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Neuroscience Bulletin 2022年第10期38卷 1199-1214页

作者： yang-wuyue liu Jingyu Zhang Wanda Bi Mi Zhou Jiabo Li Tiantian Xiong Nan yang Li Zhao Xing Chen Yuanguo Zhou Wenhui He Teng yang Hao Wang Lunshan Xu Shuang-Shuang Dai Department of Biochemistry and Molecular Biology School of Basic MedicineArmy Medical UniversityChongqing400038China Department of Neurosurgery Daping HospitalArmy Medical UniversityChongqing400042China Molecular Biology Center State Key Laboratory of TraumaBurnand Combined InjuryDaping HospitalArmy Medical UniversityChongqing400042China Department of Pathophysiology College of High Altitude MedicineArmy Medical UniversityChongqing400038China Brigade 1 of Medical Undergraduates School of Basic MedicineArmy Medical UniversityBattalion 1Chongqing400038China

The brain pericyte is a unique and indispensable part of the blood-brain barrier(BBB),and contributes to several pathological processes in traumatic brain injury(TBI).However,the cellular and molecular mechanisms by which pericytes are regulated in the damaged brain are largely ***,we show that the formation of neutrophil extracellular traps(NETs)induces the appearance of CD11b^(+)pericytes after *** CD11b^(+)pericyte subsets are characterized by increased permeability and pro-inflammatory profiles compared to ***,histones from NETs by Dectin-1 facilitate CD11b induction in brain pericytes in PKC-c-Jun dependent manner,resulting in neuroinflammation and BBB dysfunction after *** data indicate that neutrophil-NET-pericyte and histone-Dectin-1-CD11b are possible mechanisms for the activation and dysfunction of *** NETs formation and Dectin-1 are promising means of treating TBI.

关键词： Pericyte Neutrophil TBI NET Dectin-1

LPS induces mGluR5 expression of neutrophils in p65-dependent manner

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LPS induces mGluR5 expression of neutrophils in p65-dependen...

中国生物化学与分子生物学会2019年全国学术会议暨学会成立四十周年

作者： yang-wuyue liu Mi Zhou Li Zhao Teng yang Xu Tan Shan Chen Shuang-Shuang Dai Department of Biochemistry and Molecular Biology College of Basic Medical Sciences Army Military Medical University (Third Military Medical University)

Lip polysaccharide(LPS) is an important pathogenic stimulator to activate neutrophils. Metabotropic glutamate receptor 5(mGluR5) is highly expressed in central nervous system that modulates glutamate release and circuits activity. However, the roles and functions of mGluR5 in peripheral systems especially on neutrophils are poorly understood. Here we found that LPS induced both mRNA and protein expressions of mGluR5 in neutrophils. Activation of mGluR5 promotes p65 nuclear translocation in PKC-dependent manner. The ability of cytokines releasing and migration toward LPS treatment in mGluR5 KO neutrophils was dramatically impaired compared with WT neutrophils. Furthermore, LPS induced mGluR5 expression by enhancing p65 binding to mGluR5 upstream promoter element(-779 to-113), which was confirmed by Luciferace and CHIP experiments. These findings demonstrate that induction of mGluR5 by LPS is vital for neutrophils activation, which unveils the inducible functionality of mGluR5 in neutrophils.

关键词： LPS neutrophil,p65 mGluR5

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南京市六合区薄壳山核桃产业现状和发展建议

江苏林业科技 2024年第1期51卷 53-56页

作者：储吴樾刘瑜琛杜佳南京六合平山林场发展有限公司江苏南京210014 南京市六合区农业农村局江苏南京210014

通过对南京市六合区9个街镇薄壳山核桃种植地进行调研,分析了六合全区范围内薄壳山核桃种植情况。针对六合区薄壳山核桃资源发掘利用现状,分析评价六合区栽植薄壳山核桃的有利因素和发展潜力,并结合当前国内研究成果,提供相应的发展建... 详细信息

通过对南京市六合区9个街镇薄壳山核桃种植地进行调研,分析了六合全区范围内薄壳山核桃种植情况。针对六合区薄壳山核桃资源发掘利用现状,分析评价六合区栽植薄壳山核桃的有利因素和发展潜力,并结合当前国内研究成果,提供相应的发展建议。六合区薄壳山核桃种植虽然拥有企业基础及科研优势,但仍面临着经营结构单一,产业发展无规划,基层技术力量薄弱等问题。建议结合市场建立多元化发展目标;以政府为主导做出相应的产业规划,引进资本投资,建立产业链条;科研单位总结推广适用范围广、经济价值高的栽培技术,栽培种植经济适用的新品种。

关键词：薄壳山核桃产业发展苗木种植企业经营调查南京市

补肾活血方治疗股骨头坏死肝肾亏虚证的临床疗效及对骨代谢指标PINP、β-CTX的影响

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中国实验方剂学杂志 2024年第3期30卷 81-89页

作者：刘子嘉李莹崔朋涛王波文张沛刚童伍岳张智辉曹玉举南阳市第二人民医院河南南阳473000 郑州中医骨伤病医院郑州450016 河南中医药大学骨伤学院郑州450002

目的:通过观察补肾活血方治疗股骨头坏死(ONFH)肝肾亏虚证的临床疗效及对血清中骨代谢指标Ⅰ型前胶原N端前肽(PINP)、β胶原降解产物(β-CTX)的影响,从骨代谢的角度探讨其治疗机制。方法:选择郑州中医骨伤病医院2021年12月至2022年9月... 详细信息

目的:通过观察补肾活血方治疗股骨头坏死(ONFH)肝肾亏虚证的临床疗效及对血清中骨代谢指标Ⅰ型前胶原N端前肽(PINP)、β胶原降解产物(β-CTX)的影响,从骨代谢的角度探讨其治疗机制。方法:选择郑州中医骨伤病医院2021年12月至2022年9月符合标准的ONFH肝肾亏虚证患者66例,采取平行对照方法将所有患者随机分为观察组和对照组,每组各33例,观察组口服补肾活血方,对照组口服仙灵骨葆胶囊,治疗周期均为6个月,分别记录治疗前、治疗后的疼痛视觉模拟(VAS)评分、髋关节功能(Harris)评分、国际骨微循环研究协会(ARCO)分期、影像学变化、中医临床症状量化评分、骨代谢指标PINP和β-CTX水平及其他安全指标,记录不良事件及不良反应的发生情况。结果:观察组总有效率为83.87%(26/31),对照组总有效率为68.75%(22/32),观察组总有效率高于对照组(Z=-2.096,P<0.05)。与本组治疗前比较,两组患者中医症候单项及总评分、疼痛VAS评分、β-CTX均降低(P<0.05),与对照组治疗后比较,观察组患者中医症候总评分、疼痛VAS评分、β-CTX降低更明显(P<0.05),但单项证候评分中仅髋部疼痛、下肢活动度、腰膝酸软、下肢痿软无力4项差异有统计学意义(P<0.05),跛行、头晕健忘2项差异无统计学意义。两组患者影像学改善无统计学意义。与本组治疗前比较,两组患者Harris评分、PINP水平均升高(P<0.05),与对照组治疗后比较,观察组患者Harris评分、PINP水平升高更明显(P<0.05)。本次临床观察过程中,未出现严重不良事件及不良反应。结论:补肾活血方治疗ONFH肝肾亏虚证,能有效缓解疼痛,改善髋关节功能和中医临床症状,影像学提示能抑制ONFH发展,实验室检测提示能升高PINP及降低β-CTX骨代谢指标,抑制ONFH进展,临床观察过程中未发生明显不良反应,说明补肾活血方具有良好的安全性。

关键词：补肾活血方股骨头坏死肝肾亏虚证骨代谢右归丸

基于D-P准则三阶段蠕变模型的圆形隧洞黏弹塑性解

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现代隧道技术 2024年第4期61卷 105-111,118页

作者：陈福江赖万松刘金刚佘伍越曾锋高美奔刘国芯西华大学应急管理学院成都610039 四川省交通建设集团有限责任公司成都610039 岩土力学与工程国家重点实验室中国科学院武汉岩土力学研究所武汉430071 国家大坝安全工程技术研究中心武汉430010 “工业固态废弃物土木工程综合开发利用”四川省高校重点实验室攀枝花617000 中铁科学研究院集团有限公司成都610032

围岩的流变特性对隧道结构的长期变形有重要的影响。为了较好地描述圆形隧道开挖后围岩的黏弹塑性力学行为,采用分数阶蠕变模型描述围岩的流变特征,采用Drucker-Prager准则表征围岩的塑性特征,推导圆形隧道开挖后考虑支护支撑效应的围... 详细信息

围岩的流变特性对隧道结构的长期变形有重要的影响。为了较好地描述圆形隧道开挖后围岩的黏弹塑性力学行为,采用分数阶蠕变模型描述围岩的流变特征,采用Drucker-Prager准则表征围岩的塑性特征,推导圆形隧道开挖后考虑支护支撑效应的围岩应力-位移理论解。通过具体算例,分析围岩流变参数对黏弹性塑性变形的影响。结果表明:(1)解析得到的围岩蠕变位移曲线与现场实测结果平均值曲线吻合较好,证明理论推导具有正确性;(2)当考虑黏塑性区围岩的剪胀效应时,围岩的变形值增加。剪胀效应越明显,围岩变形值增加的量值越大;(3)当黏弹性体或黏塑性体的黏性增强时,围岩的蠕变位移量值和速率都会相应增加。

关键词：三阶段蠕变模型 D-P准则深埋隧道黏弹塑性位移解

Visualization of MF/Diesel RCCI Combustion Process and Soot Emission

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Journal of Thermal Science 2024年第2期33卷 779-792页

作者： HUANG Chen NI Xiao GE Dameng LI Song ZHANG Wanzhi liu Jinping ZHANG Tingting School of Mechanical and Electronic Engineering Shandong Agricultural UniversityTaian271018China Shandong Provincial Engineering Laboratory of Agricultural Equipment Intelligence Taian271018China Taian Technician Institute Taian271000China Sinotruk Taian wuyue Special Vehicle Co. Ltd.Taian271000China School of Mechanical Engineering Shaanxi University of TechnologyHanzhong723001China School of Mechanical Engineering Anyang Institute of TechnologyAnyang455000China

Based on the optical engine,the ignition characteristics,combustion process and soot emission characteristics of diesel under different 2-Methylfuran(MF) atmospheres were investigated by high-speed photography and in-cylinder combustion analysis *** results show that at the same main injection timing,the ignition time of reactivity controlled compression ignition(RCCI) combustion mode is earlier than pure diesel combustion,and the ignition point is concentrated near the *** acts as a spark plug to ignite the mixture,but the flame develops slowly in the early stages and the pressure in the cylinder rises *** with pure diesel,RCCI combustion model has smaller peak values of in-cylinder pressure and heat release rate,shorter ignition delay period,earlier combustion phase and shorter combustion *** main spray time at 6℃A BTDC and 12℃A BTDC,with the increase of MF premixing ratio from 0 to 0.75,the peak cylinder pressure decreased by 19.6% and 26% *** addition,with the increase of the MF heat value ratio,the area of KL factor> 1.5 in the combustion chamber decreased and the space integral natural luminescence(SINL) peak value decreased by 48.37%,and the soot formation rate and yield decreased ***,when the MF heat value ratio was too large(75% of the total calorific value),the ignition delay period increased,and misfire occurred at the main injection timing of 0℃A *** RCCI mode of MF/diesel dual fuel has better stability,and better control effect can be obtained at different main inj ection timing.

关键词： 2-methylfuran RCCI visualization two-color method KL factor

Near-Infrared All-Fused-Ring Nonfullerene Acceptors Achieving an Optimal Efficiency-Cost-Stability Balance in Organic Solar Cells

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CCS Chemistry 2023年第3期5卷 654-668页

作者： Wenrui liu Shengjie Xu Hanjian Lai wuyue liu Feng He Xiaozhang Zhu Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Organic Solids Institute of ChemistryChinese Academy of SciencesBeijing 100190 School of Chemical Sciences University of Chinese Academy of SciencesBeijing 100049 Department of Chemistry Shenzhen Grubbs InstituteSouthern University of Science and TechnologyShenzhen 518055

Synergistically achieving stability,cost,and efficiency is crucial for the commercialization of organic solar cells(OSCs).Despite the rapid development of 2-(3-oxo-2,3-dihydro-1H-inden-1-ylidene)malo nonitriletypenon fullerene acceptors(NFAs),they areinherently unstable due to the vulnerable exocyclic double bond and possess high synthesis complexity(SC).Based on the“all-fused-ring electron acceptor(AFAR)”concept,we report two new near-infrared NFAs,F11 and F13,featuring all fused dodecacyclic *** developing a whole set of synthetic procedures,F11 and F13 can be conveniently prepared at a 10 g scale within a notably short period,displaying both the low SC and the lowest costs among reported NFAs,even comparable to the classical photovoltaic material,*** comparison with the one-dimensional stacking of ITYM(ITYM=2,2′-(7,7,15,15-tetrahexyl-7,15-dihydro-s-indaceno[1,2-b:5,6-b′]diindeno[1,2-d]thiophene-2,10(2H)-diylidene)dimalononitrile),the first AFRA,and mixed J-and H-aggregations in Y6,F-acceptors show a compact honeycomb-type three-dimensional stacking with exclusive J-aggregations,favoring multichannel charge *** matching a medium-bandgap polymer donor,F13 delivers greater than 13%power conversion efficiencies,which is the highest performance among non-INCN acceptors,and shows device stability superior to the typical ITIC-and Y6-based OSCs as evidenced by the negligible burn-in *** work presents a first and successful example of NFAs achieving an optimal efficiency-cost-stability balance in OSCs.

关键词： nonfullerene acceptors near-infrared cost stability power conversion efficiency

Design of All-Fused-Ring Electron Acceptors with High Thermal,Chemical,and Photochemical Stability for Organic Photovoltaics

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CCS Chemistry 2021年第6期3卷 1070-1080页

作者： Xiaozhang Zhu Songjun liu Qihui Yue wuyue liu Shaoming Sun Shengjie Xu Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Organic Solids Institute of ChemistryChinese Academy of SciencesBeijing 100190 School of Chemical Sciences University of the Chinese Academy of SciencesBeijing 100190

High-performance donor-acceptor electron acceptors containing 2-(3-oxo-2,3-dihydro-1H-inden-1-ylidene)malononitrile(INCN)-type terminals are labile toward photooxidation and basic conditions,and new molecular designs toward electron acceptors that can achieve both high power conversion efficiencies and high stability are urgently *** replacing the central benzene ring in the classical ladder-type n-type semiconductor,2,2′-(indeno[1,2-b]fluorene-6,12-diylidene)dimalononitrile,with the electron-rich 4,4,9,9-tetrahexyl-4,9-dihydro-s-indaceno[1,2-b:5,6-b′]dithiophene,we report herein the design of 2,2′-(7,7,15,15-tetrahexyl-7,15-dihydro-sindaceno[1,2-b:5,6-b′]diindeno[1,2-d]thiophene-2,10(2H)-diylidene)dimalononitrile(ITYM),a new type of all-fused-ring electron acceptor(AFRA).A threestep reaction including a key Pd-catalyzed double C-H activation/intramolecular cyclization is established for the efficient synthesis of such type of electron *** is confirmed by singlecrystal X-ray analysis,which shows a planar nonacyclic structure with strongπ-π*** with the classical carbon-bridged INCN-type acceptors,ITYM exhibits extraordinary stability with very promising *** AFRA concept opens a new avenue toward high-efficiency and-stability organic photovoltaics(OPVs).

关键词： organic photovoltaics nonfullerene acceptor all-fused-ring design C-H activation stability

腹腔镜膀胱癌根治术后回肠新膀胱与Bricker膀胱远期并发症及生活质量分析

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中华全科医学 2024年第5期22卷 738-741页

作者：刘贝贝郭园园陈梦杰高五岳孙巍王金行蚌埠医科大学第一附属医院泌尿外科安徽蚌埠233004

目的比较分析原位回肠新膀胱术(IN)与Bricker回肠膀胱术(Bricker)术后远期并发症情况与生活质量,为个体化尿流改道方式提供选择依据。方法收集2020年1月—2022年12月蚌埠医科大学第一附属医院泌尿外科收治的行膀胱癌根治术男性患者60例... 详细信息

目的比较分析原位回肠新膀胱术(IN)与Bricker回肠膀胱术(Bricker)术后远期并发症情况与生活质量,为个体化尿流改道方式提供选择依据。方法收集2020年1月—2022年12月蚌埠医科大学第一附属医院泌尿外科收治的行膀胱癌根治术男性患者60例。根据尿流尿道改道方式分为IN组34例和Bricker组26例。分析比较2组术后6个月、12个月的远期并发症情况与患者生活质量。结果2组手术时间与术中出血量差异无统计学意义(P>0.05),IN组术后肠道恢复时间与住院时间长于Bricker组(P0.05),12个月总并发症(19例vs.23例)差异有统计学意义(P0.05),12个月IN组生活质量显著高于Bricker组(142.82±6.42 vs.118.69±9.92,F=11.128,P<0.001)。结论IN对比Bricker具有更少的远期并发症与更高的生活质量,在尿流改道方式的选择中应予着重考虑。

关键词：腹腔镜膀胱癌根治术回肠新膀胱 Bricker回肠膀胱远期并发症生活质量

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自体血凝块技术在输尿管软镜碎石中的应用

中华全科医学 2024年第7期22卷 1121-1124页

作者：高五岳刘贝贝郭园园孙巍王成勇李立强徐亮刘建民蚌埠医科大学第一附属医院泌尿外科安徽蚌埠233004

目的通过在输尿管软镜联合钬激光碎石手术中应用自体血凝块技术的效果比较来评价自体血凝块技术的适用性和安全性。方法收集2022年6月—2024年2月于蚌埠医科大学第一附属医院行输尿管软镜联合钬激光碎石术的65例结石患者资料进行回顾性... 详细信息

目的通过在输尿管软镜联合钬激光碎石手术中应用自体血凝块技术的效果比较来评价自体血凝块技术的适用性和安全性。方法收集2022年6月—2024年2月于蚌埠医科大学第一附属医院行输尿管软镜联合钬激光碎石术的65例结石患者资料进行回顾性分析,按照是否使用自体血凝块技术分为观察组30例、对照组35例。分析并比较2组患者手术时间、术中取石次数、住院时间、术后残留2 mm结石例数、术后残留4 mm结石例数及并发症发生情况等。结果2组患者年龄、性别、BMI、结石数量、结石位置以及累积结石大小差异均无统计学意义(P>0.05)。观察组手术时间[(54.97±7.06)min]较对照组[(68.14±9.75)min]缩短,术中取石次数[(11.50±3.04)次]明显少于对照组[(20.77±3.36)次],术后残留2 mm结石例数(8例)明显少于对照组(22例),差异均有统计学意义(P0.05)。结论输尿管软镜联合钬激光碎石术中使用自体血凝块技术具有良好的适用性及安全性。能够缩短手术时间,减少术中取石次数,提高术后无结石率,使得临床无意义残余结石碎片的发生率最小化,从而可能降低结石复发率。

关键词：自体血凝块残余碎片输尿管软镜无结石率