between the ratio of Cu+/(Cu++Cu^(0))and the amount of ZrO_(2) is presented,among which the CuZn10Zr(the molar ratio of ZrO_(2) is 10%)catalyst reaches the highest value.Correspondingly,the maximum value of space-time yield to methanol with 0.65 gMeOH/(gcat·hr)is obtained on CuZn10Zr at reaction conditions of 220°C and 3 MPa.Detailed characterizations demonstrate that dual active sites are proposed during CO_(2) hydrogenation over CuZn10Zr catalyst.The exposed Cu^(0) takes participate in the activation of H_(2),while on the Cu^(+) species,the intermediate of formate from the co-adsorption of CO_(2) and H_(2) prefers to be further hydrogenated to CH_(3)OH than decomposing into the by-product of CO,yielding a high selectivity of methanol.

关键词： Cu-ZnO-ZrO_(2) CO_(2)hydrogenation Methanol Dual active sites Formate

维普期刊数据库

Endothelial phosphodiesterase 4B inactivation ameliorates endothelial-to-mesenchymal transition and pulmonary hypertension

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2024年第4期14卷 1726-1741页

作者： yanjiang Xing Yangfeng Hou Tianfei Fan Ran Gao Xiaohang Feng Bolun Li Junling Pang Wenjun Guo Ting Shu Jinqiu Li Jie Yang Qilong Mao Ya Luo Xianmei Qi Peiran Yang Chaoyang Liang Hongmei Zhao Wenhui Chen Jing wang Chen wang State Key Laboratory of Respiratory Health and Multimorbidity Institute of Basic Medical SciencesChinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100005China Department of Lung Transplantation National Center for Respiratory MedicineNational Clinical Research Center for Respiratory DiseasesChina–Japan Friendship HospitalInstitute of Respiratory MedicineChinese Academy of Medical SciencesBeijing 100029China Haihe Laboratory of Cell Ecosystem Chinese Academy of Medical Sciences and Peking Union Medical CollegeTianjin 300051China The State Key Laboratory of Complex Severeand Rare DiseasesInstitute of Basic Medical SciencesChinese Academy of Medical SciencesDepartment of PathophysiologyPeking Union Medical CollegeBeijing 100005China Department of Pharmacy West China HospitalSichuan UniversityChengdu 610044China

Pulmonary hypertension (PH) is a fatal disorder characterized by pulmonary vascular remodeling and obstruction. The phosphodiesterase 4 (PDE4) family hydrolyzes cyclic AMP (cAMP) and is comprised of four subtypes (PDE4A–D). Previous studies have shown the beneficial effects of pan-PDE4 inhibitors in rodent PH;however, this class of drugs is associated with side effects owing to the broad inhibition of all four PDE4 isozymes. Here, we demonstrate that PDE4B is the predominant PDE isozyme in lungs and that it was upregulated in rodent and human PH lung tissues. We also confirmed that PDE4B is mainly expressed in the lung endothelial cells (ECs). Evaluation of PH in Pde4b wild type and knockout mice confirmed that Pde4b is important for the vascular remodeling associated with PH. In vivo EC lineage tracing demonstrated that Pde4b induces PH development by driving endothelial-to-mesenchymal transition (EndMT), and mechanistic studies showed that Pde4b regulates EndMT by antagonizing the cAMP-dependent PKA–CREB–BMPRII axis. Finally, treating PH rats with a PDE4B-specific inhibitor validated that PDE4B inhibition has a significant pharmacological effect in the alleviation of PH. Collectively, our findings indicate a critical role for PDE4B in EndMT and PH, prompting further studies of PDE4B-specific inhibitors as a therapeutic strategy for PH.

关键词： Phosphodiesterase 4B Pulmonary hypertension Endothelial-to-mesenchymal transition

Variant PRC1 subunit RYBP/YAF2 forms condensate with RING1B and promotes H2AK119ub deposition

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Life Sciences 2024年

作者： yanjiang Liu Gongcheng Hu Shengxiong Yang Chenghong Yan Juehan wang Guangjin Pan Hongjie Yao State Key Laboratory of Respiratory Disease Guangzhou Institutes of Biomedicine and Health Chinese Academy of Sciences Department of Basic Research Guangzhou National Laboratory CAS Key Laboratory of Regenerative Biology Guangzhou Institutes of Biomedicine and Health Chinese Academy of Sciences University of Chinese Academy of Sciences

Dear Editor,Polycomb group (PcG) proteins represent important roles in repressing gene expression throughout development. The Polycomb repressive complexes (PRCs)have been subdivided into two central protein complexes, PRC1 and PRC2.PRC1 catalyzes H2AK119ub and PRC2catalyzes H3K27me1/2/3 (Fursova et al.,2019). PRC1 is further categorized as CBX-containing canonical PRC1 (cPRC1)and RYBP/YAF2-containing variant PRC1 (vPRC1)(Blackledge and Klose,2021).

关键词：

Amplitude-frequency-aware deep fusion network for optimal contact selection on STN-DBS electrodes

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Science China(Information Sciences) 2022年第4期65卷 48-63页

作者： Linxia XIAO Caizi LI yanjiang wang Weixin SI Hai LIN Doudou ZHANG Xiaodong CAI Pheng-Ann HENG College of Control Science and Engineering China University of Petroleum (East China) Shenzhen Institute of Advanced Technology Chinese Academy of Sciences Department of Neurosurgery Shenzhen Second People's Hospital School of Medicine Shenzhen University Department of Computer Science and Engineering The Chinese University of Hong Kong

Parkinson’s disease(PD) is treated effectively by deep brain stimulation(DBS) of the subthalamic nucleus(STN), using an electrode inserted into the head of a PD patient. The electrode has multiple electrical contacts along its length, so the best may be chosen for selectively stimulating the STN. Neurosurgeons usually determine the optimal stimulated contact via the clinical experience of the neurosurgeon and the motor improvement of PD patients. This is a time-consuming and labor-intensive trial-and-error process. The selection of optimal stimulated contact highly depends on the locations of sweet spots, which are manually identified by the characteristic features of microelectrode recordings(MERs). This paper presents an amplitude-frequency-aware deep fusion network for optimal contact selection on STN-DBS electrodes.The method first obtains the amplitude-frequency fusion features by combining the MERs time sequence features and the amplitude sequence features, and then uses the convolutional neural network(CNN) with convolutional block attention module(CBAM) to identify both the border of the STN and the sweet spots to implant the electrode. The optimal stimulated contact can be selected according to the distribution of the sweet spots. Experimental results indicate that, for successful surgeries, neurosurgeons and the proposed AI solution selected the same optimal contacts. Furthermore, the proposed method outperforms the state-of-the-art methods for STN and sweet spot identification. The proposed method shows great potential for optimal contact selection to improve the efficiency of STN-DBS surgery and reduce the dependence on clinicians’ experience.

关键词： Microelectrode recordings optimal contact selection sweet spots microelectrode recordings Optimal contact selection amplitude-frequency feature Amplitude-frequency feature Deep fusion network deep fusion network

Predicting Resting-state Functional Connectivity With Efficient Structural Connectivity

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

IEEE/CAA Journal of Automatica Sinica 2018年第6期5卷 1079-1088页

作者： Xue Chen yanjiang wang College of Information and Control Engineering China University of Petroleum (East China)

The complex relationship between structural connectivity(SC) and functional connectivity(FC) of human brain networks is still a critical problem in neuroscience. In order to investigate the role of SC in shaping resting-state FC, numerous models have been proposed. Here, we use a simple dynamic model based on the susceptible-infected-susceptible(SIS) model along the shortest paths to predict FC from SC. Unlike the previous dynamic model based on SIS theory, we focus on the shortest paths as the principal routes to transmit signals rather than the empirical structural brain network. We first simplify the structurally connected network into an efficient propagation network according to the shortest paths and then combine SIS infection theory with the efficient network to simulate the dynamic process of human brain activity. Finally, we perform an extensive comparison study between the dynamic models embedded in the efficient network, the dynamic model embedded in the structurally connected network and dynamic mean field(DMF) model predicting FC from SC. Extensive experiments on two different resolution datasets indicate that i) the dynamic model simulated on the shortest paths can predict FC among both structurally connected and unconnected node pairs; ii) though there are fewer links in the efficient propagation network, the predictive power of FC derived from the efficient propagation network is better than the dynamic model simulated on a structural brain network; iii) in comparison with the DMF model,the dynamic model embedded in the shortest paths is found to perform better to predict FC.

关键词：网络功能连通性自动化技术发展现状

维普期刊数据库

Chronic hypoperfusion due to intracranial large artery stenosis is not associated with cerebralβ-amyloid deposition and brain atrophy

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2022年第5期135卷 591-597页

作者： Dongyu Fan Huiyun Li Dongwan Chen Yang Chen Xu Yi Heng Yang Qianqian Shi Fangyang Jiao Yi Tang Qiming Li Fangyang wang Shunan wang Rongbing Jin Fan Zeng yanjiang wang Department of Neurology and Centre for Clinical Neuroscience Daping HospitalThird Military Medical UniversityChongqing400042China Institute of Brain and Intelligence Third Military Medical UniversityChongqing400038China Chongqing Key Laboratory of Ageing and Brain Diseases Chongqing400042China Shigatse Branch Xinqiao HospitalThird Military Medical UniversityTibet 857012China Department of Nuclear Medicine Daping HospitalThird Military Medical UniversityChongqing400042China Department of Radiology Daping HospitalThird Military Medical UniversityChongqing400042China

Background:Insufficient cerebral perfusion is suggested to play a role in the development of Alzheimer disease(AD).However,there is a lack of direct evidence indicating whether hypoperfusion causes or aggravates AD pathology.We investigated the effect of chronic cerebral hypoperfusion on AD-related pathology in humans.Methods:We enrolled a group of cognitively normal patients(median age:64 years)with unilateral chronic cerebral hypoperfusion.Regions of interest with the most pronounced hypoperfusion changes were chosen in the hypoperfused region and were then mirrored in the contralateral hemisphere to create a control region with normal perfusion.11C-Pittsburgh compound-positron emission tomography standard uptake ratios and brain atrophy indices were calculated from the computed tomography images of each patient.Results:The median age of the 10 participants,consisting of 4 males and 6 females,was 64 years(47-76 years).We found that there were no differences in standard uptake ratios of the cortex(volume of interest[VOI]:P=0.721,region of interest[ROI]:P=0.241)and grey/white ratio(VOI:P=0.333,ROI:P=0.445)and brain atrophy indices(Bicaudate,Bifrontal,Evans,Cella,Cella media,and Ventricular index,P>0.05)between the hypoperfused regions and contralateral normally perfused regions in patients with unilateral chronic cerebral hypoperfusion.Conclusion:Our findings suggest that chronic hypoperfusion due to large vessel stenosis may not directly induce cerebralβ-amyloid deposition and neurodegeneration in humans.

关键词： Cerebral hypoperfusion β-amyloid Brain atrophy Alzheimer disease

维普期刊数据库

Correction to:Comprehensive Management of Daily Living Activities,behavioral and Psychological Symptoms,and Cognitive Function in Patients with Alzheimer’s Disease:A Chinese Consensus on the Comprehensive Management of Alzheimer’s Disease

在线全文

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2022年第3期38卷 337-338页

作者： Jianjun Jia Jun Xu Jun Liu Yongjun wang yanjiang wang Yunpeng Cao Qihao Guo Qiuming Qu Cuibai Wei Wenshi Wei Junjian Zhang Enyan Yu Department of Neurology The Second Medical CenterPeople’s Liberation Army General HospitalBeijing100853China Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijing100050China Department of Neurology Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou510120China Cognitive Impairment Department Shenzhen Kangning HospitalShenzhen518118China Department of Neurology Daping HospitalArmy Medical UniversityChongqing400042China Department of Neurology The First Hospital of China Medical UniversityShenyang210112China Department of Gerontology Shanghai Jiaotong University Affiliated Sixth People’s HospitalShanghai200233China Department of Neurology The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an710061China Department of Neurology Xuanwu Hospital Capital Medical UniversityBeijing100053China Department of Neurology Huadong Hospital Affiliated to Fudan UniversityShanghai200040China Department of Neurology Zhongnan Hospital of Wuhan UniversityWuhan430071China Department of Psychology Chinese Academy of Sciences Cancer Hospital of the University of the Chinese Academy of SciencesHangzhou310022China

The article‘Comprehensive Management of Daily Living Activities,behavioral and Psychological Symptoms,and Cognitive Function in Patients with Alzheimer’s Disease:A Chinese Consensus on the Comprehensive Management of Alzheimer’s Disease’,written by Jun Xu,Jun Liu,Yongjun wang,yanjiang wang,Yunpeng Cao,Qihao Guo,Qiuming Qu,Cuibai Wei,Wenshi Wei,Junjian Zhang&Enyan Yu,was originally published electronically on the publisher’s internet portal on 29th May 2021 without open access.With the author(s)’decision to opt for Open Choice the copyright of the article changed on 11th June 2021 to©The Author(s)2021 and the article is forthwith distributed under a Creative Commons Attribution 4.0 International License,which permits use,sharing,adaptation,distribution and reproduction in any medium or format,as long as you give appropriate credit to the original author(s)and the source,provide a link to the Creative Commons licence,and indicate if changes were made.The original article has been corrected.

关键词： Alzheimer Patients Activities