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Chinese Chemical Letters 2003年第12期14卷 1227-1229页

作者： Zheng Hong ZHOU Yi long TANG Kang Ying LI Bing LIU Chu Chi TANG State Key Laboratory of Elemento-Organic Chemistry Institute of Elemento-Oganic Chemistry Nankai UniversityTianjin 300071

A series of optically active N-protected 1,2-amino alcohols were synthesized via the reduction of the corresponding a-aminoketones starting from the readily available L-amino acids.

关键词： Optically active 1,2-amino alcohol a-aminoketone reduction.

Downregulation of miR-181a-5p alleviates oxidative stress and inflammation in coronary microembolization-induced myocardial damage by directly targeting XIAP

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Journal of Geriatric Cardiology 2021年第6期18卷 426-439页

作者： You ZHOU Man-Yun long Zhi-Qing CHEN Jun-Wen HUANG Zhen-Bai QIN Lang LI Department of Cardiology the First Affiliated Hospital of Guangxi Medical UniversityNanningChina Guangxi Key Laboratory of Precision Medicine in Cardio-cerebrovascular Diseases Control and Prevention NanningChina

BACKGROUND Coronary microembolization(CME)is a complicated problem that commonly arises in the context of coronary *** play crucial roles in cardiovascular ***,the role and mechanism of miR-181a-5p in CME-induced myocardial injury remains *** We established CME rat *** function was detected by ***-basic fuchsin-picric acid staining was used to measure micro-infarction *** samples and cell culture supernatants were evaluated via enzyme-linked immunosorbent *** reactive oxygen species were determined by dichloro-dihydro-fluorescein diacetate assay,and the other oxidative stress related parameters were assayed by *** dual-luciferase reporter(DLR)assay and RNA pulldown were conducted to validate the association between miR-181a-5p and X-linked inhibitor of apoptosis protein(XIAP).The expression of miR-181a-5p and XIAP mRNA were determined by quantitative reverse transcription polymerase chain *** were evaluated via *** viability of the cell was evaluated via cell counting kit-8 *** The miR-181a-5p level was significantly increased in CME myocardial *** of miR-181a-5p improved CME-induced cardiac dysfunction and alleviated myocardial oxidative stress and inflammatory injury,whereas miR-181a-5p exhibited the opposite ***,the DLR assay and RNA pulldown results revealed that miR-181a-5p directly targeting on *** XIAP level was found to be remarkably decreased after *** overexpression attenuated CME-induced myocardial oxidative stress and inflammatory ***,in vitro rescue experiments revealed that knockdown of XIAP could abolish the protective effects of miR-181a-5p knockdown on hypoxia-induced cardiomyocyte oxidative stress and inflammatory *** Downregulation of miR-181a-5p alleviates CME-induced myocardial damage by suppressing myocardial oxidative stress and

关键词： damage XIAP Down

Highly Efficient Photocatalytic CO_(2) Methanation over Ru-Doped TiO_(2) with Tunable Oxygen Vacancies

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Chinese Journal of Structural Chemistry 2022年第12期41卷 43-50页

作者： Zheyue Li Di Wu Wanbing Gong Jiayi Li Shuaikang Sang Hengjie Liu Ran long Yujie Xiong Hefei National Research Center for Physical Sciences at the Microscale School of Chemistry and Materials ScienceNational Synchrotron Radiation LaboratorySchool of Nuclear Science and TechnologyUniversity of Science and Technology of ChinaHefei 230026China Institute of Energy Hefei Comprehensive National Science Center350 Shushanhu Rd.Hefei 230031China

Solar-driven CO_(2) methanation is an imperative and promising approach to relieve the global warming and environmental crisis,yet remains a great challenge due to the low reaction efficiency,unsatisfactory selectivity and poor *** this work,we demonstrate a facile and efficient strategy to prepare Ru-doped TiO_(2) photocatalyst with tunable oxygen vacancies using the ascorbic acid as a reducing agent for the CO_(2) methanation *** optimal Ru-TiO_(2)-OV-50 exhibits a remarkable CH4production rate of 81.7 mmol g^(-1)h^(-1)with a 100%CH4selectivity under a 1.5 W cm^(-2)light illumination,which is significantly higher than commercial Ru/TiO_(2)and other reported *** reveal that the superior photocatalytic CO_(2) methanation performance is mainly due to the synergistic effect of Ru doping and TiO_(2) with tunable oxygen ***,the light rather than thermal effect is confirmed as the main influencing factor by experimental *** addition,in situ spectroscopic technology is performed to investigate the CO_(2) methanation reaction *** work will open an avenue to design and prepare highly efficient photocatalyst with tunable oxygen vacancies for CO_(2) conversion and other related applications.

关键词： photocatalysis CO_(2)methanation metal doping titanium oxide oxygen vacancies

Quantitative Analysis of Methanol in Methanol Gasoline by Calibration Transfer Strategy Based on Kernel Domain Adaptive Partial Least Squares(kda-PLS)

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Chemical Research in Chinese Universities 2022年第4期38卷 1057-1064页

作者： XU Yanyan LI Maogang FENG Ting JIAO long WU Fengtian ZHANG Tianlong TANG Hongsheng LI Hua Northwest University Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of EducationCollege of Chemistry&Materials ScienceXi’an710127P.R.China College of Chemistry and Chemical Engineering Xi’an Shiyou UniversityXi’an710065P.R.China

The application of near-infrared(NIR)spectroscopy combined with multivariate calibration methods can achieve the rapid analysis of methanol ***,instrumental or environmental differences found for spectra make it impossible to continuously apply the previously developed calibration ***,the calibration transfer technique would be required to solve the time-consuming and laborious problem of reestablishing a new *** this work,a calibration transfer method named kernel domain adaptive partial least squares(kda-PLS)was applied to the calibration transfer from the primary instrument to the secondary ***,wavelet transform(WT)and variable importance in projection(VIP)were employed to enhance the predictive performance of the kda-PLS transfer ***,the results found for the calibration transfer by piecewise direct standardization(PDS)and domain adaptive partial least squares(da-PLS)were compared to verify the calibration transfer(CT)effect of *** results point that the kda-PLS method can transfer the PLS model developed on the primary instrument to the secondary ones,and achieve results comparable to the those of reestablishing a new PLS model on the secondary instrument,with R_(P)^(2)=0.9979(R_(P)^(2):coefficients of determination of the prediction set),RMSEP=0.0040(RMSEP:root mean square error of the prediction set),and MREP=3.03%(MREP:mean relative error of the prediction set).Therefore,kda-PLS will provide a new method for quantitative analysis of methanol content in methanol gasoline.

关键词： Kernel domain adaptive partial least squares(kda-PLS) Calibration transfer Methanol gasoline Near infrared spectroscopy

Efficacy of electroacupuncture on myocardial protection and postoperative rehabilitation in patients undergoing cardiac surgery with cardiopulmonary bypass:a systematic review and Meta-analysis

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Journal of Traditional Chinese Medicine 2024年第1期44卷 1-15页

作者： QIN Xiaoyu WANG Chunai XUE Jianjun ZHANG Jie LU Xiaoting DING Shengshuang GE long WANG Minzhen the First Clinical Medical College Gansu University of Chinese MedicineLanzhou 730030China Department of Anesthesiology Gansu Provincial Hospital of Traditional Chinese MedicineLanzhou 730050China Evidence-based Medicine Center Lanzhou UniversityLanzhou 730030China Institute of Epidemiology and Statistics School of Public HealthLanzhou UniversityLanzhou 730030China

OBJECTIVE:To evaluate the efficacy of electroacupuncture(EA)intervention on myocardial protection and postoperative rehabilitation in patients undergoing cardiac surgery with cardiopulmonary bypass(CPB).METHODS:Eight databases,including Pub Med,Embase,the Cochrane Library,Web of Science,Chinese Bio Medical Literature Database,China National Knowledge Infrastructure Database,Wanfang Data,China Science and Technology Journal Database,and two clinical trial registries,were *** randomized controlled trials(RCTs)related to EA intervention in cardiac surgery with CPB were *** on the inclusion and exclusion criteria,two researchers independently screened articles and extracted *** the quality evaluation,RevMan 5.3 software was used for ***:Fourteen RCTs involving 836 patients were *** with the control treatment,EA significantly increased the incidence of cardiac automatic rebeat after aortic unclamping[relative risk(RR)=1.15,95%confidence interval(CI)(1.01,1.31),P<0.05;moderate].Twenty-four hours after aortic unclamping,EA significantly increased the superoxide dismutase[standardized mean difference(SMD)=0.96,95%CI(0.32,1.61),P<0.05;low],and interleukin(IL)-2[SMD=1.33,95%CI(0.19,2.47),P<0.05;very low]expression levels and decreased the malondialdehyde[SMD=-1.62,95%CI(-2.15,-1.09),P<0.05;moderate],tumour necrosis factor-α[SMD=-1.28,95%CI(-2.37,-0.19),P<0.05;moderate],and cardiac troponin I[SMD=-1.09,95%CI(-1.85,-0.32),P<0.05;low]expression levels as well as the inotrope scores[SMD=-0.77,95%CI(-1.22,-0.31),P<0.05;high].There was no difference in IL-6 and IL-10 expression *** amount of intraoperative sedative[SMD=-0.31,95%CI(-0.54,-0.09),P<0.05;moderate]and opioid analgesic[SMD=-0.96,95%CI(-1.53,-0.38),P<0.05;low]medication was significantly lower in the EA group than in the control ***,the postoperative tracheal intubation time[SMD=-0.92,95%CI(-1.40,-0.45),P<0.05;low]and intensive care unit stay[SMD=-1.

关键词： electroacupuncture cardiopulmonary bypass thoracic surgery myocardial ischaemia-reperfusion injury myocardial protection postoperative rehabilitation Meta-analysis randomized controlled trial

Genetic Analysis of Two Weak Dormancy Mutants Derived from Strong Seed Dormancy Wild Type Rice N22 (Oryza sativa)

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Journal of Integrative Plant Biology 2011年第5期53卷 338-346页

作者： Bingyue Lu KunXie Chunyan Yang long Zhang Tao Wu Xi Liu Ling Jiang Jianmin Wan National Key Laboratory for Crop Genetics and Germplasm Enhancement Jiangsu Plant Gene Engineering Research Center NanjingAgricultural University Nanjing 210095 China National Key Facility for Crop Gene Resources and Genetic Improvement Institute of Crop Science Chinese Academy of AgriculturalSciences Beijing 100081 China

Two weak dormancy mutants, designated Q4359 and Q4646, were obtained from the rice cultivar N22 after treatment with 400 Gy 6Co gamma-radiation. Compared to the N22 cultivar, the dormancy of the mutant seeds was more readily broken when exposed to a period of room temperature storage. The mutants also showed a reduced level of sensitivity to abscisic acid compared to the N22 cultivar, although Q4359 was more insensitive than Q4646. A genetic analysis indicated that in both mutants, the reduced dormancy trait was caused by a single recessive allele of a nuclear gene, but that the mutated locus was different in each case. The results of quantitative trait locus （QTL） mapping, based on the F2 population from Q4359 x Nanjing35, suggested that Q4359 lacks the QTL qSdn-1 and carries a novel allele at QTL qSdn-9, while a similar analysis of the Q4646 x Nanjing35 F2 population suggested that Q4646 lacks QTL qSdn-5, both qSdn-1 and qSdn-5 are major effect seed dormancy QTL in N22. Therefore, these two mutants were helpful to understand the mechanism of seed dormancy in N22.

关键词： Mutants Dormancy Sowing Seed Seeds Varieties Loci Political systems Genes Quantitative trait loci

Preparation of multihollow P(St-MAA) particles by sequence soap-free/soap emulsion polymerization and followed by stepwise alkali/acid posttreatment

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Chinese Chemical Letters 2007年第6期18卷 741-743页

作者： Rong long Li Cheng You Kan Ze Ping Li Yi Du Yan Nan Cui Department of Chemical Engineering and Key Laboratory of Advanced Materials of Ministry of Education Tsinghua UniversityBeijing 100084China

The effects of ionic emulsifier, sodium dodecylbenzene sulfate (SDBS), on the formation of the multihollow structures in sub-micron sized polymer particles produced by alkali/acid posttreatment were investigated. The original latex particles with narrow size distribution were synthesized by a new sequence emulsifier-free/emulsifier emulsion copolymerization of styrene (St) and methacrylic acid (MAA). Results indicated that the pore size decreased and the pore number increased with the increase of SDBS amount, and the morphology of the posttreated latex particles was also significantly influenced by the introducing time of SDBS in the preparation of the original latex particles, and a suitable introducing time was 3 h of polymerization. (c) 2007 Cheng You Kan. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

关键词： multihollow latex particles morphology emulsion polymerization emulsifier

Synthesis and antibacterial activity of novel[1,2,4]triazolo[3,4-h][1,8]naphthyridine-7-carboxylic acid derivatives

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Chinese Chemical Letters 2015年第1期26卷 149-151页

作者： Liu-Zhou Gao Yu-Suo Xie Tao Li Wen-long Huang Guo-Qiang Hu Institute of Chemical Biology.Henan University Centre of Drug Discovery China Pharmaceutical University

Novel tricyclic fluoroquinolones,[1,2,4]triazolo[3,4-h][1,8]naphthyridine-8-one-7-carboxylic acid derivatives 4a-4h bearing carrying a functional Mannich-base moiety at the C-8 position,were synthesized and evaluated for their antimicrobial *** results showed that some compounds with a piperazine side chain exhibited comparable or better antibacterial activity than comparator ***,the targeted compounds also displayed a broad spectrum of activity against resistant strains including both Gram-negative and Gram-positive *** particular,compound 4h showed an MIC of 0.25 μg/mL in antibacterial assay against multiple drug-resistant Escherichia coli,which represents an about 30-fold increase of potency compared to ***,their excellent antibacterial activity against resistant strains suggests that triazole-fused fluoroquinolones warrant further optimization as novel anti-infective chemotherapies.

关键词： Triazole Tricyclic fluoroquinolone Synthesis Antibacterial activity

Characteristics of dissolved organic matter in lakes with different eutrophic levels in southeastern Hubei Province,China

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Journal of Oceanology and Limnology 2021年第4期39卷 1256-1276页

作者： Weixiang REN Xiaodong WU Xuguang GE Guiying LIN Mengdie ZHOU Zijie long Xinhui YU Wei TIAN College of Urban and Environmental Sciences Hubei Normal UniversityHuangshi 435002China Huangshi Key Laboratory of Soil Pollution and Control Huangshi 435002China

Dissolved organic matter(DOM)plays a crucial role in both the carbon cycle and geochemical cycles of other nutrient elements,which is of importance to the management and protection of the aquatic *** achieve a more comprehensive understanding the characteristics of DOM in the Changjiang(Yangtze)River basin,water samples from four natural lakes(Xiandao,Baoan,Daye,and Qingshan)in southeastern Hubei Province in China with different eutrophication levels were collected and *** optical characteristics were analyzed using ultraviolet-visible spectrophotometry and excitation-emission matrix spectroscopy coupled with parallel factor *** results show that:(1)two humic-like components(C1 and C2)and two protein-like substances(C3 and C4)of DOM were identified in all waterbodies;(2)C3 originated primarily from the degradation of microalgae and contributed substantially to humic-like components during transformation.C4 was widely present in the Changjiang River basin and its formation was related to microbial activity,rather than algal blooms or *** by the water mixing,the protein-like components were more likely to be transformed by microorganism,whereas humic-like components were more easily to be photobleached;(3)the concentration of DOM and the fluorescence intensity of humic-like components gradually increased with rising lake eutrophication *** respect to protein-like components,only C3 showed changes along the eutrophication gradients;(4)DOM showed a high affinity with permanganate index(COD Mn)and chlorophyll a(chl a)while the relationship was variable with *** study helps us systematically understand the DOM characteristics,microbial activities,and pollutant transformation in the Changjiang River basin and provides reference to the ecological restoration of aquatic environments.

关键词： Hubei eutrophic lake dissolved organic matter(DOM) excitation-emission spectra parallel factor analysis

Preparation and stabilization mechanism of carbon dots nanofluids for drag reduction

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Petroleum Science 2020年第6期17卷 1717-1725页

作者： Yi-Ning Wu Yuan Li Meng-Jiao Cao Cai-Li Dai long He Yu-Ping Yang Shandong Key Laboratory of Oilfi eld Chemistry School of Petroleum EngineeringChina University of Petroleum(East China)Qingdao 266580China Petroleum Engineering Institute Northwest Branch of SinopecUrumchi 830000China CNPC Engineering Technology R&D Company Limited Beijing 100007China

During the development of low or ultra-low permeability oil resources,the alternative energy supply becomes a prominent *** recent years,carbon dots(CDs)have drawn much attention owing to their application potential in oil fields for reducing injection pressure and augmenting oil ***,carbon dots characterized of small size,high surface energy are faced with several challenges,such as self-aggregation and *** preparation of stably dispersed carbon dots nanofluids is the key factor to guarantee its application performance in *** this work,we investigated the stability of hydrophilic carbon dots(HICDs)and hydrophobic carbon dots-Tween 80(HOCDs)*** influences of carbon dots concentration,sorts and concentration of salt ions as well as temperature on the stability of CDs were *** results showed that HICDs are more sensitive to sort and concentration of salt ions,while HOCDs are more sensitive to *** addition,the core flooding experiments demonstrated that the pressure reduction rate of HICDs and HOCDs nanofluids can be as high as 17.88%and 26.14%,***,the HICDs and HOCDs nanofluids show a good application potential in the reduction of injection pressure during the development of low and ultra-low permeability oil resources.

关键词： Carbon dots Nanofluids Drag reduction Stabilization mechanism Salt tolerance