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Thiamine-modified metabolic reprogramming of human pluripotent stem cell-derived cardiomyocyte under space microgravity

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2132-2142页

作者： Xinglong Han Lina Qu Miao Yu Lingqun Ye Liujia Shi Guangfu Ye Jingsi Yang yaning wang Hao Fan Yong wang Yingjun Tan Chunyan wang Qi Li Wei Lei Jianghai Chen Zhaoxia Liu Zhenya Shen Yinghui Li Shijun Hu Department of Cardiovascular Surgery of the First Affiliated Hospital&Institute for Cardiovascular Science State Key Laboratory of Radiation Medicine and ProtectionSuzhou Medical CollegeSoochow UniversitySuzhouChina State Key Laboratory of Space Medicine China Astronaut Research and Training CenterBeijingChina Department of Hand Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina

During spaceflight,the cardiovascular system undergoes remarkable adaptation to microgravity and faces the risk of cardiac remodeling.Therefore,the effects and mechanisms of microgravity on cardiac morphology,physiology,metabolism,and cellular biology need to be further investigated.Since China started constructing the China Space Station(CSS)in 2021,we have taken advantage of the Shenzhou-13 capsule to send human pluripotent stem cell-derived cardiomyocytes(hPSC-CMs)to the Tianhe core module of the CSS.In this study,hPSC-CMs subjected to space microgravity showed decreased beating rate and abnormal intracellular calcium cycling.Metabolomic and transcriptomic analyses revealed a battery of metabolic remodeling of hPSC-CMs in spaceflight,especially thiamine metabolism.The microgravity condition blocked the thiamine intake in hPSC-CMs.The decline of thiamine utilization under microgravity or by its antagonistic analog amprolium affected the process of the tricarboxylic acid cycle.It decreased ATP production,which led to cytoskeletal remodeling and calcium homeostasis imbalance in hPSC-CMs.More importantly,in vitro and in vivo studies suggest that thiamine supplementation could reverse the adaptive changes induced by simulated microgravity.This study represents the first astrobiological study on the China Space Station and lays a solid foundation for further aerospace biomedical research.These data indicate that intervention of thiamine-modified metabolic reprogramming in human cardiomyocytes during spaceflight might be a feasible countermeasure against microgravity.

关键词： programming battery modified

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Three dimensional velocity model and its tectonic implications at China Seismic Experimental Site,eastern margin of the Tibetan Plateau

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Science China Earth Sciences 2024年第7期67卷 2268-2290页

作者： Jianping WU Yan CAI Wei wang Weilai wang Changzai wang Lihua FANG yaning LIU Jing LIU Institute of Geophysics China Earthquake AdministrationBeijing 100081China Beijing Bajatuan Earth Science National Observation and Research Station Beijing 1095China Beijing Earthquake Agency Beijing 100080China

The China Seismic Experimental Site(CSES)is located at the intersection of the Tibetan Plateau,South China Block,and Indian Plate and has complex geological settings and intense crustal deformation,making it one of the most seismically active areas in Chinese mainland.A high-resolution,three-dimensional(3D)crust-mantle velocity structure is crucial for understanding seismotectonic environments,lithospheric deformation mechanisms,and deep dynamic processes.We first constructed a high-vertical-resolution 3D initial velocity model using the joint inversion of receiver functions and surface waves and then obtained a 3D P-and S-wave velocity model(CSES-VM1.0)with the highest lateral resolution of 0.25°for the CSES using double-difference tomography.Owing to the limitations of the Sn observation data,the resolution of the S-wave velocity model in the lower crust and upper mantle was reduced,making it closer to the initial model provided by joint inversion.A comparison with explosive-source seismic data showed that the synthetic P-wave first-arrival travel times of the new model were closer to the observations than those of the previous velocity models.The velocity cross-sections across the source areas of the 2022 Lushan MS6.1 and Ludian MS6.8 earthquakes reveal that the former earthquake occurred near a weak contact zone between the Tibetan Plateau and Sichuan Basin,and the rupture of the latter earthquake occurred in a granitic area,with the northern end blocked by rigid high-velocity bodies.A clear high-velocity anomaly zone is distributed along the western margin of the Yangtze Block,revealing the spatial distribution of Neoproterozoic intermediate-basic intrusions.This high-velocity zone significantly controls the morphology of fault zones and influences the rupture processes of major earthquakes.Two northeast-southwest and north-south trending high-velocity anomalies were found near Panzhihua,potentially related to Neoproterozoic and Middle-Late Permian intermediate-basic intrusions.The imaging results revealed t

关键词： Eastern Tibetan Plateau China Seismic Experimental Site Yangtze Block Velocity model Double-difference tomography

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Ecological transitions in Xinjiang, China:Unraveling the impact of climate change on vegetation dynamics(1990–2020)

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Journal of Geographical Sciences 2024年第6期34卷 1039-1064页

作者： HAO Haichao YAO Junqiang CHEN yaning XU Jianhua LI Zhi DUAN Weili Sadaf ISMAIL wang Guiling Key Laboratory of Geographic Information Science(Ministry of Education) School of Geographic SciencesEast China Normal UniversityShanghai200241China Graduate School of Advanced Integrated Studies in Human Survivability Kyoto UniversityYoshida-Nakaadachi 1Sakyo-kuKyoto 606-8306Japan Field Scientific Experiment Base of Akdala Atmospheric Background Institute of Desert MeteorologyChina Meteorological AdministrationUrumqi 830011China State Key Laboratory of Desert and Oasis Ecology Key Laboratory of Ecological Safety and Sustainable Development in Arid LandsXinjiang Institute of Ecology and GeographyCASUrumqi 830011China School of Geographic Science Nantong UniversityNantong 226007JiangsuChina

For the past several decades, climate change has been driving vegetation dynamics in arid regions worldwide. This study investigates vegetation dynamics and their links to climate from 1990 to 2020 in Xinjiang, China, using data from 30-m resolution land use and cover change, remote sensing, and climate reanalysis. Our approach encompasses a range of analytical techniques, including transfer matrix analysis, modeling, correlation, regression,and trend analysis. During the study period, there were major vegetation conversions from grassland to forestland in the mountains, and from cropland to grassland in the plains. Climate change emerged as an important trigger of these changes, as evidenced by the increase in net primary productivity in most vegetation types, except for cropland-grassland and grassland-cropland conversions. Precipitation and soil moisture were the most influential climatic factors, contributing 15.1% and 15.2%, respectively, to natural vegetation changes.The study also found that evapotranspiration serves as a key mechanism for moisture dissipation in the hydrological cycle of vegetation dynamics. The interplay between precipitation,soil moisture, and evapotranspiration is a critical pattern of climatic influence that shapes vegetation dynamics across zones of intersection, increase, decrease, and change. These insights are invaluable for informing vegetation conservation and development strategies in Xinjiang and other similar environments facing climate-driven ecological transitions.

关键词： climate change ecological transitions LUCC NPP efficiency vegetation dynamics Xinjiang

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Four-birds-with-one-stone:A multifunctional Ti-based material for solar-driven water evaporation

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Nano Research 2024年第5期17卷 4498-4506页

作者： Yannan Li yaning Sun Dan Zhang Yu Xue Jie wang Nan Zhang Jun wang Jiangwei Zhang Yan Zhao Jun-Jie Liu School of Physical Science and Technology College of Energy Materials and ChemistryInner Mongolia UniversityHohhot 010021China

Sustainable,environmentally friendly and low-energy desalination materials have important research value for the increasing demand of freshwater year by year.However,it is a huge challenge to maintain high heat energy transfer efficiency without reducing the heat conversion capacity of specific solar photothermal conversion materials.Moreover,their efficiency and durability are greatly limited by the problems of seawater corrosion,oil,and bacteria pollutions.Till now,no related work has been reported to solve all the aforementioned problems via a simple four-birds-with-one-stone strategy.Herein,a class of multifunctional porous photothermal silver(Ag)modified Ti foams(Tf-TA/Ag series materials)is prepared for the development of advanced solar water evaporation devices,and provides alternative materials for alleviating freshwater crisis and treating sewage.The oil contact angle(OCA)changes from 41°to 180°,which significantly reduces the adhesion of oil.In addition,Tf-TA2/Ag sample also shows an excellent and sustained antibacterial effect,which maintains above 99.9%of antibacterial rate after repeated 5 times.The surface temperature of the Tf-TA2/Ag sample reaches 52.5℃ after simulated sun irradiation for 20 min,which is significantly higher than that of the contact groups(water:36.4℃,Ti foam:38.2℃ and Tf-TA2:40.9℃).The capacity of seawater evaporation and salt removal is enhanced due to the excellent photothermal properties,low reflectance,and uniform heat dissipation pores.The water production efficiency of Tf-TA2/Ag sample is 1.41 kg·m^(-2)·h^(-1) in artificial seawater and 0.76 kg·m^(-2)·h^(-1) in oily sewage under simulated sun irradiation.Furthermore,the hydrophilic and oleophobic properties of Tf-TA2/Ag are critical to extracting water from oil/water mixture in diverse water environments.Ultimately,this four-birds-with-one-stone approach provides a new perspective for the improvement of solar seawater desalination performance.

关键词： four-birds-with-one-stone photothermal material antibacterial material antifouling property

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Impact time control guidance against maneuvering targets based on a nonlinear virtual relative model

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Chinese Journal of Aeronautics 2023年第7期36卷 444-459页

作者： Yuru BIN Hui wang Defu LIN yaning wang Xin SUN School of Aerospace Engineering Beijing Institute of TechnologyBeijing 100081China Beijing Key Laboratory of UAV Autonomous Control Beijing Institute of TechnologyBeijing 100081China Beijing Institute Of Electronic System Engineering Beijing 100854China

Aiming at the problem of high-precision interception of air-maneuvering targets with impact time constraints,this paper proposes a novel guidance law based on a nonlinear virtual relative model in which the origin is attached to the target.In this way,the original maneuvering target is transformed into a stationary one.A polynomial function of the guidance command in the range domain with two unknown coefficients is introduced into the virtual model,one of the coefficients is determined to achieve the impact time constraint,and the other is determined to satisfy a newly defined virtual look angle constraint.For meeting the terminal constraints simultaneously,the guidance command can finally be obtained.The resulting solution is represented as a combination of proportional navigation guidance-like term which is aimed to meet the zero miss distance constraint,a bias term for impact time control by adjusting the length of the homing trajectory,and an additional term for target maneuvers.Numerous simulations demonstrate that the proposed law achieves an acceptable impact time error for various initial conditions against different types of maneuvering targets and shows more effective performance in comparison with those of other existing guidance laws.

关键词： Impact time control Maneuvering targets Polynomial guidance Virtual relative model Virtual look angle constraint

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Astragaloside in cancer chemoprevention and therapy

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Chinese Medical Journal 2023年第10期136卷 1144-1154页

作者： yaning wang Zhuo Zhang Zhaohua Cheng Wei Xie Hanjiao Qin Jiyao Sheng Department of Hepatobiliary and Pancreatic Surgery Second Hospital of Jilin UniversityChangchunJilin 130041China Department of Orthopedics China-Japan Union Hospital of Jilin UniversityChangchunJilin 13033China Department of Ophthalmology Second Hospital of Jilin UniversityChangchunJilin 130041China Department of Radiotherapy Second Hospital of Jilin UniversityChangchunJilin 130041China

Tumor chemoprevention and treatment are two approaches aimed at improving the survival of patients with cancers.An ideal anti-tumor drug is that which not only kills tumor cells but also alleviates tumor-causing risk factors,such as precancerous lesions,and prevents tumor recurrence.Chinese herbal monomers are considered to be ideal treatment agents due to their multi-target effects.Astragaloside has been shown to possess tumor chemoprevention,direct anti-tumor,and chemotherapeutic drug sensitization effects.In this paper,we review the effects of astragaloside on tumor prevention and treatment and provide directions for further research.

关键词： Astragaloside Carcinoma Chemoprevention Anti-tumor Tumor recurrence

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Genetic and pathogenic characterization of new infectious bronchitis virus strains in the GVI-1 and GI-19 lineages isolated in central China

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Journal of Integrative Agriculture 2024年第7期23卷 2407-2420页

作者： Yuhan Yang Dou wang yaning Bai Wenyan Huang Shimin Gao Xingchen Wu Ying wang Jianle Ren Jinxin He Lin Jin Mingming Hu Zhiwei wang Zhongbing wang Haili Ma Junping Li Libin Liang College of Veterinary Medicine Shanxi Agricultural UniversityJinzhong 030801China Shanxi Provincial Animal Disease Prevention and Control Center Taiyuan 030000China

Avian infectious bronchitis(IB)is a highly contagious infectious disease caused by infectious bronchitis virus(IBV),which is prevalent in many countries worldwide and causes serious harm to the poultry industry.At present,many commercial IBV vaccines have been used for the prevention and control of IB;however,IB outbreaks occur frequently.In this study,two new strains of IBV,SX/2106 and SX/2204,were isolated from two flocks which were immunized with IBV H120 vaccine in central China.Phylogenetic and recombination analysis indicated that SX/2106,which was clustered into the GI-19 lineage,may be derived from recombination events of the GI-19 and GI-7 strains and the LDT3-A vaccine.Genetic analysis showed that SX/2204 belongs to the GVI-1 lineage,which may have originated from the recombination of the GI-13 and GVI-1 strains and the H120 vaccine.The virus cross-neutralization test showed that the antigenicity of SX/2106 and SX/2204 was different from H120.Animal experiments found that both SX/2106 and SX/2204 could replicate effectively in the lungs and kidneys of chickens and cause disease and death,and H120 immunization could not provide effective protection against the two IBV isolates.It is noteworthy that the pathogenicity of SX/2204 has significantly increased compared to the GVI-1 strains isolated previously,with a mortality rate up to 60%.Considering the continuous mutation and recombination of the IBV genome to produce new variant strains,it is important to continuously monitor epidemic strains and develop new vaccines for the prevention and control of IBV epidemics.

关键词： infectious bronchitis virus GI-19 lineage GVI-1 lineage complete genome recombination pathogenicity

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A gate-tunable artificial synapse based on vertically assembled van der Waals ferroelectric heterojunction

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Journal of Materials Science & Technology 2022年第33期128卷 239-244页

作者： yaning wang Wanying Li Yimeng Guo Xin Huang Zhaoping Luo Shuhao Wu Hai wang Jiezhi Chen Xiuyan Li Xuepeng Zhan Hanwen wang Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Material Science and Engineering University of Science and Technology of ChinaShenyang 110016China Department of Applied Physics Aalto UniversityAaltoFinland School of Information Science and Engineering(ISE) Shandong UniversityQingdao 266237China

Memtransistor,a multi-terminal device that combines both the characteristics of a memristor and a transistor,has been intensively studied in two-dimensional layered materials(2 DLM),which show potential for applications in such as neuromorphic computation.However,while often based on the migration of ions or atomic defects in the conduction channels,performances of memtransistors suffer from the poor reliability and tunability.Furthermore,those known 2 DLM-based memtransistors are mostly constructed in a lateral manner,which hinders the further increasing of the transistor densities per area.Until now,fabricating non-atomic-diffusion based memtransistors with vertical structure remains challenging.Here,we demonstrate a vertically-integrated ferroelectric memristor by hetero-integrating the 2 D ferroelectric materials CuInP_(2)S_(6)(CIPS)into a graphite/CuInP_(2)S_(6)/MoS_(2)vertical heterostructure.Memristive behaviour and multi-level resistance states were realized.Essential synaptic behaviours including excitatory postsynaptic current,paired-pulse-facilitation,and spike-amplitude-dependent plasticity are successfully mimicked.Moreover,by applying a gate potential,the memristive behaviour and synaptic features can be effectively gate tuned.Our findings pave the way for the realization of novel gate-tunable ferroelectric synaptic devices with the capability to perform complex neural functions.

关键词： van der Waals heterostructures Ferroelectrics Memristor Artificial synapse Neuromorphic computing

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Successful rescue of disseminated Nocardia infection with multiple abscesses in a patient with membranous nephropathy after cardiopulmonary resuscitation:A three-year follow-up

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Journal of Biomedical Research 2024年第2期38卷 189-194,I0019,I0020页

作者： Yili Xu Hanyang Qian Wen Qian Li Dong Weiying Liu Yan Zhu yaning Mei Yi Xu Ling wang Yi Xia Xu Qi Huanping Mei Xueqiang Xu Huijuan Mao Changying Xing Ningning wang Department of Nephrology the First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjingJiangsu 210029China Department of Nephrology Nanjing Tongren HospitalNanjingJiangsu 211102China Department of Image the First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjingJiangsu 210029China Department of Infectious Disease the First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjingJiangsu 210029China Department of Nephrology the Second Hospital of NanjingNanjingJiangsu 210029China Department of Microorganism the First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjingJiangsu 210029China Department of Hematology the First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjingJiangsu 210029China Department of Rheumatology and Immunology the First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjingJiangsu 210029China

Nocardiosis manifests as an opportunistic infection,primarily affecting individuals who are immunocompromised and susceptible to the infection.We present a case study of one patient with nephrotic syndrome and membranous nephropathy,who underwent treatment with prednisone and cyclosporine in 2016.In early 2017,the patient was diagnosed with a"fungal infection"and discontinued the use of cyclosporine.After one month of anti-infection therapy,a cranial magnetic resonance imaging scan showed multiple abscesses in the right temporal region.The diagnosis of nocardiosis was confirmed based on the presence of metastatic abscess masses,multiple lung and brain lesions,and a positive culture of Nocardia in the drainage.We changed the anti-infection therapy to a combination of trimethoprim-sulfamethoxazole(TMP-SMX),minocycline,and voriconazole.However,the patient experienced a sudden cardiac arrest and subsequently recovered after cardiopulmonary resuscitation.During the five-month follow-up period following the discharge,the patient displayed an enhanced nutritional status and stable renal function.The focal infection ultimately resolved during the subsequent three years.Neuro-infection caused by Nocardia should be considered in immunocompromised patients,and TMP-SMX is the preferred initial therapy;however,because of the high mortality rate,a long-term combination therapy with imipenem,cefotaxime,amikacin,and TMP-SMX is suggested.

关键词： Nocardia infection glomerulonephritis membranous nephrology cardiopulmonary resuscitation

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Catalytic Asymmetric Addition and Telomerization of Butadiene with Enamine Intermediates

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CCS Chemistry 2022年第7期4卷 2267-2275页

作者： yaning wang Jie Zhang Chang You Xueling Mi Sanzhong Luo Key Laboratory for Molecular Recognition and Function Institute of ChemistryChinese Academy of SciencesBeijing 100190 School of Chemical Science University of Chinese Academy of SciencesBeijing 100190 College of Chemistry Beijing Normal UniversityBeijing 100875 Center of Basic Molecular Science(CBMS) Department of ChemistryTsinghua UniversityBeijing 100084

Herein,we report tunable asymmetric addition and telomerization of butadiene by synergistic chiral primary amine/achiral palladium catalysis.A selection of different achiral phosphine ligand in concert with the chiral primary amine-trifluoromethanesulfonic acid(TfOH)conjugates enables both chemo-and enantioselective control of the coupling with butadiene.Bidentate[(oxydi-2,1-phenylene)-bis-(diphenylphosphine)](DPEPhos)ligand led to 1,4-addition adduct whereas monodentate(p-Tol)3P ligand gave the telomerization product.A range ofα-branchedβ-ketoesters and aldehydes could be applied to afford allylation or telomerization products bearing allcarbon quaternary centers at high efficiency and good chemo-,regio-,and stereoselectivities.

关键词： synergetic catalysis chiral primary amine addition telomerization palladium butadiene

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